{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:09Z","timestamp":1785250989259,"version":"3.55.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C1188"],"award-info":[{"award-number":["HI18C1188"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1D1A1B03029716"],"award-info":[{"award-number":["NRF-2017R1D1A1B03029716"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Therapy-resistant cancers remain largely incurable because malignant cells acquire metabolic adaptations that sustain survival under chronic cytotoxic and oxidative stress. One such adaptation is constitutively enhanced macropinocytosis, enabling aggressive cancer cells to scavenge extracellular nutrients and maintain redox homeostasis. Here, we introduce a macropinocytosis-exploiting polymer\u2013metal strategy that converts this metabolic dependency into a lethal vulnerability. We developed PPS02, a polyaspartic acid sodium salt-based metal complex that is preferentially internalized by cancer cells via macropinocytosis, while remaining largely excluded from normal epithelial cells. This cancer-preferential uptake enables intracellular delivery of selenomethionine and ferrous iron, resulting in intracellular H2O2 accumulation, mitochondrial reactive oxygen species overload, and activation of necroptotic cell death. Macropinocytic activity was significantly elevated in patient-derived metastatic colorectal cancer cells but remained minimal in normal colonic epithelial cells, demonstrating pronounced cancer selectivity. Accordingly, PPS02 exhibited negligible cytotoxicity toward normal colonic epithelial cells while effectively suppressing the viability of both nonmetastatic and platinum-resistant metastatic colorectal cancer cells. In patient-derived xenograft models, PPS02 induced sustained tumor regression without overt systemic toxicity under the experimental conditions, whereas cisplatin failed to control metastatic tumors and caused significant adverse effects. Collectively, these findings support macropinocytosis-driven redox imbalance as a therapeutically exploitable vulnerability and demonstrate a polymer\u2013metal platform that preferentially induces necroptosis in drug-resistant cancer while sparing normal tissues.<\/jats:p>","DOI":"10.1021\/acsnano.6c04236","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:00:51Z","timestamp":1784041251000},"page":"20623-20638","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting Macropinocytosis\nDrives Redox Vulnerability\nto Preferentially Target Drug-Resistant Cancer"],"prefix":"10.1021","volume":"20","author":[{"given":"Jin Hong","family":"Lim","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine , , 211 Eonjuro, Gangnam-gu , ,","place":["Seoul, Republic of Korea, 06273"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine , , 211 Eonjuro, Gangnam-gu , ,","place":["Seoul, Republic of Korea, 06273"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine , , 211 Eonjuro, Gangnam-gu , ,","place":["Seoul, Republic of Korea, 06273"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hwa","family":"Choi","sequence":"additional","affiliation":[{"name":"CHA Bundang Medical Center, CHA University , , ,","place":["Seongnam, Republic of Korea, 13496"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhee","family":"Park","sequence":"additional","affiliation":[{"name":"TherapeuticsNMC Corp. , A-1312, 11, Beobwon-ro 11-gil, Songpa-gu , ,","place":["Seoul, Republic of Korea, 05836"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5787-1683","authenticated-orcid":true,"given":"Hyemee","family":"Yoon","sequence":"additional","affiliation":[{"name":"TherapeuticsNMC Corp. , A-1312, 11, Beobwon-ro 11-gil, Songpa-gu , ,","place":["Seoul, Republic of Korea, 05836"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keunwan","family":"Park","sequence":"additional","affiliation":[{"name":"KIST Gangneung Institute of Natural Products , , ,","place":["Gangneung, Republic of Korea, 25451"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-3985","authenticated-orcid":true,"given":"Ki Cheong","family":"Park","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine , , 50-1, Yonsei-ro, Seodaemun-gu , ,","place":["Seoul, Republic of Korea, 03722"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheolgoo","family":"Hur","sequence":"additional","affiliation":[{"name":"TherapeuticsNMC Corp. , A-1312, 11, Beobwon-ro 11-gil, Songpa-gu , ,","place":["Seoul, Republic of Korea, 05836"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026072810090415700_cit1","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.3748\/wjg.v24.i34.3834","article-title":"Drug resistance and new therapies in colorectal cancer","volume":"24","author":"Van der Jeught","year":"2018","journal-title":"World journal of gastroenterology"},{"key":"2026072810090415700_cit2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ctrv.2017.04.008","article-title":"Mechanisms of resistance\nto systemic therapy in metastatic castration-resistant prostate cancer","volume":"57","author":"Galletti","year":"2017","journal-title":"Cancer treatment reviews"},{"key":"2026072810090415700_cit3","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1158\/1535-7163.MCT-17-1299","article-title":"Resistance to Systemic Therapies\nin Clear Cell Renal\nCell Carcinoma: Mechanisms and Management Strategies","volume":"17","author":"Makhov","year":"2018","journal-title":"Molecular cancer therapeutics"},{"key":"2026072810090415700_cit4","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1136\/ijgc-2023-004740","article-title":"Systemic therapy de-escalation\nin advanced ovarian cancer: a new era on the horizon?","volume":"33","author":"Caruso","year":"2023","journal-title":"International journal of gynecological cancer: official journal\nof the International Gynecological Cancer Society"},{"key":"2026072810090415700_cit5","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.3390\/biomedicines10112988","article-title":"Cancer\nMetastasis and Treatment Resistance: Mechanistic Insights and Therapeutic\nTargeting of Cancer Stem Cells and the Tumor Microenvironment","volume":"10","author":"Kilmister","year":"2022","journal-title":"Biomedicines"},{"key":"2026072810090415700_cit6","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1007\/s12672-025-03322-4","article-title":"Role of intratumoral\nheterogeneity in metastatic progression and drug resistance","volume":"16","author":"Sinai Borker","year":"2025","journal-title":"Discover oncology"},{"key":"2026072810090415700_cit7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41698-025-01223-x","article-title":"Quantitative profiling\nof intratumor immune heterogeneity identifies loss of immune diversity\nas a hallmark of cancer progression","volume":"10","author":"Lu","year":"2026","journal-title":"NPJ. precision\noncology"},{"key":"2026072810090415700_cit8","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.3748\/wjg.v29.i10.1569","article-title":"Systemic treatment for metastatic\ncolorectal cancer","volume":"29","author":"Leowattana","year":"2023","journal-title":"World journal of gastroenterology"},{"key":"2026072810090415700_cit9","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1136\/gutjnl-2025-335412","article-title":"Current and emerging concepts for\nsystemic treatment\nof metastatic colorectal cancer","volume":"74","author":"Steup","year":"2025","journal-title":"Gut"},{"key":"2026072810090415700_cit10","doi-asserted-by":"publisher","first-page":"6261","DOI":"10.7150\/thno.42523","article-title":"Epigenetics and metabolism at the crossroads of stress-induced\nplasticity, stemness and therapeutic resistance in cancer","volume":"10","author":"Ravindran Menon","year":"2020","journal-title":"Theranostics"},{"key":"2026072810090415700_cit11","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1186\/s12935-024-03558-0","article-title":"Comprehensive review of drug resistance\nin mammalian cancer stem cells: implications for cancer therapy","volume":"24","author":"Mengistu","year":"2024","journal-title":"Cancer cell international"},{"key":"2026072810090415700_cit12","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41392-025-02266-z","article-title":"Targeting epigenetic\nregulators as a promising avenue\nto overcome cancer therapy resistance","volume":"10","author":"Song","year":"2025","journal-title":"Signal\ntransduction and targeted therapy"},{"key":"2026072810090415700_cit13","doi-asserted-by":"publisher","DOI":"10.1177\/10732748241274196","article-title":"The Role of\nTumor Stem Cells in Colorectal\nCancer Drug Resistance","volume":"31","author":"Zhong","year":"2024","journal-title":"Cancer control: journal\nof the Moffitt Cancer Center"},{"key":"2026072810090415700_cit14","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309424","article-title":"Unveiling Alterations of Epigenetic\nModifications and Chromatin Architecture Leading to Lipid Metabolic\nReprogramming during the Evolutionary Trastuzumab Adaptation of HER2-Positive\nBreast Cancer","volume":"11","author":"Duan","year":"2024","journal-title":"Advanced science"},{"key":"2026072810090415700_cit15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/s41392-025-02360-2","article-title":"Cancer stem\ncells: landscape, challenges and emerging therapeutic innovations","volume":"10","author":"Lee","year":"2025","journal-title":"Signal transduction and targeted therapy"},{"key":"2026072810090415700_cit16","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1158\/1078-0432.CCR-17-2219","article-title":"Survival of Cancer\nStem-Like Cells Under Metabolic Stress via CaMK2alpha-mediated Upregulation\nof Sarco\/Endoplasmic Reticulum Calcium ATPase Expression","volume":"24","author":"Park","year":"2018","journal-title":"Clinical cancer research: an official journal of the American\nAssociation for Cancer Research"},{"key":"2026072810090415700_cit17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12916-023-02727-8","article-title":"PMCA inhibition\nreverses drug resistance\nin clinically refractory cancer patient-derived models","volume":"21","author":"Park","year":"2023","journal-title":"BMC medicine"},{"key":"2026072810090415700_cit18","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3390\/cancers12020448","article-title":"Impact\nof Age-Related Genetic Differences on the Therapeutic Outcome of Papillary\nThyroid Cancer","volume":"12","author":"Kim","year":"2020","journal-title":"Cancers"},{"key":"2026072810090415700_cit19","doi-asserted-by":"publisher","first-page":"7469","DOI":"10.3390\/ijms21207469","article-title":"Patient-Derived, Drug-Resistant Colon Cancer Cells\nEvade Chemotherapeutic Drug Effects via the Induction of Epithelial-Mesenchymal\nTransition-Mediated Angiogenesis","volume":"21","author":"Lim","year":"2020","journal-title":"International\njournal of molecular sciences"},{"key":"2026072810090415700_cit20","doi-asserted-by":"publisher","first-page":"8215","DOI":"10.1073\/pnas.0708100105","article-title":"Starvation-dependent differential stress resistance\nprotects normal but not cancer cells against high-dose chemotherapy","volume":"105","author":"Raffaghello","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026072810090415700_cit21","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.chembiol.2023.08.011","article-title":"Tumor microenvironmental\nnutrients,\ncellular responses, and cancer","volume":"30","author":"Lobel","year":"2023","journal-title":"Cell chemical\nbiology"},{"key":"2026072810090415700_cit22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-3-030-94004-1_2","article-title":"Macropinocytosis and Cancer: From Tumor Stress to Signaling\nPathways","volume":"98","author":"Lambies","year":"2022","journal-title":"Sub-cellular biochemistry"},{"key":"2026072810090415700_cit23","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41568-025-00892-x","article-title":"Targeting macropinocytosis\nfor cancer therapy","volume":"26","author":"Tang","year":"2026","journal-title":"Nature reviews. Cancer"},{"key":"2026072810090415700_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113962","article-title":"Targeting\nand exploiting macropinocytosis in cancer therapy","volume":"385","author":"Moon","year":"2025","journal-title":"Journal of controlled release: official journal of the Controlled\nRelease Society"},{"key":"2026072810090415700_cit25","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.trecan.2019.04.002","article-title":"Macropinocytosis in Cancer: A Complex\nSignaling Network","volume":"5","author":"Zhang","year":"2019","journal-title":"Trends in cancer"},{"key":"2026072810090415700_cit26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.919819","article-title":"The Role and Therapeutic Potential of Macropinocytosis\nin Cancer","volume":"13","author":"Qiu","year":"2022","journal-title":"Frontiers in pharmacology"},{"key":"2026072810090415700_cit27","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1080\/15548627.2025.2452149","article-title":"Survival strategies\nof cancer cells: the role of macropinocytosis in nutrient acquisition,\nmetabolic reprogramming, and therapeutic targeting","volume":"21","author":"Xu","year":"2025","journal-title":"Autophagy"},{"key":"2026072810090415700_cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54788-9","article-title":"Cell polarity\nproteins promote macropinocytosis in response to metabolic stress","volume":"15","author":"Lambies","year":"2024","journal-title":"Nat. Commun."},{"key":"2026072810090415700_cit29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer\ntherapy: a novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Molecular cancer"},{"key":"2026072810090415700_cit30","doi-asserted-by":"publisher","first-page":"850","DOI":"10.20517\/cdr.2022.20","article-title":"Drug and\napoptosis resistance in cancer stem cells: a puzzle with many pieces","volume":"5","author":"Safa","year":"2022","journal-title":"Cancer drug resistance"},{"key":"2026072810090415700_cit31","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12943-019-1029-8","article-title":"The role of necroptosis in cancer biology and therapy","volume":"18","author":"Gong","year":"2019","journal-title":"Molecular cancer"},{"key":"2026072810090415700_cit32","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/cdd.2016.8","article-title":"Cancer therapy\nin the necroptosis era","volume":"23","author":"Su","year":"2016","journal-title":"Cell death and differentiation"},{"key":"2026072810090415700_cit33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semcdb.2014.08.010","article-title":"Necroptosis,\nin vivo detection in\nexperimental disease models","volume":"35","author":"Jouan-Lanhouet","year":"2014","journal-title":"Seminars in cell\n& developmental biology"},{"key":"2026072810090415700_cit34","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.570108","article-title":"The Dual Role\nof Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis\nto Participate in Anticancer Therapies as Targets","volume":"10","author":"Song","year":"2021","journal-title":"Frontiers in oncology"},{"key":"2026072810090415700_cit35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.neo.2017.12.003","article-title":"Anti-cancer\nEffects\nof HNHA and Lenvatinib by the Suppression of EMT-Mediated Drug Resistance\nin Cancer Stem Cells","volume":"20","author":"Lee","year":"2018","journal-title":"Neoplasia"},{"key":"2026072810090415700_cit36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.trecan.2021.09.004","article-title":"Exploiting\ncancer\u2019s drinking\nproblem: regulation and therapeutic potential of macropinocytosis","volume":"8","author":"Puccini","year":"2022","journal-title":"Trends in cancer"},{"key":"2026072810090415700_cit37","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3389\/fendo.2017.00261","article-title":"Macropinocytosis: A Metabolic Adaptation\nto Nutrient\nStress in Cancer","volume":"8","author":"Recouvreux","year":"2017","journal-title":"Frontiers in endocrinology"},{"key":"2026072810090415700_cit38","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/s41467-020-14928-3","article-title":"Macropinocytosis\nconfers resistance to therapies targeting\ncancer anabolism","volume":"11","author":"Jayashankar","year":"2020","journal-title":"Nat. Commun."},{"key":"2026072810090415700_cit39","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.ccell.2025.06.021","article-title":"Macropinocytosis maintains\nCAF subtype identity under\nmetabolic stress in pancreatic cancer","volume":"43","author":"Zhang","year":"2025","journal-title":"Cancer\ncell"},{"key":"2026072810090415700_cit40","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1158\/2159-8290.CD-17-1215","article-title":"PTEN Deficiency and AMPK Activation\nPromote Nutrient Scavenging and Anabolism in Prostate Cancer Cells","volume":"8","author":"Kim","year":"2018","journal-title":"Cancer discovery"},{"key":"2026072810090415700_cit41","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3390\/nu5041149","article-title":"Is selenium a potential\ntreatment\nfor cancer metastasis?","volume":"5","author":"Chen","year":"2013","journal-title":"Nutrients"},{"key":"2026072810090415700_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2024.101262","article-title":"Iron promotes\nboth ferroptosis and\nnecroptosis in the early stage of reperfusion in ischemic stroke","volume":"11","author":"Du","year":"2024","journal-title":"Genes & diseases"},{"key":"2026072810090415700_cit43","doi-asserted-by":"publisher","first-page":"R619","DOI":"10.1016\/j.cub.2021.01.036","article-title":"The cytoskeleton\nin phagocytosis\nand macropinocytosis","volume":"31","author":"Mylvaganam","year":"2021","journal-title":"Current biology: CB"},{"key":"2026072810090415700_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2021.203713","article-title":"Macropinocytosis:\nBiology and mechanisms","volume":"168","author":"Kay","year":"2021","journal-title":"Cells & development"},{"key":"2026072810090415700_cit45","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1111\/bph.17442","article-title":"Identification of\nnew small molecules for selective\ninhibition of SERCA 1 in patient-derived metastatic papillary thyroid\ncancer","volume":"182","author":"Kim","year":"2025","journal-title":"British journal of pharmacology"},{"key":"2026072810090415700_cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117424","article-title":"Discovery\nof SERCA1-specific\nsmall molecule inhibitors based on survival mechanisms in metastatic\nhepatocellular carcinoma cells that depend on CaMK2alpha-mediated\nSERCA1 expression","volume":"242","author":"Lim","year":"2025","journal-title":"Biochemical pharmacology"},{"key":"2026072810090415700_cit47","doi-asserted-by":"publisher","first-page":"7971","DOI":"10.3390\/ijms23147971","article-title":"Drug Discovery\nUsing Evolutionary Similarities in Chemical Binding to Inhibit Patient-Derived\nHepatocellular Carcinoma","volume":"23","author":"Lim","year":"2022","journal-title":"International journal\nof molecular sciences"},{"key":"2026072810090415700_cit48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with\nlow memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"2026072810090415700_cit49","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level\nexpression analysis of RNA-seq experiments with HISAT, StringTie and\nBallgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nature protocols"},{"key":"2026072810090415700_cit50","doi-asserted-by":"publisher","first-page":"7069","DOI":"10.3390\/ijms24087069","article-title":"Anti-Cancer\nSERCA Inhibitors Targeting Sorafenib-Resistant Human Papillary Thyroid\nCarcinoma","volume":"24","author":"Chang","year":"2023","journal-title":"International journal of molecular\nsciences"},{"key":"2026072810090415700_cit51","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.3390\/ijms251910646","article-title":"New Small-Molecule\nSERCA Inhibitors Enhance Treatment Efficacy in Lenvatinib-Resistant\nPapillary Thyroid Cancer","volume":"25","author":"Kim","year":"2024","journal-title":"International journal\nof molecular sciences"},{"key":"2026072810090415700_cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.124323","article-title":"PPS03 triggers cancer-selective\nnecroptosis in hepatocellular carcinoma via macropinocytosis-dependent\nROS overload","volume":"335","author":"Choi","year":"2026","journal-title":"Biomaterials"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c04236","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/29\/20623\/65917758\/acsnano.6c04236.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/29\/20623\/65917758\/acsnano.6c04236.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:43:21Z","timestamp":1785249801000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/29\/20623\/5208676\/Exploiting-Macropinocytosis-Drives-Redox"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":52,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2026,7,14]]},"published-print":{"date-parts":[[2026,7,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c04236","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]}}}