{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:01:52Z","timestamp":1787000512636,"version":"build-2736575974"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"18","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100010881","name":"Suzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["SYW2025045"],"award-info":[{"award-number":["SYW2025045"]}],"id":[{"id":"10.13039\/501100010881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010881","name":"Suzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["ZXL2024382"],"award-info":[{"award-number":["ZXL2024382"]}],"id":[{"id":"10.13039\/501100010881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20243030"],"award-info":[{"award-number":["BK20243030"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019643","name":"State Key Laboratory of Radiation Medicine and Protection","doi-asserted-by":"publisher","award":["GZK12024016"],"award-info":[{"award-number":["GZK12024016"]}],"id":[{"id":"10.13039\/501100019643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Jiangsu Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["BZ2025036"],"award-info":[{"award-number":["BZ2025036"]}],"id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2325019"],"award-info":[{"award-number":["T2325019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changzhi Medical College","award":["HZZD202405"],"award-info":[{"award-number":["HZZD202405"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2026,5,12]]},"DOI":"10.1021\/acsnano.6c02626","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:22:28Z","timestamp":1777317748000},"page":"13830-13840","source":"Crossref","is-referenced-by-count":3,"title":["Chemotherapeutic Agent-Loaded Nanoparticles Synergizing with X-ray Irradiation to Regulate Fibroblast-like Synoviocytes for Rheumatoid Arthritis Treatment"],"prefix":"10.1021","volume":"20","author":[{"given":"Zhixin","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology","place":["Suzhou, China"]},{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxiang","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhong","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology","place":["Suzhou, China"]},{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-9126","authenticated-orcid":true,"given":"Haibin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology","place":["Suzhou, China"]},{"name":"The Second Affiliated Hospital of Soochow University","place":["Suzhou, China"]},{"name":"State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Centre of Radiological Medicine of Jiangsu Higher Education Institutions","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.009"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2021.101740"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01525-8"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0413-5"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2023.105685"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.11.003"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223365"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-004886"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead088"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01088-7"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409154"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225565"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307338"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222708"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/art.42856"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.605616"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/art.42378"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6418"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03015-6"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205809"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/cells12081149"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181245"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jm500031w"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07461-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c20602"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/cbmi.6c00005"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-020-09909-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1616618"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c04787"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-025-07636-x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-025-11610-4"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c03279"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2213373119"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22454-z"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216268"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308905"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.4110\/in.2024.24.e32"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-07058-4"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.23736\/S1824-4785.22.03470-7"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3161750"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209124.151"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02184-0"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3270"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v5.i4.106"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.408"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c06584"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/nn500685h"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202503133"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02206"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08068"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/srep10120"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071397"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2025.114619"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c02626","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c02626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:32:33Z","timestamp":1779003153000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.6c02626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":53,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,5,12]]}},"alternative-id":["10.1021\/acsnano.6c02626"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c02626","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}