{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:05:41Z","timestamp":1789506341454,"version":"build-2803163510"},"reference-count":83,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["952183"],"award-info":[{"award-number":["952183"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["CN00000041"],"award-info":[{"award-number":["CN00000041"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["CUP B13C22001010001"],"award-info":[{"award-number":["CUP B13C22001010001"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","award":["P2022RBF5P - CUP B53D23025810001"],"award-info":[{"award-number":["P2022RBF5P - CUP B53D23025810001"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell?Istruzione, dell?Universit? e della Ricerca","doi-asserted-by":"publisher","award":["B96C1700020008"],"award-info":[{"award-number":["B96C1700020008"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell?Istruzione, dell?Universit? e della Ricerca","doi-asserted-by":"publisher","award":["CUP B53C26001260001 (FIS-2024-00672)"],"award-info":[{"award-number":["CUP B53C26001260001 (FIS-2024-00672)"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipid nanoparticles (LNPs) are central to nanomedicine, yet their clinical translation is limited by the difficulty of predicting structure-bioactivity relationships. Although the biomolecular corona is known to define the nanoparticle biological identity by modifying surface properties, its effect on internal nanoparticle organization remains largely unexplored. Since the internal lipid organization of LNPs governs key properties, including stability, cargo protection, internalization and intracellular trafficking, understanding this coupling is critical to correlate synthetic design to therapeutic outcome. Here, combining structural and mechanistic evidence, we show that plasma lipoproteins engage in molecular-scale lipid exchange with the LCNP membrane, rather than persisting as an adsorbed layer of intact particles, actively remodeling the internal nanoparticle structure. Using model lipid liquid-crystalline nanoparticles with well-defined cubic and inverse hexagonal phases, we systematically investigate how lipoproteins modulate LNP structure. Combining fluorescence nanoparticle tracking, synchrotron small-angle X-ray scattering, cryo-electron microscopy, and neutron reflectometry with isotopic contrast matching, we provide evidence of lipoprotein-driven lipid transfer and phase reorganization at the nanoscale. We observe a phase-selective response: inverse hexagonal LNPs remain structurally stable despite lipid exchange, whereas cubic LNPs undergo pronounced remodeling, including significant change in size and lattice ordering. These transformations correlate with distinct cellular uptake profiles. Our findings suggest that in soft lipid nanoparticles, the biological identity commonly described as a biomolecular corona is not merely a surface event but an interface-mediated process that reshapes the nanoparticle internal structure, with direct implications for next-generation nanomedicine design.<\/jats:p>","DOI":"10.1021\/acsnano.6c09400","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:26:41Z","timestamp":1788452801000},"page":"24915-24933","source":"Crossref","is-referenced-by-count":0,"title":["Lipoprotein Corona\nReshapes the Internal Structure\nof Lipid Nanoparticles"],"prefix":"10.1021","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-8816","authenticated-orcid":true,"given":"Lucrezia","family":"Caselli","sequence":"first","affiliation":[{"name":"University of Florence , , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]},{"name":"CSGI, Center for Colloid and Surface Science , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rojas-Rodri\u0301guez","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy , Via Nello Carrara 1 , ,","place":["Sesto Fiorentino, Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9931-6256","authenticated-orcid":true,"given":"Valentina","family":"Pacciani","sequence":"additional","affiliation":[{"name":"University of Florence , , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]},{"name":"CSGI, Center for Colloid and Surface Science , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-7235","authenticated-orcid":true,"given":"Martino","family":"Calamai","sequence":"additional","affiliation":[{"name":"European Laboratory for Non-Linear Spectroscopy , Via Nello Carrara 1 , ,","place":["Sesto Fiorentino, Italy, 50019"]},{"name":"National Institute of Optics\u2500National Research Council , Via Nello Carrara 1-I , , ,","place":["Sesto-Fiorentino, Firenze, Italia, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Frigerio","sequence":"additional","affiliation":[{"name":"Institute for Chemical and Bioengineering , , ,","place":["Zu\u0308rich, Switzerland, 8093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Zendrini","sequence":"additional","affiliation":[{"name":"Institute for Chemical and Bioengineering , , ,","place":["Zu\u0308rich, Switzerland, 8093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Sanita\u0300","sequence":"additional","affiliation":[{"name":"National Research Council , , Via Pietro Castellino 111 , ,","place":["Napoli, Italy, 80131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-247X","authenticated-orcid":true,"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"National Research Council , , Via Pietro Castellino 111 , ,","place":["Napoli, Italy, 80131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8196-9774","authenticated-orcid":true,"given":"Anna","family":"Leung","sequence":"additional","affiliation":[{"name":"European Spallation Source ERIC , P.O. Box 176, ,","place":["Lund, Sweden, SE 22100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Wacklin-Knecht","sequence":"additional","affiliation":[{"name":"European Spallation Source ERIC , P.O. Box 176, ,","place":["Lund, Sweden, SE 22100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Humphreys","sequence":"additional","affiliation":[{"name":"Institut Laue-Langevin , 71 Avenue des Martyrs, CS20156 , ,","place":["Grenoble, France, 38042"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Arosio","sequence":"additional","affiliation":[{"name":"Institute for Chemical and Bioengineering , , ,","place":["Zu\u0308rich, Switzerland, 8093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Cardellini","sequence":"additional","affiliation":[{"name":"University of Florence , , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]},{"name":"CSGI, Center for Colloid and Surface Science , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-560X","authenticated-orcid":true,"given":"Debora","family":"Berti","sequence":"additional","affiliation":[{"name":"University of Florence , , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]},{"name":"CSGI, Center for Colloid and Surface Science , , ,","place":["Sesto Fiorentino, Florence, Italy, 50019"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"12","key":"2026091516133944800_cit1","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid Nanoparticles\nfor mRNA Delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"2026091516133944800_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103553","article-title":"Lipid Nanoparticles in the Development of mRNA Vaccines\nfor COVID-19","volume":"74","author":"Wilson","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"2","key":"2026091516133944800_cit3","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202100109","article-title":"Lipid Nanoparticles\nfor Drug Delivery","volume":"2","author":"Xu","year":"2022","journal-title":"Adv. NanoBiomed Res."},{"issue":"8","key":"2026091516133944800_cit4","doi-asserted-by":"publisher","first-page":"4691","DOI":"10.1021\/jacs.2c12893","article-title":"Ionizable\nLipid Nanoparticles for In Vivo mRNA Delivery to\nthe Placenta during Pregnancy","volume":"145","author":"Swingle","year":"2023","journal-title":"J. Am. Chem.\nSoc."},{"issue":"35","key":"2026091516133944800_cit5","doi-asserted-by":"publisher","first-page":"31530","DOI":"10.1021\/jacs.5c05367","article-title":"Breaking Endosomal\nBarriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient\nmRNA Vaccine Delivery","volume":"147","author":"Lian","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"2026091516133944800_cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115065","article-title":"In Vitro and in Vivo Evaluation of\nClinically-Approved Ionizable Cationic Lipids Shows Divergent Results\nbetween mRNA Transfection and Vaccine Efficacy","volume":"165","author":"Escalona-Rayo","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"2026091516133944800_cit7","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1021\/acs.nanolett.8b00432","article-title":"A Direct Comparison\nof in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds\nof Nanoparticles Reveals a Weak Correlation","volume":"18","author":"Paunovska","year":"2018","journal-title":"Nano Lett."},{"issue":"36","key":"2026091516133944800_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202301838","article-title":"An Overview\nof Nanoparticle\nProtein Corona Literature","volume":"19","author":"Hajipour","year":"2023","journal-title":"Small"},{"key":"2026091516133944800_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114356","article-title":"The Effects of Protein\nCorona on in Vivo Fate of Nanocarriers","volume":"186","author":"Xiao","year":"2022","journal-title":"Adv.\nDrug Delivery Rev."},{"issue":"24","key":"2026091516133944800_cit10","doi-asserted-by":"publisher","first-page":"10025","DOI":"10.1021\/acs.nanolett.2c03741","article-title":"The Extent\nto Which Lipid Nanoparticles\nRequire Apolipoprotein E and Low-Density Lipoprotein Receptor for\nDelivery Changes with Ionizable Lipid Structure","volume":"22","author":"Paunovska","year":"2022","journal-title":"Nano Lett."},{"issue":"8","key":"2026091516133944800_cit11","doi-asserted-by":"publisher","first-page":"8147","DOI":"10.1021\/jacs.5c16025","article-title":"Structural\nChange of ApoE\u2013Lipid Nanoparticles Alters Receptor-Mediated\nEndocytosis and Induces Endosomal Disruption","volume":"148","author":"Mo","year":"2026","journal-title":"J. Am. Chem. Soc."},{"key":"2026091516133944800_cit12","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202517893","article-title":"Potent Liver-Tropic\nmRNA Lipid Nanoparticles: ApoE-Mediated\nDelivery Through a Low-Density Lipoprotein Receptor Independent Uptake\nMechanism","volume":"38","author":"Sarode","year":"2026","journal-title":"Adv. Mater."},{"issue":"40","key":"2026091516133944800_cit13","doi-asserted-by":"publisher","first-page":"35675","DOI":"10.1021\/acsnano.5c11552","article-title":"Flower-Shaped\nLipid Nanoparticles Evade Apolipoprotein E-Mediated Liver Tropism\nfor Safe and Enhanced Cytokine-Based Cancer Immunotherapy","volume":"19","author":"Qi","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"2026091516133944800_cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63726-2","article-title":"Protein Corona Formed on Lipid Nanoparticles\nCompromises Delivery Efficiency of mRNA Cargo","volume":"16","author":"Voke","year":"2025","journal-title":"Nat. Commun."},{"issue":"2","key":"2026091516133944800_cit15","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1021\/acsnano.2c10790","article-title":"Interactions of Apolipoproteins\nwith\nLipid-Based Nanoparticles","volume":"17","author":"Dalhaimer","year":"2023","journal-title":"ACS Nano"},{"issue":"11","key":"2026091516133944800_cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307803120","article-title":"A Magnetic Separation Method for\nIsolating and Characterizing the Biomolecular Corona of Lipid Nanoparticles","volume":"121","author":"Francia","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"14","key":"2026091516133944800_cit17","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416525","article-title":"Lung-Specific mRNA\nDelivery by Ionizable Lipids with Defined Structure-Function\nRelationship and Unique Protein Corona Feature","volume":"12","author":"He","year":"2025","journal-title":"Adv. Sci."},{"issue":"12","key":"2026091516133944800_cit18","doi-asserted-by":"publisher","first-page":"20163","DOI":"10.1021\/acsnano.2c04829","article-title":"Interaction Kinetics of Individual mRNA-Containing\nLipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on\npH, Protein Corona Formation, and Lipoprotein Depletion","volume":"16","author":"Aliakbarinodehi","year":"2022","journal-title":"ACS Nano"},{"issue":"9","key":"2026091516133944800_cit19","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/s41565-023-01455-7","article-title":"Cholesterol Modulates\nthe Physiological Response to Nanoparticles\nby Changing the Composition of Protein Corona","volume":"18","author":"Tang","year":"2023","journal-title":"Nat. Nanotechnol."},{"issue":"11","key":"2026091516133944800_cit20","doi-asserted-by":"publisher","first-page":"8971","DOI":"10.1021\/acsnano.5c21857","article-title":"Mechanistic and Strategic Insights\ninto How Lipid Nanoparticles Interact with Membrane-Based Biological\nBarriers","volume":"20","author":"Zhao","year":"2026","journal-title":"ACS Nano"},{"issue":"4","key":"2026091516133944800_cit21","doi-asserted-by":"publisher","first-page":"6709","DOI":"10.1021\/acsnano.0c10064","article-title":"Apolipoprotein\nE Binding Drives Structural and Compositional\nRearrangement of mRNA-Containing Lipid Nanoparticles","volume":"15","author":"Sebastiani","year":"2021","journal-title":"ACS Nano"},{"key":"2026091516133944800_cit22","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jconrel.2022.07.014","article-title":"Tailoring the Multi-Functional\nProperties of Phospholipids for Simple to Complex Self-Assemblies","volume":"349","author":"Waghule","year":"2022","journal-title":"J. Controlled Release"},{"issue":"7","key":"2026091516133944800_cit23","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41578-023-00552-2","article-title":"The Protein\nCorona\nfrom Nanomedicine to Environmental Science","volume":"8","author":"Mahmoudi","year":"2023","journal-title":"Nat. Rev. Mater."},{"key":"2026091516133944800_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jciso.2023.100088","article-title":"On the Interaction and Nanoplasmonics\nof Gold Nanoparticles\nand Lipoproteins","volume":"11","author":"Zendrini","year":"2023","journal-title":"JCIS Open"},{"issue":"19","key":"2026091516133944800_cit25","doi-asserted-by":"publisher","first-page":"18942","DOI":"10.1021\/acsnano.3c04293","article-title":"Membrane Tension\nInhibits Lipid Mixing by Increasing the Hemifusion Stalk Energy","volume":"17","author":"Shendrik","year":"2023","journal-title":"ACS Nano"},{"key":"2026091516133944800_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2026.139966","article-title":"Multiphasic Lipid Nanoparticles:\nStructural Heterogeneity Drives Endosomal Bypass for Enhanced RNA\nDelivery","volume":"709","author":"Conti","year":"2026","journal-title":"J. Colloid Interface Sci."},{"issue":"12","key":"2026091516133944800_cit27","doi-asserted-by":"publisher","first-page":"10430","DOI":"10.1021\/jacs.4c18308","article-title":"Lipid-siRNA Organization\nModulates the Intracellular Dynamics of Lipid Nanoparticles","volume":"147","author":"Mo","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026091516133944800_cit28","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/acs.accounts.1c00544","article-title":"Chemistry of Lipid\nNanoparticles for RNA Delivery","volume":"55","author":"Eygeris","year":"2022","journal-title":"Acc. Chem. Res."},{"issue":"31","key":"2026091516133944800_cit29","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303370","article-title":"Induction of Bleb Structures in Lipid Nanoparticle\nFormulations of mRNA Leads to Improved Transfection Potency","volume":"35","author":"Cheng","year":"2023","journal-title":"Adv. Mater."},{"key":"2026091516133944800_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120964","article-title":"Gene-Engineered\nExosomes-Thermosensitive Liposomes Hybrid Nanovesicles by the Blockade\nof CD47 Signal for Combined Photothermal Therapy and Cancer Immunotherapy","volume":"275","author":"Cheng","year":"2021","journal-title":"Biomaterials"},{"issue":"6","key":"2026091516133944800_cit31","doi-asserted-by":"publisher","first-page":"6178","DOI":"10.1021\/acsnano.8b07961","article-title":"Non-Lamellar Lyotropic\nLiquid Crystalline Lipid Nanoparticles for the Next Generation of\nNanomedicine","volume":"13","author":"Zhai","year":"2019","journal-title":"ACS Nano"},{"issue":"17","key":"2026091516133944800_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202413016","article-title":"Cubic Phase-Inducible\nZwitterionic Phospholipids Improve the Functional\nDelivery of mRNA","volume":"12","author":"Iwakawa","year":"2025","journal-title":"Adv. Sci."},{"key":"2026091516133944800_cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c22972","article-title":"Ethanol-Guided Hybridization of Extracellular Vesicles with Liquid-Crystalline\nLipid Nanoparticles","volume":"18","author":"Pacciani","year":"2026","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"2026091516133944800_cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45666-5","article-title":"Liquid Crystalline\nInverted Lipid Phases Encapsulating\nsiRNA Enhance Lipid Nanoparticle Mediated Transfection","volume":"15","author":"Pattipeiluhu","year":"2024","journal-title":"Nat. Commun."},{"key":"2026091516133944800_cit35","doi-asserted-by":"publisher","DOI":"10.3389\/frsfm.2023.1109508","article-title":"Non-Lamellar Lipid Liquid Crystalline\nNanoparticles:\nA Smart Platform for Nanomedicine Applications","volume":"3","author":"Fornasier","year":"2023","journal-title":"Front. Soft Matter"},{"key":"2026091516133944800_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2024.103156","article-title":"Small-Angle X-Ray and\nNeutron Scattering Applied to Lipid-Based Nanoparticles: Recent Advancements\nacross Different Length Scales","volume":"327","author":"Caselli","year":"2024","journal-title":"Adv. Colloid\nInterface Sci."},{"key":"2026091516133944800_cit37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/B978-044453219-0.50019-2","article-title":"Lipoprotein\nStructure","volume-title":"Biochemistry of Lipids, Lipoproteins\nand Membranes","author":"Jonas","year":"2008"},{"issue":"45","key":"2026091516133944800_cit38","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.1021\/acs.biochem.0c00748","article-title":"Lipoprotein Particles Interact with\nMembranes and Transfer Their Cargo without Receptors","volume":"59","author":"Plochberger","year":"2020","journal-title":"Biochemistry"},{"key":"2026091516133944800_cit39","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jcis.2025.02.131","article-title":"The Interaction\nof Human Serum Components with Model\nMembranes Containing Phospholipids and Lipopolysaccharides","volume":"688","author":"Paracini","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"2026091516133944800_cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43713-6","article-title":"Time-Resolved\nSmall-Angle Neutron\nScattering as a Probe for the Dynamics of Lipid Exchange between Human\nLipoproteins and Naturally Derived Membranes","volume":"9","author":"Maric","year":"2019","journal-title":"Sci. Rep."},{"key":"2026091516133944800_cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08729","article-title":"Inverse Cubic and Hexagonal Mesophase Evolution within Ionizable\nLipid Nanoparticles Correlates with mRNA Transfection in Macrophages","author":"Yu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"2026091516133944800_cit42","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.848687","article-title":"Interaction of Metallic Nanoparticles\nWith Biomimetic Lipid Liquid Crystalline Cubic Interfaces","volume":"10","author":"Cardellini","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"11","key":"2026091516133944800_cit43","doi-asserted-by":"publisher","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid Nanoparticles\u2500From\nLiposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity\nand Advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"issue":"6","key":"2026091516133944800_cit44","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","article-title":"Lipid-Based Nanoparticles\nfor Drug\/Gene Delivery: An Overview of\nthe Production Techniques and Difficulties Encountered in Their Industrial\nDevelopment","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater. Au"},{"issue":"38","key":"2026091516133944800_cit45","doi-asserted-by":"publisher","first-page":"33991","DOI":"10.1021\/acsnano.5c09800","article-title":"Manufacturing mRNA-Loaded Lipid Nanoparticles\nwith\nPrecise Size and Morphology Control","volume":"19","author":"Devos","year":"2025","journal-title":"ACS Nano"},{"issue":"8","key":"2026091516133944800_cit46","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/aps.2010.98","article-title":"Novel Vehicle\nBased on Cubosomes for Ophthalmic Delivery\nof Flurbiprofen with Low Irritancy and High Bioavailability","volume":"31","author":"Han","year":"2010","journal-title":"Acta Pharmacol. 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