{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:55:48Z","timestamp":1785851748705,"version":"3.56.0"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52333011"],"award-info":[{"award-number":["52333011"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52471261"],"award-info":[{"award-number":["52471261"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20763"],"award-info":[{"award-number":["U24A20763"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes serious joint damage and functional loss, which is predominantly associated with the aberrant activation of synovial macrophages. Herein, we report an injectable ion-coordinated bionic lubricant to efficiently reprogram synovial macrophages into pro-regenerative phenotypes for RA treatment. For this purpose, rhein (Rh)-modified PEGylated liposomes were integrated with coenzyme Q10 (CoQ10) for macrophage-targeted delivery (LipQ10-Rh), which were subsequently embedded into dynamic hyaluronic acid (HA)-based hydrogel matrices cross-linked by acylhydrazone bonding and Zn2+ ion-mediated coordination (HALZ). Owing to the intrinsic reversibility of the dynamic bonding network, the HALZ lubricant could be facilely injected into RA-affected joint cavity and provide immediate relief through biolubrication. Meanwhile, the LipQ10-Rh liposomes and Zn ions could be gradually released from the dynamic hydrogels and taken in by synovial macrophages, where the Zn ions could activate the anti-inflammatory metabolism while CoQ10 alleviated mitochondrial ROS stress to restore their reparative functions, which acted in a cooperative manner to reprogram the inflammatory synovial macrophages into pro-regenerative phenotypes. In vivo results evidently suggested that the injectable HALZ biolubricant efficiently abolished RA-associated joint damage on rat models in a durable manner, providing an approach for improving RA recession in the clinic.<\/jats:p>","DOI":"10.1021\/acsnano.6c05740","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:48:26Z","timestamp":1784738906000},"page":"21245-21262","source":"Crossref","is-referenced-by-count":0,"title":["Intra-Articularly\nInjectable Ion-Coordinated Bionic\nLubricants Improve Rheumatoid Arthritis Recession via Pro-Regenerative\nReprogramming of Synovial Macrophages"],"prefix":"10.1021","volume":"20","author":[{"given":"Jiayi","family":"Lin","sequence":"first","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wei","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-7648","authenticated-orcid":true,"given":"Menghuan","family":"Li","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Hu","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-3314","authenticated-orcid":true,"given":"Zhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9029-680X","authenticated-orcid":true,"given":"Kaiyong","family":"Cai","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7133-8525","authenticated-orcid":true,"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"Chongqing University , , ,","place":["Chongqing, China, 400044"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2026080409284529800_cit1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The Pathogenesis of Rheumatoid Arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2026080409284529800_cit2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid Arthritis-Common Origins, Divergent Mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"2026080409284529800_cit3","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","article-title":"Macrophage Heterogeneity in the Context\nof Rheumatoid Arthritis","volume":"12","author":"Udalova","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026080409284529800_cit4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","article-title":"Synovial Tissue Macrophages in Joint\nHomeostasis, Rheumatoid\nArthritis and Disease Remission","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026080409284529800_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502147","article-title":"Biocatalytic and Redox-Regulated\nNanoarchitectures for Precision Inflammation and Immune Homeostasis\nModulation to Combat Rheumatoid Arthritis","volume":"37","author":"Xiao","year":"2025","journal-title":"Adv.\nMater."},{"key":"2026080409284529800_cit6","doi-asserted-by":"publisher","first-page":"1394108","DOI":"10.3389\/fimmu.2024.1394108","article-title":"Macrophage Polarization\nin Rheumatoid Arthritis: Signaling Pathways, Metabolic Reprogramming,\nand Crosstalk with Synovial Fibroblasts","volume":"15","author":"Zheng","year":"2024","journal-title":"Front.\nImmunol."},{"key":"2026080409284529800_cit7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in Immunoregulation\nand Therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduction Targeted\nTher."},{"key":"2026080409284529800_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202310061","article-title":"A Nanomedicine-Enabled\nIon-Exchange\nStrategy for Enhancing Curcumin-Based Rheumatoid Arthritis Therapy","volume":"62","author":"Yang","year":"2023","journal-title":"Angew. Chem."},{"key":"2026080409284529800_cit9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrrheum.2016.69","article-title":"Hypoxia, Mitochondrial\nDysfunction and Synovial Invasiveness in Rheumatoid Arthritis","volume":"12","author":"Fearon","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026080409284529800_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309725","article-title":"Lactobacillus\nReuteri Vesicles Regulate Mitochondrial Function of Macrophages to\nPromote Mucosal and Cutaneous Wound Healing","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci."},{"key":"2026080409284529800_cit11","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1016\/j.apsb.2022.11.020","article-title":"Ultrasmall\nIron-Quercetin Metal Natural Product Nanocomplex with Antioxidant\nand Macrophage Regulation in Rheumatoid Arthritis","volume":"13","author":"Han","year":"2023","journal-title":"Acta Pharm. Sin. 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Sci."},{"key":"2026080409284529800_cit24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.addr.2021.01.019","article-title":"Overcoming Barriers\nby Local Drug Delivery with Liposomes","volume":"174","author":"Antimisiaris","year":"2021","journal-title":"Adv.\nDrug Delivery Rev."},{"key":"2026080409284529800_cit25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2020.06.022","article-title":"Recent\nAdvancements in Liposome Technology","volume":"156","author":"Filipczak","year":"2020","journal-title":"Adv. Drug\nDelivery Rev."},{"key":"2026080409284529800_cit26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.addr.2020.07.002","article-title":"Liposomes: Advancements and Innovation\nin the Manufacturing\nProcess","volume":"154\u2013155","author":"Shah","year":"2020","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026080409284529800_cit27","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/s41551-025-01373-0","article-title":"Generation\nof Tolerogenic Antigen-Presenting Cells in Vivo via the Delivery of\nmRNA Encoding PDL1 within Lipid Nanoparticles","volume":"9","author":"Liu","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"2026080409284529800_cit28","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/s41565-023-01444-w","article-title":"Transport\nby Circulating Myeloid Cells Drives Liposomal Accumulation in Inflamed\nSynovium","volume":"18","author":"Deprez","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"2026080409284529800_cit29","doi-asserted-by":"publisher","first-page":"122706","DOI":"10.1016\/j.biomaterials.2024.122706","article-title":"Injectable Bioadhesive Hydrogel as\na Local Nanomedicine Depot for Targeted Regulation of Inflammation\nand Ferroptosis in Rheumatoid Arthritis","volume":"311","author":"Yang","year":"2024","journal-title":"Biomaterials"},{"key":"2026080409284529800_cit30","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1021\/acs.chemrev.2c00179","article-title":"Self-Healing\nInjectable Hydrogels for Tissue Regeneration","volume":"123","author":"Bertsch","year":"2023","journal-title":"Chem. 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Mater."},{"key":"2026080409284529800_cit40","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/s41467-019-09601-3","article-title":"Directed Self-Assembly\nof Herbal Small Molecules into Sustained Release\nHydrogels for Treating Neural Inflammation","volume":"10","author":"Zheng","year":"2019","journal-title":"Nat. Commun."},{"key":"2026080409284529800_cit41","doi-asserted-by":"publisher","first-page":"2300342","DOI":"10.1002\/adfm.202300342","article-title":"Folate\nReceptor-Targeted NIR-II Dual-Model Nanoprobes for Multiscale Visualization\nof Macrophages in Rheumatoid Arthritis","volume":"33","author":"Lan","year":"2023","journal-title":"Adv.\nFunct. 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Sci."},{"key":"2026080409284529800_cit47","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6449","article-title":"Injectable Hydrogel Microspheres\nwith Self-Renewable Hydration Layers\nAlleviate Osteoarthritis","volume":"8","author":"Lei","year":"2022","journal-title":"Sci. Adv."},{"key":"2026080409284529800_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202515734","article-title":"Lubrication Barriers\nHydrogel Microspheres Improve Dynamic Tissue Repair via the Blockade\nof Inflammatory Communication","volume":"36","author":"Xiao","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"2026080409284529800_cit49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2424529122","article-title":"Gelated\nMicrovesicle-Mediated Delivery of Mesenchymal Stem Cell Mitochondria\nfor the Treatment of Myocardial Infarction","volume":"122","author":"Chu","year":"2025","journal-title":"Proc. Natl. Acad. 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