{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:32:47Z","timestamp":1790004767820,"version":"4.0.1"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["3-IND-2024-1549-I-X"],"award-info":[{"award-number":["3-IND-2024-1549-I-X"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["3-SRA-2023-1379-S-B"],"award-info":[{"award-number":["3-SRA-2023-1379-S-B"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["3-SRA-2026-1848-S-B"],"award-info":[{"award-number":["3-SRA-2026-1848-S-B"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"The Leona M. & Harry B. 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Helmsley Charitable Trust","doi-asserted-by":"publisher","award":["R-2207-05413"],"award-info":[{"award-number":["R-2207-05413"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"EFSD and Sanofi European Diabetes Research Programme on Autoimmunity in T1D 2024","doi-asserted-by":"publisher","award":["T1D 2024"],"award-info":[{"award-number":["T1D 2024"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Beyond their deployment as COVID-19 vaccines, lipid nanoparticles (LNPs) have emerged as versatile vehicles for therapeutic nucleic acid delivery. However, achieving efficient and cell-targeted transfection in extrahepatic tissues, particularly pancreatic \u03b2 cells, remains a major challenge. Here, we develop a dual-targeting LNP engineering strategy that integrates high-throughput compositional screening with surface conjugation of \u03b2 cell-specific targeting ligands to enable selective gene delivery to pancreatic \u03b2 cells. Compositional optimization identified LNP formulations that achieved over a 148-fold increase in \u03b2 cell transfection efficiency in vitro and more than an 8-fold increase in pancreatic selectivity in vivo compared to the Moderna LNP formulation. Surface conjugation of the ZnT8-specific monoclonal antibody (mAb43), which recognizes the zinc transporter ZnT8 highly expressed on murine \u03b2 cells, further increased pancreatic transgene expression by more than 2-fold and achieved over 70% \u03b2 cell transfection in murine models. To improve translational potential, we conjugated a high-affinity camelid single-domain antibody (4hD29 nanobody) targeting dipeptidyl peptidase-6 (DPP6), a biomarker enriched on human \u03b2 cells, to compositionally optimized LNPs to deliver human STAT2-siRNA. These dual-targeting LNPs reduced STAT2 expression in human \u03b2 cells under IFN-\u03b1 stimulation to below baseline levels observed in unstimulated controls and induced &amp;gt; 4-fold increase in PDL1 expression. Together, this integrated LNP design for \u03b2 cell-directed gene delivery establishes a versatile platform for RNA therapeutics and gene-editing applications in a pro-inflammatory type 1 diabetes context.<\/jats:p>","DOI":"10.1021\/acsnano.6c06440","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:01:57Z","timestamp":1786618917000},"page":"23296-23313","source":"Crossref","is-referenced-by-count":1,"title":["Engineering Lipid\nNanoparticles through Integrated\nCompositional and Ligand Targeting Enhances \u03b2 Cell-Directed\nRNA Delivery"],"prefix":"10.1021","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5000-2100","authenticated-orcid":true,"given":"Di","family":"Yu","sequence":"first","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-0097","authenticated-orcid":true,"given":"Yining","family":"Zhu","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Roca-Rivada","sequence":"additional","affiliation":[{"name":"Universite\u0301 Libre de Bruxelles , , ,","place":["Brussels, Belgium, 1070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene","family":"Weng","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu Han","family":"Toh","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Martin-Vazquez","sequence":"additional","affiliation":[{"name":"Universite\u0301 Libre de Bruxelles , , ,","place":["Brussels, Belgium, 1070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Buemi","sequence":"additional","affiliation":[{"name":"Universite\u0301 Catholique de Louvain , , ,","place":["Brussels, Belgium, 1200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar I.","family":"Mourad","sequence":"additional","affiliation":[{"name":"Universite\u0301 Catholique de Louvain , , ,","place":["Brussels, Belgium, 1200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devi","family":"Kasinathan","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21205"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Ma","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Lin","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Kong","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-482X","authenticated-orcid":true,"given":"Stephany Y.","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Lu","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6319-7858","authenticated-orcid":true,"given":"Yunhe","family":"Su","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtian","family":"Shen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailei D.","family":"Goodier","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wei","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn H.","family":"Greco","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-3264","authenticated-orcid":true,"given":"Joshua C.","family":"Doloff","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decio L.","family":"Eizirik","sequence":"additional","affiliation":[{"name":"Universite\u0301 Libre de Bruxelles , , ,","place":["Brussels, Belgium, 1070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4262-9988","authenticated-orcid":true,"given":"Hai-Quan","family":"Mao","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21231"]},{"name":"Johns Hopkins University School of Medicine , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026083119010655500_cit1","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic \u03b2-Cells in Type\n1 and Type 2 Diabetes Mellitus: Different Pathways to Failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"2026083119010655500_cit2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2009.21","article-title":"The Role of\nInflammation in Insulitis\nand \u03b2-Cell Loss in Type 1 Diabetes","volume":"5","author":"Eizirik","year":"2009","journal-title":"Nat.\nRev. Endocrinol."},{"key":"2026083119010655500_cit3","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 Diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"2026083119010655500_cit4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S2213-8587(26)00003-3","article-title":"From Survival\nto Freedom: Redefining Success in Type 1 Diabetes","volume":"14","author":"Piemonti","year":"2026","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2026083119010655500_cit5","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1001\/jama.2026.0048","article-title":"Type 1 Diabetes: A Review","volume":"335","author":"Jacobsen","year":"2026","journal-title":"JAMA"},{"key":"2026083119010655500_cit6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1056\/NEJMoa1902226","article-title":"An Anti-CD3\nAntibody, Teplizumab, in Relatives at Risk\nfor Type 1 Diabetes","volume":"381","author":"Herold","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"2026083119010655500_cit7","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.2337\/db18-0065","article-title":"Strength\nin Numbers:\nOpportunities for Enhancing the Development of Effective Treatments\nfor Type 1 Diabetes-The TrialNet Experience","volume":"67","author":"Greenbaum","year":"2018","journal-title":"Diabetes"},{"key":"2026083119010655500_cit8","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.2337\/dbi24-0020","article-title":"Evolving\nConcepts in Pathophysiology,\nScreening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus\nInteragency Coordinating Committee Workshop","volume":"73","author":"Greenbaum","year":"2024","journal-title":"Diabetes"},{"key":"2026083119010655500_cit9","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.2337\/dbi20-0046","article-title":"From Pancreatic \u03b2-Cell\nGene Networks to Novel Therapies for Type 1 Diabetes","volume":"70","author":"Eizirik","year":"2021","journal-title":"Diabetes"},{"key":"2026083119010655500_cit10","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1038\/s41588-019-0524-6","article-title":"The Impact of Proinflammatory\nCytokines on the \u0392-Cell Regulatory Landscape Provides Insights\ninto The Genetics of Type 1 Diabetes","volume":"51","author":"Ramos-Rodri\u0301guez","year":"2019","journal-title":"Nat. Genet."},{"key":"2026083119010655500_cit11","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ebiom.2018.09.040","article-title":"PDL1 Is Expressed in the Islets of People with Type\n1 Diabetes and Is Up-Regulated by Interferons-\u03b1 and-\u03b3\nvia IRF1 Induction","volume":"36","author":"Colli","year":"2018","journal-title":"EBioMedicine"},{"key":"2026083119010655500_cit12","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.1038\/s41467-022-31993-y","article-title":"Multi-step screening\nof DNA\/lipid nanoparticles and co-delivery with siRNA to enhance and\nprolong gene expression","volume":"13","author":"Zhu","year":"2022","journal-title":"Nat. Commun."},{"key":"2026083119010655500_cit13","doi-asserted-by":"publisher","first-page":"122559","DOI":"10.1016\/j.biomaterials.2024.122559","article-title":"Optimization of lipid nanoparticles for gene editing\nof the liver via intraduodenal delivery","volume":"308","author":"Zhu","year":"2024","journal-title":"Biomaterials"},{"key":"2026083119010655500_cit14","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles\nfor mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"2026083119010655500_cit15","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/s41565-019-0591-y","article-title":"The Onpattro story\nand the clinical translation of nanomedicines containing nucleic acid-based\ndrugs","volume":"14","author":"Akinc","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"2026083119010655500_cit16","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade1444","article-title":"Ionizable\nlipid nanoparticles deliver mRNA to pancreatic \u03b2 cells via macrophage-mediated\ngene transfer","volume":"9","author":"Melamed","year":"2023","journal-title":"Sci. Adv."},{"key":"2026083119010655500_cit17","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s41565-020-0669-6","article-title":"Selective\norgan targeting (SORT) nanoparticles for tissue-specific mRNA delivery\nand CRISPR\u2013Cas gene editing","volume":"15","author":"Cheng","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"2026083119010655500_cit18","doi-asserted-by":"publisher","first-page":"2507657","DOI":"10.1002\/adma.202507657","article-title":"Reengineering\nEndogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery\nof mRNA to Pancreas","volume":"37","author":"Isaac","year":"2025","journal-title":"Adv. Mater."},{"key":"2026083119010655500_cit19","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/s41551-023-01131-0","article-title":"Screening\nfor lipid nanoparticles that modulate the immune activity of helper\nT cells towards enhanced antitumour activity","volume":"8","author":"Zhu","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"2026083119010655500_cit20","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1038\/s41565-025-01954-9","article-title":"A versatile antibody\ncapture system drives specific\nin vivo delivery of mRNA-loaded lipid nanoparticles","volume":"20","author":"Chen","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"2026083119010655500_cit21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jconrel.2024.05.036","article-title":"EGFR-targeted ionizable\nlipid nanoparticles enhance in vivo mRNA delivery to the placenta","volume":"371","author":"Geisler","year":"2024","journal-title":"J. Controlled Release"},{"key":"2026083119010655500_cit22","doi-asserted-by":"publisher","first-page":"2304378","DOI":"10.1002\/smll.202304378","article-title":"In Vivo mRNA CAR\nT Cell Engineering via Targeted Ionizable Lipid Nanoparticles with\nExtrahepatic Tropism","volume":"20","author":"Billingsley","year":"2024","journal-title":"Small"},{"key":"2026083119010655500_cit23","doi-asserted-by":"publisher","first-page":"102634","DOI":"10.1016\/j.xcrm.2026.102634","article-title":"Messenger\nRNA Delivery to Islet \u03b2 Cells Using Conjugated Lipid Nanoparticles","volume":"7","author":"Enriquez","year":"2026","journal-title":"Cell Rep. Med."},{"key":"2026083119010655500_cit24","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2337\/db22-0477","article-title":"Cell-Surface\nAutoantibody Targets Zinc Transporter-8 (ZnT8) for In\nVivo \u03b2-Cell Imaging and Islet-Specific Therapies","volume":"72","author":"Guo","year":"2023","journal-title":"Diabetes"},{"key":"2026083119010655500_cit25","doi-asserted-by":"publisher","first-page":"4639","DOI":"10.1038\/ncomms5639","article-title":"Reversible changes in pancreatic\nislet structure and function produced by elevated blood glucose","volume":"5","author":"Brereton","year":"2014","journal-title":"Nat. Commun."},{"key":"2026083119010655500_cit26","doi-asserted-by":"publisher","first-page":"806","DOI":"10.2337\/db23-0568","article-title":"Cell-Surface\nZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice","volume":"73","author":"Kasinathan","year":"2024","journal-title":"Diabetes"},{"key":"2026083119010655500_cit27","doi-asserted-by":"publisher","first-page":"15130","DOI":"10.1038\/s41598-017-15417-2","article-title":"A nanobody-based tracer targeting\nDPP6 for non-invasive\nimaging of human pancreatic endocrine cells","volume":"7","author":"Balhuizen","year":"2017","journal-title":"Sci. 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