{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:23:59Z","timestamp":1793881439541,"version":"4.7.0"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81620108017"],"award-info":[{"award-number":["81620108017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071977"],"award-info":[{"award-number":["82071977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92059104"],"award-info":[{"award-number":["92059104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2018YFC0910600"],"award-info":[{"award-number":["2018YFC0910600"]}]},{"name":"COVID-19 Emerging Prevention Products, Research Special Fund of Zhuhai City","award":["ZH22036302200024PWC"],"award-info":[{"award-number":["ZH22036302200024PWC"]}]},{"name":"High-level Health Team of Zhuhai","award":["ZH22036302200024PWC"],"award-info":[{"award-number":["ZH22036302200024PWC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2021,12,28]]},"DOI":"10.1021\/acsnano.1c07112","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T11:44:55Z","timestamp":1636112695000},"page":"19138-19149","source":"Crossref","is-referenced-by-count":31,"title":["Molecular Imaging of Collagen Destruction of the Spine"],"prefix":"10.1021","volume":"15","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"},{"name":"Department of Spine Surgery, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongmao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Radiology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-1390","authenticated-orcid":true,"given":"Hong","family":"Shan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"},{"name":"Department of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4729-7860","authenticated-orcid":true,"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30480-X"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30970-9"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137836"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2010.01045.x"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2320-6"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200109010-00011"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.03.028"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-062117-120924"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.06.004"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-020-00125-x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.199"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14913"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.160"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/89126"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.009"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1129"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.11.1462"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1042\/bj2470725"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600318"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209721109"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba2795"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.039"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1201-1148"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0049-z"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-0033(98)00105-3"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23634"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b03150"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8994-2_16"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-018-0040-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200206150-00008"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.11.019"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1014"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201404930"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ja807099s"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1041"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2116"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201502287"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2012.02.027"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119520"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/art.38957"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.06.006"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-016-1038-6"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.036012"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00070"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406182"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1042\/bj1570267"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2009.07.002"},{"key":"ref48\/cit48","first-page":"89","volume-title":"Biomechanics of the Spine","author":"Malandrino A.","year":"2018"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101432"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01322.2013"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118884"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23195"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/jsp2.1126"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.2.S26"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00009"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.1c07112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:13:11Z","timestamp":1681690391000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.1c07112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,28]]}},"alternative-id":["10.1021\/acsnano.1c07112"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.1c07112","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]}}}