{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:52:23Z","timestamp":1785851543919,"version":"3.56.0"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22276209"],"award-info":[{"award-number":["22276209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22476033"],"award-info":[{"award-number":["22476033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22576212"],"award-info":[{"award-number":["22576212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Label-free quantitative detection of chemically diverse molecules is of critical importance across fields spanning medical diagnostics, food safety, and law enforcement. Surface-enhanced Raman spectroscopy (SERS) provides powerful molecular identification through fingerprint spectra, capable of achieving single-molecule detection limits when analytes are positioned directly at the plasmonic hotspots of Au\/Ag substrates. Yet conventional contact-mode SERS, which relies on the direct adsorption of analytes onto bare metal surfaces, is limited by poor reproducibility and signal heterogeneity arising from random molecular orientations and competitive binding. Here, we present a proof-of-concept noncontact mode SERS platform that routinely delivers reproducible, predictable, and quantitative spectra readout, including discrimination of subtle enantiomeric differences. This platform utilizes fluorenylmethoxycarbonyl-lysine (Fmoc-Lys) scaffolds confined within 1\u20132 nm channels of nanoporous gold nanospheres. The Fmoc core captures target analytes through hydrophobic interactions, while the chiral center regulates the adsorption configuration\/strength. This design fixes analyte distance and orientation relative to the metal surface, thereby minimizing stochastic spectral variation. We applied this platform to quantitatively analyzed methamphetamine (METH), a globally prevalent abused drug, in complex human urine samples and achieved accuracy comparable to mass spectrometry without requiring analyte-specific reference spectra. Our results highlight noncontact SERS as a general strategy for reliable, ultrasensitive molecular analysis, especially for targets lacking standard spectral libraries.<\/jats:p>","DOI":"10.1021\/acsnano.6c07883","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:19:32Z","timestamp":1784812772000},"page":"21363-21375","source":"Crossref","is-referenced-by-count":0,"title":["Noncontact Mode\nSurface-Enhanced Raman Spectroscopy\nAnalysis Empowered by Molecular-Scaffold-Gifting Au Nanochannel"],"prefix":"10.1021","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2052-0363","authenticated-orcid":true,"given":"Bingyong","family":"Lin","sequence":"first","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]},{"name":"Jiaxing University , , ,","place":["Jiaxing, China, 314001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefang","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]},{"name":"Beijing Center for Disease Prevention and Control , , ,","place":["Beijing, China, 100013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"China University of Political Science and Law , , ,","place":["Beijing, China, 100088"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control , , ,","place":["Beijing, China, 100013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control , , ,","place":["Beijing, China, 100013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6285-9425","authenticated-orcid":true,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Prevention and Control , , ,","place":["Beijing, China, 100013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7134-7026","authenticated-orcid":true,"given":"Jingfu","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-3917","authenticated-orcid":true,"given":"Guibin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-6193","authenticated-orcid":true,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , , ,","place":["Beijing, China, 100085"]},{"name":"University of Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"Hangzhou Institute of Advanced Study, UCAS , , ,","place":["Hangzhou, China, 310024"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"issue":"5303","key":"2026080409272082300_cit1","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1126\/science.275.5303.1102","article-title":"Probing single molecules and single nanoparticles by\nsurface-enhanced Raman scattering","volume":"275","author":"Nie","year":"1997","journal-title":"Science"},{"issue":"19","key":"2026080409272082300_cit2","doi-asserted-by":"publisher","first-page":"4756","DOI":"10.1002\/anie.201205748","article-title":"Surface-Enhanced\nRaman Spectroscopy: Concepts and Chemical Applications","volume":"53","author":"Schlu\u0308cker","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"2026080409272082300_cit3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s43586-021-00083-6","article-title":"Surface-enhanced\nRaman spectroscopy","volume":"1","author":"Han","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"issue":"6","key":"2026080409272082300_cit4","doi-asserted-by":"publisher","first-page":"16021","DOI":"10.1038\/natrevmats.2016.21","article-title":"Nanostructure-based\nplasmon-enhanced Raman spectroscopy\nfor surface analysis of materials","volume":"1","author":"Ding","year":"2016","journal-title":"Nat. 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Soc."},{"issue":"14","key":"2026080409272082300_cit14","doi-asserted-by":"publisher","first-page":"5454","DOI":"10.1002\/anie.201908154","article-title":"Towards Reliable\nand Quantitative Surface-Enhanced Raman Scattering (SERS): From Key\nParameters to Good Analytical Practice","volume":"59","author":"Bell","year":"2020","journal-title":"Angew.\nChem., Int. 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Rev."},{"key":"2026080409272082300_cit25","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/s41467-018-02930-9","article-title":"A general\nsoft-enveloping strategy in the templating synthesis of mesoporous\nmetal nanostructures","volume":"9","author":"Fang","year":"2018","journal-title":"Nat. Commun."},{"issue":"26","key":"2026080409272082300_cit26","doi-asserted-by":"publisher","first-page":"6423","DOI":"10.1039\/C9SC01728C","article-title":"Mesoporous gold nanospheres thiolate-Au(I)\nintermediates","volume":"10","author":"Lv","year":"2019","journal-title":"Chem. Sci."},{"key":"2026080409272082300_cit27","doi-asserted-by":"publisher","first-page":"13285","DOI":"10.1021\/jacs.2c04514","article-title":"All-Hot-Spot\nBulk Surface-Enhanced Raman Scattering (SERS) Substrates:\nAttomolar Detection of Adsorbates with Designer Plasmonic Nanoparticles","volume":"144","author":"Zhao","year":"2022","journal-title":"J. Am. Chem. 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Sci."},{"issue":"4","key":"2026080409272082300_cit40","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/jat\/30.4.232","article-title":"High-performance\nliquid chromatographic-mass spectrometric determination of methamphetamine\nand amphetamine enantiomers, desmethylselegiline and selegiline, in\nhair samples of long-term methamphetamine abusers or selegiline users","volume":"30","author":"Nishida","year":"2006","journal-title":"J. Anal. Toxicol."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c07883","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/30\/21363\/66233552\/acsnano.6c07883.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/30\/21363\/66233552\/acsnano.6c07883.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:27:31Z","timestamp":1785850051000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/30\/21363\/5231007\/Noncontact-Mode-Surface-Enhanced-Raman"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":40,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,23]]},"published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c07883","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]}}}