{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:51:40Z","timestamp":1790783500779,"version":"4.1.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"4","funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000142"],"award-info":[{"award-number":["UL1 TR000142"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS095817"],"award-info":[{"award-number":["NS095817"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007445","name":"Matthew Larson Foundation for Pediatric Brain Tumors","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007445","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State of Connecticut"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2016,4,26]]},"DOI":"10.1021\/acsnano.5b07573","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T20:39:28Z","timestamp":1457728768000},"page":"4209-4218","source":"Crossref","is-referenced-by-count":119,"title":["Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging"],"prefix":"10.1021","volume":"10","author":[{"given":"Liang","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K.","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-qiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasidhar","family":"Murikinati","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daofeng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Holden","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June-Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Leon","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Grutzendler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Piepmeier","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, #Department of Biomedical\rEngineering, \u2021PET Center, Department\rof Diagnostic Radiology, \u00a7Department of Neurology, and \u22a5Department of Pathology, Yale University, New Haven, Connecticut 06511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"ref1\/cit1","unstructured":"Ferlay, J.; Soerjomataram, I.; Ervik, M.Globocan 2012 V1. 0, Cancer Incidence and Mortality Worldwide; Iarc Cancer Base No. 10 [Internet];International Agency for Research on Cancer:Lyon, 2013."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)85345-X"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-011-1468-z"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-131"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-008-0036-8"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1658-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304504110"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016083113123"},{"key":"ref9\/cit9","first-page":"672","volume":"58","author":"Fung L. K.","year":"1998","journal-title":"Cancer Res."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2854"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.12.006"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318244d8ae"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/nn300240p"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.08.030"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20998"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1157"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006839"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205662200"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3337-11.2011"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3187"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra46918b"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.061"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2395-y"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1514-2"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov081"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.03.075"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.079"},{"key":"ref28\/cit28","first-page":"8899","volume":"63","author":"Ningaraj N. S.","year":"2003","journal-title":"Cancer Res."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.08.004"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nri3405"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2012.05.001"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/926321"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0339"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3316"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1486"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-1564"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0132"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.077933"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/bc200362a"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/nn5003375"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.07.006"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2946"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2995"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-011-9222-2"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-015-0017-7"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1828-13.2013"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02607-5"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423088112"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.08.008"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.053132"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)02187-3"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-280-9_2"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5b07573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T20:58:56Z","timestamp":1682542736000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5b07573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4,26]]}},"alternative-id":["10.1021\/acsnano.5b07573"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5b07573","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]}}}