{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:11:27Z","timestamp":1790417487879,"version":"4.1.0"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21807097"],"award-info":[{"award-number":["21807097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51573186"],"award-info":[{"award-number":["51573186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973222"],"award-info":[{"award-number":["51973222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2024,4,9]]},"DOI":"10.1021\/acsnano.3c09532","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T06:11:58Z","timestamp":1711519918000},"page":"9895-9916","source":"Crossref","is-referenced-by-count":38,"title":["Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment"],"prefix":"10.1021","volume":"18","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8297-0876","authenticated-orcid":true,"given":"Zhifang","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozheng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4431-4434","authenticated-orcid":true,"given":"Qiang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China"},{"name":"Key Laboratory of Polymeric Materials Design and Synthesis for Biomedical Function, Soochow University, Suzhou, Jiangsu 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1787"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00690-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04379-z"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.10.001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37689-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.21"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.51"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05454-9"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3802"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00863-5"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10523"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00139-y"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00910"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.34133\/research.0180"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.067"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.03.029"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.05.029"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.10.004"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14061122"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903759"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00903-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121395"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200206"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040703"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.04.003"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400016"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b20594"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5471347"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112123"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.04.018"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.01.038"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020342"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805781"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2015.08.044"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2018.09.010"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c05105"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121904"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01064-1"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO00419A"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0229-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.2.14043"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2017.08.001"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-014-0354-x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1851897"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0033-y"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.01.007"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00757-x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113611"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.022701"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00908C"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119902"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c07030"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33421-7"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2021.06.017"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b01526"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9761539"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/am5091462"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00076"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003937"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-017-0316-z"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.012328"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201909999"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c00231"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00804"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202107126"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.201900073"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c00741"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802309"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200517"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c09532","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c09532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T05:17:07Z","timestamp":1712639827000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.3c09532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,27]]},"references-count":69,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2024,4,9]]}},"alternative-id":["10.1021\/acsnano.3c09532"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.3c09532","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,27]]}}}