{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:23:25Z","timestamp":1793226205928,"version":"4.5.0"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2018YFA0209800"],"award-info":[{"award-number":["2018YFA0209800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M662483"],"award-info":[{"award-number":["2019M662483"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800841"],"award-info":[{"award-number":["31800841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071388"],"award-info":[{"award-number":["32071388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101152"],"award-info":[{"award-number":["32101152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51803049"],"award-info":[{"award-number":["51803049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2004171"],"award-info":[{"award-number":["U2004171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Science & Technology Innovation Talents in Universities of Henan Province","award":["21HASTIT033"],"award-info":[{"award-number":["21HASTIT033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2022,4,26]]},"DOI":"10.1021\/acsnano.2c00320","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:59:18Z","timestamp":1648648758000},"page":"6293-6308","source":"Crossref","is-referenced-by-count":108,"title":["Brain-Targeted Codelivery of Bcl-2\/Bcl-xl and Mcl-1 Inhibitors by Biomimetic Nanoparticles for Orthotopic Glioblastoma Therapy"],"prefix":"10.1021","volume":"16","author":[{"given":"Wenya","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Morsch","sequence":"additional","affiliation":[{"name":"Center for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-0040","authenticated-orcid":true,"given":"Fawad Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-1062","authenticated-orcid":true,"given":"Meng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Chung","sequence":"additional","affiliation":[{"name":"Center for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zou","sequence":"additional","affiliation":[{"name":"Center for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1043-3163","authenticated-orcid":true,"given":"Bingyang","family":"Shi","sequence":"additional","affiliation":[{"name":"Center for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0177-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30990-5"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.024"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02249"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02509"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89587"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9717"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00984-9"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1448-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0089-8"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3722"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-010-0709-x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0144"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210220"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/150845"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1407-6"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7403747"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1356286"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5836"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12445"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1030638"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7898"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3090"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.259"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-13-0650"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082137"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113038"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07551-w"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.01.076"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14773"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9257"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25802-0"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3993"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0928"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.561"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15838-0"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09263"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.413"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/chemosensors8040117"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210149"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2019.02.005"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201803717"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05265"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b04683"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/bi036208p"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1222742110"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1356286"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913615107"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.02.007"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0955"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030621"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106634108"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr03064d"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.10.006"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.243"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/ar2003336"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0600-4"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210003"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08133"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V108.11.1107.1107"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.15761\/ICST.1000109"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3727\/000000003772462298"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00691"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01070"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00448-0"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24093"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.10"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.2c00320","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.2c00320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T12:03:09Z","timestamp":1682596989000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.2c00320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,26]]}},"alternative-id":["10.1021\/acsnano.2c00320"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.2c00320","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,30]]}}}