{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:01:19Z","timestamp":1785852079826,"version":"3.56.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["JYB2025XDXM906"],"award-info":[{"award-number":["JYB2025XDXM906"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004945","name":"Nankai University","doi-asserted-by":"publisher","award":["63241208"],"award-info":[{"award-number":["63241208"]}],"id":[{"id":"10.13039\/501100004945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004945","name":"Nankai University","doi-asserted-by":"publisher","award":["63241324"],"award-info":[{"award-number":["63241324"]}],"id":[{"id":"10.13039\/501100004945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B17025"],"award-info":[{"award-number":["B17025"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiovascular disease continues to be a leading cause of mortality worldwide, but the mechanistic interplay between hypercholesterolemia and environmental pollutants in the progression of atherosclerosis remains poorly understood. This study investigated the role of silver nanoparticles (AgNPs), a typical particulate contaminant, in promoting atherogenic risk under dyslipidemic conditions. Elevated serum cholesterol levels significantly promoted the adsorption of low-molecular-weight hydrophobic proteins to AgNPs. The hyperlipidemia-specific PC facilitated macrophage uptake of AgNPs through lipid-raft-dependent, scavenger receptor-B1-mediated endocytosis, altered intracellular journey to target the endoplasmic reticulum and Golgi apparatus, and exploited Golgi secretory vesicles for exocytosis. Due to dynamic intracellular exchange, the recruitment of chaperones by AgNPs acted as an initiating event to activate endoplasmic reticulum stress (ERS). The in vitro macrophage model showed that AgNPs further triggered M1 polarization and lipid accumulation, ultimately driving foam cell transformation and exacerbating atherogenic risk. In addition, in vivo assays strongly corroborated that AgNPs accelerated atherosclerotic progression in hyperlipidemic mice, which could be reversed by 4-phenylbutyric acid, a chemical chaperone that inhibits ERS. These findings underscore the significant impact of the physiological microenvironment on nano-bio interactions and provide mechanistic insights into the aggravation of cardiovascular diseases by environmental nanoparticles under hypercholesterolemic conditions.<\/jats:p>","DOI":"10.1021\/acsnano.6c00675","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:51:49Z","timestamp":1784386309000},"page":"21039-21053","source":"Crossref","is-referenced-by-count":0,"title":["Hyperlipidemia-Specific\nProtein Corona Formed on Silver\nNanoparticles Aggravates Atherosclerosis by Facilitating Macrophage\nLipid Accumulation"],"prefix":"10.1021","volume":"20","author":[{"given":"Yi","family":"Yang","sequence":"first","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-7940","authenticated-orcid":true,"given":"Lingyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"2026080409280393200_cit1","doi-asserted-by":"publisher","first-page":"e153","DOI":"10.1161\/CIR.0000000000001052","article-title":"Heart disease and stroke statistics\u20132022\nupdate: A report from the American heart association","volume":"145","author":"Tsao","year":"2022","journal-title":"Circulation"},{"key":"2026080409280393200_cit2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41586-024-07993-x","article-title":"Early\nintermittent hyperlipidaemia alters tissue macrophages\nto fuel atherosclerosis","volume":"634","author":"Takaoka","year":"2024","journal-title":"Nature"},{"key":"2026080409280393200_cit3","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1016\/j.cmet.2021.09.001","article-title":"Cholesterol-induced\ntoxicity: An integrated view of the role of cholesterol in multiple\ndiseases","volume":"33","author":"Song","year":"2021","journal-title":"Cell Metab."},{"key":"2026080409280393200_cit4","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s41565-023-01455-7","article-title":"Cholesterol\nmodulates the physiological response to nanoparticles\nby changing the composition of protein corona","volume":"18","author":"Tang","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"2026080409280393200_cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-16224-3","article-title":"The impact of dyslipidemia on lumbar intervertebral\ndisc degeneration\nand vertebral endplate Modic changes: a cross-sectional study of 1035\ncitizens in China","volume":"23","author":"Yuan","year":"2023","journal-title":"BMC Public Health"},{"key":"2026080409280393200_cit6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.atherosclerosis.2016.02.006","article-title":"The prevalence, awareness,\ntreatment and control of dyslipidemia among adults in China","volume":"248","author":"Pan","year":"2016","journal-title":"Atherosclerosis"},{"key":"2026080409280393200_cit7","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41569-021-00541-4","article-title":"Global\nepidemiology of dyslipidaemias","volume":"18","author":"Pirillo","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"2026080409280393200_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205876","article-title":"Long-chain acyl carnitines\naggravate polystyrene nanoplastics-induced\natherosclerosis by upregulating MARCO","volume":"10","author":"Wang","year":"2023","journal-title":"Adv.\nSci."},{"key":"2026080409280393200_cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-00863-y","article-title":"Phagocytosis of polymeric\nnanoparticles aided activation of macrophages to increase atherosclerotic\nplaques in ApoE\u2013\/\u2013 mice","volume":"19","author":"Yin","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"2026080409280393200_cit10","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.scitotenv.2018.02.312","article-title":"Silica nanoparticles\npromote oxLDL-induced macrophage lipid accumulation and apoptosis\nvia endoplasmic reticulum stress signaling","volume":"631\u2013632","author":"Guo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"2026080409280393200_cit11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/BF00396598","article-title":"Biologic\nmonitoring of workers exposed\nto silver","volume":"56","author":"DiVincenzo","year":"1985","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"2026080409280393200_cit12","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/s41565-023-01409-z","article-title":"Developing trends in\nnanomaterials and their environmental implications","volume":"18","author":"Keller","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"2026080409280393200_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2025.115567","article-title":"Ferroptosis effects and behavioral\nchanges associated\nwith high accumulation and low elimination percentage of silver in\nbrain following a 28-day nasal instillation of silver nanoparticles\nin mice","volume":"202","author":"Niu","year":"2025","journal-title":"Food Chem. Toxicol."},{"key":"2026080409280393200_cit14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1039\/B916107D","article-title":"Biodistribution\nand long-term fate of silver nanoparticles\nfunctionalized with bovine serum albumin in rats\u2020","volume":"2","author":"Garza-Ocan\u0303as","year":"2010","journal-title":"Metallomics"},{"key":"2026080409280393200_cit15","doi-asserted-by":"publisher","first-page":"4924","DOI":"10.1166\/jnn.2009.1269","article-title":"Distribution, Translocation\nand Accumulation of Silver Nanoparticles in Rats","volume":"9","author":"Tang","year":"2009","journal-title":"J. Nanosci. Nanotechnol."},{"key":"2026080409280393200_cit16","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41578-024-00658-1","article-title":"In vivo biomolecule\ncorona and the transformation of a foe into an ally for nanomedicine","volume":"9","author":"Hadjidemetriou","year":"2024","journal-title":"Nat. Rev. Mater."},{"key":"2026080409280393200_cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35902-9","article-title":"Endosomal sorting results in a selective separation\nof the protein corona from nanoparticles","volume":"14","author":"Han","year":"2023","journal-title":"Nat.\nCommun."},{"key":"2026080409280393200_cit18","doi-asserted-by":"publisher","first-page":"12458","DOI":"10.1021\/acsnano.3c02041","article-title":"Identification\nof the proteins determining the blood\ncirculation time of nanoparticles","volume":"17","author":"Marques","year":"2023","journal-title":"ACS Nano"},{"key":"2026080409280393200_cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53966-z","article-title":"Small\nmolecule modulation of protein corona for deep\nplasma proteome profiling","volume":"15","author":"Ashkarran","year":"2024","journal-title":"Nat. Commun."},{"key":"2026080409280393200_cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56210-4","article-title":"Inflammatory disease\nprogression\nshapes nanoparticle biomolecular corona-mediated immune activation\nprofiles","volume":"16","author":"Shaw","year":"2025","journal-title":"Nat. Commun."},{"key":"2026080409280393200_cit21","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41569-021-00629-x","article-title":"Macrophage-targeted nanomedicine\nfor the diagnosis and treatment\nof atherosclerosis","volume":"19","author":"Chen","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"2026080409280393200_cit22","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41569-023-00957-0","article-title":"Programmed\ndeath of macrophages in atherosclerosis: mechanisms and therapeutic\ntargets","volume":"21","author":"De Meyer","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"2026080409280393200_cit23","doi-asserted-by":"publisher","first-page":"16100","DOI":"10.1039\/C5NR04200C","article-title":"Silver nanoparticles\nimpede phorbol myristate acetate-induced monocyte\u2013macrophage\ndifferentiation and autophagy","volume":"7","author":"Xu","year":"2015","journal-title":"Nanoscale"},{"key":"2026080409280393200_cit24","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1021\/acs.est.3c05493","article-title":"Intracellular protein adsorption\nbehavior and biological effects\nof polystyrene nanoplastics in THP-1 cells","volume":"58","author":"Liu","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"2026080409280393200_cit25","doi-asserted-by":"publisher","first-page":"4978","DOI":"10.1021\/acs.analchem.4c00050","article-title":"Unraveling intracellular protein corona components\nof nanoplastics via photocatalytic protein proximity\nlabeling","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal. Chem."},{"key":"2026080409280393200_cit26","doi-asserted-by":"publisher","DOI":"10.1289\/ehp13869","article-title":"Phenotypic and functional\noutcomes in macrophages exposed to an environmentally relevant mixture\nof organophosphate rsters in vitro","volume":"132","author":"Braeden","year":"2024","journal-title":"Environ. Health Perspect."},{"key":"2026080409280393200_cit27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065939","article-title":"The effect of cholesterol\nefflux on endothelial dysfunction caused by oxidative stress","volume":"24","author":"Ye","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026080409280393200_cit28","doi-asserted-by":"publisher","first-page":"10517","DOI":"10.1021\/acsnano.2c01778","article-title":"Turning hot into cold:\nImmune microenvironment reshaping for atherosclerosis attenuation\nbased on pH-responsive shSiglec-1 delivery system","volume":"16","author":"Zhou","year":"2022","journal-title":"ACS Nano"},{"key":"2026080409280393200_cit29","doi-asserted-by":"publisher","first-page":"14296","DOI":"10.1021\/acs.est.9b04332","article-title":"Sulfidation of Ag and\nZnO nanomaterials significantly affects protein corona composition:\nImplications for human exposure to environmentally aged nanomaterials","volume":"53","author":"Du","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"2026080409280393200_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2023.120990","article-title":"Formation of extracellular polymeric substances corona on TiO2 nanoparticles: Roles of crystalline phase and exposed facets","volume":"249","author":"Du","year":"2024","journal-title":"Water Res."},{"key":"2026080409280393200_cit31","doi-asserted-by":"publisher","first-page":"7122","DOI":"10.1021\/nn302186n","article-title":"Scavenger receptor\nmediated endocytosis of silver nanoparticles\ninto J774A.1 macrophages is heterogeneous","volume":"6","author":"Wang","year":"2012","journal-title":"ACS\nNano"},{"key":"2026080409280393200_cit32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.jconrel.2024.02.020","article-title":"Lipid-mediated protein\ncorona regulation with increased\napolipoprotein A-I recruitment for glioma targeting","volume":"368","author":"Zhang","year":"2024","journal-title":"J. Controlled Release"},{"key":"2026080409280393200_cit33","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/s41565-024-01629-x","article-title":"Genome-wide forward\ngenetic screening to identify receptors and proteins mediating nanoparticle\nuptake and intracellular processing","volume":"19","author":"Montizaan","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"2026080409280393200_cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40814-9","article-title":"Cholesterol removal\nimproves performance of a model biomimetic system\nto co-deliver a photothermal agent and a STING agonist for cancer\nimmunotherapy","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"2026080409280393200_cit35","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41565-023-01551-8","article-title":"Intracerebral fate of organic and inorganic nanoparticles\nis dependent on microglial extracellular vesicle function","volume":"19","author":"Gao","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"2026080409280393200_cit36","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1039\/C4NR06545J","article-title":"Local pH\ntracking in living cells","volume":"7","author":"Tsou","year":"2015","journal-title":"Nanoscale"},{"key":"2026080409280393200_cit37","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1039\/C9EN00303G","article-title":"Effects of organic matter on uptake\nand intracellular trafficking\nof nanoparticles in Tetrahymena thermophila","volume":"6","author":"Wang","year":"2019","journal-title":"Environ. Sci.: Nano"},{"key":"2026080409280393200_cit38","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nrm2820","article-title":"Sensors and regulators of intracellular\npH","volume":"11","author":"Casey","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026080409280393200_cit39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.actbio.2023.10.010","article-title":"Proteomics\nreveals time-dependent protein corona changes in the intracellular\npathway","volume":"172","author":"Marques","year":"2023","journal-title":"Acta Biomater."},{"key":"2026080409280393200_cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200363119","article-title":"Dynamic intracellular\nexchange of nanomaterials\u2019 protein corona\nperturbs proteostasis and remodels cell metabolism","volume":"119","author":"Cai","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026080409280393200_cit41","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1021\/acsnano.0c09649","article-title":"Composition of intracellular\nprotein corona around nanoparticles during internalization","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"2026080409280393200_cit42","doi-asserted-by":"publisher","first-page":"8629","DOI":"10.1021\/nn202155y","article-title":"Gold nanoparticles induce autophagosome accumulation\nthrough size-dependent nanoparticle uptake and lysosome impairment","volume":"5","author":"Ma","year":"2011","journal-title":"ACS Nano"},{"key":"2026080409280393200_cit43","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1042\/BJ20130945","article-title":"The interaction of\nenolase-1 with caveolae-associated proteins regulates its subcellular\nlocalization","volume":"460","author":"Zakrzewicz","year":"2014","journal-title":"Biochem. J."},{"key":"2026080409280393200_cit44","doi-asserted-by":"publisher","first-page":"5629","DOI":"10.1073\/pnas.1614075114","article-title":"Structural\ninsights into the activation mechanism of dynamin-like EHD ATPases","volume":"114","author":"Melo","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026080409280393200_cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05370-y","article-title":"EGFR tyrosine kinase activity and Rab GTPases\ncoordinate EGFR trafficking\nto regulate macrophage activation in sepsis","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"2026080409280393200_cit46","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nm0410-396","article-title":"Endoplasmic\nreticulum stress and atherosclerosis","volume":"16","author":"Hotamisligil","year":"2010","journal-title":"Nat. Med."},{"key":"2026080409280393200_cit47","doi-asserted-by":"publisher","first-page":"25462","DOI":"10.1074\/jbc.M116.729202","article-title":"Adaptor\nprotein CD2AP and L-type lectin LMAN2 regulate exosome cargo protein\ntrafficking through the Golgi complex","volume":"291","author":"Kwon","year":"2016","journal-title":"J. Biol.\nChem."},{"key":"2026080409280393200_cit48","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1096899","article-title":"The many hats of transmembrane emp24 domain protein\nTMED9 in secretory pathway homeostasis","volume":"10","author":"Roberts","year":"2023","journal-title":"Front.\nCell Dev. Biol."},{"key":"2026080409280393200_cit49","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.261319","article-title":"ARF6 plays\na general role in targeting palmitoylated proteins from the Golgi\nto the plasma membrane","volume":"136","author":"Wang","year":"2023","journal-title":"J. Cell Sci."},{"key":"2026080409280393200_cit50","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions\nof the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev.\nMol. Cell Biol."},{"key":"2026080409280393200_cit51","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41569-021-00511-w","article-title":"Endoplasmic\nreticulum\nstress and unfolded protein response in cardiovascular diseases","volume":"18","author":"Ren","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"2026080409280393200_cit52","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan5835","article-title":"Here, there, and everywhere: The\nimportance of ER membrane contact sites","volume":"361","author":"Wu","year":"2018","journal-title":"Science"},{"key":"2026080409280393200_cit53","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the Pathogenesis of\nAtherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"2026080409280393200_cit54","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-020-00380-0","article-title":"Amorphous\nsilica nanoparticles\naccelerated atherosclerotic lesion progression in ApoE\u2013\/\u2013 mice through endoplasmic reticulum stress-mediated CD36 up-regulation\nin macrophage","volume":"17","author":"Ma","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"2026080409280393200_cit55","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1021\/acs.chemrestox.0c00123","article-title":"Polychlorinated Biphenyl Quinone\nPromotes Atherosclerosis through\nLipid Accumulation and Endoplasmic Reticulum Stress via CD36","volume":"33","author":"Yang","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"2026080409280393200_cit56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17020193","article-title":"The Role of Endoplasmic\nReticulum Stress and Unfolded\nProtein Response in Atherosclerosis","volume":"17","author":"Ivanova","year":"2016","journal-title":"Int. J.\nMol. Sci."},{"key":"2026080409280393200_cit57","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1039\/C4NR05509H","article-title":"Cationic\npolystyrene nanospheres induce autophagic cell death through the induction\nof endoplasmic reticulum stress","volume":"7","author":"Chiu","year":"2015","journal-title":"Nanoscale"},{"key":"2026080409280393200_cit58","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/j.cmet.2024.10.002","article-title":"Hexokinase 2 senses\nfructose in tumor-associated macrophages\nto promote colorectal cancer growth","volume":"36","author":"Yan","year":"2024","journal-title":"Cell Metab."},{"key":"2026080409280393200_cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43283-2","article-title":"SEPTIN2 suppresses an\nIFN-\u03b3-independent, proinflammatory macrophage\nactivation pathway","volume":"14","author":"Fu","year":"2023","journal-title":"Nat. Commun."},{"key":"2026080409280393200_cit60","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1074\/jbc.M113.524512","article-title":"Endoplasmic\nReticulum Stress Promotes Macrophage-derived Foam Cell Formation by\nUp-regulating Cluster of Differentiation 36 (CD36) Expression","volume":"289","author":"Yao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2026080409280393200_cit61","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1039\/D4FO04461D","article-title":"Obesity phenotype and gut microbiota alterations are\nnot associated with anxiety-like behaviour in high-fat diet-fed mice","volume":"16","author":"Wong","year":"2025","journal-title":"Food Funct."},{"key":"2026080409280393200_cit62","doi-asserted-by":"publisher","first-page":"4330","DOI":"10.1021\/acs.est.4c12616","article-title":"Chronic\nExposure to Environmental Concentrations of Tetrabromobisphenol A\nDisrupts Insulin and Lipid Homeostasis in Diet-Induced Obese Mice","volume":"59","author":"Ding","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"2026080409280393200_cit63","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1039\/D0EN01142H","article-title":"New insights into the facilitated\ndissolution and sulfidation of silver nanoparticles under simulated\nsunlight irradiation in aquatic environments by extracellular polymeric\nsubstances","volume":"8","author":"Yang","year":"2021","journal-title":"Environ. Sci.: Nano"},{"key":"2026080409280393200_cit64","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf2165","article-title":"Airborne\nfine particles drive H1N1 viruses deep into the lower respiratory\ntract and distant organs","volume":"9","author":"Dong","year":"2023","journal-title":"Sci. Adv."},{"key":"2026080409280393200_cit65","doi-asserted-by":"publisher","first-page":"14695","DOI":"10.1039\/D2NR03611H","article-title":"Surface charge\ninfluences protein corona, cell uptake and biological effects of carbon\ndots","volume":"14","author":"Arezki","year":"2022","journal-title":"Nanoscale"},{"key":"2026080409280393200_cit66","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1038\/nm.2067","article-title":"Reducing\nendoplasmic reticulum stress\nthrough a macrophage lipid chaperone alleviates atherosclerosis","volume":"15","author":"Erbay","year":"2009","journal-title":"Nat. Med."},{"key":"2026080409280393200_cit67","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg2252","article-title":"Peripheral\nnerves directly mediate the transneuronal translocation of silver\nnanomaterials from the gut to central nervous system","volume":"9","author":"Wang","year":"2023","journal-title":"Sci. Adv."},{"key":"2026080409280393200_cit68","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.jes.2025.06.012","article-title":"The sequestration\nof metal nanoparticles in the liver: A trade-off\nbetween density and degradability","volume":"160","author":"Ma","year":"2026","journal-title":"J. Environ.\nSci."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c00675","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/30\/21039\/66021799\/acsnano.6c00675.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/30\/21039\/66021799\/acsnano.6c00675.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:36:47Z","timestamp":1785850607000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/30\/21039\/5215149\/Hyperlipidemia-Specific-Protein-Corona-Formed-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":68,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,18]]},"published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c00675","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]}}}