{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:17:56Z","timestamp":1788218276368,"version":"build-2803163510"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52273287"],"award-info":[{"award-number":["52273287"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52494931"],"award-info":[{"award-number":["52494931"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52494934"],"award-info":[{"award-number":["52494934"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52572300"],"award-info":[{"award-number":["52572300"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20339"],"award-info":[{"award-number":["U20A20339"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Radioimmunotherapy holds great promise for the treatment of solid tumors. However, radioresistance and immunosuppression mediated by a tumor microenvironment (TME) severely restrict radiation-induced immunogenic cell death (ICD), facilitate tumor relapse and metastatic dissemination, and ultimately compromise the therapeutic efficacy of radioimmunotherapy. Herein, we report a multifunctional cascade AuPt\/SnO2\u2013x@MOF@Arg nanoplatform to remodel TME and boost radioimmunotherapy synergistically. This system integrates X-ray-responsive peroxidase (POD), catalase(CAT), glucose oxidase (GOD), and glutathione oxidase (GSHOx) activities to achieve cascade-amplified reactive oxygen species (ROS) and controllable NO release. The structure, X-ray-induced cascade multienzyme functions, ICD activation by efficient ROS, and controllable release of high-concentration NO have been proved fully in the APSMA NPs. In vitro experiments demonstrate that a high apoptosis rate of 94.8% against 4T1 cells can be achieved by a synergistic cascade therapeutic system through inducing cell apoptosis via efficient production of ROS and arresting the cell cycle at the radiation-sensitive G2\/M phase. In an in situ breast cancer model, the combined therapy effectively reduces tumor volume, and the final tumor volume is 4% of that in the X-ray group. Studies on the mechanisms underlying the immunosuppressive microenvironment reveal that NO remodels the TME by downregulating transforming growth factor beta (TGF-\u03b2), thereby inhibiting epithelial-mesenchymal transition (EMT)-associated proteins to suppress tumor metastasis and abnormal angiogenesis. Furthermore, TGF-\u03b2 suppression enhances the infiltration of CD8+ T cells and reduces the proportion of FOXP3+ regulatory T cells, reversing immune suppression. This multifunctional nanozyme platform provides a robust strategy for efficient radioimmunotherapy.<\/jats:p>","DOI":"10.1021\/acsnano.6c09676","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:36:30Z","timestamp":1785854190000},"page":"23486-23506","source":"Crossref","is-referenced-by-count":0,"title":["X-ray-Responsive\nCascade System for Radioimmunotherapy:\nTumor Microenvironment Remodeling and Controllable NO Release"],"prefix":"10.1021","volume":"20","author":[{"given":"Yunsong","family":"Wang","sequence":"first","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]},{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]},{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-9669","authenticated-orcid":true,"given":"Shujuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]},{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2622-3849","authenticated-orcid":true,"given":"Shiping","family":"Yuan","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]},{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Harbin Medical University , , ,","place":["Harbin, China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Engineering University , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Gao","sequence":"additional","affiliation":[{"name":"University College London , , ,","place":["London, U.K., WC1E 6BT"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-9535","authenticated-orcid":true,"given":"Liangcan","family":"He","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]},{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6990-8728","authenticated-orcid":true,"given":"Shaoqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]},{"name":"Harbin Institute of Technology , , ,","place":["Harbin, P. R. China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"issue":"22","key":"2026083119012241000_cit1","doi-asserted-by":"publisher","first-page":"13566","DOI":"10.1021\/acs.chemrev.7b00258","article-title":"Nanotechnology for\nMultimodal Synergistic Cancer Therapy","volume":"117","author":"Fan","year":"2017","journal-title":"Chem.\nRev."},{"issue":"3","key":"2026083119012241000_cit2","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1021\/acs.chemrev.0c00779","article-title":"The Use of Alternative\nStrategies for Enhanced Nanoparticle Delivery to Solid Tumors","volume":"121","author":"Izci","year":"2021","journal-title":"Chem. 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Physiol."},{"issue":"43","key":"2026083119012241000_cit19","doi-asserted-by":"publisher","first-page":"29689","DOI":"10.1021\/acsnano.4c09021","article-title":"Cold Exposure Therapy\nSensitizes Nanodrug-Mediated Radioimmunotherapy of Breast Cancer","volume":"18","author":"Qiao","year":"2024","journal-title":"ACS Nano"},{"key":"2026083119012241000_cit20","doi-asserted-by":"publisher","first-page":"102447","DOI":"10.1016\/j.nantod.2024.102447","article-title":"Bioinspired\nHf-based Metal-Organic Framework Radiosensitizer for Nitric Oxide-Assisted\nRadio-Immunotherapy","volume":"58","author":"Li","year":"2024","journal-title":"Nano Today"},{"issue":"1","key":"2026083119012241000_cit21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s40820-020-00431-3","article-title":"Near-Infrared Light-Responsive Nitric Oxide Delivery\nPlatform for Enhanced Radioimmunotherapy","volume":"12","author":"Zhou","year":"2020","journal-title":"Nanomicro.\nLett."},{"issue":"12","key":"2026083119012241000_cit22","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1007\/s13361-019-02337-w","article-title":"Electron Ionization of Imidazole and Its Derivative\n2-Nitroimidazole","volume":"30","author":"Meissner","year":"2019","journal-title":"J. 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Chem."},{"issue":"9","key":"2026083119012241000_cit34","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.3390\/plants12091760","article-title":"Pluronic-F-127-Passivated SnO2 Nanoparticles\nDerived by Using Polygonum cuspidatum Root Extract: Synthesis, Characterization\nand Anticancer Properties","volume":"12","author":"Alzahrani","year":"2023","journal-title":"Plants"},{"issue":"1","key":"2026083119012241000_cit35","doi-asserted-by":"publisher","first-page":"107","DOI":"10.7150\/thno.50486","article-title":"Facile Engineering of Silk Fibroin\nCapped AuPt Bimetallic Nanozyme Responsive to Tumor Microenvironmental\nFactors for Enhanced Nanocatalytic Therapy","volume":"11","author":"Yang","year":"2021","journal-title":"Theranostics"},{"issue":"39","key":"2026083119012241000_cit36","doi-asserted-by":"publisher","first-page":"16113","DOI":"10.1021\/jacs.1c06652","article-title":"Plasmonic AuPt@CuS Heterostructure\nwith Enhanced Synergistic Efficacy\nfor Radiophotothermal Therapy","volume":"143","author":"Cai","year":"2021","journal-title":"J. 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Eng. J."},{"key":"2026083119012241000_cit42","doi-asserted-by":"publisher","first-page":"134194","DOI":"10.1016\/j.matlet.2023.134194","article-title":"Fabrication\nand Enhanced Visible Photocatalytic Activity of AuPt@g-C3N4 Foam","volume":"341","author":"Lin","year":"2023","journal-title":"Mater. Lett."},{"key":"2026083119012241000_cit43","doi-asserted-by":"publisher","first-page":"7687","DOI":"10.2147\/IJN.S267321","article-title":"Multifunctional Hf\/Mn-TCPP Metal-Organic\nFramework\nNanoparticles for Triple-Modality Imaging-Guided PTT\/RT Synergistic\nCancer Therapy","volume":"15","author":"Bao","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"2026083119012241000_cit44","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1038\/cdd.2017.107","article-title":"Synergy\nBetween\nPrkdc and Trp53 Regulates Stem Cell Proliferation and GI-ARS After\nIrradiation","volume":"24","author":"Gurley","year":"2017","journal-title":"Cell Death Differ."},{"issue":"1","key":"2026083119012241000_cit45","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13046-025-03394-8","article-title":"Reprogramming the Breast Tumor Immune Microenvironment: Cold-to-Hot\nTransition for Enhanced Immunotherapy","volume":"44","author":"Imani","year":"2025","journal-title":"J. Exp.\nClin. Cancer Res."},{"issue":"10","key":"2026083119012241000_cit46","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.ccell.2021.08.008","article-title":"Simultaneous Targeting\nof TGF-beta\/PD-L1 Synergizes with Radiotherapy by Reprogramming the\nTumor Microenvironment to Overcome Immune Evasion","volume":"39","author":"Lan","year":"2021","journal-title":"Cancer Cell"},{"issue":"9","key":"2026083119012241000_cit47","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/ncb3595","article-title":"A Regulated\nPNUTS mRNA to lncRNA Splice Switch Mediates EMT and Tumour Progression","volume":"19","author":"Grelet","year":"2017","journal-title":"Nat. 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