{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:07:01Z","timestamp":1787965621165,"version":"build-2784847793"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ40923"],"award-info":[{"award-number":["2021JJ40923"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ4131"],"award-info":[{"award-number":["2020JJ4131"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019054","name":"Changsha Science and Technology Project","doi-asserted-by":"publisher","award":["kh2201057"],"award-info":[{"award-number":["kh2201057"]}],"id":[{"id":"10.13039\/501100019054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971748"],"award-info":[{"award-number":["81971748"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016104","name":"Key Project of Research and Development Plan of Hunan Province","doi-asserted-by":"publisher","award":["2022SK2004"],"award-info":[{"award-number":["2022SK2004"]}],"id":[{"id":"10.13039\/100016104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016104","name":"Key Project of Research and Development Plan of Hunan Province","doi-asserted-by":"publisher","award":["2022SK2020"],"award-info":[{"award-number":["2022SK2020"]}],"id":[{"id":"10.13039\/100016104","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Self-Exploration and Innovation Project of Hunan of China","award":["CX20230285"],"award-info":[{"award-number":["CX20230285"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2023,12,26]]},"DOI":"10.1021\/acsnano.3c03267","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T19:48:26Z","timestamp":1698176906000},"page":"24632-24653","source":"Crossref","is-referenced-by-count":14,"title":["Multifunctional Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-Based Nanobomb against Carbapenem-Resistant <i>Acinetobacter baumannii<\/i> Infection through Cascade Reaction and Amplification Synergistic Effect"],"prefix":"10.1021","volume":"17","author":[{"given":"Xisheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-ju","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9902-3506","authenticated-orcid":true,"given":"Xinmin","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.11.008"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp428"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1086\/533452"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-00228-x"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.03.014"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-022-01052-8"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.03.001"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00047-19"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-013-0640-7"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx131"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2578-z"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.112408.134123"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12279"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1936-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.350.6266.1299"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nature17946"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0070-x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.08.008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20200007"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.9b00188"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.128607"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84768-8"},{"key":"ref24\/cit24","volume-title":"The FDA and Generally Recognized as Safe (GRAS) Substances","author":"Monahan J. C.","year":"2011"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09724"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.03.008"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1080\/02772248.2013.803796"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.82"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-014-3413-7"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c01336"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2020.123541"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.049"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00632A"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.224"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03629"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07483"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202100637"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800594"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/333664a0"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.019"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201000173"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/nn700191f"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.4161\/viru.20328"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b04236"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03233-9"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01010"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900256"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2013.10.008"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR05429G"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.6b02154"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC00637G"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c00269"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c05705"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2017.12.002"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.109.073510"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900608"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c01206"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/nn202054f"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121597"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.04.093"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.11.057"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700141"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.10.014"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.06.009"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.6b00398"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.066"},{"key":"ref68\/cit68","first-page":"917","volume":"18","author":"Ng P. Y.","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c10309"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c03267","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c03267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T09:17:40Z","timestamp":1703582260000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.3c03267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":69,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12,26]]}},"alternative-id":["10.1021\/acsnano.3c03267"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.3c03267","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]}}}