{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:28:01Z","timestamp":1787315281914,"version":"build-2736575974"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100001243","name":"Micron Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-OFLCG18May-0023"],"award-info":[{"award-number":["MOH-OFLCG18May-0023"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-OFLCG18May-0028"],"award-info":[{"award-number":["MOH-OFLCG18May-0028"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["MOE2019-T2-1-115"],"award-info":[{"award-number":["MOE2019-T2-1-115"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["R-397-000-333-114"],"award-info":[{"award-number":["R-397-000-333-114"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["AISG-GC-2019-002"],"award-info":[{"award-number":["AISG-GC-2019-002"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["NRF-CRP-2017-05"],"award-info":[{"award-number":["NRF-CRP-2017-05"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001463","name":"Ministry of Defence, Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001463","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sun Life Singapore"},{"name":"Yong Loo Lin School of Medicine","award":["R-719-000-037-733"],"award-info":[{"award-number":["R-719-000-037-733"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2022,9,27]]},"DOI":"10.1021\/acsnano.2c06366","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T16:19:10Z","timestamp":1660753150000},"page":"15141-15154","source":"Crossref","is-referenced-by-count":17,"title":["IDentif.AI-Omicron: Harnessing an AI-Derived and Disease-Agnostic Platform to Pinpoint Combinatorial Therapies for Clinically Actionable Anti-SARS-CoV-2 Intervention"],"prefix":"10.1021","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-7611","authenticated-orcid":true,"given":"Agata","family":"Blasiak","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"},{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-4437","authenticated-orcid":true,"given":"Anh T. L.","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4925-1738","authenticated-orcid":true,"given":"Peter","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissa","family":"Hooi","sequence":"additional","affiliation":[{"name":"Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De Hoe","family":"Chye","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Bei","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-4528","authenticated-orcid":true,"given":"Kui","family":"You","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-7933","authenticated-orcid":true,"given":"Alexandria","family":"Remus","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-1258","authenticated-orcid":true,"given":"David Michael","family":"Allen","sequence":"additional","affiliation":[{"name":"Infectious Diseases Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 117545, Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore"},{"name":"Division of Infectious Disease, Department of Medicine, National University Hospital, 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis Yi Ann","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore"},{"name":"Division of Infectious Disease, Department of Medicine, National University Hospital, 119074, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad E.Z.","family":"Chan","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, 117510, Singapore"},{"name":"National Centre for Infectious Diseases (NCID), Jalan Tan Tock Seng, 308442, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C. B.","family":"Lye","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore"},{"name":"National Centre for Infectious Diseases (NCID), Jalan Tan Tock Seng, 308442, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore"},{"name":"Department of Infectious Diseases, Tan Tock Seng Hospital, 308433, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gek-Yen G.","family":"Tan","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley G. K.","family":"Seah","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Kai-Hua","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"},{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore"},{"name":"Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, 117583, Singapore"},{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02395-21"},{"key":"ref2\/cit2","unstructured":"Laday, J. Sotrovimab No Longer Authorized to Treat COVID-19 in Areas with High BA.2 Frequency.\n                      Healio\n                      . https:\/\/www.healio.com\/news\/rheumatology\/20220325\/sotrovimab-no-longer-authorized-to-treat-covid19-in-areas-with-high-ba2-frequency (accessed 2022-04-23)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2202160"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-00823-y"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1588371\/v3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2021.05.008"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c01835"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.09.011"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c03152"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00060"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ar200023x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-073009-100847"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0133"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b02774"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz3023"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000034"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/aisy.202000070"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500439"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06174"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10196"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-022-00627-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04482-x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-022-01692-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118542"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b00638"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600812113"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0941"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1177\/108705719900400206"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26239-2"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab361"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103595"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103663"},{"key":"ref33\/cit33","unstructured":"Coronavirus (COVID-19) Update: FDA Authorizes\nAdditional Oral Antiviral\nfor Treatment of COVID-19 in Certain Adults. U.S.\nFood and Drug Administration. https:\/\/www.fda.gov\/news-events\/press-announcements\/coronavirus-covid-19-update-fda-authorizes-additional-oral-antiviral-treatment-covid-19-certain (accessed 2022-03-25)."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116044"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00651-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101992"},{"key":"ref37\/cit37","unstructured":"Schmidt, C. There Are Few Good COVID Antivirals, but That Could Be Changing.\n                      Scientific American\n                      , July 15, 2021. https:\/\/www.scientificamerican.com\/article\/there-are-few-good-covid-antivirals-but-that-could-be-changing\/ (accessed 2022-03-17)."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-20900-6"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00665"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00659-21"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-022-00618-w"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv522"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9061306"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abm3410"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-00919-5"},{"key":"ref46\/cit46","unstructured":"Emergency Use Authorization (EUA) for Paxlovid\n(Nirmatrelvir Tablets\nPackaged with Ritonavir Tablets). U.S. Food and Drug\nAdministration. https:\/\/www.fda.gov\/media\/155194\/download (accessed 2022-03-15)."},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02657-X"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-5-88"},{"key":"ref49\/cit49","unstructured":"O\u2019Connor, J. B. W. Atea Pharmaceuticals Highlights Strategic Priorities for 2022. https:\/\/ir.ateapharma.com\/news-releases\/news-release-details\/atea-pharmaceuticals-highlights-strategic-priorities-2022 (accessed 2022-03-19)."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03347-21"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12020"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nature02145"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2713"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2022.01.004"},{"issue":"2","key":"ref55\/cit55","first-page":"49","volume":"33","author":"Farrance I.","year":"2012","journal-title":"Clin. Biochem. Rev."},{"key":"ref56\/cit56","unstructured":"Fact Sheet for Healthcare Providers: Emergency Use Authorization\nfor Lagevrio (Molnupiravir) Capsules\n                      . U.S. Food and Drug\nAdministration. https:\/\/www.fda.gov\/media\/155054\/download (accessed 2022-03-20)."},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01201-19"},{"key":"ref58\/cit58","unstructured":"Report on the Deliberation Results - Favipiravir\n                      . Pharmacueticals\nand Medical Devices Agency. https:\/\/www.pmda.go.jp\/files\/000210319.pdf (accessed 2022-03-15)."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01947-16"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.2c06366","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.2c06366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T15:28:11Z","timestamp":1682522891000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.2c06366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,27]]}},"alternative-id":["10.1021\/acsnano.2c06366"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.2c06366","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]}}}