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In the present work, we report the establishment of self-assembled strontium-caffeic acid nanoparticles (CA-Sr NPs) through metal-polyphenol coordination, which function as an integrated neuro-immune-bone modulator for inflammatory arthritis therapy. By coupling redox catalysis with TRPV1-associated Ca2+ antagonism and Sr2+-enabled osteoregulation, CA-Sr NPs exhibit combined effects of sustained reactive oxygen species scavenging and enhanced regulation of the Ca2+-permeable TRPV1 channel on macrophages and dorsal root ganglion (DRG) neurons, thus repolarizing macrophages from M1 to M2 phenotype and suppressing the pathological Ca2+ influx and neuronal hyperexcitability, respectively. Meanwhile, CA-Sr NPs promote osteoblast activity while inhibiting osteoclast differentiation. In the Complete Freund\u2019s Adjuvant-induced murine arthritis model, CA-Sr NPs markedly alleviated multiple inflammatory arthritis symptoms, including joint swelling, pain, and bone erosion. Collectively, this study highlights highly promising therapeutic potentials of CA-Sr NPs for inflammatory arthritis management and broadens the scope of metal-phenolic nanocatalysts toward treating neuro-immune-bone disorders.<\/jats:p>","DOI":"10.1021\/acsnano.6c09403","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:49:55Z","timestamp":1788263395000},"page":"24512-24530","source":"Crossref","is-referenced-by-count":0,"title":["Metal-Phenolic Nanocatalysts\nBlock Transient Receptor\nPotential Vanilloid 1 and Regulate Bone Homeostasis for Arthritic\nAnalgesia and Therapeutics"],"prefix":"10.1021","volume":"20","author":[{"given":"Penghao","family":"Ji","sequence":"first","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, P. R. China, 200331"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Li","sequence":"additional","affiliation":[{"name":"Tongji University , , ,","place":["Shanghai, P. R. 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