{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:10Z","timestamp":1792784710288,"version":"4.5.0"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100015397","name":"Department of Science and Technology of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["XM2024XTGXQ13"],"award-info":[{"award-number":["XM2024XTGXQ13"]}],"id":[{"id":"10.13039\/501100015397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["22425503"],"award-info":[{"award-number":["22425503"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B18030"],"award-info":[{"award-number":["B18030"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Tianjin City","award":["25JCZDJC01120"],"award-info":[{"award-number":["25JCZDJC01120"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["22371131"],"award-info":[{"award-number":["22371131"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is a chronic inflammatory disease driven by dynamic microenvironmental imbalances, progressing through successive stages of bacterial infection, immune dysregulation, and tissue destruction. This complex microenvironment exhibits high spatiotemporal heterogeneity, rendering conventional therapies insufficient for stage-specific requirements. This work synthesizes nine-coordinated cerium atomic clusters alongside single atoms anchored on a nitrogen-doped carbon substrate (Ce ACSA@NC). Compared to conventional four-coordinated cerium single-atom structure (Ce SA@NC), Ce ACSA@NC possesses enhanced multi-enzyme mimetic activities, enabling spatiotemporally programed catalytic selectivity aligned with distinct pathological phases. Ce ACSA@NC performs multimodal cascade therapy: rapid antibacterial activity, sustained antioxidant activity, immune regulation, inhibition of bone resorption, and promotion of bone regeneration. Integrated with Pluronic F-127, an injectable thermosensitive hydrogel (Ce ACSA@NC\/PF127) ensures precision and durability via staged intervention. This system rapidly eliminates bacteria and scavenges reactive oxygen species (ROS), disrupts the ROS-inflammatory feedback loop, reprograms macrophage polarization, suppresses pro-inflammatory cytokines while enhancing anti-inflammatory secretion, and coordinately modulates the NF-\u03baB pathway and Nrf2 pathways. Through its intrinsic osteogenic properties, Ce ACSA@NC shields bone cells from inflammation, concurrently inhibiting resorption and fostering regeneration. Consequently, the Ce ACSA@NC\/PF127 nanoplatform synergistically integrates antibacterial, antioxidant, anti-inflammatory, and osteogenic functions, offering a spatiotemporally adaptive strategy for precision periodontitis therapy with significant clinical potential.<\/jats:p>","DOI":"10.1021\/acsnano.6c09745","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:01:32Z","timestamp":1789412492000},"page":"26112-26133","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporally\nProgrammable Adaptive Nanozyme Hydrogels\nwith Ce Single-Atom\/Cluster Heterostructures for Durable Multimodal\nPeriodontitis Therapy"],"prefix":"10.1021","volume":"20","author":[{"given":"Mengdie","family":"Jin","sequence":"first","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Dong","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , , ,","place":["Tianjin, P. R. China, 300070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Peng","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Huang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Liang","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Fu","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-6633","authenticated-orcid":true,"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Tianjin University , , ,","place":["Tianjin, P. R. China, 300211"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-8307","authenticated-orcid":true,"given":"Jin-Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tianjin Nankai Hospital , , ,","place":["Tianjin, P. R. China, 300100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration , , ,","place":["Tianjin, P. R. China, 300070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Zhai","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-2087","authenticated-orcid":true,"given":"Yaping","family":"Du","sequence":"additional","affiliation":[{"name":"Nankai University , , ,","place":["Tianjin, P. R. China, 300350"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"2026092909132106700_cit1","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.1016\/j.cell.2021.05.013","article-title":"Human oral mucosa cell atlas reveals a stromal-neutrophil\naxis regulating tissue immunity","volume":"184","author":"Williams","year":"2021","journal-title":"Cell"},{"key":"2026092909132106700_cit2","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic\nmechanisms linking periodontal disease\nand inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"2026092909132106700_cit3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/prd.12200","article-title":"Periodontitis epidemiology:\nis periodontitis under-recognized, over-diagnosed,\nor both?","volume":"75","author":"Papapanou","year":"2017","journal-title":"Periodontol"},{"key":"2026092909132106700_cit4","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12326","article-title":"The association of periodontal diseases\nwith metabolic syndrome and obesity","volume":"83","author":"Jepsen","year":"2020","journal-title":"Periodontol"},{"key":"2026092909132106700_cit5","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1161\/CIRCULATIONAHA.115.020869","article-title":"Increasing evidence for an association between periodontitis and\ncardiovascular disease","volume":"133","author":"Stewart","year":"2016","journal-title":"Circulation"},{"key":"2026092909132106700_cit6","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1177\/0022034515602879","article-title":"Global economic impact\nof dental diseases","volume":"94","author":"Listl","year":"2015","journal-title":"J. Dent. Res."},{"key":"2026092909132106700_cit7","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1111\/jgs.15828","article-title":"Association of chronic\nperiodontitis on Alzheimer\u2019s\ndisease or vascular dementia","volume":"67","author":"Choi","year":"2019","journal-title":"J. Am. Geriatr.\nSoc."},{"key":"2026092909132106700_cit8","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1016\/j.apsb.2022.10.026","article-title":"Functional\nbiomaterials for comprehensive\nperiodontitis therapy","volume":"13","author":"Luan","year":"2023","journal-title":"Acta Pharm. Sin. 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Eng."},{"key":"2026092909132106700_cit14","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1039\/D1NR06043K","article-title":"Cerium oxide nanozyme\nattenuates periodontal bone destruction by inhibiting the ROS-NF\u03baB\npathway","volume":"14","author":"Yu","year":"2022","journal-title":"Nanoscale"},{"key":"2026092909132106700_cit15","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1021\/acsbiomaterials.3c00508","article-title":"Nanoparticles\nof cerium-doped zeolitic imidazolate framework-8 promote soft tissue\nintegration by reprogramming the metabolic pathways of macrophages","volume":"9","author":"Yan","year":"2023","journal-title":"ACS Biomater. Sci. 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Mater."},{"key":"2026092909132106700_cit46","doi-asserted-by":"publisher","first-page":"107565","DOI":"10.1016\/j.nanoen.2022.107565","article-title":"A highly efficient\naxial coordinated CoN5 electrocatalyst via pyrolysis-free\nstrategy for alkaline polymer electrolyte fuel cells","volume":"101","author":"Yang","year":"2022","journal-title":"Nano Energy"},{"key":"2026092909132106700_cit47","doi-asserted-by":"publisher","first-page":"26701","DOI":"10.1021\/acsnano.5c06244","article-title":"Thermal-driven\ncoordination microenvironment reconstruction in single-atom catalysts\nunlocks ultrafast water remediation","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"2026092909132106700_cit48","doi-asserted-by":"publisher","first-page":"106868","DOI":"10.1016\/j.nanoen.2021.106868","article-title":"Materials informatics-guided superior electrocatalyst: A case of\npyrolysis-free single-atom coordinated with N-graphene nanomesh","volume":"94","author":"Xia","year":"2022","journal-title":"Nano Energy"},{"key":"2026092909132106700_cit49","doi-asserted-by":"publisher","first-page":"122199","DOI":"10.1016\/j.apcatb.2022.122199","article-title":"Nitrogen-rich carbon nitride inducing\nelectron delocalization of\nCo-N4 site to enhance electrocatalytic carbon dioxide reduction","volume":"323","author":"Masana","year":"2023","journal-title":"Appl. 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