{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:01:38Z","timestamp":1793192498352,"version":"4.5.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0710700"],"award-info":[{"award-number":["2020YFA0710700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1201200"],"award-info":[{"award-number":["2021YFA1201200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1206000"],"award-info":[{"award-number":["2022YFA1206000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1206100"],"award-info":[{"award-number":["2022YFA1206100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81627901"],"award-info":[{"award-number":["81627901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073796"],"award-info":[{"award-number":["82073796"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272844"],"award-info":[{"award-number":["82272844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,4,1]]},"DOI":"10.1021\/acsnano.4c13277","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T09:32:27Z","timestamp":1742549547000},"page":"11756-11773","source":"Crossref","is-referenced-by-count":13,"title":["Spatial Regulation of Cancer-Associated Fibroblasts and Tumor Cells via pH-Responsive Bispecific Antibody Delivery for Enhanced Chemo-Immunotherapy Synergy"],"prefix":"10.1021","volume":"19","author":[{"given":"Haojie","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuying","family":"Yong","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohan","family":"Wei","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Bie","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Xu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuhan YZY Biopharma Co., Ltd.","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuhan YZY Biopharma Co., Ltd.","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangliang","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-867X","authenticated-orcid":true,"given":"Lu","family":"Gan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02179-2"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat3504"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02461-x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5447"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210106"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20210171"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01658-3"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30306-7"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110614"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1893"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03745-1"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1730-1"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adj5705"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0994-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh8005"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00582-0"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg3840"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abg8191"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05351-1"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0004-1"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01013-0"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz4028"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33991-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01155-6"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01363-8"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01045-x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00803-z"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31551-6"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20723-x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41438-9"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11718-4"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211980"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0405-4"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39035-x"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nature25501"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay8456"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-1545"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2152"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.107"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aae0105"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00920-9"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nri2216"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.012"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0770-1"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.04.002"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301661"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01684-7"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.05.003"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-021-01556-0"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-07970-x"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c13277","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c13277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T14:40:37Z","timestamp":1743518437000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.4c13277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.1021\/acsnano.4c13277"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.4c13277","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]}}}