{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:10Z","timestamp":1792784710394,"version":"4.5.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/na","name":"UCOP CRCC","doi-asserted-by":"publisher","award":["C25CR8638"],"award-info":[{"award-number":["C25CR8638"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET 1845006"],"award-info":[{"award-number":["CBET 1845006"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Lamp Chair Endowment","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/na","name":"MSU Research Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE029524 and R01 DE033797"],"award-info":[{"award-number":["R01 DE029524 and R01 DE033797"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Cancer Institute of the National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA270136"],"award-info":[{"award-number":["R01CA270136"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Institute of Environmental Health Sciences of the National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES030695"],"award-info":[{"award-number":["R01ES030695"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"},{"id":"https:\/\/ror.org\/00j4k1h63","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat without substantial functional and cosmetic morbidity, as current management relies largely on surgery, radiation, and chemotherapy. However, these approaches often fail to achieve effective tumor control in therapy-resistant HNSCC. Photodynamic therapy (PDT) has strong potential for HNSCC treatment because it enables spatially restricted tumor ablation while limiting damage to surrounding healthy tissue. Here, we apply a near-infrared (NIR) cyanine\u2013carborate photosensitizer (PS) platform to HNSCC to identify a redox-based mechanism that limits PDT response in resistant cells and evaluate a strategy for sensitizing resistant cells. Using complementary human papillomavirus (HPV)-positive and -negative HNSCC models, we show that PDT induces acute oxidative stress and lipid peroxidation in both sensitive and resistant cells. However, resistant cells counter this stress through an adaptive redox response marked by increased xCT (SLC7A11)-dependent cystine utilization. This response sustains glutathione-linked antioxidant buffering, limits lipid peroxidation, and promotes survival under PDT. Genetic or pharmacologic disruption of cystine uptake prevents this adaptive defense, restores oxidative vulnerability, and sensitizes PDT-resistant HNSCC cells to treatment. Consistent with these mechanistic findings, cyanine\u2013carborate-induced PDT with xCT (SLC7A11) inhibition markedly suppressed tumor growth in vivo. Together, these findings identify xCT-dependent cystine metabolism as a targetable vulnerability for therapeutic sensitization of resistant HNSCC to PDT.<\/jats:p>","DOI":"10.1021\/acsnano.6c10240","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:01:48Z","timestamp":1788768108000},"page":"25531-25546","source":"Crossref","is-referenced-by-count":0,"title":["Cystine-Dependent\nRedox Metabolism Determines Photodynamic\nTherapy Response in Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1021","volume":"20","author":[{"given":"Amir","family":"Roshanzadeh","sequence":"first","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyllana C. D.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Jordan","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Malhado","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Espinoza","family":"Morelos","sequence":"additional","affiliation":[{"name":"University of California Riverside , , , ,","place":["Riverside, California, United States, 92521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Khalil","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]},{"name":"National Research Center , , ,","place":["Giza, Egypt, 12622"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyashri","family":"Muthukumar","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Favazza","sequence":"additional","affiliation":[{"name":"Henry Ford Health , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Chang","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]},{"name":"Henry Ford Health , , , ,","place":["Detroit, Michigan, United States, 48202"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Hamby","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Cesa","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohun","family":"Pyeon","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-3038","authenticated-orcid":true,"given":"Vincent","family":"Lavallo","sequence":"additional","affiliation":[{"name":"University of California Riverside , , , ,","place":["Riverside, California, United States, 92521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-6312","authenticated-orcid":true,"given":"Richard R.","family":"Lunt","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]},{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-6065","authenticated-orcid":true,"given":"Sophia Y.","family":"Lunt","sequence":"additional","affiliation":[{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]},{"name":"Michigan State University , , , ,","place":["East Lansing, Michigan, United States, 48824"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"3","key":"2026092216102294600_cit1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics\n2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for\n36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"2026092216102294600_cit2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-07140-6","article-title":"Global burden and trends\nof common head and neck cancers\nbetween 1990 and 2021: findings from the Global Burden of Disease\nStudy 2021","volume":"25","author":"Lin","year":"2025","journal-title":"BMC Oral Health"},{"issue":"5","key":"2026092216102294600_cit3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrc.2018.11","article-title":"The molecular\nlandscape of head and\nneck cancer","volume":"18","author":"Leemans","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"19","key":"2026092216102294600_cit4","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab\nfor Recurrent Squamous-Cell Carcinoma of the Head and Neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"2026092216102294600_cit5","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1001\/jamaoncol.2017.0973","article-title":"Patterns of Treatment Failure and\nPostrecurrence Outcomes Among Patients\nWith Locally Advanced Head and Neck Squamous Cell Carcinoma After\nChemoradiotherapy Using Modern Radiation Techniques","volume":"3","author":"Leeman","year":"2017","journal-title":"JAMA Oncol."},{"issue":"3","key":"2026092216102294600_cit6","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1002\/hed.70065","article-title":"Patient-Reported\nDysphagia and Swallowing-Related Quality of Life up to 10 Years After\n(Chemo)radiotherapy for Head and Neck Cancer: A Cross-Sectional Study","volume":"48","author":"Frowen","year":"2026","journal-title":"Head Neck"},{"issue":"5","key":"2026092216102294600_cit7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/lsm.22802","article-title":"Photodynamic\ntherapy in patients with head and neck squamous cell carcinoma","volume":"50","author":"Hosokawa","year":"2018","journal-title":"Lasers Surg. Med."},{"issue":"8","key":"2026092216102294600_cit8","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1001\/archoto.2009.98","article-title":"Photodynamic\ntherapy for head and neck dysplasia and cancer","volume":"135","author":"Rigual","year":"2009","journal-title":"Arch Otolaryngol. Head Neck Surg."},{"issue":"12","key":"2026092216102294600_cit9","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1002\/hed.21368","article-title":"Temoporfin-mediated\nphotodynamic therapy in patients\nwith advanced, incurable head and neck cancer: A multicenter study","volume":"32","author":"Tan","year":"2010","journal-title":"Head Neck"},{"issue":"6","key":"2026092216102294600_cit10","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/S0901-5027(98)80040-4","article-title":"Treatment\nof oral leukoplakia by topical application of 5-aminolevulinic acid","volume":"27","author":"Ku\u0308bler","year":"1998","journal-title":"Int. J. Clin. Maxillofac. Surg."},{"key":"2026092216102294600_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2019.101627","article-title":"Porfimer sodium-mediated\nphotodynamic therapy in patients with head and neck squamous cell\ncarcinoma","volume":"29","author":"Hosokawa","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"9","key":"2026092216102294600_cit12","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1097\/00005537-199809000-00001","article-title":"Photodynamic\ntherapy and the treatment of head and neck neoplasia","volume":"108","author":"Biel","year":"1998","journal-title":"Laryngoscope"},{"issue":"4","key":"2026092216102294600_cit13","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1002\/jcb.26541","article-title":"Resistance\nof oral cancer cells to 5-ALA-mediated photodynamic therapy","volume":"119","author":"Rosin","year":"2018","journal-title":"J. Cell Biochem."},{"issue":"4","key":"2026092216102294600_cit14","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/s41588-023-01357-3","article-title":"Cellular states are coupled to genomic\nand viral heterogeneity in HPV-related oropharyngeal carcinoma","volume":"55","author":"Puram","year":"2023","journal-title":"Nat. Genet."},{"issue":"10166","key":"2026092216102294600_cit15","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","article-title":"Radiotherapy plus\ncetuximab or cisplatin in human papillomavirus-positive\noropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre,\nnon-inferiority trial","volume":"393","author":"Gillison","year":"2019","journal-title":"Lancet"},{"issue":"10166","key":"2026092216102294600_cit16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(18)32752-1","article-title":"Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive\noropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled\nphase 3 trial","volume":"393","author":"Mehanna","year":"2019","journal-title":"Lancet"},{"issue":"3","key":"2026092216102294600_cit17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011171","article-title":"HPV upregulates MARCHF8\nubiquitin ligase and inhibits apoptosis by\ndegrading the death receptors in head and neck cancer","volume":"19","author":"Khalil","year":"2023","journal-title":"PLoS Pathog."},{"issue":"8","key":"2026092216102294600_cit18","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1001\/jamaoto.2025.1722","article-title":"HPV Status\nand Survival Outcomes in Patients 70 Years and Older After Surgery\nfor Oropharyngeal Carcinoma","volume":"151","author":"Boscolo-Rizzo","year":"2025","journal-title":"JAMA Otolaryngol.\nHead Neck Surg."},{"issue":"31","key":"2026092216102294600_cit19","doi-asserted-by":"publisher","first-page":"51530","DOI":"10.18632\/oncotarget.17887","article-title":"HPV-associated differential regulation\nof tumor metabolism in oropharyngeal head and neck cancer","volume":"8","author":"Jung","year":"2017","journal-title":"Oncotarget"},{"issue":"20","key":"2026092216102294600_cit20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205206","article-title":"The Key Differences between Human\nPapillomavirus-Positive and -Negative Head and Neck Cancers: Biological\nand Clinical Implications","volume":"13","author":"Powell","year":"2021","journal-title":"Cancers"},{"key":"2026092216102294600_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.115395","article-title":"Pembrolizumab\nwith or without chemotherapy in recurrent or metastatic head and neck\nsquamous cell carcinoma: 5-year follow-up from the randomized phase\nIII KEYNOTE-048 study","volume":"221","author":"Tahara","year":"2025","journal-title":"Eur. J. Cancer"},{"issue":"17","key":"2026092216102294600_cit22","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1200\/JCO.20.02903","article-title":"Tipifarnib\nin Head and Neck Squamous\nCell Carcinoma With HRAS Mutations","volume":"39","author":"Ho","year":"2021","journal-title":"J. Clin.\nOncol."},{"key":"2026092216102294600_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104104","article-title":"Photodynamic\ntherapy inhibits cancer progression and induces ferroptosis and apoptosis\nby targeting P53\/GPX4\/SLC7A11 signaling pathways in cholangiocarcinoma","volume":"47","author":"Yan","year":"2024","journal-title":"Photodiagn. Photodyn. Ther."},{"issue":"1","key":"2026092216102294600_cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39401-9","article-title":"SLC7A11 expression level dictates\ndifferential responses to oxidative stress in cancer cells","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"issue":"12","key":"2026092216102294600_cit25","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114351","article-title":"YAP\/TAZ and ATF4 drive resistance\nto Sorafenib in hepatocellular carcinoma by preventing ferroptosis","volume":"13","author":"Gao","year":"2021","journal-title":"EMBO Mol. Med."},{"issue":"9","key":"2026092216102294600_cit26","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419759","article-title":"Next-Generation Photosensitizers:\nCyanine-Carborane Salts for Superior Photodynamic Therapy of Metastatic\nCancer","volume":"64","author":"Roshanzadeh","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"issue":"48","key":"2026092216102294600_cit27","doi-asserted-by":"publisher","first-page":"53511","DOI":"10.1021\/acsami.2c16252","article-title":"Counterion Tuning of Near-Infrared Organic Salts Dictates\nPhototoxicity to Inhibit Tumor Growth","volume":"14","author":"Broadwater","year":"2022","journal-title":"ACS Appl.\nMater. Interfaces"},{"issue":"1","key":"2026092216102294600_cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51593-z","article-title":"Modulating cellular cytotoxicity\nand phototoxicity of fluorescent organic salts through counterion\npairing","volume":"9","author":"Broadwater","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"2026092216102294600_cit29","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jhep.2023.03.016","article-title":"ATF4 suppresses\nhepatocarcinogenesis\nby inducing SLC7A11 (xCT) to block stress-related ferroptosis","volume":"79","author":"He","year":"2023","journal-title":"J. Hepatol."},{"issue":"5","key":"2026092216102294600_cit30","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole\nKetone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse\nLymphoma Model","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem. Biol."},{"issue":"11","key":"2026092216102294600_cit31","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1001\/archoto.2009.159","article-title":"Immune response\nduring therapy with cisplatin or radiation for human papillomavirus-related\nhead and neck cancer","volume":"135","author":"Spanos","year":"2009","journal-title":"Arch. Otolaryngol. Head\nNeck Surg."},{"issue":"23","key":"2026092216102294600_cit32","doi-asserted-by":"publisher","first-page":"9818","DOI":"10.1021\/ac1021166","article-title":"Metabolomic\nAnalysis and Visualization\nEngine for LC\u2013MS Data","volume":"82","author":"Melamud","year":"2010","journal-title":"Anal. Chem."},{"issue":"5","key":"2026092216102294600_cit33","doi-asserted-by":"publisher","first-page":"4463","DOI":"10.1021\/acsnano.7b00715","article-title":"Near-Infrared-Triggered\nPhotodynamic Therapy with Multitasking Upconversion Nanoparticles\nin Combination with Checkpoint Blockade for Immunotherapy of Colorectal\nCancer","volume":"11","author":"Xu","year":"2017","journal-title":"ACS Nano"},{"issue":"1","key":"2026092216102294600_cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24564-0","article-title":"Engineered\nmacrophages as near-infrared light activated drug vectors for chemo-photodynamic\ntherapy of primary and bone metastatic breast cancer","volume":"12","author":"Huang","year":"2021","journal-title":"Nat. Commun."},{"issue":"30","key":"2026092216102294600_cit35","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu9555","article-title":"DNA damage\nresponse pathway regulates Nrf2 in response to oxidative stress","volume":"11","author":"Jiang","year":"2025","journal-title":"Sci. Adv."},{"issue":"7","key":"2026092216102294600_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112724","article-title":"The integrated stress response effector\nATF4 is an obligatory metabolic activator of NRF2","volume":"42","author":"Kre\u00df","year":"2023","journal-title":"Cell Rep."},{"key":"2026092216102294600_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103247","article-title":"Heme oxygenase-1\nprotects cells from\nreplication stress","volume":"75","author":"Chudy","year":"2024","journal-title":"Redox Biol."},{"issue":"19","key":"2026092216102294600_cit38","doi-asserted-by":"publisher","first-page":"9433","DOI":"10.1073\/pnas.1821323116","article-title":"Cystine\/glutamate antiporter xCT\n(SLC7A11) facilitates\noncogenic RAS transformation by preserving intracellular redox balance","volume":"116","author":"Lim","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"10","key":"2026092216102294600_cit39","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1007\/s00726-021-03071-y","article-title":"Extracellular\ncystine influences human preadipocyte differentiation and correlates\nwith fat mass in healthy adults","volume":"53","author":"Elkafrawy","year":"2021","journal-title":"Amino Acids"},{"issue":"3","key":"2026092216102294600_cit40","doi-asserted-by":"publisher","first-page":"608","DOI":"10.2144\/01313pf01","article-title":"Detection\nof caspase activation in situ by fluorochrome-labeled caspase inhibitors","volume":"31","author":"Amstad","year":"2001","journal-title":"Biotechniques"},{"issue":"5","key":"2026092216102294600_cit41","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis:\nAn Iron-Dependent Form of Nonapoptotic Cell Death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"3","key":"2026092216102294600_cit42","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1158\/2767-9764.CRC-23-0269","article-title":"Nanoparticle-mediated\nPhotodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell\nCarcinoma in Preclinical Models","volume":"4","author":"Sahovaler","year":"2024","journal-title":"Cancer Res.\nCommun."},{"issue":"1","key":"2026092216102294600_cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07985-3","article-title":"Transcriptional activation\nof PHKG2 by TP53 promotes ferroptosis through nuclear export of NRF2\nin head and neck squamous cell carcinoma","volume":"16","author":"Yu","year":"2025","journal-title":"Cell\nDeath Dis."},{"issue":"6","key":"2026092216102294600_cit44","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061670","article-title":"Acquisition\nof Cisplatin Resistance\nShifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization\nof Oxidative Stress","volume":"12","author":"Yu","year":"2020","journal-title":"Cancers"},{"issue":"8","key":"2026092216102294600_cit45","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1158\/0008-5472.CAN-18-3037","article-title":"The Deubiquitylase\nOTUB1 Mediates Ferroptosis via Stabilization of SLC7A11","volume":"79","author":"Liu","year":"2019","journal-title":"Cancer Res."},{"key":"2026092216102294600_cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.103011","article-title":"Thiol starvation\ntriggers melanoma state switching in an ATF4 and NRF2-dependent manner","volume":"70","author":"Meinert","year":"2024","journal-title":"Redox Biol."},{"issue":"4","key":"2026092216102294600_cit47","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.bbrc.2020.09.134","article-title":"SLC7A11 as\na biomarker and therapeutic target in HPV-positive head and neck Squamous\nCell Carcinoma","volume":"533","author":"He\u0301mon","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"2026092216102294600_cit48","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1021\/acsbiomedchemau.2c00053","article-title":"Unraveling\nthe Chemistry of meso-Cl Tricarbocyanine Dyes in Conjugation Reactions\nfor the Creation of Peptide Bonds","volume":"2","author":"Exner","year":"2022","journal-title":"ACS Bio Med.\nChem. Au"},{"issue":"11","key":"2026092216102294600_cit49","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1111\/cas.14182","article-title":"Glutaminolysis-related genes determine sensitivity\nto xCT-targeted therapy in head and neck squamous cell carcinoma","volume":"110","author":"Okazaki","year":"2019","journal-title":"Cancer Sci."},{"key":"2026092216102294600_cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217089","article-title":"A genome-wide\nCRISPR screen reveals that antagonism of glutamine metabolism sensitizes\nhead and neck squamous cell carcinoma to ferroptotic cell death","volume":"598","author":"Allevato","year":"2024","journal-title":"Cancer Lett."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c10240","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/37\/25531\/68399883\/acsnano.6c10240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/37\/25531\/68399883\/acsnano.6c10240.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:10:58Z","timestamp":1790107858000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/37\/25531\/5422130\/Cystine-Dependent-Redox-Metabolism-Determines"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":50,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,7]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c10240","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]}}}