{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:07:05Z","timestamp":1788876425798,"version":"build-2803163510"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi?an Jiaotong University","doi-asserted-by":"publisher","award":["QY6J003"],"award-info":[{"award-number":["QY6J003"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009996","name":"Shaanxi Province Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024BSHSDZZ041"],"award-info":[{"award-number":["2024BSHSDZZ041"]}],"id":[{"id":"10.13039\/501100009996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52411540232"],"award-info":[{"award-number":["52411540232"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The inflammation-related tissue injury repair is still a challenge, in which the metabolic disturbance of macrophages induces cascade amplification of inflammatory mediators and hinders tissue repair. Herein, we developed covalently self-assembled poly(dopamine\u2013silicon) nanoparticles (DS NPs) that integrate enzyme-mimetic catalysis with bioactive ion release to achieve sequential redox modulation and metabolic immune regulation in infected wounds and lung injury models. The covalent linkage reorganized dopamine into a stable amorphous network, preventing \u03c0\u2013\u03c0 stacking and exposing reactive catechol groups, thereby enhancing antioxidant and superoxide dismutase-like activities, which efficiently eliminated reactive oxygen\/nitrogen species and corrected oxidative imbalance. Meanwhile, DS NPs supported mitochondrial oxidative phosphorylation and modulated macrophage polarization toward an M2 phenotype with an 89% reduction in TNF-\u03b1 expression. The immunometabolic reprogramming promoted the transition from inflammation to regeneration, while the sustained release of bioactive silicate ions synergistically promoted angiogenesis by upregulating ANG expression in HUVECs by 2.06-fold. As a proof of concept, in MRSA-infected wound and the early inflammatory stage of acute lung injury models, DS NPs suppressed cytokine overexpression, accelerated re-epithelialization, and restored microvascular integrity. This work demonstrates a biomimetic hybrid platform that can integrate modulation of the inflammatory microenvironment, metabolic reprogramming, and tissue regeneration, offering a promising therapeutic strategy for early intervention in inflammation-associated tissue injuries.<\/jats:p>","DOI":"10.1021\/acsnano.5c20148","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:01:32Z","timestamp":1788285692000},"page":"24284-24304","source":"Crossref","is-referenced-by-count":0,"title":["Covalently\nSelf-Polymerized Bioactive Poly(dopamine\u2013silicon)\nNanoplatform Reprograms Macrophage Metabolism, Modulates Redox Homeostasis,\nand Promotes Efficient Angiogenesis for Inflammation Injury Repair"],"prefix":"10.1021","volume":"20","author":[{"given":"Yidan","family":"Wang","sequence":"first","affiliation":[{"name":"Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710054"]},{"name":"Northwest Institute for Non-Ferrous Metal Research , , ,","place":["Xi\u2019an, China, 710016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Leng","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710054"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Luo","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710054"]},{"name":"Xidian University , , ,","place":["Xi\u2019an, China, 710126"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Chen","sequence":"additional","affiliation":[{"name":"Northwest Institute for Non-Ferrous Metal Research , , ,","place":["Xi\u2019an, China, 710016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Northwest Institute for Non-Ferrous Metal Research , , ,","place":["Xi\u2019an, China, 710016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8253-7634","authenticated-orcid":true,"given":"Bo","family":"Lei","sequence":"additional","affiliation":[{"name":"Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710054"]},{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710000"]},{"name":"Xi\u2019an Jiaotong University , , ,","place":["Xi\u2019an, China, 710054"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026090809084269700_cit1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2018.07.014","article-title":"Role of Inflammation in the Pathogenesis\nof Atherosclerosis and Therapeutic Interventions","volume":"276","author":"Raggi","year":"2018","journal-title":"Atherosclerosis"},{"issue":"9","key":"2026090809084269700_cit2","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A Guide to Immunometabolism for Immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"2026090809084269700_cit3","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.immuni.2023.01.011","article-title":"Oxidative Phosphorylation\nSelectively Orchestrates Tissue Macrophage Homeostasis","volume":"56","author":"Wculek","year":"2023","journal-title":"Immunity"},{"issue":"32","key":"2026090809084269700_cit4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401369","article-title":"Stem Cell-Derived Nanovesicles\nEmbedded in Dual-Layered Hydrogel\nfor Programmed ROS Regulation and Comprehensive Tissue Regeneration\nin Burn Wound Healing","volume":"36","author":"Zhao","year":"2024","journal-title":"Adv. Mater."},{"issue":"7","key":"2026090809084269700_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410107","article-title":"Metabolic Reprogramming of Macrophages by Biomimetic\nMelatonin-Loaded Liposomes Effectively Attenuates Acute Gouty Arthritis\nin a Mouse Model","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci."},{"key":"2026090809084269700_cit6","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.jconrel.2021.12.018","article-title":"RBC-Hitchhiking Chitosan\nNanoparticles Loading Methylprednisolone\nfor Lung-Targeting Delivery","volume":"341","author":"Ding","year":"2022","journal-title":"J. Controlled Release"},{"issue":"23","key":"2026090809084269700_cit7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz5466","article-title":"Squalene-Based Multidrug\nNanoparticles for Improved\nMitigation of Uncontrolled Inflammation in Rodents","volume":"6","author":"Dormont","year":"2020","journal-title":"Sci. Adv."},{"issue":"19","key":"2026090809084269700_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202313528","article-title":"Composition-Reinforced\nPolydopamine Nanoenzyme for Improved Impairment of Prostatitis-Damaged\nSexual Behavior and Enhanced Anti-Prostate Cancer","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"32","key":"2026090809084269700_cit9","doi-asserted-by":"publisher","first-page":"35782","DOI":"10.1021\/acsami.0c05497","article-title":"Polydopamine Nanoparticles as an\nOrganic and Biodegradable Multitasking Tool for Neuroprotection and\nRemote Neuronal Stimulation","volume":"12","author":"Battaglini","year":"2020","journal-title":"ACS Appl. Mater.\nInterfaces"},{"issue":"5","key":"2026090809084269700_cit10","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s10311-020-01033-6","article-title":"Toxicity of Metal and Metal Oxide Nanoparticles: A\nReview","volume":"18","author":"Sengul","year":"2020","journal-title":"Environ. Chem. Lett."},{"issue":"9","key":"2026090809084269700_cit11","doi-asserted-by":"publisher","first-page":"8882","DOI":"10.1021\/acsnano.8b04022","article-title":"Polydopamine\nNanoparticles as Efficient Scavengers for Reactive Oxygen Species\nin Periodontal Disease","volume":"12","author":"Bao","year":"2018","journal-title":"ACS Nano"},{"key":"2026090809084269700_cit12","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.actbio.2023.02.026","article-title":"ROS Scavenging and Inflammation-Directed Polydopamine\nNanoparticles Regulate Gut Immunity and Flora Therapy in Inflammatory\nBowel Disease","volume":"161","author":"Bao","year":"2023","journal-title":"Acta Biomater."},{"key":"2026090809084269700_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129284","article-title":"Polydopamine\nNanoparticles as Dual-Task Platform for Osteoarthritis Therapy: A\nScavenger for Reactive Oxygen Species and Regulator for Cellular Powerhouses","volume":"417","author":"Wang","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"13","key":"2026090809084269700_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207216","article-title":"Polydopamine Nanoparticles Targeting Ferroptosis Mitigate\nIntervertebral\nDisc Degeneration via Reactive Oxygen Species Depletion, Iron Ions\nChelation, and GPX4 Ubiquitination Suppression","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"2026090809084269700_cit15","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2289846","article-title":"Polydopamine Nanomaterials\nand Their Potential Applications\nin the Treatment of Autoimmune Diseases","volume":"30","author":"Wu","year":"2023","journal-title":"Drug\nDelivery"},{"issue":"21","key":"2026090809084269700_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202213151","article-title":"Nanomodulators\nCapable of Timely Scavenging ROS for Inflammation and Prognosis Control\nFollowing Photothermal Tumor Therapy","volume":"33","author":"Wang","year":"2023","journal-title":"Adv. Funct.\nMater."},{"key":"2026090809084269700_cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100544","article-title":"Ultra-Small Polydopamine\nNanomedicine-Enabled Antioxidation\nAgainst Senescence","volume":"19","author":"Han","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"3","key":"2026090809084269700_cit18","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1039\/D1CS01022K","article-title":"Silicon-Containing\nNanomedicine and\nBiomaterials: Materials Chemistry, Multi-Dimensional Design, and Biomedical\nApplication","volume":"53","author":"Chen","year":"2024","journal-title":"Chem. Soc. Rev."},{"key":"2026090809084269700_cit19","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.bioactmat.2023.01.019","article-title":"Multi-Layer-Structured\nBioactive Glass Nanopowder for Multistage-Stimulated Hemostasis and\nWound Repair","volume":"25","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"8","key":"2026090809084269700_cit20","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and Molecular\nMechanisms of Skin Wound Healing","volume":"25","author":"Pen\u0303a","year":"2024","journal-title":"Nat. Rev.\nMol. Cell Biol."},{"key":"2026090809084269700_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102199","article-title":"Application of Nanoparticles\nin the Treatment of Acute Lung Injury:\nCurrent Situation and Future Directions","volume":"34","author":"Zhang","year":"2025","journal-title":"Mater.\nToday Bio"},{"issue":"78","key":"2026090809084269700_cit22","doi-asserted-by":"publisher","first-page":"74087","DOI":"10.1039\/C6RA01658H","article-title":"Glycidyl Alkoxysilane\nReactivities Towards Simple Nucleophiles in Organic Media for Improved\nMolecular Structure Definition in Hybrid Materials","volume":"6","author":"Guillory","year":"2016","journal-title":"RSC Adv."},{"issue":"7","key":"2026090809084269700_cit23","doi-asserted-by":"publisher","DOI":"10.3390\/app10072287","article-title":"Sol-Gel Treatment of\nTextiles for the Entrapping of an Antioxidant\/Anti-Inflammatory Molecule:\nFunctional Coating Morphological Characterization and Drug Release\nEvaluation","volume":"10","author":"Puoci","year":"2020","journal-title":"Appl. Sci"},{"issue":"5","key":"2026090809084269700_cit24","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1021\/ma062091b","article-title":"Self-Assembly of a Bridged Silsesquioxane\nContaining a Pendant Hydrophobic Chain in the Organic Bridge","volume":"40","author":"Romeo","year":"2007","journal-title":"Macromolecules"},{"issue":"28","key":"2026090809084269700_cit25","doi-asserted-by":"publisher","first-page":"10781","DOI":"10.1021\/acs.inorgchem.2c00996","article-title":"Transformation of\nL-DOPA and Dopamine on the Surface of Gold Nanoparticles: An NMR and\nComputational Study","volume":"61","author":"Kalc\u030cec","year":"2022","journal-title":"Inorg. Chem."},{"issue":"35","key":"2026090809084269700_cit26","doi-asserted-by":"publisher","first-page":"12018","DOI":"10.1002\/anie.201903527","article-title":"Mussel-Inspired Two-Dimensional\nFreestanding Alkyl-Polydopamine Janus\nNanosheets","volume":"58","author":"Sheng","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"issue":"10","key":"2026090809084269700_cit27","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1002\/adfm.201202127","article-title":"Building-Block\nDiversity in Polydopamine Underpins a Multifunctional Eumelanin-Type\nPlatform Tunable Through a Quinone Control Point","volume":"23","author":"Della Vecchia","year":"2013","journal-title":"Adv. Funct. Mater."},{"issue":"33","key":"2026090809084269700_cit28","doi-asserted-by":"publisher","first-page":"10539","DOI":"10.1021\/la4020288","article-title":"Structure\nof Polydopamine: A Never-Ending Story?","volume":"29","author":"Liebscher","year":"2013","journal-title":"Langmuir"},{"issue":"34","key":"2026090809084269700_cit29","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1002\/anie.200902208","article-title":"Organic-Inorganic\nNanospheres with Responsive Molecular\nGates for Drug Storage and Release","volume":"48","author":"Corma","year":"2009","journal-title":"Angew. Chem.,\nInt. Ed."},{"key":"2026090809084269700_cit30","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.jpowsour.2016.10.102","article-title":"Synthesis\nand Properties of Reprocessable Sulfonated Polyimides Cross-Linked\nvia Acid Stimulation for Use as Proton Exchange Membranes","volume":"337","author":"Zhang","year":"2017","journal-title":"J. Power Sources"},{"key":"2026090809084269700_cit31","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.jpowsour.2015.03.058","article-title":"An All-Solid-State\nLithium Ion Battery\nElectrolyte Membrane Fabricated by Hot-Pressing Method","volume":"284","author":"Han","year":"2015","journal-title":"J. Power Sources"},{"key":"2026090809084269700_cit32","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.cej.2016.10.038","article-title":"Facile\nImmobilization of Ag Nanoparticles\non Microchannel Walls in Microreactors for Catalytic Applications","volume":"309","author":"Zhang","year":"2017","journal-title":"Chem. Eng. J."},{"issue":"5","key":"2026090809084269700_cit33","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1039\/D0TC04800C","article-title":"Facile Synthesis\nof\nSolid-State Fluorescent Organosilica Nanoparticles with a Photoluminescence\nQuantum Yield of 73.3% for Fingerprint Recognition and White-Light-Emitting\nDiodes","volume":"9","author":"Liang","year":"2021","journal-title":"J. Mater. Chem. C"},{"issue":"9","key":"2026090809084269700_cit34","doi-asserted-by":"publisher","first-page":"7523","DOI":"10.1021\/acsami.7b19865","article-title":"Polydopamine Surface Chemistry: A\nDecade of Discovery","volume":"10","author":"Ryu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"2026090809084269700_cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36303-8","article-title":"New Insights in Polydopamine Formation via Surface\nAdsorption","volume":"14","author":"Hemmatpour","year":"2023","journal-title":"Nat. Commun."},{"key":"2026090809084269700_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.nxnano.2025.100220","article-title":"Distinctive Asymmetric Bowl-Like Nanoparticles: Synthesis,\nProperties\nand Applications","volume":"8","author":"Fang","year":"2025","journal-title":"Next Nanotechnol."},{"issue":"35","key":"2026090809084269700_cit37","doi-asserted-by":"publisher","first-page":"11306","DOI":"10.1021\/jacs.6b06558","article-title":"Formation\nof Asymmetric Bowl-Like Mesoporous Particles via Emulsion-Induced\nInterface Anisotropic Assembly","volume":"138","author":"Guan","year":"2016","journal-title":"J. Am. Chem.\nSoc."},{"issue":"1","key":"2026090809084269700_cit38","doi-asserted-by":"publisher","DOI":"10.1186\/s41181-023-00227-x","article-title":"Intranasal Administration Enhances\nSize-Dependent Pulmonary Phagocytic Uptake of Poly(Lactic-Co-Glycolic\nAcid) Nanoparticles","volume":"9","author":"Baek","year":"2024","journal-title":"EJNMMI Radiopharmacy Chem."},{"issue":"12","key":"2026090809084269700_cit39","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122742","article-title":"Lipid and Polymeric\nNanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery\nin the Treatment of Depression and Anxiety Disorders","volume":"14","author":"Alberto","year":"2022","journal-title":"Pharmaceutics"},{"issue":"9","key":"2026090809084269700_cit40","doi-asserted-by":"publisher","first-page":"15124","DOI":"10.1021\/acsnano.2c06357","article-title":"Hybrid Biomimetic Nanovesicles\nto Drive High Lung Biodistribution and Prevent Cytokine Storm for\nARDS Treatment","volume":"16","author":"Qiao","year":"2022","journal-title":"ACS Nano"},{"issue":"19","key":"2026090809084269700_cit41","doi-asserted-by":"publisher","first-page":"10033","DOI":"10.1021\/acs.analchem.5b02639","article-title":"Reversible or Not? Distinguishing\nAgglomeration and\nAggregation at the Nanoscale","volume":"87","author":"Sokolov","year":"2015","journal-title":"Anal. Chem."},{"key":"2026090809084269700_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.113530","article-title":"Review on Polydopamine\nSupramolecular Ordering-Mechanism Elucidation and Application in 2D\nNanocomposites Fabrication","volume":"221","author":"Szewczyk","year":"2024","journal-title":"Eur. Polym. J."},{"issue":"8","key":"2026090809084269700_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202500151","article-title":"Polydopamine-Coated\nSelenium Nanoparticles as a Stable Catalyst for Tunable and Sustained\nNitric Oxide Generation","volume":"5","author":"Geng","year":"2025","journal-title":"Small Sci."},{"key":"2026090809084269700_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.123107","article-title":"Rapid Preparation\nof Adsorbent Based on Mussel Inspired Chemistry and Simultaneous Removal\nof Heavy Metal Ions in Water","volume":"383","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"issue":"10","key":"2026090809084269700_cit45","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1021\/acsabm.9b00747","article-title":"Synthesis\nof Ultrasmall Synthetic\nMelanin Nanoparticles by UV Irradiation in Acidic and Neutral Conditions","volume":"2","author":"Lemaster","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"issue":"8","key":"2026090809084269700_cit46","doi-asserted-by":"publisher","first-page":"5081","DOI":"10.1039\/D2RA06669F","article-title":"Kinetic\nStudy of Polydopamine Sphere Synthesis Using TRIS: Relationship Between\nSynthesis Conditions and Final Properties","volume":"13","author":"Garci\u0301a-Mayorga","year":"2023","journal-title":"RSC\nAdv."},{"issue":"2","key":"2026090809084269700_cit47","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.471","article-title":"Nonconventional\nAggregation-Induced Emission Polysiloxanes: Structures, Characteristics,\nand Applications","volume":"5","author":"Zhao","year":"2024","journal-title":"Aggregate"},{"issue":"3","key":"2026090809084269700_cit48","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1039\/C9MH01197H","article-title":"Recent Developments in Polydopamine Fluorescent Nanomaterials","volume":"7","author":"Yang","year":"2020","journal-title":"Mater. Horiz."},{"issue":"3","key":"2026090809084269700_cit49","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1021\/acs.joc.1c02308","article-title":"Antiradical Activity of Dopamine, L-DOPA, Adrenaline,\nand Noradrenaline in Water\/Methanol and in Liposomal Systems","volume":"87","author":"Jodko-Pio\u0301recka","year":"2022","journal-title":"J. Org. Chem."},{"key":"2026090809084269700_cit50","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several Lines of Antioxidant\nDefense\nAgainst Oxidative Stress: Antioxidant Enzymes, Nanomaterials with\nMultiple Enzyme-Mimicking Activities, and Low-Molecular-Weight Antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"29","key":"2026090809084269700_cit51","doi-asserted-by":"publisher","first-page":"32901","DOI":"10.1021\/acsami.2c06981","article-title":"Polydopamine-Based\nNanocomposite as a Biomimetic Antioxidant with a Variety of Enzymatic\nActivities for Parkinson\u2019s Disease","volume":"14","author":"Wang","year":"2022","journal-title":"ACS\nAppl. Mater. Interfaces"},{"key":"2026090809084269700_cit52","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.actbio.2019.02.032","article-title":"Role of Polydopamine\u2019s Redox-Activity\non Its Pro-Oxidant, Radical-Scavenging, and Antimicrobial Activities","volume":"88","author":"Liu","year":"2019","journal-title":"Acta Biomater."},{"issue":"2","key":"2026090809084269700_cit53","doi-asserted-by":"publisher","first-page":"128","DOI":"10.31635\/ccschem.020.201900077","article-title":"Structural\nand Functional\nTailoring of Melanin-Like Polydopamine Radical Scavengers","volume":"2","author":"Yang","year":"2020","journal-title":"CCS Chem."},{"issue":"32","key":"2026090809084269700_cit54","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb1311","article-title":"Multifunctional Bioactive Nd-Ca-Si Glasses for Fluorescence\nThermometry,\nPhotothermal Therapy, and Burn Tissue Repair","volume":"6","author":"Ma","year":"2020","journal-title":"Sci. Adv."},{"issue":"4","key":"2026090809084269700_cit55","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3892\/ijmm.2017.3110","article-title":"Role of Interferon Regulatory Factor-1 in Lipopolysaccharide-Induced\nMitochondrial Damage and Oxidative Stress Responses in Macrophages","volume":"40","author":"Deng","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"2026090809084269700_cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.160171","article-title":"Self-Assembling Natural\nFlavonoid Nanomedicines for Alveolar Macrophage Reprogramming by Restoring\nMitochondrial Function in Acute Lung Injury Therapy","volume":"506","author":"Pang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"7","key":"2026090809084269700_cit57","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11070410","article-title":"Non-Invasive Differentiation\nof M1\nand M2 Activation in Macrophages Using Hyperpolarized 13C MRS of Pyruvate and DHA at 1.47 T","volume":"11","author":"Qiao","year":"2021","journal-title":"Metabolites"},{"issue":"14","key":"2026090809084269700_cit58","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202408791","article-title":"A Constant Filgotinib\nDelivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel\nfor Accelerating Wound Healing via Restoring Macrophage Mitochondrial\nHomeostasis","volume":"21","author":"Xie","year":"2025","journal-title":"Small"},{"issue":"19","key":"2026090809084269700_cit59","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415459","article-title":"Silicon\nEnhances Functional Mitochondrial Transfer to Improve Neurovascularization\nin Diabetic Bone Regeneration","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci."},{"issue":"29","key":"2026090809084269700_cit60","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200521","article-title":"Immunoregulation in Diabetic Wound\nRepair with a Photoenhanced\nGlycyrrhizic Acid Hydrogel Scaffold","volume":"34","author":"Qian","year":"2022","journal-title":"Adv. Mater."},{"issue":"52","key":"2026090809084269700_cit61","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202006454","article-title":"Bioinspired Nanofibrous Glycopeptide\nHydrogel Dressing for Accelerating Wound Healing: A Cytokine-Free,\nM2-Type Macrophage Polarization Approach","volume":"30","author":"Feng","year":"2020","journal-title":"Adv.\nFunct. Mater."},{"issue":"20","key":"2026090809084269700_cit62","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100505","article-title":"Natural Melanin\/Alginate\nHydrogels Achieve Cardiac Repair through ROS Scavenging and Macrophage\nPolarization","volume":"8","author":"Zhou","year":"2021","journal-title":"Adv. Sci."},{"issue":"1\u20132","key":"2026090809084269700_cit63","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","article-title":"Dopamine Controls\nSystemic Inflammation\nthrough Inhibition of NLRP3 Inflammasome","volume":"160","author":"Yan","year":"2015","journal-title":"Cell"},{"issue":"1","key":"2026090809084269700_cit64","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.molcel.2020.01.022","article-title":"Dopamine Uses the DRD5-ARRB2-PP2A\nSignaling Axis to Block the TRAF6-Mediated NF-\u03baB Pathway and\nSuppress Systemic Inflammation","volume":"78","author":"Wu","year":"2020","journal-title":"Mol. Cell"},{"key":"2026090809084269700_cit65","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120772","article-title":"A Co-delivery Platform for Synergistic Promotion of Angiogenesis\nBased on Biodegradable, Therapeutic and Self-Reporting Luminescent\nPorous Silicon Microparticles","volume":"272","author":"Duan","year":"2021","journal-title":"Biomaterials"},{"issue":"7","key":"2026090809084269700_cit66","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1089\/wound.2017.0761","article-title":"Immune Regulation\nof Skin Wound Healing: Mechanisms and Novel Therapeutic Targets","volume":"7","author":"Larouche","year":"2018","journal-title":"Adv. Wound Care"},{"issue":"39","key":"2026090809084269700_cit67","doi-asserted-by":"publisher","first-page":"26983","DOI":"10.1021\/jacs.4c08336","article-title":"Synthesis of Mesoporous\nCatechin Nanoparticles as Biocompatible Drug-Free Antibacterial Mesoformulation","volume":"146","author":"Lin","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"37","key":"2026090809084269700_cit68","doi-asserted-by":"publisher","first-page":"33184","DOI":"10.1021\/acsnano.5c07062","article-title":"Inhalation of Mesenchymal-Stem-Cell-Derived\nNanovesicles Delivering Catalase Enhances the Treatment for Acute\nLung Injury","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"2026090809084269700_cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102278","article-title":"Prolonged\nResident Nanoparticles Effectively Treat Acute Lung Injury\nvia the Selective Upregulation of Intracellular Hydrogen Peroxide","volume":"56","author":"Wang","year":"2024","journal-title":"Nano Today"},{"issue":"10","key":"2026090809084269700_cit70","doi-asserted-by":"publisher","first-page":"9614","DOI":"10.1021\/nn507485j","article-title":"Hybrid Mesoporous Silica-Based Drug\nCarrier Nanostructures with Improved\nDegradability by Hydroxyapatite","volume":"9","author":"Hao","year":"2015","journal-title":"ACS Nano"},{"issue":"7","key":"2026090809084269700_cit71","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70073","article-title":"Highly Stable Aggregation-Induced\nEmission-Functionalized Histatin1\nCoated with Platelet Vesicles for Diabetic Wound Healing","volume":"6","author":"Lei","year":"2025","journal-title":"Aggregate"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5c20148","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/35\/24284\/67487583\/acsnano.5c20148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/35\/24284\/67487583\/acsnano.5c20148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:08:50Z","timestamp":1788872930000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/35\/24284\/5336989\/Covalently-Self-Polymerized-Bioactive-Poly"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":71,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,27]]},"published-print":{"date-parts":[[2026,9,8]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.5c20148","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]}}}