{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:23:58Z","timestamp":1791685438482,"version":"4.3.4"},"reference-count":80,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["DP2NS111507"],"award-info":[{"award-number":["DP2NS111507"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000082","name":"Division of Graduate Education","doi-asserted-by":"publisher","award":["DGE-2038238"],"award-info":[{"award-number":["DGE-2038238"]}],"id":[{"id":"10.13039\/100000082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["HT94252410494"],"award-info":[{"award-number":["HT94252410494"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000146","name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"publisher","award":["2046926"],"award-info":[{"award-number":["2046926"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2024,9,17]]},"DOI":"10.1021\/acsnano.4c06052","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T22:13:40Z","timestamp":1725574420000},"page":"25565-25576","source":"Crossref","is-referenced-by-count":10,"title":["Spatial Measurement and Inhibition of Calpain Activity in Traumatic Brain Injury with an Activity-Based Nanotheranostic Platform"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-7952","authenticated-orcid":true,"given":"Marianne I.","family":"Madias","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilyane N.","family":"Stessman","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia J.","family":"Warlof","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3022-0058","authenticated-orcid":true,"given":"Julia A.","family":"Kudryashev","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-9681","authenticated-orcid":true,"given":"Ester J.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref1\/cit1","unstructured":"Thurman, D. J. Traumatic Brain Injury in the United States: A Report to Congress; National Center for Injury Prevention and Control (U.S.) Division of Acute Care, Rehabilitation Research, and Disability Prevention, 1999. https:\/\/stacks.cdc.gov\/view\/cdc\/13632."},{"key":"ref2\/cit2","unstructured":"Peterson, A. B.; Xu, L.; Daugherty, J.; Breiding, M. J. Surveillance Report of Traumatic Brain Injury-Related Emergency Department Visits, Hospitalizations, and Deaths, United States; National Center for Injury Prevention and Control (U.S.), 2014. https:\/\/stacks.cdc.gov\/view\/cdc\/78062."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.261"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411090"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404304"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2015.1065344"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7072"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6295"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.06.008"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00528"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.735365"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.9b01812"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.11.002"},{"issue":"2","key":"ref14\/cit14","first-page":"25","volume":"50","author":"Cardali S.","year":"2006","journal-title":"J. Neurosurg. Sci."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.023"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68041612.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.111.6.713"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19980601)52:5<505::AID-JNR3>3.0.CO;2-G"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199612200-00050"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1474"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.04.022"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5024"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12144"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00483-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7122"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.198001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2473"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.1.152"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122698"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba5547"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.1181"},{"key":"ref32\/cit32","volume-title":"Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects","author":"Cagmat E. B.","year":"2015"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.2174\/156802610790725489"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.08.010"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208350200"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2005.22.252"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1997.14.369"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3854"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1089\/neur.2020.0046"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1089\/0897715041526177"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199607000-00010"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181996bfe"},{"issue":"6","key":"ref43\/cit43","first-page":"1575","volume":"147","author":"Rink A.","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-15-05663.1998"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62339-7"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2371"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1385\/1-59259-050-0:117","volume-title":"Calpain Methods and Protocols","volume":"144","author":"Zhao X.","year":"2000"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051342"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf8020"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.5.5.721"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1506925112"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2464"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0054"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09064"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300218"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/nature07451"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2004.054"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-9-35"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a122844"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)47235-9"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.11.039"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.01.007"},{"key":"ref63\/cit63","first-page":"OL267\u2013270","volume":"48","author":"Perrin C.","year":"2002","journal-title":"Cell Mol. Biol."},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.11.037"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp333"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00134"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6346-7_14"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093344"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1998.15.1047"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7071"},{"issue":"2","key":"ref71\/cit71","first-page":"65","volume":"13","author":"Momeni H. R.","year":"2011","journal-title":"Cell J."},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.1241"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13774"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199808030-00002"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.025"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21677"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.8.813"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.07.007"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.01014"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4097"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c06052","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c06052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T19:19:28Z","timestamp":1726600768000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.4c06052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":80,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2024,9,17]]}},"alternative-id":["10.1021\/acsnano.4c06052"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.4c06052","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]}}}