{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T16:20:23Z","timestamp":1794500423988,"version":"4.9.1"},"reference-count":239,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2320-B-001-004-MY3"],"award-info":[{"award-number":["MOST 107-2320-B-001-004-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2021,9,28]]},"DOI":"10.1021\/acsnano.1c05922","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T14:00:57Z","timestamp":1630504857000},"page":"14022-14048","source":"Crossref","is-referenced-by-count":590,"title":["Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies"],"prefix":"10.1021","volume":"15","author":[{"given":"Bing-Mae","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-4731","authenticated-orcid":true,"given":"Tian-Lu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Center for Biomarkers and Biotech Drugs, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-7295","authenticated-orcid":true,"given":"Steve R.","family":"Roffler","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03575-0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.19"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2035343"},{"key":"ref4\/cit4","unstructured":"Trafton, A. Explained: Why RNA Vaccines for Covid-19 Raced to the Front of the Pack.\n                      MIT News\n                      , Dec 11, 2020. https:\/\/news.mit.edu\/2020\/rna-vaccines-explained-covid-19-1211 (accessed Aug 13, 2021)."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1169"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/ar4500"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22739"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02439"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.08.015"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1339"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.025"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.09.012"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/bc200478w"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.040"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/14686996.2019.1627174"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.024"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bc980143z"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/bc050133f"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/bc100067t"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03614"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03109"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00622-4"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22164"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b07218"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12010015"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.071977"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.08.032"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0151"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05661"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah6228"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15507"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00323A"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.029"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-020-00752-w"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1088\/1367-2630\/1\/1\/006"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21482"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.11813"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab314"},{"key":"ref39\/cit39","first-page":"556A","volume":"102","author":"Armstrong J.","year":"2003","journal-title":"Blood"},{"key":"ref40\/cit40","first-page":"559A","volume":"102","author":"Fisher T.","year":"2003","journal-title":"Blood"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03437"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nri2901"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700943"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-275859"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-0971-z"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.06.001"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nri3383"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1159\/000233512"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2004.06.005"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/art.22403"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2011.07.003"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.10.034"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.4155\/bio.15.36"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-016-1961-x"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.258525"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.016"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5373.96"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030150"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.004"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055605"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001001"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80029-6"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.07.009"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090248"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.023"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.4.513"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac4919"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.032"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.001"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80029-1"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141107"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2511"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.198"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.04.003"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/nri799"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737210"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/nri2572"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/ni829"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032000"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1914"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2194"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00366"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01769-6"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-004-1204-7"},{"issue":"1","key":"ref85\/cit85","first-page":"S29","volume":"17","author":"Ryff J. C.","year":"1997","journal-title":"J. Interferon Cytokine Res."},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80075-3"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/nrd818"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208024"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516437"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2003.11.016"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1177\/2040620712464509"},{"key":"ref92\/cit92","unstructured":"Kaushal, M.; George, B. STN: 125661\/0 As an Original Biologics License Application (BLA) Submitted for the Recombinant B-Domain Deleted (BDD) Human Coagulation Factor VIII (rFVIII) Product Conjugated with a 60 kDa Branched Polyethylene Glycol (PEG), 2018. https:\/\/www.fda.gov\/media\/116354\/download (accessed Aug 13, 2021)."},{"key":"ref93\/cit93","unstructured":"Bouchkouj, N.; George, B. STN: 125671\/0 As an Original Biologics license Application (BLA) Submitted for N8-GP, 2019. https:\/\/www.fda.gov\/media\/129160\/download (accessed Aug 13, 2021)."},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.3109\/10428199309149129"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-8-991"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1186\/ar1861"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1186\/ar4497"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61841-3"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.10.038"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00144"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.01.015"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.6.9194525"},{"key":"ref103\/cit103","first-page":"171","volume":"122","author":"De Groot A. S.","year":"2005","journal-title":"Dev. Biol. (Basel)"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014739108"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.041"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15660"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.01.005"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.08.001"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.078113"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00562"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.08.274"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2015.06.005"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.12.011"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.08.017"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b03942"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.050"},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4049\/jimmunol.143.4.1239","volume":"143","author":"Dintzis R. Z.","year":"1989","journal-title":"J. Immunol."},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.02.029"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.06.007"},{"key":"ref120\/cit120","first-page":"607","volume":"298","author":"Laverman P.","year":"2001","journal-title":"J. Pharm. Exp. Ther."},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.07.049"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.12.0011"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.08.030"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.11.015"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.09.047"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S41701"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23254"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7232"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(97)00178-6"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(00)00178-4"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.01.012"},{"key":"ref132\/cit132","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2007.179"},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068810"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1081"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1021\/jm900730r"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1021\/jm8014316"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2015.0575"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1955"},{"key":"ref139\/cit139","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.03.023"},{"key":"ref140\/cit140","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007657109012"},{"key":"ref141\/cit141","doi-asserted-by":"publisher","DOI":"10.1161\/circ.116.suppl_16.II_724"},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V120.21.2207.2207"},{"key":"ref143\/cit143","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V120.21.1104.1104"},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.205930"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv459"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2014.32"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)81016-H"},{"key":"ref148\/cit148","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"ref149\/cit149","doi-asserted-by":"publisher","DOI":"10.1021\/bi00063a030"},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0591-y"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18136"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9348-7"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11525"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0918-777"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1480"},{"key":"ref156\/cit156","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.1126\/science.371.6524.10"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1021\/bc990147j"},{"key":"ref159\/cit159","first-page":"1071","volume":"292","author":"Dams E. T.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-009-9943-x"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.02.006"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.07.019"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.06.004"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22682"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.04.049"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.08.022"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.11.016"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.06.002"},{"key":"ref169\/cit169","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.05.010"},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.110973"},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.727"},{"key":"ref172\/cit172","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868080-00009"},{"key":"ref173\/cit173","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba6322"},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1007\/s002620000120"},{"key":"ref175\/cit175","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314526475"},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050396"},{"key":"ref177\/cit177","doi-asserted-by":"crossref","unstructured":"Chang, T. C.; Chen, B. M.; Cheng, T. L.; Roffler, S. R. Affinity of Anti-PEG Antibodies Determines Accelerated Blood Clearance of Pegylated Epoetin Beta in Mice. Manuscript in preparation, 2021.","DOI":"10.1016\/j.biopha.2021.112502"},{"key":"ref178\/cit178","first-page":"37","volume":"10","author":"Sroda K.","year":"2005","journal-title":"Cell Mol. Biol. Lett."},{"key":"ref179\/cit179","volume-title":"The Immune Response: Basic and Clinical Principles","author":"Mak T. W.","year":"2005"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(86)90168-4"},{"key":"ref181\/cit181","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.4049\/jimmunol.100.6.1145","volume":"100","author":"Ishizaka T.","year":"1968","journal-title":"J. Immunol."},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248943"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)04004-2"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.07.008"},{"key":"ref185\/cit185","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.04.040186.002443"},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.08.276"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00653"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.02.019"},{"key":"ref189\/cit189","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071700"},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b01235"},{"key":"ref191\/cit191","first-page":"25","volume-title":"Liposome Technology","author":"Barenholz Y.","year":"2016"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4007"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01336-6"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1007\/BF02737644"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.09.014"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg374"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.06.038"},{"key":"ref198\/cit198","volume-title":"BioMarin PALYNZIQ","year":"2018"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26200"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1177\/1043454217741868"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26873"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs232"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00515-2"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.058"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70761-X"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(92)70454-4"},{"key":"ref207\/cit207","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70150-5"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-09-00176"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1177\/0091270012447122"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2015.13.1.90"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12760"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2016.1218467"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1400883"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.06.017"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2011.06.003"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.08.009"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0064"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.258012"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.12.003"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.11.011"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.033"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.06.003"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aan5997"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00147"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.1021\/bc200551b"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.07.014"},{"key":"ref227\/cit227","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.04.023"},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23823"},{"key":"ref229\/cit229","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0589-7"},{"key":"ref230\/cit230","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-020-00369-y"},{"key":"ref231\/cit231","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2942"},{"key":"ref232\/cit232","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321126111"},{"key":"ref233\/cit233","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzv041"},{"key":"ref234\/cit234","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12537"},{"key":"ref235\/cit235","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzt023"},{"key":"ref236\/cit236","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200901607"},{"key":"ref237\/cit237","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2012.08.001"},{"key":"ref238\/cit238","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1588"},{"key":"ref239\/cit239","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201379"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.1c05922","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.1c05922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:15:21Z","timestamp":1682644521000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.1c05922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":239,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9,28]]}},"alternative-id":["10.1021\/acsnano.1c05922"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.1c05922","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acsnano.1c05922.s001","asserted-by":"subject"}]},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,1]]}}}