{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:34:12Z","timestamp":1793968452222,"version":"4.8.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2023YFC3605502"],"award-info":[{"award-number":["2023YFC3605502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012649"],"award-info":[{"award-number":["2023A1515012649"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["TSQN202306320"],"award-info":[{"award-number":["TSQN202306320"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20220530140605012"],"award-info":[{"award-number":["JCYJ20220530140605012"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20230807090100002"],"award-info":[{"award-number":["JCYJ20230807090100002"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20240813111300001"],"award-info":[{"award-number":["JCYJ20240813111300001"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["JCRCFZ-2022-031"],"award-info":[{"award-number":["JCRCFZ-2022-031"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477129"],"award-info":[{"award-number":["22477129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62425116"],"award-info":[{"award-number":["62425116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071339"],"award-info":[{"award-number":["82071339"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171336"],"award-info":[{"award-number":["82171336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271370"],"award-info":[{"award-number":["82271370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273796"],"award-info":[{"award-number":["82273796"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371346"],"award-info":[{"award-number":["82371346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82427807"],"award-info":[{"award-number":["82427807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92359301"],"award-info":[{"award-number":["92359301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MB085"],"award-info":[{"award-number":["ZR2023MB085"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Laboratory Program","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]},{"name":"Special Supporting Funds for Leading Talents at or above the Provincial Level in Yantai"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,3,18]]},"DOI":"10.1021\/acsnano.4c18035","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:28:41Z","timestamp":1741177721000},"page":"10323-10336","source":"Crossref","is-referenced-by-count":37,"title":["Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke"],"prefix":"10.1021","volume":"19","author":[{"given":"Kai","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Fu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Molecular Imaging, Institute of Automation","place":["Beijing, China"]},{"name":"Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"School of Artificial Intelligence","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-4556","authenticated-orcid":true,"given":"Yu","family":"Chao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering","place":["Wuhan, China"]},{"name":"Hubei University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zeng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"Shandong Laboratory of Yantai Drug Discovery","place":["Yantai, China"]},{"name":"Bohai Rim Advanced Research Institute for Drug Discovery","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5875-583X","authenticated-orcid":true,"given":"Yonggang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"State Key Laboratory of Drug Research","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"Shenzhen Institute of Wuhan University","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binchun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Precision Instrument","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Hu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Molecular Imaging, Institute of Automation","place":["Beijing, China"]},{"name":"Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"School of Artificial Intelligence","place":["Beijing, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"National Key Laboratory of Kidney Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-3278","authenticated-orcid":true,"given":"Xuechuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Central Laboratory, Renmin Hospital of Wuhan University, School of Pharmaceutical Sciences","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"State Key Laboratory of Drug Research","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]},{"name":"Wuhan University","place":["Wuhan, China"]},{"name":"State Key Laboratory of Drug Research","place":["Shanghai, China"]},{"name":"Shanghai Institute of Materia Medica, Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"Shandong Laboratory of Yantai Drug Discovery","place":["Yantai, China"]},{"name":"Bohai Rim Advanced Research Institute for Drug Discovery","place":["Yantai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32130-X"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30034-1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0072-x"},{"issue":"9727","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(10)60491-6","volume":"375","author":"Lees K. R.","year":"2010","journal-title":"Lancet"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0002-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13647"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nri3705"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2018.1400910"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31874-9"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908503116"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.689"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nature07758"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2742"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-024-2192-9"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302425"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-017-2434-3"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11090478"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24339"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.498212"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04560"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.053"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S168556"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.11.001"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.95"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nphoton.2014.166"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014501108"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900159"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0494-0"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00773-2"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.01.005"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01208"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101275"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c07988"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0239-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4106"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2019.12.005"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02157-4"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60768-5"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14255"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410505"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/86684"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.024"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1039\/b105159h"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010715-103633"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3978"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.166"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00297-x"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0284-0"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008897"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c18035","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.4c18035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T04:49:03Z","timestamp":1742273343000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.4c18035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,3,18]]}},"alternative-id":["10.1021\/acsnano.4c18035"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.4c18035","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,5]]}}}