{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T17:49:59Z","timestamp":1794505799928,"version":"4.9.1"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61625404"],"award-info":[{"award-number":["61625404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61888102"],"award-info":[{"award-number":["61888102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62174152"],"award-info":[{"award-number":["62174152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foshan Innovative and Entrepreneurial Research Team Program","award":["2018IT100031"],"award-info":[{"award-number":["2018IT100031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dental diseases resulting from movement disorders and volatile gases are very common. The classic method for detecting occlusal force is effective; however, its function is one-time rather than real-time monitoring, and the technology is very time-consuming. Herein, we report a multifunctional, flexible, and degradable bacterial cellulose\/Ti3C2Tx MXene bioaerogel for the accurate detection of occlusal force and early diagnosis of periodontal diseases. Combining the mechanical properties of MXene and the abundant functional groups of bacterial cellulose, 3D porous bioaerogels exhibit both pressure-sensitive and ammonia (NH3)-sensitive responses. By integrating these substances into a flexible array, the resulting device can distinguish the intensity, location, and even the time sequence of the occlusion force; moreover, it can provide NH3 gas and occlusion force response signals. Therefore, this technology is promising for both disease diagnosis and oral health. In addition, the introduction of a renewable biomaterial allows the bioaerogel to degrade completely using a low-concentration hydrogen peroxide solution, making the device environmentally friendly and satisfying the demands for sustainable development.<\/jats:p>","DOI":"10.1021\/acsnano.1c07891","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T12:49:24Z","timestamp":1636116564000},"page":"18385-18393","source":"Crossref","is-referenced-by-count":117,"title":["Assessment\nof Occlusal Force and Local Gas Release\nUsing Degradable Bacterial Cellulose\/Ti3C2T\n                    <i>x<\/i>\n                    MXene Bioaerogel for Oral Healthcare"],"prefix":"10.1021","volume":"15","author":[{"given":"Xiujuan","family":"Jin","sequence":"first","affiliation":[{"name":"Henan University of Science and Technology , , ,","place":["Luoyang, China, 471023"]},{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Li","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufang","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Henan University of Science and Technology , , ,","place":["Luoyang, China, 471023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Chinese PLA , , ,","place":["Beijing, China, 100853"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Shen","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100083"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"2026081810254236500_cit1","doi-asserted-by":"publisher","first-page":"1703257","DOI":"10.1002\/adma.201703257","article-title":"Functional,\nRF-Trilayer Sensors for Tooth-Mounted, Wireless Monitoring of the\nOral Cavity and Food Consumption","volume":"30","author":"Tseng","year":"2018","journal-title":"Adv. Mater."},{"key":"2026081810254236500_cit2","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1039\/C7LC00810D","article-title":"Toward Breath Analysis\non a Chip for Disease Diagnosis\nUsing Cemiconductor-Based Chemiresistors: Recent Progress and Future\nPerspectives","volume":"17","author":"Yoon","year":"2017","journal-title":"Lab Chip"},{"key":"2026081810254236500_cit3","doi-asserted-by":"publisher","first-page":"100592","DOI":"10.1016\/j.eml.2019.100592","article-title":"Soft Sensor\nfor Full Dentition Dynamic Bite Force","volume":"34","author":"Cheng","year":"2020","journal-title":"Extreme\nMech. Lett."},{"key":"2026081810254236500_cit4","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.3390\/s20143953","article-title":"Development of a\nDental Implantable Temperature Sensor for Real-Time Diagnosis of Infectious\nDisease","volume":"20","author":"Kim","year":"2020","journal-title":"Sensors"},{"key":"2026081810254236500_cit5","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/ncomms1767","article-title":"Graphene-Based Wireless\nBacteria Detection on Tooth Enamel","volume":"3","author":"Mannoor","year":"2012","journal-title":"Nat. Commun."},{"key":"2026081810254236500_cit6","doi-asserted-by":"publisher","first-page":"2000060","DOI":"10.1002\/adma.202000060","article-title":"A Transparent, Wearable\nFluorescent Mouthguard for\nHigh-Sensitive Visualization and Accurate Localization of Hidden Dental\nLesion Sites","volume":"32","author":"Li","year":"2020","journal-title":"Adv. Mater."},{"key":"2026081810254236500_cit7","doi-asserted-by":"publisher","first-page":"7671","DOI":"10.1038\/s41598-021-87252-5","article-title":"A Lower Maximum Bite\nForce Is a Risk Factor for Developing Cardiovascular Disease: The\nSuita Study","volume":"11","author":"Hashimoto","year":"2021","journal-title":"Sci. Rep."},{"key":"2026081810254236500_cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04191-1","article-title":"Comparison of Two Different\nDigital\nOcclusal Analysis Methods","author":"Bostancioglu","year":"2021","journal-title":"Clin. Oral. Invest."},{"key":"2026081810254236500_cit9","doi-asserted-by":"publisher","first-page":"105921","DOI":"10.1016\/j.nanoen.2021.105921","article-title":"Highly-Stable\nPolymer-Crosslinked 2D MXene-Based Flexible Biocompatible\nElectronic Skins for in Vivo Biomonitoring","volume":"84","author":"Zhao","year":"2021","journal-title":"Nano Energy"},{"key":"2026081810254236500_cit10","doi-asserted-by":"publisher","first-page":"7229","DOI":"10.1039\/D0CS00022A","article-title":"MXene Hydrogels: Fundamentals and\nApplications","volume":"49","author":"Zhang","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"2026081810254236500_cit11","doi-asserted-by":"publisher","first-page":"2010533","DOI":"10.1002\/adfm.202010533","article-title":"Controlled Assembly\nof MXene Nanosheets as an Electrode and Active Layer for High-Performance\nElectronic Skin","volume":"31","author":"Fu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026081810254236500_cit12","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1021\/acsnano.0c07998","article-title":"Ti3C2Tx MXene-Activated Fast Gelation of\nStretchable and Self-Healing Hydrogels: A Molecular Approach","volume":"15","author":"Ge","year":"2021","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit13","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1021\/acsnano.7b07460","article-title":"Metallic Ti3C2Tx MXene Gas Sensors with Ultrahigh Signal-to-Noise Ratio","volume":"12","author":"Kim","year":"2018","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit14","doi-asserted-by":"publisher","first-page":"2101378","DOI":"10.1002\/adfm.202101378","article-title":"A Moisture-Driven\nActuator Based on Polydopamine-Modified MXene\/Bacterial Cellulose\nNanofiber Composite Film","volume":"31","author":"Yang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026081810254236500_cit15","doi-asserted-by":"publisher","first-page":"8439","DOI":"10.1021\/acsnano.0c10666","article-title":"Ultrathin,\nStrong, and Highly Flexible\nTi3C2Tx MXene\/Bacterial Cellulose Composite\nFilms for High-Performance Electromagnetic Interference Shielding","volume":"15","author":"Wan","year":"2021","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit16","doi-asserted-by":"publisher","first-page":"126438","DOI":"10.1016\/j.cej.2020.126438","article-title":"Wearable, Ultrathin and Transparent\nBacterial Celluloses\/MXene Film with Janus Structure and Excellent\nMechanical Property for Electromagnetic Interference Shielding","volume":"403","author":"Ma","year":"2021","journal-title":"Chem. Eng. J."},{"key":"2026081810254236500_cit17","doi-asserted-by":"publisher","first-page":"2038560","DOI":"10.34133\/2020\/2038560","article-title":"Highly\nStretchable, Elastic, and Sensitive MXene-Based Hydrogel for Flexible\nStrain and Pressure Sensors","volume":"2020","author":"Lu","year":"2020","journal-title":"Research"},{"key":"2026081810254236500_cit18","doi-asserted-by":"publisher","first-page":"105252","DOI":"10.1016\/j.nanoen.2020.105252","article-title":"Biomimetic,\nBiocompatible and Robust Silk Fibroin-MXene Film with Stable 3D Cross-Link\nStructure for Flexible Pressure Sensors","volume":"78","author":"Wang","year":"2020","journal-title":"Nano\nEnergy"},{"key":"2026081810254236500_cit19","doi-asserted-by":"publisher","first-page":"8716847","DOI":"10.34133\/2020\/8716847","article-title":"Biocompatible\nand Biodegradable Functional Polysaccharides for Flexible Humidity\nSensors","volume":"2020","author":"Wang","year":"2020","journal-title":"Research"},{"key":"2026081810254236500_cit20","doi-asserted-by":"publisher","first-page":"106151","DOI":"10.1016\/j.nanoen.2021.106151","article-title":"MXene\/Cellulose\nNanofiber-Foam Based High Performance Degradable Piezoresistive Sensor\nwith Greatly Expanded Interlayer Distances","volume":"87","author":"Su","year":"2021","journal-title":"Nano Energy"},{"key":"2026081810254236500_cit21","doi-asserted-by":"publisher","first-page":"2000872","DOI":"10.1002\/adhm.202000872","article-title":"Biodegradable\nand Electroactive\nRegenerated Bacterial Cellulose\/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating\nSkin Wound Healing under Electrical Stimulation","volume":"9","author":"Mao","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"2026081810254236500_cit22","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1021\/acsnano.8b00997","article-title":"Binary Strengthening and Toughening of MXene\/Cellulose\nNanofibers Composite Paper with Nacre-Inspired Structure and Superior\nElectromagnetic Interference Shielding Properties","volume":"12","author":"Cao","year":"2018","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit23","doi-asserted-by":"publisher","first-page":"9139","DOI":"10.1021\/acsnano.9b03454","article-title":"Bioinspired Interlocked Structure-Induced\nHigh Deformability for Two-Dimensional Titanium Carbide (MXene)\/Natural\nMicrocapsule-Based Flexible Pressure Sensors","volume":"13","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.nanoen.2017.05.024","article-title":"Ultrasensitive and\nUltraflexible E-Skins with Dual Functionalities for Wearable Electronics","volume":"38","author":"Lou","year":"2017","journal-title":"Nano Energy"},{"key":"2026081810254236500_cit25","doi-asserted-by":"publisher","first-page":"16033","DOI":"10.1021\/acs.analchem.0c03664","article-title":"Humidity-Enabled\nIonic\nConductive Trace Carbon Dioxide Sensing of Nitrogen-Doped Ti3C2Tx MXene\/Polyethyleneimine Composite Films\nDecorated with Reduced Graphene Oxide Nanosheets","volume":"92","author":"Zhou","year":"2020","journal-title":"Anal. Chem."},{"key":"2026081810254236500_cit26","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/inf2.12032","article-title":"High-Performance\nFlexible Sensing Devices Based on Polyaniline\/MXene Nanocomposites","volume":"1","author":"Zhao","year":"2019","journal-title":"InfoMat"},{"key":"2026081810254236500_cit27","doi-asserted-by":"publisher","first-page":"129647","DOI":"10.1016\/j.snb.2021.129647","article-title":"Wearable and Flexible\nBacterial Cellulose\/Polyaniline Ammonia Sensor Based on a Synergistic\nDoping Strategy","volume":"334","author":"Yang","year":"2021","journal-title":"Sens. Actuators, B"},{"key":"2026081810254236500_cit28","doi-asserted-by":"publisher","first-page":"9332","DOI":"10.1021\/acsnano.9b03971","article-title":"Continuous\nMeter-Scale Synthesis of Wearable Tunicate\nCellulose\/Carbon Nanotube Fibers for High-Performance Wearable Sensors","volume":"13","author":"Cho","year":"2019","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit29","doi-asserted-by":"publisher","first-page":"45987","DOI":"10.1021\/acsami.1c12991","article-title":"Flexible Ti3C2Tx MXene\/PANI\/Bacterial Cellulose\nAerogel for E-Skins and Gas Sensing","volume":"13","author":"Zhi","year":"2021","journal-title":"ACS Appl.\nMater. Interfaces"},{"key":"2026081810254236500_cit30","doi-asserted-by":"publisher","first-page":"12071","DOI":"10.1021\/acsanm.0c02577","article-title":"Polymeric Ti3C2Tx MXene Composites\nfor Room Temperature Ammonia Sensing","volume":"3","author":"Jin","year":"2020","journal-title":"ACS Appl.\nNano Mater."},{"key":"2026081810254236500_cit31","doi-asserted-by":"publisher","first-page":"37184","DOI":"10.1021\/acsami.7b11055","article-title":"Room Temperature\nGas Sensing of Two-Dimensional Titanium\nCarbide (MXene)","volume":"9","author":"Lee","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026081810254236500_cit32","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1021\/acssensors.9b01308","article-title":"Ti3C2 MXene-Based Sensors with High Selectivity\nfor NH3 Detection at Room Temperature","volume":"4","author":"Wu","year":"2019","journal-title":"ACS Sens."},{"key":"2026081810254236500_cit33","doi-asserted-by":"publisher","first-page":"1804583","DOI":"10.1002\/adma.201804583","article-title":"Grain-Boundary-Induced Drastic Sensing Performance Enhancement of\nPolycrystalline-Microwire Printed Gas Sensors","volume":"31","author":"Wang","year":"2019","journal-title":"Adv. Mater."},{"key":"2026081810254236500_cit34","doi-asserted-by":"publisher","first-page":"2102302","DOI":"10.1002\/adma.202102302","article-title":"A Bioresorbable\nDynamic Pressure Sensor for Cardiovascular Postoperative Care","volume":"33","author":"Ouyang","year":"2021","journal-title":"Adv. Mater."},{"key":"2026081810254236500_cit35","doi-asserted-by":"publisher","first-page":"8157","DOI":"10.1002\/anie.202014852","article-title":"Biodegradable Charge-Transfer\nComplexes for Glutathione Depletion Induced Ferroptosis and NIR-II\nPhotoacoustic Imaging Guided Cancer Photothermal Therapy","volume":"60","author":"Ou","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081810254236500_cit36","doi-asserted-by":"publisher","first-page":"9746","DOI":"10.1021\/acsnano.1c00472","article-title":"Breathable\nTi3C2Tx MXene\/Protein Nanocomposites for Ultrasensitive\nMedical Pressure Sensor with Degradability in Solvents","volume":"15","author":"Chao","year":"2021","journal-title":"ACS Nano"},{"key":"2026081810254236500_cit37","doi-asserted-by":"publisher","DOI":"10.1088\/1674-4926\/41\/4\/041605","article-title":"Nanofiber\/Nanowires-Based Flexible\nand Stretchable Sensors","volume":"41","author":"Wang","year":"2020","journal-title":"J. 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