{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T10:24:47Z","timestamp":1794219887813,"version":"4.8.0"},"reference-count":97,"publisher":"American Chemical Society (ACS)","issue":"47","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA257837"],"award-info":[{"award-number":["R01-CA257837"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,12,2]]},"DOI":"10.1021\/acsnano.5c13083","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:58:16Z","timestamp":1763567896000},"page":"40456-40472","source":"Crossref","is-referenced-by-count":12,"title":["Precise Ratiometric Drug Delivery for the Treatment of Triple-Negative Breast Cancer"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9380-6553","authenticated-orcid":true,"given":"Rae Hyung","family":"Kang","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Division, School of Pharmacy","place":["Madison, United States"]},{"name":"University of Wisconsin-Madison","place":["Madison, United States"]},{"name":"Department of Pharmaceutical Engineering","place":["Cheonan, Republic of Korea"]},{"name":"Dankook University","place":["Cheonan, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Rasoulianboroujeni","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, School of Pharmacy","place":["Madison, United States"]},{"name":"University of Wisconsin-Madison","place":["Madison, United States"]},{"name":"Department of Pharmaceutical Sciences, Gatton College of Pharmacy","place":["Johnson City, United States"]},{"name":"East Tennessee State University","place":["Johnson City, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Kianpour","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, School of Pharmacy","place":["Madison, United States"]},{"name":"University of Wisconsin-Madison","place":["Madison, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Repp","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, School of Pharmacy","place":["Madison, United States"]},{"name":"University of Wisconsin-Madison","place":["Madison, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1367-4349","authenticated-orcid":true,"given":"Suzanne M.","family":"Ponik","sequence":"additional","affiliation":[{"name":"Department of Cell and Regenerative Biology, School of Medicine and Public Health","place":["Madison, United States"]},{"name":"University of Wisconsin-Madison","place":["Madison, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-652X","authenticated-orcid":true,"given":"Glen S.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Division, School of Pharmacy","place":["Madison, United States"]},{"name":"University of Wisconsin-Madison","place":["Madison, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.4147"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9756-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001389"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0957-x"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0091-6"},{"issue":"8","key":"ref6\/cit6","first-page":"806","volume":"5","author":"Ueng S. H.","year":"2012","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S86105"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2574"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00624.x"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1997"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.27.5.1441"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204042200"},{"issue":"1","key":"ref13\/cit13","first-page":"261","volume":"29","author":"Xu R.","year":"2009","journal-title":"Anticancer Res."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000684200"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4856-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1145720"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2012.11.002"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.09.008"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-014-0434-6"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.1196"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-698"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00368"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu124"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S67673"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-017-2185-4"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2015.03.003"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj100"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604851"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-3055"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1124\/mi.7.4.8"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.06.028"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0118"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2010.538678"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0607"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/nn405674m"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3355"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2992"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107960"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201204750"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201401076"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/mp200243k"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.01.008"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S143047"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C3SC53106F"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03995"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.02.017"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2600-0"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/nano11102745"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-023-00807-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.032"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1576"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1921078"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.10"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-007-0609-2"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24837"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.02.009"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"ref58\/cit58","first-page":"61","author":"Chou T.","year":"1991","journal-title":"Synergism Antagonism Chemother."},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.02.009"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2015.12.383"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-022-01310-1"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0361"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.12.018"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404471"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp504"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2501"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.1605.3.12"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.27"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1634"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.002"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0242"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.043"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305559"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01668-1"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145906"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.3635"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00529-3"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V112.11.2984.2984"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003510"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.01.015"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.7150\/thno.32416"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.13.118"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104161"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.06.005"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.01.004"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b09340"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.12.005"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b11998"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.007"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.10.032"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.055"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR04473A"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110490"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01614-x"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2069883"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1039\/D0NH00077A"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c07037"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c13083","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c13083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:10:43Z","timestamp":1764666643000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c13083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":97,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2025,12,2]]}},"alternative-id":["10.1021\/acsnano.5c13083"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c13083","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}