{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:54:20Z","timestamp":1784573660013,"version":"3.55.0"},"reference-count":97,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004080","name":"Korea Drug Development Fund","doi-asserted-by":"publisher","award":["HN22C0632"],"award-info":[{"award-number":["HN22C0632"]}],"id":[{"id":"10.13039\/501100004080","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019M2D2A1A01058210"],"award-info":[{"award-number":["NRF-2019M2D2A1A01058210"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1C1C1009000"],"award-info":[{"award-number":["NRF-2020R1C1C1009000"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021M2E8A1039564"],"award-info":[{"award-number":["NRF-2021M2E8A1039564"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A6A1A03063039"],"award-info":[{"award-number":["NRF-2022R1A6A1A03063039"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003662","name":"Korea Evaluation Institute of Industrial Technology","doi-asserted-by":"publisher","award":["20018522"],"award-info":[{"award-number":["20018522"]}],"id":[{"id":"10.13039\/501100003662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2023,3,14]]},"DOI":"10.1021\/acsnano.2c08898","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T11:45:54Z","timestamp":1675683954000},"page":"4327-4345","source":"Crossref","is-referenced-by-count":74,"title":["Development of Spleen Targeting H<sub>2<\/sub>S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease"],"prefix":"10.1021","volume":"17","author":[{"given":"Chiwoo","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooseung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongbin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyeong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Na","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Seob","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee-Eun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MinKyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungki","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-6685","authenticated-orcid":true,"given":"Hyung-Jun","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea"},{"name":"Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea"},{"name":"Cancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea"},{"name":"Research Institute for Convergence Science, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.116"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2002697"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.006"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv129"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0273-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1159\/000366463"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1907607"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.268re2"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1139\/y03-077"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179333"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4451"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.07.060"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000345"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.012"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8669com"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-00810-2"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b02796"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi6326"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.010"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01830-8"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18144-8_1"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.09.049"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6577"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8249"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308887110"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.061846"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344401"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21132"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(03)00068-4"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2019.01.002"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.5.G802"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RU0914-443R"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.02.006"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-199911000-00009"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.5784"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708469104"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-11093-2_5"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9647809"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.2007"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1525s104"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303207"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069936"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1240-3"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.1"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.03.003"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413390111"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1461-5"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00499"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz027"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051047"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abl4135"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.5.718"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90211-X"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.12.008"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12016"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4351"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.017"},{"key":"ref63\/cit63","first-page":"4557","volume":"7","author":"Erben U.","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0356-y"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-97"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.217117"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2425-3"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.08.012"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/nri1669"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830110311"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.6923"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9406-8"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314331"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.5002"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175202"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004175"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08721-0"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.005"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR03626G"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1148"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/bc00032a006"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701351"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.08.037"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.10.014"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b06451"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1038\/nature18300"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.753467"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021077"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1021\/ja207851s"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02244"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202201091"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2011.236"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303333"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.044"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.07.020"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/718617"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02391-6"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.2c08898","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.2c08898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T10:43:06Z","timestamp":1678790586000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.2c08898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":97,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,3,14]]}},"alternative-id":["10.1021\/acsnano.2c08898"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.2c08898","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]}}}