{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:13:40Z","timestamp":1789647220603,"version":"4.0.0"},"reference-count":89,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2013\/08293-7"],"award-info":[{"award-number":["2013\/08293-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2018\/18503-2"],"award-info":[{"award-number":["2018\/18503-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/03410-4"],"award-info":[{"award-number":["2022\/03410-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR077793"],"award-info":[{"award-number":["R01AR077793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CMMI 1548571"],"award-info":[{"award-number":["CMMI 1548571"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,9,9]]},"DOI":"10.1021\/acsnano.5c04697","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:37:31Z","timestamp":1756327051000},"page":"31350-31362","source":"Crossref","is-referenced-by-count":3,"title":["Molecular-Scale Interactions at Mineralized Collagen Interfaces Prevent Network Percolation, Preserving Compliance"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-0827","authenticated-orcid":true,"given":"Amadeus","family":"C. S. de Alc\u00e2ntara","sequence":"first","affiliation":[{"name":"Laboratory for Atomistic and Molecular Mechanics (LAMM)","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]},{"name":"Department of Computational Mechanics, School of Mechanical Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, Sao Paulo 13083-860, Brazil"},{"name":"Center for Computing in Engineering & Sciences (CCES), Universidade Estadual de Campinas (UNICAMP), Campinas, Sao Paulo 13084-862, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-5544","authenticated-orcid":true,"given":"Mario","family":"Milazzo","sequence":"additional","affiliation":[{"name":"Department of Civil and Industrial Engineering","place":["Pisa, Italy"]},{"name":"University of Pisa","place":["Pisa, Italy"]},{"name":"Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM)","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-9821","authenticated-orcid":true,"given":"Eesha","family":"Khare","sequence":"additional","affiliation":[{"name":"Laboratory for Atomistic and Molecular Mechanics (LAMM)","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]},{"name":"Department of Materials Science and Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-1228","authenticated-orcid":true,"given":"Munir S.","family":"Skaf","sequence":"additional","affiliation":[{"name":"Center for Computing in Engineering & Sciences (CCES), Universidade Estadual de Campinas (UNICAMP), Campinas, Sao Paulo 13084-862, Brazil"},{"name":"Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP), Campinas, Sao Paulo 13083-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Thomopoulos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Department of Biomedical Engineering","place":["New York, United States"]},{"name":"Columbia University","place":["New York, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-4729","authenticated-orcid":true,"given":"Guy M.","family":"Genin","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering & Materials Science","place":["St. Louis, United States"]},{"name":"Washington University in St. Louis","place":["St. Louis, United States"]},{"name":"NSF Science and Technology Center for Engineering MechanoBiology","place":["St. Louis, United States"]},{"name":"Washington University in St. Louis","place":["St. Louis, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4173-9659","authenticated-orcid":true,"given":"Markus J.","family":"Buehler","sequence":"additional","affiliation":[{"name":"Laboratory for Atomistic and Molecular Mechanics (LAMM)","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]},{"name":"Center for Computational Science and Engineering, Schwarzman College of Computing","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi5584"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.05.043"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1557\/s43577-023-00479-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2009.05.001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmps.2012.03.002"},{"key":"ref6\/cit6","volume-title":"Structural Interfaces and Attachments in Biology","author":"Thomopoulos S.","year":"2012"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2013.0835"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-04933-5_5"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2004.10.1148"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00180-X"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7225(73)90018-9"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/ma13010106"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01742"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071516-044555"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199173070-00004"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200402000-00002"},{"issue":"1","key":"ref17\/cit17","first-page":"35","volume":"10","author":"Thomopoulos S.","year":"2010","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref18\/cit18","first-page":"582","author":"Woo S. L.","year":"2000","journal-title":"Orthop. basic Sci. Biol. blamechanics Musculoskelet. Syst."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2006.00540.x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2020.139437"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.5963\/AMSA0101001"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2024.112677"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2025.101474"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603216103"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/18\/29\/295102"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2007.04.001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2720"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02180"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM02003F"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/ma15062274"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00728"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-024-00753-3"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1088\/0965-0393\/18\/1\/015012"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.08.002"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-matsci-070909-104427"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/min12020170"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4719"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2189"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115304"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2011.0880"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.06.008"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.2138\/am-2016-5732"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-022-00288-0"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803354105"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1103\/physreve.100.052104"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.55.1896"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.33.2842"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900287"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(95)00147-6"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1996.0066"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-52794-9_10"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2022.105102"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2022.105139"},{"key":"ref54\/cit54","volume-title":"Bones: Structure and Mechanics","author":"Currey J. D.","year":"2006"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.05.023"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2010.0413"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1115\/1.4024131"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.10.008"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1114\/1.1615571"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.12.013"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-009-9687-0"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-002-0004-1"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.03.005"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2007.03.019"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.008"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00837"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2009.01.005"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.03.034"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmps.2020.103920"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnonlinmec.2013.03.012"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.05.033"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1039\/d3ma00799e"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57460-y"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502718103"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1052"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/la3038846"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21224"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18846-2"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2021.108171"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1063\/5.0014475"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/jp973084f"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/ja036959e"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/ct300400x"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.5b12504"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1080\/08927022.2017.1313418"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1063\/1.437577"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c04697","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c04697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T09:22:22Z","timestamp":1757409742000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c04697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,27]]},"references-count":89,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2025,9,9]]}},"alternative-id":["10.1021\/acsnano.5c04697"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c04697","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,27]]}}}