{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:31:51Z","timestamp":1790289111227,"version":"4.1.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2014-3981"],"award-info":[{"award-number":["2014-3981"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"ESS and MAX IV Cross Border Science and Society","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Atherosclerosis and its clinical consequences are the leading cause of death in the western hemisphere. While many studies throughout the last decades have aimed at understanding the disease, the clinical markers in use today still fail to accurately predict the risks. The role of the current main clinical indicator, low density lipoprotein (LDL), in depositing fat to the vessel wall is believed to be the onset of the process. However, many subfractions of the LDL, which differ both in structure and composition, are present in the blood and among different individuals. Understanding the relationship between LDL structure and composition is key to unravel the specific role of various LDL components in the development and\/or prevention of atherosclerosis. Here, we describe a model for analyzing small-angle X-ray scattering data for rapid and robust structure determination for the LDL. The model not only gives the overall structure but also the particular internal layering of the fats inside the LDL core. Thus, the melting of the LDL can be followed in situ as a function of temperature for samples extracted from healthy human patients and purified using a double protocol based on ultracentrifugation and size-exclusion chromatography. The model provides information on: (i) the particle-specific melting temperature of the core lipids, (ii) the structural organization of the core fats inside the LDL, (iii) the overall shape of the particle, and (iv) the flexibility and overall conformation of the outer protein\/hydrophilic layer at a given temperature as governed by the organization of the core. The advantage of this method over other techniques such as cryo-TEM is the possibility of in situ experiments under near-physiological conditions which can be performed relatively fast (minutes at home source, seconds at synchrotron). This approach now allows the monitoring of structural changes in the LDL upon different stresses from the environment, such as changes in temperature, oxidation, or external agents used or currently in development against atherosclerotic plaque build-up and which are targeting the LDL.<\/jats:p>","DOI":"10.1021\/acsnano.6b08089","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T17:22:32Z","timestamp":1483464152000},"page":"1080-1090","source":"Crossref","is-referenced-by-count":33,"title":["Modeling\nSmall-Angle X-ray Scattering Data\nfor Low-Density Lipoproteins: Insights into the Fatty Core Packing\nand Phase Transition"],"prefix":"10.1021","volume":"11","author":[{"given":"Selma","family":"Maric","sequence":"first","affiliation":[{"name":"Malmo\u0308 University , , ,","place":["Malmo\u0308, Sweden, 20506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania Kjellerup","family":"Lind","sequence":"additional","affiliation":[{"name":"Malmo\u0308 University , , ,","place":["Malmo\u0308, Sweden, 20506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Lyngs\u00f8","sequence":"additional","affiliation":[{"name":"Aarhus University , , ,","place":["Aarhus, Denmark, 8000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-3540","authenticated-orcid":true,"given":"Marite\u0301","family":"Ca\u0301rdenas","sequence":"additional","affiliation":[{"name":"Malmo\u0308 University , , ,","place":["Malmo\u0308, Sweden, 20506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Skov","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus University , , ,","place":["Aarhus, Denmark, 8000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,1,3]]},"reference":[{"key":"2026090203552886000_cit1","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1093\/eurheartj\/ehu299","article-title":"Cardiovascular Disease\nIn Europe 2014: Epidemiological Update","volume":"35","author":"Nichols","year":"2014","journal-title":"Eur.\nHeart J."},{"key":"2026090203552886000_cit2","doi-asserted-by":"publisher","first-page":"III2","DOI":"10.1161\/01.CIR.0000131511.50734.44","article-title":"Atherogenic Lipoprotein Particles\nIn Atherosclerosis","volume":"109","author":"Carmena","year":"2004","journal-title":"Circulation"},{"key":"2026090203552886000_cit3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1046\/j.1365-2125.1999.00991.x","article-title":"LDL Particle Size:\nAn Important Drug Target?","volume":"48","author":"Rajman","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2026090203552886000_cit4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0022-2275(20)38518-7","article-title":"Further Resolution\nOf The Low Density\nLipoprotein Spectrum In Normal Human Plasma: Physicochemical Characteristics\nOf Discrete Subspecies Separated By Density Gradient Ultracentrifugation","volume":"29","author":"Chapman","year":"1988","journal-title":"J. Lipid Res."},{"key":"2026090203552886000_cit5","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/(SICI)1097-0134(199706)28:2&lt;293::AID-PROT17&gt;3.3.CO;2-L","article-title":"Crystallization And Preliminary X-Ray\nDiffraction Data Of Two Different Human Low-Density Lipoprotein (LDL)\nSubfractions","volume":"28","author":"Ritter","year":"1997","journal-title":"Proteins: Struct., Funct., Genet."},{"key":"2026090203552886000_cit6","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S0022-0248(98)00846-X","article-title":"Crystallization\nOf Human Low Density Lipoprotein (LDL),\nA Large Lipid-Protein Complex - Collection Of X-Ray Data At Very Low\nResolution","volume":"196","author":"Ritter","year":"1999","journal-title":"J. Cryst. Growth"},{"key":"2026090203552886000_cit7","doi-asserted-by":"publisher","first-page":"28731","DOI":"10.1074\/jbc.271.46.28731","article-title":"Crystallization And\nPreliminary X-Ray Analysis Of A Low Density Lipoprotein From Human\nPlasma","volume":"271","author":"Prassl","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2026090203552886000_cit8","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1073\/pnas.72.6.2270","article-title":"Neutron Scattering Study Of Human\nSerum Low Density Lipoprotein","volume":"72","author":"Stuhrmann","year":"1975","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"key":"2026090203552886000_cit9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1515\/bchm2.1977.358.2.771","article-title":"Molecular Packing And Fluidity Of\nLipids In Human Serum Low Density Lipoproteins","volume":"358","author":"Laggner","year":"1977","journal-title":"Hoppe-Seyler's Z. Physiol. Chem."},{"key":"2026090203552886000_cit10","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1073\/pnas.74.3.1042","article-title":"Structure Of Human\nPlasma Low-Density Lipoproteins: Molecular Organization Of The Central\nCore","volume":"74","author":"Atkinson","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026090203552886000_cit11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1432-1033.1978.tb11998.x","article-title":"The Structure Of Human-Plasma\nLow-Density Lipoprotein B. An X-Ray Small-Angle Scattering Study","volume":"82","author":"Muller","year":"1978","journal-title":"Eur. J. Biochem."},{"key":"2026090203552886000_cit12","doi-asserted-by":"crossref","first-page":"11832","DOI":"10.1016\/S0021-9258(19)68481-4","article-title":"Neutron Small\nAngle Scattering On Selectively Deuterated Human Plasma Low Density\nLipoproteins. The Location Of Polar Phospholipid Headgroups","volume":"256","author":"Laggner","year":"1981","journal-title":"J. Biol. Chem."},{"key":"2026090203552886000_cit13","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1042\/bj3100407","article-title":"Characterization\nOf The Structure Of Polydisperse Human Low-Density Lipoprotein By\nNeutron Scattering","volume":"310","author":"Meyer","year":"1995","journal-title":"Biochem. J."},{"key":"2026090203552886000_cit14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00249-008-0368-y","article-title":"Molecular Structure\nOf Low Density Lipoprotein: Current\nStatus And Future Challenges","volume":"38","author":"Prassl","year":"2009","journal-title":"Eur. Biophys.\nJ."},{"key":"2026090203552886000_cit15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/0167-4838(90)90100-T","article-title":"Structure\nof Human Low-Density Lipoprotein Subfractions, Determined by X-Ray\nSmall-Angle Scattering","volume":"1037","author":"Baumstark","year":"1990","journal-title":"Biochim. Biophys. Acta,\nProtein Struct. Mol. Enzymol."},{"key":"2026090203552886000_cit16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0021-9258(17)32781-3","article-title":"Structure And Interactions\nOf Lipids\nIn Human Plasma Low Density Lipoproteins","volume":"252","author":"Deckelbaum","year":"1977","journal-title":"J.\nBiol. Chem."},{"key":"2026090203552886000_cit17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1388-1981(00)00123-2","article-title":"Structure\nOf Low Density Lipoprotein (LDL) Particles: Basis For Understanding\nMolecular Changes In Modified LDL","volume":"1488","author":"Hevonoja","year":"2000","journal-title":"Biochim.\nBiophys. Acta, Mol. Cell Biol. Lipids"},{"key":"2026090203552886000_cit18","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1073\/pnas.92.7.2509","article-title":"Core Lipid\nStructure Is a Major Determinant of the Oxidative Resistance of Low-Density-Lipoprotein","volume":"92","author":"Schuster","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026090203552886000_cit19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1194\/jlr.M011569","article-title":"Human LDL\nCore Cholesterol Ester Packing: Three-Dimensional\nImage Reconstruction And SAXS Simulation Studies","volume":"52","author":"Liu","year":"2011","journal-title":"J. Lipid Res."},{"key":"2026090203552886000_cit20","doi-asserted-by":"publisher","first-page":"8420","DOI":"10.1073\/pnas.96.15.8420","article-title":"Three-Dimensional Structure Of Low\nDensity Lipoproteins By Electron Cryomicroscopy","volume":"96","author":"Orlova","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026090203552886000_cit21","doi-asserted-by":"publisher","first-page":"e18841","DOI":"10.1371\/journal.pone.0018841","article-title":"Three-Dimensional Cryoem Reconstruction Of Native LDL\nParticles To 16A Resolution At Physiological Body Temperature","volume":"6","author":"Kumar","year":"2011","journal-title":"PLoS One"},{"key":"2026090203552886000_cit22","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1172\/JCI103182","article-title":"Distribution And Chemical Composition\nOf Ultracentrifugally Separated Lipoproteins In Human Serum","volume":"34","author":"Havel","year":"1955","journal-title":"J. Clin. Invest."},{"key":"2026090203552886000_cit23","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/clinchem\/43.10.1904","article-title":"Measurement Of Low-Density\nLipoprotein Particle Size By High-Performance Gel-Filtration Chromatography","volume":"43","author":"Scheffer","year":"1997","journal-title":"Clin Chem."},{"key":"2026090203552886000_cit24","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid\nAnd Sensitive Method For The Quantitation Of Microgram Quantities\nOf Protein Utilizing The Principle Of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"2026090203552886000_cit25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1109\/MCG.1981.1673799","article-title":"Superquadrics\nand Angle-Preserving Transformations","volume":"1","author":"Barr","year":"1981","journal-title":"IEEE Comput.\nGraph. Appl."},{"key":"2026090203552886000_cit26","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1073\/pnas.0908004107","article-title":"Model Of\nHuman Low-Density Lipoprotein\nAnd Bound Receptor Based On Cryoem","volume":"107","author":"Ren","year":"2010","journal-title":"Proc. Natl.\nAcad. Sci. U. S. A."},{"key":"2026090203552886000_cit27","doi-asserted-by":"publisher","first-page":"12495","DOI":"10.1074\/jbc.M110.209130","article-title":"The Low Resolution Structure Of Apoa1 In Spherical\nHigh Density Lipoprotein Revealed By Small Angle Neutron Scattering","volume":"286","author":"Wu","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2026090203552886000_cit28","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jmb.2009.06.019","article-title":"The Role Of Decorated\nSDS Micelles In Sub-CMC Protein Denaturation And Association","volume":"391","author":"Andersen","year":"2009","journal-title":"J. Mol. Biol."},{"key":"2026090203552886000_cit29","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1002\/cbic.201402407","article-title":"Generic Structures\nOf Cytotoxic Liprotides:\nNano-Sized Complexes With Oleic Acid Cores And Shells Of Disordered\nProteins","volume":"15","author":"Kaspersen","year":"2014","journal-title":"ChemBioChem"},{"key":"2026090203552886000_cit30","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1016\/j.bpj.2014.04.049","article-title":"Effect\nOf Oxidation On The Structure Of Human Low- And High-Density Lipoproteins","volume":"106","author":"Oliveira","year":"2014","journal-title":"Biophys. J."},{"key":"2026090203552886000_cit31","doi-asserted-by":"crossref","first-page":"5955","DOI":"10.1016\/S0021-9258(19)67691-X","article-title":"Mapping Apolipoprotein B On The Low\nDensity Lipoprotein\nSurface By Immunoelectron Microscopy","volume":"266","author":"Chatterton","year":"1991","journal-title":"J. Biol.\nChem."},{"key":"2026090203552886000_cit32","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0022-2275(20)37233-3","article-title":"Cryo-Electron Microscopy Of Low Density\nLipoprotein And Reconstituted Discoidal High Density Lipoprotein:\nImaging Of The Apolipoprotein Moiety","volume":"38","author":"van Antwerpen","year":"1997","journal-title":"J. Lipid\nRes."},{"key":"2026090203552886000_cit33","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.abb.2004.08.031","article-title":"Preferred Orientations Of LDL In Vitreous Ice Indicate\nA Discoid Shape Of The Lipoprotein Particle","volume":"432","author":"van Antwerpen","year":"2004","journal-title":"Arch. Biochem. Biophys."},{"key":"2026090203552886000_cit34","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1126\/science.170681","article-title":"Thermal\nTransitions In Human Plasma Low Density Lipoproteins","volume":"190","author":"Deckelbaum","year":"1975","journal-title":"Science"},{"key":"2026090203552886000_cit35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0163-7827(84)90002-X","article-title":"Physical Properties Of Cholesteryl\nEsters","volume":"23","author":"Ginsburg","year":"1984","journal-title":"Prog. Lipid Res."},{"key":"2026090203552886000_cit36","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0065-3233(08)60641-5","article-title":"Apolipoprotein\nB And Low-Density\nLipoprotein Structure: Implications For Biosynthesis Of Triglyceride-Rich\nLipoproteins","volume":"45","author":"Schumaker","year":"1994","journal-title":"Adv. Protein Chem."},{"key":"2026090203552886000_cit37","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0022-2275(20)30267-4","article-title":"Structure Of Apolipoprotein\nB-100 In Low Density Lipoproteins","volume":"42","author":"Segrest","year":"2001","journal-title":"J. Lipid\nRes."},{"key":"2026090203552886000_cit38","doi-asserted-by":"publisher","first-page":"19732","DOI":"10.1074\/jbc.M601688200","article-title":"Modular Structure Of\nSolubilized Human Apolipoprotein\nB-100. Low Resolution Model Revealed By Small Angle Neutron Scattering","volume":"281","author":"Johs","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2026090203552886000_cit39","doi-asserted-by":"publisher","first-page":"e4079","DOI":"10.1371\/journal.pone.0004079","article-title":"Low Density Lipoproteins\nAs Circulating Fast Temperature Sensors","volume":"3","author":"Prassl","year":"2008","journal-title":"PLoS\nOne"},{"key":"2026090203552886000_cit40","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1016\/j.bbamem.2011.07.022","article-title":"Fluid Phase\nLipid Areas And Bilayer\nThicknesses Of Commonly Used Phosphatidylcholines As A Function Of\nTemperature","volume":"1808","author":"Kucerka","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"2026090203552886000_cit41","doi-asserted-by":"publisher","first-page":"6871","DOI":"10.1073\/pnas.0602213103","article-title":"Apolipoprotein\nB Is Conformationally\nFlexible But Anchored At A Triolein\/Water Interface: A Possible Model\nFor Lipoprotein Surfaces","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad.\nSci. U. S. A."},{"key":"2026090203552886000_cit42","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1016\/j.bpj.2012.03.071","article-title":"Structure of Immune Stimulating Complex\nMatrices and Immune Stimulating Complexes in Suspension Determined\nby Small-Angle X-Ray Scattering","volume":"102","author":"Pedersen","year":"2012","journal-title":"Biophys. J."},{"key":"2026090203552886000_cit43","doi-asserted-by":"publisher","first-page":"12867","DOI":"10.1021\/bi980828m","article-title":"Apolipoprotein B-100\nConformation And Particle Surface Charge In Human LDL Subspecies:\nImplication For LDL Receptor Interaction","volume":"37","author":"Lund-Katz","year":"1998","journal-title":"Biochemistry"},{"key":"2026090203552886000_cit44","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF02668129","article-title":"Quantitative\nAnalysis Of Phospholipids\nBy Thin-Layer Chromatography And Phosphorus Analysis Of Spots","volume":"1","author":"Rouser","year":"1966","journal-title":"Lipids"},{"key":"2026090203552886000_cit45","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.nimb.2014.11.049","article-title":"Combining SAXS And\nDLS For Simultaneous Measurements And Time-Resolved Monitoring Of\nNanoparticle Synthesis","volume":"343","author":"Schwamberger","year":"2015","journal-title":"Nucl. Instrum. Methods\nPhys. Res., Sect. B"},{"key":"2026090203552886000_cit46","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1107\/S0021889808031129","article-title":"Scatterless\nHybrid Metal-Single-Crystal Slit For Small-Angle X-Ray Scattering\nAnd High-Resolution X-Ray Diffraction","volume":"41","author":"Li","year":"2008","journal-title":"J. Appl.\nCrystallogr."},{"key":"2026090203552886000_cit47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0001-8686(97)00312-6","article-title":"Analysis\nOf Small-Angle Scattering Data From Colloids And Polymer Solutions:\nModeling And Least-Squares Fitting","volume":"70","author":"Pedersen","year":"1997","journal-title":"Adv. Colloid\nInterface Sci."},{"key":"2026090203552886000_cit48","first-page":"137","article-title":"Rigid Physically\nBased Superquadrics","volume-title":"Graphics Gems III","author":"Barr","year":"1992"},{"key":"2026090203552886000_cit49","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.0954-6820.1966.tb02409.x","article-title":"The Structure Of The VLD And The B-Lipoproteins","volume":"179","year":"1966","journal-title":"Acta Med. Scand."},{"key":"2026090203552886000_cit50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.chemphyslip.2006.04.002","article-title":"Partial Molecular\nVolumes Of Lipids\nAnd Cholesterol","volume":"143","author":"Greenwood","year":"2006","journal-title":"Chem. Phys. Lipids"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6b08089","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/11\/1\/1080\/67653365\/acsnano.6b08089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/11\/1\/1080\/67653365\/acsnano.6b08089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:55:33Z","timestamp":1788335733000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/11\/1\/1080\/743766\/Modeling-Small-Angle-X-ray-Scattering-Data-for-Low"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,3]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,3]]},"published-print":{"date-parts":[[2017,1,24]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6b08089","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,3]]}}}