{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:40:17Z","timestamp":1786466417884,"version":"build-2736575974"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810300"],"award-info":[{"award-number":["2023YFB3810300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","award":["KY09060001"],"award-info":[{"award-number":["KY09060001"]}],"id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","award":["PT32271434"],"award-info":[{"award-number":["PT32271434"]}],"id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020757","name":"Guangzhou First People's Hospital","doi-asserted-by":"publisher","award":["PTHW20231101"],"award-info":[{"award-number":["PTHW20231101"]}],"id":[{"id":"10.13039\/501100020757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025ZYGXZR036"],"award-info":[{"award-number":["2025ZYGXZR036"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275056"],"award-info":[{"award-number":["22275056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271434"],"award-info":[{"award-number":["32271434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nanoparticles show great potential for the management of acute kidney injuries (AKIs). It is well known that nanoparticle size plays a critical role in targeting renal tubules due to the pore structure and kidney filtration threshold (KFT) of the glomerulus. However, AKI can compromise the physiological barriers, which might render the established KFT (\u223c6 nm) and size laws under healthy conditions not applicable in AKI conditions. Reinvestigating the nanoparticle size effect on targeting injured kidneys is thus essential for developing efficacious AKI nanomedicine. Herein, using different-sized gold nanoparticles (AuNPs) ranging from 4 to 60 nm as a model of renal nanomedicine, we discovered that the KFT for AuNPs expands from \u223c6 nm to \u223c10\u201340 nm under rhabdomyolysis-induced AKI conditions. After loading curcumin, a natural antioxidant, into 5, 16, and 60 nm AuNPs to compare their efficacies against AKI, we found that 5 and 16 nm AuNPs both effectively delivered drugs into renal tubules, resulting in their equal therapeutic performance and significantly better efficacy than 60 nm ones, further validating the enlarged KFT under AKI. Our results provide valuable insights for size engineering of nanomedicine for better AKI management and enable a deeper understanding of AKI renal physiology at the nanoscale.<\/jats:p>","DOI":"10.1021\/acsnano.6c04725","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:23:08Z","timestamp":1785849788000},"page":"21812-21826","source":"Crossref","is-referenced-by-count":0,"title":["Size Effect of Nanoparticles\non Targeting Injured\nKidneys for Enhanced Intervention in Acute Kidney Injury"],"prefix":"10.1021","volume":"20","author":[{"given":"Yiqiao","family":"Chen","sequence":"first","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Xu","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Qi","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexi","family":"Peng","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixu","family":"Lu","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Guangzhou International Campus , ,","place":["Guangzhou, PR China, 511442"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyang","family":"Zhong","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Guangzhou International Campus , ,","place":["Guangzhou, PR China, 511442"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoshuo","family":"Liu","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Liang","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Guangzhou International Campus , ,","place":["Guangzhou, PR China, 511442"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieman","family":"Liu","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Guangzhou International Campus , ,","place":["Guangzhou, PR China, 511442"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"Wang","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Guangzhou International Campus , ,","place":["Guangzhou, PR China, 511442"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1725-5221","authenticated-orcid":true,"given":"Xingya","family":"Jiang","sequence":"additional","affiliation":[{"name":"South China University of Technology , , Guangzhou International Campus , ,","place":["Guangzhou, PR China, 511442"]},{"name":"South China University of Technology , , ,","place":["Guangzhou, PR China, 510006"]},{"name":"South China University of Technology , , ,","place":["Guangzhou, PR China, 510006"]},{"name":"South China University of Technology , , ,","place":["Guangzhou, PR China, 510006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5625-8521","authenticated-orcid":true,"given":"Bujie","family":"Du","sequence":"additional","affiliation":[{"name":"the Second Affiliated Hospital of South China University of Technology (Guangzhou First People\u2019s Hospital) , , ,","place":["Guangzhou, P.R. China, 510180"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"1","key":"2026081111114940800_cit1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev.\nDis. Primers"},{"issue":"7","key":"2026081111114940800_cit2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41581-024-00820-6","article-title":"Chronic kidney disease\nand the global public health agenda: an international consensus","volume":"20","author":"Francis","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"7","key":"2026081111114940800_cit3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41581-024-00829-x","article-title":"Kidney disease: a global health priority","volume":"20","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"2026081111114940800_cit4","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1038\/s41551-025-01402-y","article-title":"NAD+ biosynthesis and mitochondrial\nrepair in acute kidney injury via ultrasound-responsive thylakoid-integrating\nliposomes","volume":"9","author":"Lei","year":"2025","journal-title":"Nat. Biomed. Eng."},{"issue":"12","key":"2026081111114940800_cit5","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/nrneph.2016.156","article-title":"Nanomedicines\nfor renal disease: current status and future applications","volume":"12","author":"Kamaly","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"19","key":"2026081111114940800_cit6","doi-asserted-by":"publisher","first-page":"8978","DOI":"10.1021\/acs.nanolett.3c02531","article-title":"A Polymeric Nanosponge\nas a Broad-Spectrum\nReactive Oxygen Species Scavenger for Acute Kidney Injury Treatment","volume":"23","author":"He","year":"2023","journal-title":"Nano Lett."},{"issue":"1","key":"2026081111114940800_cit7","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/s41467-021-21714-2","article-title":"Catalytic activity tunable ceria nanoparticles\nprevent chemotherapy-induced\nacute kidney injury without interference with chemotherapeutics","volume":"12","author":"Weng","year":"2021","journal-title":"Nat. Commun."},{"issue":"11","key":"2026081111114940800_cit8","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/s41551-018-0317-8","article-title":"DNA origami nanostructures can exhibit preferential\nrenal uptake\nand alleviate acute kidney injury","volume":"2","author":"Jiang","year":"2018","journal-title":"Nat. Biomed.\nEng."},{"issue":"9","key":"2026081111114940800_cit9","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1021\/acs.accounts.0c00323","article-title":"Nanomedicines for Renal Management:\nFrom Imaging to Treatment","volume":"53","author":"Jiang","year":"2020","journal-title":"Acc. Chem. Res."},{"issue":"6","key":"2026081111114940800_cit10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/s41581-024-00819-z","article-title":"Physiological principles\nunderlying the kidney targeting of renal nanomedicines","volume":"20","author":"Huang","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"issue":"10","key":"2026081111114940800_cit11","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s41578-018-0038-3","article-title":"Transport\nand interactions of nanoparticles in the\nkidneys","volume":"3","author":"Du","year":"2018","journal-title":"Nat. Rev. Mater."},{"issue":"11","key":"2026081111114940800_cit12","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/nnano.2017.170","article-title":"Glomerular\nbarrier behaves as an atomically precise\nbandpass filter in a sub-nanometre regime","volume":"12","author":"Du","year":"2017","journal-title":"Nat.\nNanotechnol."},{"issue":"2","key":"2026081111114940800_cit13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1021\/acs.bioconjchem.9b00707","article-title":"Tailoring Kidney Transport of Organic Dyes with Low-Molecular-Weight\nPEGylation","volume":"31","author":"Du","year":"2020","journal-title":"Bioconjugate Chem."},{"issue":"21","key":"2026081111114940800_cit14","doi-asserted-by":"publisher","first-page":"20825","DOI":"10.1021\/acsnano.3c05853","article-title":"Size-Dependent\nIn Vivo Transport of Nanoparticles: Implications for Delivery, Targeting,\nand Clearance","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"},{"issue":"52","key":"2026081111114940800_cit15","doi-asserted-by":"publisher","first-page":"16039","DOI":"10.1002\/anie.201609043","article-title":"Tailoring Renal Clearance and Tumor\nTargeting of Ultrasmall Metal\nNanoparticles with Particle Density","volume":"55","author":"Tang","year":"2016","journal-title":"Angew.\nChem., Int. Ed."},{"issue":"24","key":"2026081111114940800_cit16","doi-asserted-by":"publisher","first-page":"9825","DOI":"10.1021\/acs.nanolett.5c02262","article-title":"Impact of Renal-Targeting Ligand Density on\nKidney\nTargeting, Clearance, and Off-Target Effects of Renal-Clearable Nanoparticles","volume":"25","author":"Song","year":"2025","journal-title":"Nano Lett."},{"issue":"10","key":"2026081111114940800_cit17","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/nbt1340","article-title":"Renal clearance\nof quantum dots","volume":"25","author":"Soo Choi","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"2026081111114940800_cit18","doi-asserted-by":"publisher","first-page":"F605","DOI":"10.1152\/ajprenal.00171.2004","article-title":"Ficoll and\ndextran vs. globular proteins as probes for testing glomerular\npermselectivity: effects of molecular size, shape, charge, and deformability","volume":"288","author":"Venturoli","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"2026081111114940800_cit19","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1021\/nl803405h","article-title":"Fluorescent\nSilica Nanoparticles with Efficient Urinary Excretion for Nanomedicine","volume":"9","author":"Burns","year":"2009","journal-title":"Nano Lett."},{"issue":"5","key":"2026081111114940800_cit20","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417024","article-title":"Nanoparticle Transport in Proximal\nTubules with Rhabdomyolysis-Induced Necrosis","volume":"64","author":"Huang","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081111114940800_cit21","doi-asserted-by":"publisher","first-page":"119368","DOI":"10.1016\/j.biomaterials.2019.119368","article-title":"Size and temporal-dependent efficacy of oltipraz-loaded\nPLGA nanoparticles\nfor treatment of acute kidney injury and fibrosis","volume":"219","author":"Yu","year":"2019","journal-title":"Biomaterials"},{"issue":"31","key":"2026081111114940800_cit22","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh7828","article-title":"Bioactive NIR-II gold clusters for three-dimensional\nimaging and acute inflammation inhibition","volume":"9","author":"Ma","year":"2023","journal-title":"Sci.\nAdv."},{"issue":"20","key":"2026081111114940800_cit23","doi-asserted-by":"publisher","first-page":"9904","DOI":"10.7150\/thno.66518","article-title":"Clinically translatable gold nanozymes\nwith broad spectrum antioxidant and anti-inflammatory activity for\nalleviating acute kidney injury","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"2026081111114940800_cit24","doi-asserted-by":"publisher","first-page":"2309949","DOI":"10.1002\/adfm.202309949","article-title":"Cucurbit[7]uril-Mediated\nOrgan-Specific Delivery of Ultrasmall NIR-II Luminescent Gold Nanocarriers\nfor Therapy of Acute Kidney Injury","volume":"34","author":"He","year":"2024","journal-title":"Adv. Funct.\nMater."},{"key":"2026081111114940800_cit25","doi-asserted-by":"publisher","first-page":"102209","DOI":"10.1016\/j.nantod.2024.102209","article-title":"STING antagonist-loaded renal tubule epithelial cell-mimicking nanoparticles\nameliorate acute kidney injury by orchestrating innate and adaptive\nimmunity","volume":"55","author":"Shen","year":"2024","journal-title":"Nano Today"},{"issue":"41","key":"2026081111114940800_cit26","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb7422","article-title":"ROS-responsive\nchitosan-SS31 prodrug for AKI therapy via rapid distribution in the\nkidney and long-term retention in the renal tubule","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"issue":"1","key":"2026081111114940800_cit27","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/s41467-025-56257-3","article-title":"Barcoded screening identifies\nnanocarriers for protein\ndelivery to kidney","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"issue":"12","key":"2026081111114940800_cit28","doi-asserted-by":"publisher","first-page":"2000420","DOI":"10.1002\/advs.202000420","article-title":"Selenium-Doped\nCarbon Quantum Dots Act as Broad-Spectrum Antioxidants\nfor Acute Kidney Injury Management","volume":"7","author":"Rosenkrans","year":"2020","journal-title":"Adv. Sci."},{"issue":"1","key":"2026081111114940800_cit29","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1038\/s41467-020-16544-7","article-title":"Ultrasmall copper-based nanoparticles for reactive\noxygen species scavenging and alleviation of inflammation related\ndiseases","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"issue":"28","key":"2026081111114940800_cit30","doi-asserted-by":"publisher","first-page":"2301283","DOI":"10.1002\/adma.202301283","article-title":"Reversing Acute Kidney\nInjury through Coordinated Interplay of Anti-Inflammation\nand Iron Supplementation","volume":"35","author":"Duan","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"2026081111114940800_cit31","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/s41467-025-56223-z","article-title":"High-density lipoprotein\nnanoparticles spontaneously target to damaged\nrenal tubules and alleviate renal fibrosis by remodeling the fibrotic\nniches","volume":"16","author":"He","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"2026081111114940800_cit32","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1681\/ASN.0000000608","article-title":"Nanotherapeutics in\nKidney Disease: Innovations, Challenges, and Future Directions","volume":"36","author":"Roointan","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"issue":"25","key":"2026081111114940800_cit33","doi-asserted-by":"publisher","first-page":"8479","DOI":"10.1002\/anie.201903256","article-title":"Tuning the\nIn Vivo Transport of Anticancer Drugs Using Renal-Clearable Gold Nanoparticles","volume":"58","author":"Peng","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"issue":"12","key":"2026081111114940800_cit34","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1038\/s41563-020-0755-z","article-title":"The\ndose threshold for nanoparticle tumour delivery","volume":"19","author":"Ouyang","year":"2020","journal-title":"Nat. Mater."},{"issue":"8","key":"2026081111114940800_cit35","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1021\/acs.bioconjchem.4c00312","article-title":"Early Detection and\nNoninvasive Staging of Kidney Dysfunction by\na PEGylated Conventional Fluorophore via GFR-Sensitive Renal Transport","volume":"35","author":"Peng","year":"2024","journal-title":"Bioconjugate Chem."},{"issue":"2","key":"2026081111114940800_cit36","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1002\/cphy.c110041","article-title":"Pathophysiology\nof acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol."},{"issue":"36","key":"2026081111114940800_cit37","doi-asserted-by":"publisher","first-page":"2402479","DOI":"10.1002\/adma.202402479","article-title":"Gold Nanoparticle Transport\nin the Injured Kidneys with Elevated Renal Function Biomarkers","volume":"36","author":"Ning","year":"2024","journal-title":"Adv. Mater."},{"key":"2026081111114940800_cit38","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1021\/acsnanomed.5c00050","article-title":"Quantitative\nDetection of Bilateral and Unilateral Renal Dysfunction by Gold Nanoparticles\nthrough CT Imaging","volume":"1","author":"Yang","year":"2026","journal-title":"ACS Nano Med."},{"key":"2026081111114940800_cit39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.addr.2017.01.005","article-title":"Xenobiotic transporters and kidney\ninjury","volume":"116","author":"George","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"issue":"4","key":"2026081111114940800_cit40","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1124\/dmd.107.019869","article-title":"Altered Pharmacokinetics of Cationic Drugs Caused by\nDown-Regulation of Renal Rat Organic Cation Transporter 2 (Slc22a2)\nand Rat Multidrug and Toxin Extrusion 1 (Slc47a1) in Ischemia\/Reperfusion-Induced\nAcute Kidney Injury","volume":"36","author":"Matsuzaki","year":"2008","journal-title":"Drug Metab. Dispos."},{"issue":"11","key":"2026081111114940800_cit41","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin:\nFrom ancient medicine to current clinical trials","volume":"65","author":"Hatcher","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"2026081111114940800_cit42","doi-asserted-by":"publisher","first-page":"154306","DOI":"10.1016\/j.phymed.2022.154306","article-title":"Role of curcumin in the treatment of acute kidney injury: research\nchallenges and opportunities","volume":"104","author":"Cai","year":"2022","journal-title":"Phytomedicine"},{"key":"2026081111114940800_cit43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s40256-024-00715-8","article-title":"Kidney Injury Following Cardiac Surgery:\nA Review of Our Current Understanding","volume":"25","author":"Kamla","year":"2025","journal-title":"Am. J.\nCardiovasc. Drugs"},{"issue":"1","key":"2026081111114940800_cit44","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1038\/s41467-023-40036-z","article-title":"A renal\nYY1-KIM1-DR5 axis regulates the progression of acute kidney injury","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"2026081111114940800_cit45","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433","article-title":"Kidney\nInjury Molecule-1 (KIM-1): a novel biomarker for human renal proximal\ntubule injury","volume":"62","author":"Han","year":"2002","journal-title":"Kidney Int."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c04725","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/31\/21812\/66342702\/acsnano.6c04725.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/31\/21812\/66342702\/acsnano.6c04725.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:43:38Z","timestamp":1786463018000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/31\/21812\/5237401\/Size-Effect-of-Nanoparticles-on-Targeting-Injured"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":45,"journal-issue":{"issue":"31","published-online":{"date-parts":[[2026,7,30]]},"published-print":{"date-parts":[[2026,8,11]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c04725","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}