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By coordinating drug interactions within the confined inner compartment of core\u2013shell nanomedicines, we conceived multicomponent nanomedicines directed to achieve synchronized and synergistic drug cooperation within tumor cells as a strategy for enhancing efficacy, overcoming drug resistance, and eradicating CSCs. The approach was validated by using polymeric micellar nanomedicines co-incorporating the pan-kinase inhibitor staurosporine (STS), which was identified as the most potent CSC inhibitor from a panel of signaling-pathway inhibitors, and the cytotoxic agent epirubicin (Epi), through rationally contriving the affinity between the drugs. The micelles released both drugs simultaneously, triggered by acidic endosomal pH, attaining concurrent intracellular delivery, with STS working as a companion for Epi, down-regulating efflux transporters and resistance mechanisms induced by Epi. These features prompted the nanomedicines to eradicate orthotopic xenografts of Epi-resistant mesothelioma bearing a CSC subpopulation.<\/jats:p>","DOI":"10.1021\/acsnano.6b00900","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T15:08:13Z","timestamp":1461078493000},"page":"5643-5655","source":"Crossref","is-referenced-by-count":68,"title":["Nanomedicines\nEradicating Cancer Stem-like Cells\n                    <i>in Vivo<\/i>\n                    by pH-Triggered\nIntracellular Cooperative Action of Loaded Drugs"],"prefix":"10.1021","volume":"10","author":[{"given":"Hiroaki","family":"Kinoh","sequence":"first","affiliation":[{"name":"Innovation Center of NanoMedicine , 3-25-14 Tonomachi , Kawasaki-ku, ,","place":["Kawasaki, Japan, 210-0821"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Miura","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Chida","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Liu","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Mizuno","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-0033"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Fukushima","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-8656"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Morodomi","sequence":"additional","affiliation":[{"name":"Kyushu University , , 3-1-1 Maidashi , Higashi-ku, , ,","place":["Fukuoka, Japan, 812-8582"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Tokyo Institute of Technology , , R1-11, 4259 Nagatsuta , Midori-ku, ,","place":["Yokohama, Japan, 226-8503"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Cabral","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-8656"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Innovation Center of NanoMedicine , 3-25-14 Tonomachi , Kawasaki-ku, ,","place":["Kawasaki, Japan, 210-0821"]},{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-0033"]},{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-8656"]},{"name":"The University of Tokyo , , 7-3-1 Hongo , Bunkyo-ku, ,","place":["Tokyo, Japan, 113-8656"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"2026090404231443000_cit1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/nrc2499","article-title":"Cancer Stem Cells\nin Solid Tumours: Accumulating Evidence and Unresolved Questions","volume":"8","author":"Visvader","year":"2008","journal-title":"Nat. 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