{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:35:37Z","timestamp":1784205337212,"version":"3.55.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFA053"],"award-info":[{"award-number":["2024AFA053"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272277"],"award-info":[{"award-number":["82272277"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472135"],"award-info":[{"award-number":["82472135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530073"],"award-info":[{"award-number":["82530073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82561128249"],"award-info":[{"award-number":["82561128249"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0509900"],"award-info":[{"award-number":["2023ZD0509900"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0509904"],"award-info":[{"award-number":["2023ZD0509904"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Scientific and Technological Innovation Projects of Hubei Province","award":["2025BCB005"],"award-info":[{"award-number":["2025BCB005"]}]},{"name":"Major Scientific and Technological Innovation Projects of Hubei Province","award":["2025BCB128"],"award-info":[{"award-number":["2025BCB128"]}]},{"name":"Major Scientific and Technological Innovation Projects of Wuhan","award":["2025020602030088"],"award-info":[{"award-number":["2025020602030088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2026,5,5]]},"DOI":"10.1021\/acsnano.6c00855","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:47:39Z","timestamp":1776692859000},"page":"13086-13104","source":"Crossref","is-referenced-by-count":1,"title":["A Self-Assembled Irinotecan Nanomedicine Abrogates Steatohepatitis-Induced Liver Metastasis and Potentiates Antitumor Efficacy against Colorectal Cancer"],"prefix":"10.1021","volume":"20","author":[{"given":"Mengxi","family":"Xiang","sequence":"first","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chundong","family":"Yao","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5716-6587","authenticated-orcid":true,"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Department of Clinical Laboratory, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9330-0728","authenticated-orcid":true,"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research","place":["Wuhan, China"]},{"name":"Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment","place":["Wuhan, China"]},{"name":"Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College","place":["Wuhan, China"]},{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"Key Laboratory of Biological Targeted Therapy (Huazhong University of Science and Technology), Ministry of Education","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0012"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i10.1569"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.04.012"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12639"},{"key":"ref6\/cit6","first-page":"2182","volume":"7","author":"Mathijssen R. H.","year":"2001","journal-title":"Clin. Cancer Res"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104398"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144919"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.1.45"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2438-8"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5719"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3074"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.62347\/JHMS4303"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1697231"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-018-1095-z"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9057"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.04.013"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.031"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.051"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau0159"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.06.002"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127551"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407957200"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-food-060721-025531"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.11.007"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/nu17101681"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1500293"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.11.011"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4589"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2020.1797051"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300319"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.24641"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10562-w"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903483215"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.09.007"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121471"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/srep01142"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.05.001"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-021-01306-w"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052383"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/srep32733"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02042-5"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23621"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101122"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56458-w"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.64894"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.08.179"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.048"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2020.1870323"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c00855","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c00855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:12:11Z","timestamp":1777968731000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.6c00855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":51,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5,5]]}},"alternative-id":["10.1021\/acsnano.6c00855"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c00855","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}