{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:06:44Z","timestamp":1788876404385,"version":"build-2803163510"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"35","funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK112251"],"award-info":[{"award-number":["R01DK112251"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK124290"],"award-info":[{"award-number":["R01DK124290"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK127531"],"award-info":[{"award-number":["R01DK127531"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK131782"],"award-info":[{"award-number":["R01DK131782"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35HL167143"],"award-info":[{"award-number":["R35HL167143"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity is a risk factor for high-mortality health conditions, including cardiovascular diseases and type 2 diabetes, which makes the advancement of efficacious and safe weight loss therapies a high priority in pharmacology. The causal link between obesity and its comorbid conditions is believed to be a chronic state of inflammation originating within adipose tissue, with macrophages playing central roles, an axis that is not targeted directly by current therapies. Here, we use nanocarriers to deliver an anti-inflammatory glucocorticoid receptor agonist to adipose tissue macrophages and report the impact of size on therapeutic effect. Three dextran nanocarriers between 4\u201330 nm in hydrodynamic diameter released molecular drug cargo at equivalent rates and exhibited similar biological potency in vitro. In vivo in a mouse model of obesity, body weight and body fat were reduced in a size-dependent manner after 2\u20134 weeks of treatment. Unlike current clinical pharmacotherapies for weight loss, these body composition changes were not associated with changes in food intake. Greater retention of larger dextran nanocarriers in visceral adipose tissue appears to elicit a local change to promote browning by increasing mitochondrial abundance and lipid droplet fragmentation. Further development of this platform may result in a safe and potent modulator of adipose tissue in the state of obesity without direct action on nutrient intake to address malnutrition and lean body mass deficiencies observed with current weight loss pharmacotherapies.<\/jats:p>","DOI":"10.1021\/acsnano.6c00432","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:58:06Z","timestamp":1788202686000},"page":"24305-24317","source":"Crossref","is-referenced-by-count":0,"title":["Weight\nLoss without Food Intake Suppression through\nSize-Dependent Retention of Anti-Inflammatory Nanomedicines"],"prefix":"10.1021","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-5834","authenticated-orcid":true,"given":"Natalia Gonzalez","family":"Medina","sequence":"first","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Cui","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-2426","authenticated-orcid":true,"given":"Donglai","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-701X","authenticated-orcid":true,"given":"Muhammad","family":"Fayyaz","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshad","family":"Mirshafeeyan","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-4816","authenticated-orcid":true,"given":"Andrew M.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]},{"name":"University of Illinois Urbana\u2212Champaign , , , ,","place":["Urbana, Illinois, United States, 61801"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"2026090809080363300_cit1","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: Global\nEpidemiology and Pathogenesis","volume":"15","author":"Blu\u0308her","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"2026090809080363300_cit2","unstructured":"Stierman, B.; Afful, J.; Carroll, M. D.; Chen, T.-C.; Davy, O.; Fink, S.; Fryar, C. D.; Gu, Q.; Hales, C. M.; Hughes, J. P.; Ostchega, Y.; Storandt, R. J.; Akinbami, L. J.\n          National Health and Nutrition Examination Survey\n2017-March 2020 Prepandemic Data Files-Development of Files and Prevalence\nEstimates for Selected Health Outcomes\n          Natl.\nHealth Stat. Rep.\n          2021; Vol. 158."},{"key":"2026090809080363300_cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48587-2","article-title":"An Anti-Inflammatory\nPhenotype in Visceral Adipose Tissue of Old Lean Mice, Augmented by\nExercise","volume":"9","author":"Ziegler","year":"2019","journal-title":"Sci. Rep."},{"key":"2026090809080363300_cit4","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1080\/17425247.2025.2554718","article-title":"Drug Depots for Obesity Targeting\nMetabolism, Appetite,\nand Inflammation","volume":"22","author":"Fayyaz","year":"2025","journal-title":"Expert Opin. Drug Delivery"},{"key":"2026090809080363300_cit5","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1111\/dom.14794","article-title":"In Vivo\nand in Vitro Characterization of Gl0034, a Novel Long-Acting Glucagon-Like\nPeptide-1 Receptor Agonist","volume":"24","author":"Jones","year":"2022","journal-title":"Diabetes, Obes.\nMetab."},{"key":"2026090809080363300_cit6","doi-asserted-by":"publisher","first-page":"101533","DOI":"10.1016\/j.molmet.2022.101533","article-title":"Next Generation\nGLP-1\/GIP\/Glucagon\nTriple Agonists Normalize Body Weight in Obese Mice","volume":"63","author":"Knerr","year":"2022","journal-title":"Mol. Metab."},{"key":"2026090809080363300_cit7","doi-asserted-by":"publisher","first-page":"101765","DOI":"10.1016\/j.molmet.2023.101765","article-title":"Effects of\na Long-Acting Secretin\nPeptide Analog Alone and in Combination with a GLP-1R Agonist in a\nDiet-Induced Obesity Mouse Model","volume":"74","author":"Loeffler","year":"2023","journal-title":"Mol. Metab."},{"key":"2026090809080363300_cit8","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1093\/jn\/131.8.2164","article-title":"A Glucagon-Like\nPeptide-1 Receptor Agonist and an Antagonist Modify Macronutrient\nSelection by Rats","volume":"131","author":"Peters","year":"2001","journal-title":"J. Nutr."},{"key":"2026090809080363300_cit9","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ajcnut.2025.04.023","article-title":"Nutritional Priorities\nto Support\nGLP-1 Therapy for Obesity: A Joint Advisory from the American College\nof Lifestyle Medicine, the American Society for Nutrition, the Obesity\nMedicine Association, and the Obesity Society","volume":"122","author":"Mozaffarian","year":"2025","journal-title":"Am. J. Clin. Nutr."},{"key":"2026090809080363300_cit10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/dom.15728","article-title":"Changes\nin Lean Body Mass with Glucagon-Like\nPeptide-1-Based Therapies and Mitigation Strategies","volume":"26","author":"Neeland","year":"2024","journal-title":"Diabetes, Obes. Metab."},{"key":"2026090809080363300_cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00098","article-title":"The Impact\nof Glucagon-Like Peptide-1 on Bone Metabolism and Its Possible Mechanisms","volume":"8","author":"Zhao","year":"2017","journal-title":"Front. Endocrinol."},{"key":"2026090809080363300_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2025.101865","article-title":"Malnutrition\nIs Common in Patients Utilizing Glucagon-Like\nPeptide-1 Agonists Prior to Total Joint Arthroplasty","volume":"35","author":"Jodoin","year":"2025","journal-title":"Arthroplasty Today"},{"key":"2026090809080363300_cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1566498","article-title":"Investigating Nutrient\nIntake During Use of Glucagon-Like Peptide-1 Receptor Agonist: A Cross-Sectional\nStudy","volume":"12","author":"Johnson","year":"2025","journal-title":"Front. Nutr."},{"key":"2026090809080363300_cit14","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1111\/dom.15113","article-title":"Effect of the Glucagon-Like Peptide-1\nReceptor Agonist Liraglutide, Compared to Caloric Restriction, on\nAppetite, Dietary Intake, Body Fat Distribution and Cardiometabolic\nBiomarkers: A Randomized Trial in Adults with Obesity and Prediabetes","volume":"25","author":"Silver","year":"2023","journal-title":"Diabetes, Obesity Metab."},{"key":"2026090809080363300_cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170259","article-title":"Systematic\nReview of the Toxicity\nof Long-Course Oral Corticosteroids in Children","volume":"12","author":"Aljebab","year":"2017","journal-title":"PLoS One"},{"key":"2026090809080363300_cit16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.phrs.2016.02.020","article-title":"Acetaminophen\nfrom\nLiver to Brain: New Insights into Drug Pharmacological Action and\nToxicity","volume":"109","author":"Ghanem","year":"2016","journal-title":"Pharmacol. Res."},{"key":"2026090809080363300_cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10720-4","article-title":"Aspirin Inhibits LPS-Induced\nMacrophage Activation Via the NF-\u03baB Pathway","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"2026090809080363300_cit18","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.therap.2020.05.003","article-title":"Non-Steroidal\nAnti-Inflammatory\nDrugs, Pharmacology, and COVID-19 Infection","volume":"75","author":"Micallef","year":"2020","journal-title":"Therapies"},{"key":"2026090809080363300_cit19","doi-asserted-by":"publisher","first-page":"6952","DOI":"10.1021\/acsnano.6b02878","article-title":"Efficient Targeting\nof Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers","volume":"10","author":"Ma","year":"2016","journal-title":"ACS Nano"},{"key":"2026090809080363300_cit20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41419-021-03872-9","article-title":"Adipocyte Death Triggers a Pro-Inflammatory\nResponse and Induces Metabolic Activation of Resident Macrophages","volume":"12","author":"Lindhorst","year":"2021","journal-title":"Cell Death Dis."},{"key":"2026090809080363300_cit21","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.tem.2025.03.010","article-title":"Adipose Tissue-Targeting Nanomedicines\nfor Obesity Pharmacotherapy","volume":"36","author":"Wang","year":"2025","journal-title":"Trends Endocrinol.\nMetab."},{"key":"2026090809080363300_cit22","doi-asserted-by":"publisher","first-page":"371","DOI":"10.18433\/J3N590","article-title":"Targeting the C-Type\nLectins-Mediated Host-Pathogen Interactions with Dextran","volume":"17","author":"Pustylnikov","year":"2014","journal-title":"J. Pharm. Pharm. Sci."},{"key":"2026090809080363300_cit23","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1039\/D0BM01142H","article-title":"Nanocarriers Targeting\nAdipose Macrophages Increase Glucocorticoid Anti-Inflammatory Potency\nto Ameliorate Metabolic Dysfunction","volume":"9","author":"Prabhu","year":"2021","journal-title":"Biomater.\nSci."},{"key":"2026090809080363300_cit24","doi-asserted-by":"publisher","DOI":"10.3390\/app132212526","article-title":"Dextran of Diverse\nMolecular-Configurations Used as\na Blood-Plasma Substitute, Drug-Delivery Vehicle and Food Additive\nBiosynthesized by Leuconostoc, Lactobacillus and Weissella","volume":"13","author":"Dahiya","year":"2023","journal-title":"Appl. Sci."},{"key":"2026090809080363300_cit25","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.26355\/eurrev_201905_17955","article-title":"Postsurgical Antithrombotic Therapy\nin Microsurgery: Our Protocol and Literature Review","volume":"23","author":"Kaciulyte","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"2026090809080363300_cit26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081340","article-title":"Dextran:\nInfluence of Molecular Weight in Antioxidant Properties and Immunomodulatory\nPotential","volume":"17","author":"Soeiro","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2026090809080363300_cit27","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.2337\/db11-1508","article-title":"Adipose Tissue\nMicroRNAs as Regulators of CCL2 Production in Human Obesity","volume":"61","author":"Arner","year":"2012","journal-title":"Diabetes"},{"key":"2026090809080363300_cit28","doi-asserted-by":"publisher","first-page":"22079","DOI":"10.1021\/acsnano.5c02111","article-title":"Nanocoding: Lipid Nanoparticle Barcoding\nfor Multiplexed Single-Cell RNA Sequencing","volume":"19","author":"Feng","year":"2025","journal-title":"ACS Nano"},{"key":"2026090809080363300_cit29","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-Associated\nMacrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"key":"2026090809080363300_cit30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1153915","article-title":"Adipose Tissue Macrophages\nas Potential Targets for\nObesity and Metabolic Diseases","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"key":"2026090809080363300_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202400203","article-title":"Mechanisms of Lipid-Associated Macrophage\nAccrual in Metabolically Stressed Adipose Tissue","volume":"47","author":"Reinisch","year":"2025","journal-title":"BioEssays"},{"key":"2026090809080363300_cit32","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1002\/oby.24323","article-title":"Lipid-Associated\nMacrophages Are\nMore Abundant in Subcutaneous Than Visceral Adipose Tissue in Patients\nwith Obesity","volume":"33","author":"Reyes-Farias","year":"2025","journal-title":"Obesity"},{"key":"2026090809080363300_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114447","article-title":"Lipid-Associated Macrophages Reshape Bat Cell Identity\nin Obesity","volume":"43","author":"Sciarretta","year":"2024","journal-title":"Cell Rep."},{"key":"2026090809080363300_cit34","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads3731","article-title":"Nanomedicine\nTargeting PPAR in Adipose Tissue Macrophages Improves Lipid Metabolism\nand Obesity-Induced Metabolic Dysfunction","volume":"11","author":"Applegate","year":"2025","journal-title":"Sci.\nAdv."},{"key":"2026090809080363300_cit35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/imr.12853","article-title":"Adipose\nTissue Macrophages:\nUnique Polarization and Bioenergetics in Obesity","volume":"295","author":"Caslin","year":"2020","journal-title":"Immunol. Rev."},{"key":"2026090809080363300_cit36","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6067349","article-title":"Mitochondria in White,\nBrown, and Beige Adipocytes","volume":"2016","author":"Cedikova","year":"2016","journal-title":"Stem Cells Int."},{"key":"2026090809080363300_cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.845158","article-title":"Spontaneous Browning of White Adipose\nTissue Improves\nAngiogenesis and Reduces Macrophage Infiltration after Fat Grafting\nin Mice","volume":"10","author":"Lin","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"2026090809080363300_cit38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.585887","article-title":"Leptin and Obesity:\nRole and Clinical Implication","volume":"12","author":"Obradovic","year":"2021","journal-title":"Front. Endocrinol."},{"key":"2026090809080363300_cit39","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1021\/acsnano.9b06504","article-title":"Multimodal Nanocarrier\nProbes Reveal Superior Biodistribution\nQuantification by Isotopic Analysis over Fluorescence","volume":"14","author":"Deng","year":"2020","journal-title":"ACS Nano"},{"key":"2026090809080363300_cit40","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe2480","article-title":"3D Microscopy and\nDeep Learning Reveal the Heterogeneity of Crown-Like Structure Microenvironments\nin Intact Adipose Tissue","volume":"7","author":"Geng","year":"2021","journal-title":"Sci. Adv."},{"key":"2026090809080363300_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42770-1","article-title":"Role of Adipose\nTissue GLP-1R Expression in Metabolic Improvement after Bariatric\nSurgery in Patients with Type 2 Diabetes","volume":"9","author":"Ejarque","year":"2019","journal-title":"Sci.\nRep."},{"key":"2026090809080363300_cit42","doi-asserted-by":"publisher","first-page":"355","DOI":"10.2353\/ajpath.2009.080703","article-title":"High Fat Diet Induced Hepatic Steatosis\nEstablishes\na Permissive Microenvironment for Colorectal Metastases and Promotes\nPrimary Dysplasia in a Murine Model","volume":"175","author":"VanSaun","year":"2009","journal-title":"Am. J.\nPathol."},{"key":"2026090809080363300_cit43","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/S2213-8587(25)00251-7","article-title":"Glucocorticoid-Induced\nOsteoporosis: Novel Concepts and Clinical Implications","volume":"13","author":"Hofbauer","year":"2025","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2026090809080363300_cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00483-4","article-title":"Weight Loss Induced\nBone Loss: Mechanism of Action and Clinical Implications","volume":"13","author":"Liu","year":"2025","journal-title":"Bone Res."},{"key":"2026090809080363300_cit45","doi-asserted-by":"publisher","first-page":"100127","DOI":"10.1016\/j.obpill.2024.100127","article-title":"Glucagon-Like Receptor-1\nAgonists for Obesity: Weight\nLoss Outcomes, Tolerability, Side Effects, and Risks","volume":"12","author":"Ghusn","year":"2024","journal-title":"Obesity Pillars"},{"key":"2026090809080363300_cit46","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.416","article-title":"Glucagon-Like\nPeptide-1 Receptor Agonist Regulates Fat Browning by Altering the\nGut Microbiota and Ceramide Metabolism","volume":"4","author":"Lin","year":"2023","journal-title":"MedComm"},{"key":"2026090809080363300_cit47","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/cbf.3751","article-title":"Semaglutide\n(GLP-1 Receptor Agonist) Stimulates Browning on Subcutaneous Fat Adipocytes\nand Mitigates Inflammation and Endoplasmic Reticulum Stress in Visceral\nFat Adipocytes of Obese Mice","volume":"40","author":"Martins","year":"2022","journal-title":"Cell Biochem.\nFunct."},{"key":"2026090809080363300_cit48","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s00125-016-3896-5","article-title":"GLP-1 Receptor Agonist Promotes Brown\nRemodelling in Mouse White Adipose Tissue through SIRT1","volume":"59","author":"Xu","year":"2016","journal-title":"Diabetologia"},{"key":"2026090809080363300_cit49","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1210\/js.2017-00020","article-title":"Effects\nof Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and\nMetabolism in Obese Postmenopausal Women","volume":"1","author":"Alema\u0301n","year":"2017","journal-title":"J.\nEndocrine Soc."},{"key":"2026090809080363300_cit50","doi-asserted-by":"publisher","first-page":"3466","DOI":"10.1172\/JCI42845","article-title":"Weight Loss and\nLipolysis Promote a Dynamic Immune Response in Murine Adipose Tissue","volume":"120","author":"Kosteli","year":"2010","journal-title":"J. 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