{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:42:29Z","timestamp":1792791749815,"version":"4.5.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022JH1\/10800073"],"award-info":[{"award-number":["2022JH1\/10800073"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52321001"],"award-info":[{"award-number":["52321001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2026,6,9]]},"DOI":"10.1021\/acsnano.6c02723","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:17:10Z","timestamp":1779952630000},"page":"16144-16168","source":"Crossref","is-referenced-by-count":6,"title":["Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment"],"prefix":"10.1021","volume":"20","author":[{"given":"Xinyue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongnan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-6517","authenticated-orcid":true,"given":"Huazhe","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Intelligent Medicine","place":["Shenyang, China"]},{"name":"China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghanqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingsen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, State Key Laboratory of Common Mechanism Research forMajor Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]},{"name":"Chinese Academy of MedicalSciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Key Laboratory of Oral Diseases","place":["Shenyang, China"]},{"name":"China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7059-7417","authenticated-orcid":true,"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24978"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1421674"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2018.0326"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06171-w"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00178G"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s11751-016-0261-7"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00842"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-022-00411-1"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c00898"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101892"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202311344"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23005-2"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.09.039"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c02147"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.06.182"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122375"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c05254"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/foods11182829"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121683"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c23320"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2020.104222"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1177\/20417314241263689"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.slast.2023.04.004"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adi6799"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.03.023"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111922"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-023-00422-6"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49280-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202766"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2025.106923"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213901"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-15029-1"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203734"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c01739"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040506"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.036"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.03.024"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.02.016"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.71392"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-4756-6_7"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202200386"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-024-01344-z"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07634-3"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt103"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0470"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100816"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3683"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b05893"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2025.100109"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2025.100095"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c16459"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c02723","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c02723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:17:00Z","timestamp":1780993020000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.6c02723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":51,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,9]]}},"alternative-id":["10.1021\/acsnano.6c02723"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c02723","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]}}}