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Here, we report an injectable, biodegradable biotelemetric implant for accurate, continuous wireless monitoring of intracompartmental pressure (IcP), and further establish a predictive model that converts pressure-duration signals into quantitative assessment of ACS progression, providing a clinically relevant framework for diagnosis and intervention. Our platform integrates an ultraminiaturized iontronic pressure transducer as the implant with a parity-time symmetric wireless readout circuit, enabling precise sensing and mapping of pressure-time load onto a two-dimensional ACS matrix for quantitative prediction of disease progression. The device functions throughout the clinically relevant monitoring window and then degrades naturally, eliminating the need for retrieval surgery. This work offers a transient, minimally invasive strategy for continuous ACS surveillance, and highlights the translational potential of biodegradable implantable bioelectronics for trauma care.<\/jats:p>","DOI":"10.1021\/acsnano.6c10349","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:50:31Z","timestamp":1788432631000},"page":"25002-25016","source":"Crossref","is-referenced-by-count":0,"title":["Injectable Biodegradable\nNon-Hermitian Biotelemetric\nSystem Enabling Early Diagnosis of Acute Compartment Syndrome"],"prefix":"10.1021","volume":"20","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Hangzhou Dianzi University , , ,","place":["Hangzhou, China, 310018"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congying","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiafeng","family":"Ni","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangquan","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wan","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanrui","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinku","family":"Hazarika","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weipeng","family":"Xuan","sequence":"additional","affiliation":[{"name":"Hangzhou Dianzi University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-9632","authenticated-orcid":true,"given":"Jinkai","family":"Chen","sequence":"additional","affiliation":[{"name":"Hangzhou Dianzi University , , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Qi","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2683-3353","authenticated-orcid":true,"given":"Gang","family":"Feng","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine , , ,","place":["Hangzhou, China, 310009"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Cao","sequence":"additional","affiliation":[{"name":"Fourth Military Medical University , , ,","place":["Xi\u2019an, China, 710072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minye","family":"Yang","sequence":"additional","affiliation":[{"name":"Northwestern Polytechnical University , , ,","place":["Xi\u2019an, China, 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314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-2443","authenticated-orcid":true,"given":"Jikui","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310027"]},{"name":"Zhejiang University , , ,","place":["Haining, China, 314400"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"1","key":"2026091510110565300_cit1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2174\/1874325001408010185","article-title":"The Pathophysiology, Diagnosis and\nCurrent Management of Acute Compartment Syndrome","volume":"8","author":"Donaldson","year":"2014","journal-title":"TOORTHJ"},{"issue":"5","key":"2026091510110565300_cit2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.2106\/00004623-200205000-00022","article-title":"Muscle Injuries\nand Repair: Current Trends in 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Mater."},{"issue":"14","key":"2026091510110565300_cit18","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1039\/b922220k","article-title":"Solvent Induced Shape\nRecovery of Shape Memory Polymer Based on Chemically\nCross-Linked Poly(Vinyl Alcohol)","volume":"6","author":"Du","year":"2010","journal-title":"Soft Matter"},{"key":"2026091510110565300_cit19","doi-asserted-by":"publisher","first-page":"152450","DOI":"10.1016\/j.cej.2024.152450","article-title":"Freeze-Drying\nInduced Gradient Microporous\nComposite Film with High Ionic Conductivity for Ultrasensitive Wearable\nIontronic Pressure Sensor","volume":"493","author":"Li","year":"2024","journal-title":"Chem. Eng. 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Immunol."},{"issue":"2","key":"2026091510110565300_cit36","doi-asserted-by":"publisher","first-page":"113746","DOI":"10.1016\/j.celrep.2024.113746","article-title":"Lactic\nAcid Induces Transcriptional Repression of Macrophage Inflammatory\nResponse via Histone Acetylation","volume":"43","author":"Shi","year":"2024","journal-title":"Cell Rep."},{"issue":"5","key":"2026091510110565300_cit37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41928-018-0072-6","article-title":"Generalized\nParity\u2013Time Symmetry\nCondition for Enhanced Sensor Telemetry","volume":"1","author":"Chen","year":"2018","journal-title":"Nat.\nElectron."},{"issue":"23","key":"2026091510110565300_cit38","doi-asserted-by":"publisher","first-page":"9548","DOI":"10.1109\/JSEN.2018.2870322","article-title":"Ultrasensitive, Parity\u2013Time-Symmetric\nWireless\nReactive and Resistive Sensors","volume":"18","author":"Sakhdari","year":"2018","journal-title":"IEEE Sensors\nJ."},{"issue":"16","key":"2026091510110565300_cit39","doi-asserted-by":"publisher","first-page":"164103","DOI":"10.1063\/5.0170824","article-title":"The Sensitivity of\nPT-Symmetric LC\nWireless Sensors around an Exceptional Point","volume":"123","author":"Zhou","year":"2023","journal-title":"Appl. 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