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Draw inspiration from the inherent electroactive features of bone and nerve, bioelectric implant providing wireless delivery of electrical stimulation (ES), is an emerging alternative to conventional invasive electrode-based therapy. Herein, we develop a lead-free magnetoelectric (ME) core\u2013shell MnFe2O4@Ba0.85Ca0.15Zr0.1Ti0.9O3 (MFO@BCZT) nanoheterostructure-integrated biodegradable 3D-printed hydrogel implant providing high-performance wireless ES for neurovascularized bone regeneration. Under low-intensity magnetic field stimulation (20 mT, 50 Hz), the strain generated by the magnetostriction of MFO core is directly transmitted into BCZT piezoelectric shell to generate electrical signals. Thus, 3D-printed ME implants activate multiple neurogenesis- and osteogenesis-related signals including calcium ion-mediated CaMKII\/CREB and CaMKK\u03b2\/AMPK\/Nrf2 pathway, as well as other pro-regenerative pathways including PI3K-AKT and TGF-\u03b2 signaling. The implants recreate electrophysiological microenvironments of bone defect in vivo, thereby inducing early neuroangiogenesis and recruiting endogenous stem cells, resulting in 3.1-fold and 4.6-fold increase in innervation and bone formation, respectively. Beyond bone repair, this magnetically driven electrical stimulation strategy establishes a ME-multicellular coupling platform for minimally invasive complex tissue regenerative therapies. Furthermore, the stimuli-responsive 3D-printed ME hydrogel implant establishes a versatile foundation for multifunctional wireless bioelectronic interfaces, allowing a single system to integrate therapeutic and neuroelectronic functions with potential applications in treating traumatic brain injury and neurological disorders, as well as in next-generation brain\u2013machine interfaces.<\/jats:p>","DOI":"10.1021\/acsnano.6c06339","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:06:12Z","timestamp":1784527572000},"page":"21294-21315","source":"Crossref","is-referenced-by-count":0,"title":["Wireless Magnetoelectric\nStimulation Platform Orchestrating\nMulticellular Coupling in Complex Neurovascularized Tissue Regeneration"],"prefix":"10.1021","volume":"20","author":[{"given":"Hongjian","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Institute of Ceramics, Chinese Academy of Sciences , , ,","place":["Shanghai, P. R. China, 200050"]},{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, P. R. China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9461-7110","authenticated-orcid":true,"given":"Polina V.","family":"Chernozem","sequence":"additional","affiliation":[{"name":"National Research Tomsk Polytechnic University , , ,","place":["Tomsk, Russia, 634050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-3047","authenticated-orcid":true,"given":"Roman A.","family":"Surmenev","sequence":"additional","affiliation":[{"name":"National Research Tomsk Polytechnic University , , ,","place":["Tomsk, Russia, 634050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Surmeneva","sequence":"additional","affiliation":[{"name":"National Research Tomsk Polytechnic University , , ,","place":["Tomsk, Russia, 634050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry V.","family":"Wagner","sequence":"additional","affiliation":[{"name":"National Research Tomsk State University , ,","place":["Tomsk, Russia, 634050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3230-3335","authenticated-orcid":true,"given":"Evgeny Yu.","family":"Gerasimov","sequence":"additional","affiliation":[{"name":"Boreskov Institute of Catalysis , ,","place":["Novosibirsk, Russia, 630090"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-2063","authenticated-orcid":true,"given":"Abdulkarim A.","family":"Amirov","sequence":"additional","affiliation":[{"name":"National University of Science and Technology MISIS , , ,","place":["Moscow, Russia, 119049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei L.","family":"Kholkin","sequence":"additional","affiliation":[{"name":"University of Aveiro , , ,","place":["Aveiro, Portugal, 3810-193"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Huan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Ceramics, Chinese Academy of Sciences , , ,","place":["Shanghai, P. R. China, 200050"]},{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, P. R. China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Ceramics, Chinese Academy of Sciences , , ,","place":["Shanghai, P. R. China, 200050"]},{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, P. R. China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman V.","family":"Chernozem","sequence":"additional","affiliation":[{"name":"National Research Tomsk Polytechnic University , , ,","place":["Tomsk, Russia, 634050"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-591X","authenticated-orcid":true,"given":"Chengtie","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Ceramics, Chinese Academy of Sciences , , ,","place":["Shanghai, P. 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