{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T19:12:24Z","timestamp":1794510744431,"version":"4.9.1"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"46","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2023844"],"award-info":[{"award-number":["BE2023844"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632024PY06"],"award-info":[{"award-number":["2632024PY06"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632024TD02"],"award-info":[{"award-number":["2632024TD02"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272415"],"award-info":[{"award-number":["32272415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072017"],"award-info":[{"award-number":["82072017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400252"],"award-info":[{"award-number":["82400252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472206"],"award-info":[{"award-number":["82472206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813170700001"],"award-info":[{"award-number":["JCYJ20240813170700001"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province Outstanding Youth Fund","award":["BK20240093"],"award-info":[{"award-number":["BK20240093"]}]},{"name":"Key Science and Technology Plan Project of Lhasa","award":["LSKJ202419"],"award-info":[{"award-number":["LSKJ202419"]}]},{"name":"Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine","award":["YBZX2022"],"award-info":[{"award-number":["YBZX2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2025,11,25]]},"DOI":"10.1021\/acsnano.5c14974","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T20:11:23Z","timestamp":1763151083000},"page":"40061-40071","source":"Crossref","is-referenced-by-count":6,"title":["Nanosensor-Based Pattern-Generating Probe Accelerates Sepsis Diagnosis"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-5046","authenticated-orcid":true,"given":"Weiwei","family":"Ni","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, College of Engineering","place":["Nanjing, China"]},{"name":"China Pharmaceutical University","place":["Nanjing, China"]},{"name":"Department of Neuroscience","place":["Stockholm, Sweden"]},{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-4552","authenticated-orcid":true,"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, College of Engineering","place":["Nanjing, China"]},{"name":"China Pharmaceutical University","place":["Nanjing, China"]},{"name":"Department of Neuroscience","place":["Stockholm, Sweden"]},{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyan","family":"Yue","sequence":"additional","affiliation":[{"name":"Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine","place":["Nanjing, China"]},{"name":"Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine","place":["Nanjing, China"]},{"name":"Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7995-4330","authenticated-orcid":true,"given":"Shujun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine","place":["Nanjing, China"]},{"name":"Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, College of Engineering","place":["Nanjing, China"]},{"name":"China Pharmaceutical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuming","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, College of Engineering","place":["Nanjing, China"]},{"name":"China Pharmaceutical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, College of Engineering","place":["Nanjing, China"]},{"name":"China Pharmaceutical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine","place":["Nanjing, China"]},{"name":"Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine","place":["Nanjing, China"]},{"name":"Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neuroscience","place":["Stockholm, Sweden"]},{"name":"Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1832-2641","authenticated-orcid":true,"given":"Jinsong","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, College of Engineering","place":["Nanjing, China"]},{"name":"China Pharmaceutical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60136f"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201809607"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b03657"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC02792H"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00538B"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c03001"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00226"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00267A"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800634"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.6b00564"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfutfo.2023.05.004"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00746"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00240H"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804607"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2017.04.008"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201602385"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.8b00371"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201706101"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318483"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00162"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11594"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10809"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC07095E"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ja4081748"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c05644"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201206374"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.175"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402501"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ja710644g"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00199"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00132"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c05948"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05196"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00811-9"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0781OC"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nri3552"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0036CP"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b08965"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703058"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002262"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.2c02236"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.6b00691"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.09.004"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23588-w"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32118-1"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2012.10.013"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c14974","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c14974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:13:21Z","timestamp":1764062001000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5c14974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":48,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2025,11,25]]}},"alternative-id":["10.1021\/acsnano.5c14974"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c14974","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1021\/acsnano.5c14974.s001","asserted-by":"subject"}]},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]}}}