{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:42:03Z","timestamp":1794285723622,"version":"4.9.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012847"],"award-info":[{"award-number":["2025A1515012847"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Areas of Excellence from the Research Grants Council of Hong Kong","award":["AoE\/M-402\/20"],"award-info":[{"award-number":["AoE\/M-402\/20"]}]},{"name":"NSFC\/RGC Joint Research Scheme","award":["N_CUHK405\/21"],"award-info":[{"award-number":["N_CUHK405\/21"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["32401100"],"award-info":[{"award-number":["32401100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic wounds are characterized by unsatisfactory clinical outcomes due to persistent inflammation, excessive oxidative stress, and impaired neurovascular function, which conventional dressings cannot adequately address. This study presents a promising strategy for sequentially reversing these multifactorial wound conditions. We engineered a sprayable Mg-ZIF-8@TP@Alg hydrogel by integrating a Mg\u2013Zn bimetallic metal\u2013organic framework (Mg-ZIF-8) with tea polyphenol (TP), achieving differential release and pH-responsive therapeutic kinetics. In vitro assays demonstrated that Mg-ZIF-8@TP exerted synergistic ROS-scavenging activity, promoted M2 macrophage polarization, and enhanced angiogenic and neurogenic outcomes. These effects are attributed to TP-mediated attenuation of oxidative stress, together with activation of Mg2+\/Zn2+-driven cellular behaviors. In a clinically relevant porcine model, the Mg-ZIF-8@TP@Alg hydrogel significantly accelerated wound healing. It sequentially remodelled the immune microenvironment by decreasing pro-inflammatory iNOS+ cells and increasing reparative CD163+ macrophages. Moreover, it enhanced CD31+ vascular neogenesis and \u03b23-tubulin+ peripheral nerve regeneration. Transcriptomic analysis revealed that the hydrogel orchestrated chronic wound repair by modulating key pathways associated with ion transport, immune response suppression, and skin development. Overall, this work presents an innovative sprayable Mg-MOF hydrogel with synergistic, stage-specific therapeutic functionality, offering a potential strategy for chronic wound management.<\/jats:p>","DOI":"10.1021\/acsnano.6c05950","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:18:17Z","timestamp":1785849497000},"page":"21921-21938","source":"Crossref","is-referenced-by-count":2,"title":["An Innovative Sprayable\nMg-MOF Hydrogel Enhances Healing\nof Chronic Wounds with Multifaceted Pathologies in a Porcine Model"],"prefix":"10.1021","volume":"20","author":[{"given":"Shunxiang","family":"Xu","sequence":"first","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]},{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Normal University , , ,","place":["Shanghai, P. R. China, 200234"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Shao","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]},{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Tian","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]},{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]},{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"Xu","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]},{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3725-5600","authenticated-orcid":true,"given":"Congqin","family":"Ning","sequence":"additional","affiliation":[{"name":"Shanghai Normal University , , ,","place":["Shanghai, P. R. China, 200234"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-6167","authenticated-orcid":true,"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]},{"name":"The Chinese University of Hong Kong , , , ,","place":["New Territories, Hong Kong SAR, P. R. China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"3","key":"2026081111112241400_cit1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic Wound Healing: A Review of Current Management\nand Treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"key":"2026081111112241400_cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic wounds","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. 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Chem."},{"key":"2026081111112241400_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.173231","article-title":"The Self-assembling\namphibian-derived peptide (RADA)4-FZ1 pioneers a novel therapeutic\nplatform for diabetic skin wound management","volume":"530","author":"Fu","year":"2026","journal-title":"Chem. Eng. J."},{"issue":"19","key":"2026081111112241400_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415459","article-title":"Silicon enhances functional mitochondrial\ntransfer to improve neurovascularization in diabetic bone regeneration","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci."},{"key":"2026081111112241400_cit44","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202309974","article-title":"Metal-organic frameworks\nfor nerve repair and neural stem cell therapy","volume":"34","author":"Meng","year":"2024","journal-title":"Adv. Funct. 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Mater."},{"issue":"1","key":"2026081111112241400_cit46","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13233","article-title":"Recent advances in\nbioactive wound dressings","volume":"33","author":"Nur","year":"2025","journal-title":"Wound Repair Regener."},{"issue":"5","key":"2026081111112241400_cit47","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/idm2.70003","article-title":"Magnesium\nsilicate composite patch\nwith neurovascular regenerative properties promotes diabetic wound\nhealing in mice","volume":"4","author":"Xu","year":"2025","journal-title":"Interdiscip. 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