{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:46:05Z","timestamp":1790847965161,"version":"4.1.0"},"reference-count":89,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001692","name":"Croucher Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chow Yuk Ho Technology Centre for Innovative Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2026,1,13]]},"DOI":"10.1021\/acsnano.5c14751","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T02:45:37Z","timestamp":1766457937000},"page":"683-699","source":"Crossref","is-referenced-by-count":13,"title":["Small Gold Nanoparticles Alleviate Huntington\u2019s Disease via Modulating p38\u03b1 Mitogen-Activated Protein Kinase and Pyruvate Dehydrogenase Kinase 1"],"prefix":"10.1021","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-069X","authenticated-orcid":true,"given":"Leo Kit Cheung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lok I","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moldir","family":"Shyngys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Lam","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaorui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Ka Wing","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3247-8255","authenticated-orcid":true,"given":"Wing-Hoi","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Ming","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yin Edwin","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-7217","authenticated-orcid":true,"given":"Chung Hang Jonathan","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Neuromusculoskeletal Restorative Medicine","place":["Shatin, Hong Kong"]},{"name":"Hong Kong Science Park","place":["Shatin, Hong Kong"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3721"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00293-z"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","unstructured":"Meredith, W. Promising Drug for Huntington Disease Fails in Major Trial\n                      Science\n                      2021 10.1126\/science.abi6722.","DOI":"10.1126\/science.abi6722"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-10852-1"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00087-x"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00506"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114820"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103573108"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307152110"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509425103"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003594"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81369-0"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02899"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2305662120"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06081"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511733"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ja2084338"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.5353"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006839"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505413"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/srep41316"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24406"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10674"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00507G"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01481-9"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1016\/B978-0-12-386456-7.07603-6","volume-title":"Pathobiology of Human Disease","author":"Woods K.","year":"2014"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/pr070092s"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/BF00514327"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20354"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00394-w"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009568118"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/978-1-4899-1054-7_21","volume-title":"New Concepts of a Blood\u2013Brain Barrier","author":"Felgenhauer K.","year":"1995"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022940118"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-5-18"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03783.x"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201068"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/nl403490e"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-025-00321-6"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.147"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/292376"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.8.5082"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.026"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1392.1392"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304082"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad275"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2006-14.2016"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130116"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.10.007"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2017.07.009"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05980-8"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.12.019"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1085"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9427"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111941"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2063"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00886-5"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050405"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.05.009"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9502-2"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04906"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-0755-z"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18525-2"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08675"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00631"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201443119"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109256118"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301929"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.11.007"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2022.01.025"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2018-0227"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201528"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-8-16"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.12.035"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.2.137"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10776"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-23-10428.1999"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619302114"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1177\/1091581812465969"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202515906"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-0978"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2007285117"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911734116"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616400113"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25074057"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.12.013"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.04.014"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0496-9"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.12.032"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c14751","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c14751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:43:33Z","timestamp":1768567413000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c14751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,13]]}},"alternative-id":["10.1021\/acsnano.5c14751"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c14751","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}