{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:41:34Z","timestamp":1793108494207,"version":"4.5.0"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX112-11128EI"],"award-info":[{"award-number":["NHRI-EX112-11128EI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["OMRPD2N0011"],"award-info":[{"award-number":["OMRPD2N0011"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPD2M0181"],"award-info":[{"award-number":["CMRPD2M0181"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST110-2314-B-182-008-MY3"],"award-info":[{"award-number":["MOST110-2314-B-182-008-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST111-2811-B-182-010"],"award-info":[{"award-number":["MOST111-2811-B-182-010"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2023,12,26]]},"DOI":"10.1021\/acsnano.3c07817","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T11:49:11Z","timestamp":1701776951000},"page":"25118-25135","source":"Crossref","is-referenced-by-count":130,"title":["Unveiling the Power of Gabapentin-Loaded Nanoceria with Multiple Therapeutic Capabilities for the Treatment of Dry Eye Disease"],"prefix":"10.1021","volume":"17","author":[{"given":"Chia-Jung","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-1129","authenticated-orcid":true,"given":"Chih-Ching","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung 202301, Taiwan"},{"name":"Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 202301, Taiwan"},{"name":"School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-8549","authenticated-orcid":true,"given":"Jui-Yang","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan"},{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33305, Taiwan"},{"name":"Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33303, Taiwan"},{"name":"Center for Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2022.06.004"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1407936"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021580"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010147"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.06.027"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1998.14.99"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186668"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13243"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.08.003"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106206"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2022.0133"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-27843"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.143968"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134970"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.931759"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01567-7"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.03.002"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.04.001"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/polym10030267"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S36111"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020470"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.027"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(03)00061-4"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.7150\/thno.54525"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138620"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210819"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtnano.2022.100218"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119961"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140387"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202102342"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.12.048"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/la300709n"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41157-6"},{"key":"ref35\/cit35","first-page":"976","volume":"7","author":"Chinnu M. K.","year":"2013","journal-title":"Optoelectron. Adv. Mater., Rapid Commun."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102451"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07306"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302174"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2137(01)80007-8"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.06.003"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-112"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2021.03.007"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054578"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-512749"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118847"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2010.02.006"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0565"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.10.022"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.11.5981"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001057"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1444"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.06.006"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.08.019"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0255-7"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2001.0990"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.07.005"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.11.037"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.04.014"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11125256"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2010.02.024"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1972.360110807"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.2147\/MNM.S107246"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.5897\/AJBR12.002"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10145"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.671238"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111095"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/la4022646"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12977"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2015.03.031"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24031889"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01240"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.04.003"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.021"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23500"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05447"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09913-8"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23623"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S65601"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.11.014"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c07817","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c07817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T04:43:08Z","timestamp":1703565788000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.3c07817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,5]]},"references-count":79,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2023,12,26]]}},"alternative-id":["10.1021\/acsnano.3c07817"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.3c07817","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,5]]}}}