{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:55:41Z","timestamp":1793814941992,"version":"4.6.1"},"reference-count":77,"publisher":"American Chemical Society (ACS)","issue":"18","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005407","name":"Food and Health Bureau","doi-asserted-by":"publisher","award":["20190682"],"award-info":[{"award-number":["20190682"]}],"id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301133"],"award-info":[{"award-number":["32301133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801012"],"award-info":[{"award-number":["81801012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,5,13]]},"DOI":"10.1021\/acsnano.5c00561","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:33:23Z","timestamp":1746185603000},"page":"17554-17577","source":"Crossref","is-referenced-by-count":30,"title":["Berberine-Functionalized Bismuth-Doped Carbon Dots in a Pathogen-Responsive Hydrogel System: A Multifaceted Approach to Combating Periodontal Diseases"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-5507","authenticated-orcid":true,"given":"Xuan","family":"Li","sequence":"first","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Huang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pugeng","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology","place":["Guangzhou, PR China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung Kit","family":"Tang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology","place":["Guangzhou, PR China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology","place":["Guangzhou, PR China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-6310","authenticated-orcid":true,"given":"Xinmiao","family":"Lan","sequence":"additional","affiliation":[{"name":"Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Centre of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, School of Pharmaceutical Science","place":["Beijing, PR China"]},{"name":"Capital Medical University","place":["Beijing, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinna","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Sze Wah","family":"Wong","sequence":"additional","affiliation":[{"name":"Immunology of Fungal Infections Unit","place":["Paris, France"]},{"name":"Institut Pasteur","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-9710","authenticated-orcid":true,"given":"Lijian","family":"Jin","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0349-0418","authenticated-orcid":true,"given":"Ken Cham-Fai","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Kowloon, PR China"]},{"name":"The Hong Kong Baptist University","place":["Kowloon, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-6442","authenticated-orcid":true,"given":"Hai Ming","family":"Wong","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry","place":["Hong Kong SAR, PR China"]},{"name":"The University of Hong Kong","place":["Hong Kong SAR, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica","place":["Beijing, PR China"]},{"name":"China Academy of Chinese Medical Sciences","place":["Beijing, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanping","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica","place":["Beijing, PR China"]},{"name":"China Academy of Chinese Medical Sciences","place":["Beijing, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Hui","family":"Ding","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang","place":["Hangzhou, PR China"]},{"name":"University School of Medicine","place":["Hangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Yu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology","place":["Guangzhou, PR China"]},{"name":"Sun Yat-sen University","place":["Guangzhou, PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02811-3"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12428"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.725460"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13554"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2022.12.011"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2025.1488941"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12371"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13002"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02529-19"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02261-y"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1020995"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01175-x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13141"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00802-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s42490-020-00044-2"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2022-0153"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111793"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-74273-z"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05756"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.4c02187"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/c9mt00085b"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.748121"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100507"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7806"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1015045"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.125"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S431256"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666230207112539"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-022-00706-x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109131"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.65476"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2022.2100682"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.02.026"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17019"},{"key":"ref36\/cit36","first-page":"23","author":"Li T.","year":"2023","journal-title":"Int. J. Biomed. Eng."},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C9QM00658C"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14702"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b18003"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.133101"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001341"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/gels9100838"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405499"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202403386"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202409121"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR04267K"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.172149"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1039\/c2sm07236j"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC01334G"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2009.12.050"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/nano12244482"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/ja2013278"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00791-0"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02750-06"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.01.010"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12915"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231151921"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016972"},{"issue":"9","key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1039\/D0CS01127D","volume":"50","author":"de Almeida M. S.","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-022-00215-y"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202200033"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1289103"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2018-0215"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-155"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1159\/000181144"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00467.x"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2205291"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054544"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03288-22"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033487036"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.2174\/1389203033487027"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1039\/D4DT00778F"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000640"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26497-0"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02664-7"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2021.09.005"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.02.009"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c00561","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c00561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T08:24:39Z","timestamp":1747124679000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c00561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":77,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,5,13]]}},"alternative-id":["10.1021\/acsnano.5c00561"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c00561","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]}}}