{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:24:51Z","timestamp":1787073891033,"version":"build-2736575974"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Construction Project for the Graded Diagnosis and Treatment of Complex Gynecological Tumors and a Training Base for Precision Radiotherapy","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Construction Project of the Clinical Medical Research Center in Jilin Province","award":["no"],"award-info":[{"award-number":["no"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["52371254"],"award-info":[{"award-number":["52371254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"crossref","award":["82404194"],"award-info":[{"award-number":["82404194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Radiotherapy plays a pivotal role in the management of nonsmall-cell lung cancer (NSCLC), particularly for patients who are not candidates for surgical intervention. Despite its significance, the issue of radioresistance remains a substantial challenge in the treatment of the NSCLC. Therefore, it is crucial to uncover new targets to enhance radiotherapy and investigate the mechanisms underlying radioresistance. Cuproptosis, as an emerging form of cell death dependent on intracellular copper (Cu) ions, remains unclear in its role in radioresistant NSCLCs. This study investigates the development of radioresistant NSCLC models, focusing on the role of the FOS-like antigen 1 (FOSL1) as a significant factor in mediating radioresistance. The FOSL1 gene is downregulated in radioresistant cells. Overexpression of FOSL1 induces mitochondrial damage and dysfunction, causing cuproptosis in radioresistant cells. To tackle the challenge of radioresistance in NSCLC, we propose an innovative nanostrategy focused on cuproptosis, aiming to enhance the efficacy of radiotherapy specifically in radioresistant NSCLC. This intervention could significantly enhance an increase in intracellular Cu2+ concentration and glutathione depletion while also increasing irradiation (IR)-induced oxidative stress and mitochondrial damage. The resulting mitochondrial dysfunction leads to tricarboxylic acid cycle disruption and Fe\u2013S cluster protein destabilization. These cumulative effects ultimately induced cuproptosis and enhanced the response of radioresistant NSCLC cells to IR. Our findings highlight the potential of combining cuproptosis targeting with nanotechnology to enhance the efficacy of radiotherapy, presenting a promising strategy to address radioresistance in clinical contexts.<\/jats:p>","DOI":"10.1021\/acsnano.6c08145","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:35:26Z","timestamp":1785854126000},"page":"22804-22822","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Activator\nProtein-1 Transcription\nFactor Subunit FOSL1-Mediated Cuproptosis Sensitizes Radioresistant\nNon-Small Cell Lung Cancer"],"prefix":"10.1021","volume":"20","author":[{"given":"Xiqian","family":"Zhuo","sequence":"first","affiliation":[{"name":"The Second Hospital of Jilin University , , ,","place":["Changchun, China, 130062"]},{"name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , , ,","place":["Changchun, China, 130022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qiu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyida","family":"Aishajiang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University , , ,","place":["Changchun, China, 130062"]},{"name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , , ,","place":["Changchun, China, 130022"]},{"name":"The Affiliated Cancer Hospital of Xinjiang Medical University , , ,","place":["Xinjiang, China, 830011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-5199","authenticated-orcid":true,"given":"Pengpeng","family":"Lei","sequence":"additional","affiliation":[{"name":"Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , , ,","place":["Changchun, China, 130022"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University , , ,","place":["Changchun, China, 130062"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0869-1940","authenticated-orcid":true,"given":"Duo","family":"Yu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Jilin University , , ,","place":["Changchun, China, 130062"]},{"name":"China-Japan Union Hospital of Jilin University , , ,","place":["Changchun, China, 130033"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026081810290145000_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN\nestimates of incidence and mortality worldwide for 36 cancers in 185\ncountries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. Clin."},{"key":"2026081810290145000_cit2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/resp.13870","article-title":"Radiotherapy treatment for lung cancer: Current status and future\ndirections","volume":"25","author":"Vinod","year":"2020","journal-title":"Respirology"},{"key":"2026081810290145000_cit3","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41419-024-07017-6","article-title":"Radiation-induced YAP\/TEAD4 binding confers non-small cell lung cancer\nradioresistance via promoting NRP1 transcription","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"key":"2026081810290145000_cit4","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/s12276-021-00640-9","article-title":"Tumor microenvironment\nand radioresistance","volume":"53","author":"Suwa","year":"2021","journal-title":"Exp. Mol. 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