{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:34:39Z","timestamp":1772735679275,"version":"3.50.1"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFA0208900"],"award-info":[{"award-number":["2018YFA0208900"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","award":["2019JYCXJJ034"],"award-info":[{"award-number":["2019JYCXJJ034"]}],"id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2019CFB483"],"award-info":[{"award-number":["2019CFB483"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900904"],"award-info":[{"award-number":["31900904"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2021,8,24]]},"DOI":"10.1021\/acsnano.1c03083","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T07:39:49Z","timestamp":1627025989000},"page":"13319-13328","source":"Crossref","is-referenced-by-count":10,"title":["Hierarchical Vitalization of Oligotyrosine in Mitigating Islet Amyloid Polypeptide Amyloidogenesis through Multivalent Macromolecules with Conformation-Restrained Nanobody Ligands"],"prefix":"10.1021","volume":"15","author":[{"given":"Yanru","family":"Xin","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichuan","family":"Ke","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidan","family":"Tian","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujuan","family":"Cao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanda","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhu","family":"Shang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangliang","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-7312","authenticated-orcid":true,"given":"Fanling","family":"Meng","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-1866","authenticated-orcid":true,"given":"Liang","family":"Luo","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China"},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00042.2009"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.23.8628"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.39.5.634"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.11.3881"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5036"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406847102"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05367.x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3422"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0442-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31823e46ef"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1185-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0802893"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3109\/2000-1967-113"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201502317"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b11078"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.05.001"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.062"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100937"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2046327"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1930-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bi100939a"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01384"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/ja072157y"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ja1046186"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56500-0"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.0c00416"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c01234"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.8b00797"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/78682"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802979"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jp1116728"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/bi100773g"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/bi902075h"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.01.029"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906908"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00318"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/bm401795e"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acscombsci.6b00116"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1413"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-822"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111232108"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.682336"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208797109"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/ja501102f"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00289"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708536200"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0734"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2018.11.012"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0405"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0037"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02771"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11762-0"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b02446"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.1c03083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T22:12:04Z","timestamp":1682460724000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.1c03083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,24]]}},"alternative-id":["10.1021\/acsnano.1c03083"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.1c03083","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]}}}