{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:40:25Z","timestamp":1793724025503,"version":"4.6.1"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"26","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20240202002GX"],"award-info":[{"award-number":["20240202002GX"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173147"],"award-info":[{"award-number":["52173147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52425312"],"award-info":[{"award-number":["52425312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,7,8]]},"DOI":"10.1021\/acsnano.5c01678","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:22:47Z","timestamp":1750771367000},"page":"23629-23646","source":"Crossref","is-referenced-by-count":21,"title":["A Metal\u2013Organic Framework-Based Immune-Regulating Nanocarrier Depot for Enhanced Combination Cancer Immunotherapy"],"prefix":"10.1021","volume":"19","author":[{"given":"Tianran","family":"Wang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Ding","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Yuan","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Wu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7433-3437","authenticated-orcid":true,"given":"Yan","family":"Rong","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1171-9179","authenticated-orcid":true,"given":"Gao","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3542-9256","authenticated-orcid":true,"given":"Xuesi","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6407-1367","authenticated-orcid":true,"given":"Chaoliang","family":"He","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry","place":["Changchun, China"]},{"name":"Chinese Academy of Sciences","place":["Changchun, China"]},{"name":"School of Applied Chemistry and Engineering","place":["Hefei, China"]},{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10673"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0127-6"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034339"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201903242"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/ni758"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0236-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.168"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00179"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/90609"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801389"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b03288"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.178"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b10904"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202003543"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/245804"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/c3bm60087d"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00313"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230444"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201201743"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201907152"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2608"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214804"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200501612"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202312360"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801527"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308894"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa128"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c18306"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121506"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2021.04.004"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012589"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006614"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh4327"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145212"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/cg301738p"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/la203570h"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b07981"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2007.09.063"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR09858E"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4373"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.017"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102044"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2006.09.004"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070260509"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.04.011"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.01.018"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA05633A"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.807"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-1942-x"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.11.001"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1007\/s40820-021-00647-x"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c01216"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c01678","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c01678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T08:13:28Z","timestamp":1751962408000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c01678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":60,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7,8]]}},"alternative-id":["10.1021\/acsnano.5c01678"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c01678","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}