{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T12:59:13Z","timestamp":1794315553322,"version":"4.9.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"16","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023-MS-306"],"award-info":[{"award-number":["2023-MS-306"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301558"],"award-info":[{"award-number":["82301558"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,4,29]]},"DOI":"10.1021\/acsnano.4c16161","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T15:59:41Z","timestamp":1744991981000},"page":"15491-15508","source":"Crossref","is-referenced-by-count":40,"title":["Brain Targeting Bacterial Extracellular Vesicles Enhance Ischemic Stroke Therapy via Efficient ROS Elimination and Suppression of Immune Infiltration"],"prefix":"10.1021","volume":"19","author":[{"given":"Mengdi","family":"Sun","sequence":"first","affiliation":[{"name":"School of Pharmacy","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Ma","sequence":"additional","affiliation":[{"name":"Institution of Life Science","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhen","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liang","sequence":"additional","affiliation":[{"name":"Institution of Life Science","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]},{"name":"Key Laboratory of Neurodegenerative Diseases of Liaoning Province","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]},{"name":"Collaborative Innovation Center for Age-related Disease","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-211X","authenticated-orcid":true,"given":"Yijie","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-6956","authenticated-orcid":true,"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]},{"name":"Key Laboratory of Neurodegenerative Diseases of Liaoning Province","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]},{"name":"Collaborative Innovation Center for Age-related Disease","place":["Jinzhou, PR China"]},{"name":"Jinzhou Medical University","place":["Jinzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31179-X"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169366"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.06.011"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1039241"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.03.040"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-023-00690-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092429"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.98"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.615039"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00175"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18219"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.09.057"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.21"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158367"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.01.006"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106332"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S137368"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.695899"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.04.031"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-020-00532-4"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1032202"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0483-x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01774-3"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200302"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/35048596"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222313029"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2018-0222"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01390-15"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07314-2"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104841"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.136"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025371"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.24641"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.11.019"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104877"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00076"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.11.009"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.08.010"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13062"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19882264"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0372-1"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12695"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00294"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678744"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01751-2"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0422-8"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-020-01372-7"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01040"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.7150\/thno.33872"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818544116"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.131582"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154108"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c16161","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c16161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T08:12:56Z","timestamp":1745914376000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.4c16161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":52,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2025,4,29]]}},"alternative-id":["10.1021\/acsnano.4c16161"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.4c16161","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acsnano.4c16161.s001","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acsnano.4c16161.s002","asserted-by":"subject"}]},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]}}}