{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:08:11Z","timestamp":1791389291907,"version":"4.3.3"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCJQJC00080"],"award-info":[{"award-number":["23JCJQJC00080"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCQNJC00620"],"award-info":[{"award-number":["23JCQNJC00620"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500400"],"award-info":[{"award-number":["2021YFC2500400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500402"],"award-info":[{"award-number":["2021YFC2500402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010590","name":"Tianjin Municipal Bureau of Public Health","doi-asserted-by":"publisher","award":["TJSQNYXXR-D2-158"],"award-info":[{"award-number":["TJSQNYXXR-D2-158"]}],"id":[{"id":"10.13039\/501100010590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202830"],"award-info":[{"award-number":["82202830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272008"],"award-info":[{"award-number":["82272008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Construction Project of Cancer Precision Diagnosis and Drug Treatment Technology","award":["ZLJZZDYYWZL16"],"award-info":[{"award-number":["ZLJZZDYYWZL16"]}]},{"name":"Tianjin Institute of Urology","award":["MYSRC202305"],"award-info":[{"award-number":["MYSRC202305"]}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-009A"],"award-info":[{"award-number":["TJYXZDXK-009A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,6,17]]},"DOI":"10.1021\/acsnano.5c05698","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T14:45:18Z","timestamp":1749048318000},"page":"21807-21819","source":"Crossref","is-referenced-by-count":13,"title":["Preoperative Identification of Papillary Thyroid Carcinoma Subtypes and Lymph Node Metastasis via Deep Learning-Assisted Surface-Enhanced Raman Spectroscopy"],"prefix":"10.1021","volume":"19","author":[{"given":"Ze-Kai","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Urology","place":["Tianjin, China"]},{"name":"The Second Hospital of Tianjin Medical University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Ultrasonography","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre of Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Ultrasonography","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Ultrasonography","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre of Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre of Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxiang","family":"Ye","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre of Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiliang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Urology","place":["Tianjin, China"]},{"name":"The Second Hospital of Tianjin Medical University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Ultrasonography","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-9822","authenticated-orcid":true,"given":"Dingbin","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre of Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital","place":["Tianjin, China"]},{"name":"College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Recognition and Biosensing","place":["Tianjin, China"]},{"name":"Nankai University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9004-2543","authenticated-orcid":true,"given":"Cai","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre of Cancer, Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Department of Radiology","place":["Tianjin, China"]},{"name":"Tianjin Medical University Cancer Institute and Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26348"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09707-3"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4126-3"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.12.029"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18497-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.24"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2016.1256429"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nature13438"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00027"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nature14581"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00897"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07218-1"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11829-y"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh8362"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c00668"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c14454"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41566-024-01486-z"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00668"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.4c00407"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116101"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115779"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.2c00598"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-2146"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116855"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08169-3"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2024.116931"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c08233"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202307584"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau4506"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay5206"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1701156"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010203"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01273"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.6495"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00538"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c05633"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09101"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09119"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202103382"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.8b00676"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201001836"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0141"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1080\/05704920701551530"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.1236"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.039"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"issue":"1","key":"ref48\/cit48","first-page":"14","volume":"48","author":"Huang L.","year":"2023","journal-title":"Nat. Commun."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9547-2"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.0003"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0007"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.04.046"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1080\/05704928.2014.923902"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c05698","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c05698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:13:03Z","timestamp":1750147983000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c05698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":53,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2025,6,17]]}},"alternative-id":["10.1021\/acsnano.5c05698"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c05698","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]}}}