{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:30:30Z","timestamp":1793194230900,"version":"4.5.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173763"],"award-info":[{"award-number":["82173763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771686"],"award-info":[{"award-number":["81771686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91842305"],"award-info":[{"award-number":["91842305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010896","name":"International Cooperation and Exchange Programme","doi-asserted-by":"publisher","award":["52161145501"],"award-info":[{"award-number":["52161145501"]}],"id":[{"id":"10.13039\/501100010896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2021CXGC010515"],"award-info":[{"award-number":["2021CXGC010515"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds of Shandong Province","award":["ZR2022ZD18"],"award-info":[{"award-number":["ZR2022ZD18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2024,1,23]]},"DOI":"10.1021\/acsnano.3c10109","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T17:00:21Z","timestamp":1704992421000},"page":"2261-2278","source":"Crossref","is-referenced-by-count":103,"title":["mRNA-Laden Lipid-Nanoparticle-Enabled\n                    <i>in Situ<\/i>\n                    CAR-Macrophage Engineering for the Eradication of Multidrug-Resistant Bacteria in a Sepsis Mouse Model"],"prefix":"10.1021","volume":"18","author":[{"given":"Chunwei","family":"Tang","sequence":"first","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Han","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenmei","family":"Yang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengchang","family":"Zhang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Zhao","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongdeng","family":"Shi","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Chai","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Li","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maosen","family":"Han","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Fu","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuolin","family":"Zheng","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3916-3192","authenticated-orcid":true,"given":"Danqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, 4572A Academic Building, Clear\rWater Bay, Kowloon, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College of Shandong University, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong Province 250101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong Province 250101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-579X","authenticated-orcid":true,"given":"Shilei","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, 107 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qilu Hospital, Shandong University, 107 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-4336","authenticated-orcid":true,"given":"Jiwei","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong Province 250100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-6876","authenticated-orcid":true,"given":"Xinyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Cultural West Road, Jinan, Shandong Province 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130327"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-022-00422-y"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-061121-040214"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2023.103604"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122108599"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3521"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0315-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.607650"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.10.010"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nm0697-678"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021333"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70001-X"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0462-y"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23817-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.57"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.25996-0"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149460"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1289"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2008.11.005"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.014"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948109"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg3365"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2020.09.020"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27493-0"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.03.013"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf4398"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203263"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.01.030"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.03.010"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202204692"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303958110"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322937111"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07822"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121632"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.014"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102158"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0600-1"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43074-9"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04390-7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.03.009"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b01101"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.09.025"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306529110"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2021.03.002"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.11.006"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.03.019"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.10.005"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nature09973"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.012"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.01.006"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30696-2"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022139"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0143"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4357"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0594"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.10.015"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.06.004"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-023-00683-y"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.12.007"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202103258"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201805097"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c10109","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.3c10109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T11:43:26Z","timestamp":1706183006000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.3c10109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,1,23]]}},"alternative-id":["10.1021\/acsnano.3c10109"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.3c10109","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]}}}