{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:46:25Z","timestamp":1793738785122,"version":"4.6.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2406102"],"award-info":[{"award-number":["2022YFC2406102"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2022ZDZX0029-1"],"award-info":[{"award-number":["2022ZDZX0029-1"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571568"],"award-info":[{"award-number":["32571568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2026,3,17]]},"DOI":"10.1021\/acsnano.6c00168","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:21:45Z","timestamp":1772763705000},"page":"8862-8878","source":"Crossref","is-referenced-by-count":9,"title":["An Acidosis-Activatable Nanocomposite for Synergistic Microenvironment Remodeling and Reprogramming of Innate\u2013Adaptive Immune Crosstalk in Rheumatoid Arthritis"],"prefix":"10.1021","volume":"20","author":[{"given":"Haoyu","family":"Qiu","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wen","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingli","family":"Dong","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxuan","family":"Shui","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanling","family":"Dai","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zou","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-9858","authenticated-orcid":true,"given":"Fang","family":"Lan","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-4042","authenticated-orcid":true,"given":"Yao","family":"Wu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials, College of Biomedical Engineering","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.213"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.91"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404198"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/art.41752"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01880-6"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508072"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.08.043"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101358"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01523-y"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.03.023"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101838"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36468-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29735-1"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406027"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c16772"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00790-8"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01169-7"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210262"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/ar2099"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.02.034"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3432"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08785"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.010"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202305197"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202104640"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c09127"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtnano.2022.100218"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408436"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21714-2"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01994"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307094"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404813"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c01963"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411193"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.01.026"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nature23475"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122534"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/ni1109-1141"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00244-1"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100622"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c06549"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.034"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.655477"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/art.40398"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124263"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102322"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c00168","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c00168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:32:01Z","timestamp":1773768721000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.6c00168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,3,17]]}},"alternative-id":["10.1021\/acsnano.6c00168"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c00168","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}