{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:58Z","timestamp":1792784758376,"version":"4.5.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Shandong Provincial Natural Science Foundation","award":["ZR2022QH069"],"award-info":[{"award-number":["ZR2022QH069"]}]},{"name":"Shandong Provincial Natural Science Foundation","award":["ZR2023QE322"],"award-info":[{"award-number":["ZR2023QE322"]}]},{"name":"Jinan Central Hospital","award":["YJ0054"],"award-info":[{"award-number":["YJ0054"]}],"id":[{"id":"https:\/\/ror.org\/01fr19c68","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rational design of single-atom nanozymes (SAzymes) can be achieved by regulation of the first and second coordination shells near the metal coordination center. However, the impact of structural changes at distances further away from the metal coordination center on the catalytic activity has been rarely reported. Herein, graphdiyne (GDY)-derived Fe SAzymes (GFeN SAzymes) with tunable N dopants (amino-N, pyridinic-N, graphitic-N) were synthesized via controlled NH3 pyrolysis. Fe-centered single-atom sites were stabilized within the GDY-derived framework, while N dopants modulated their catalytic behavior through long-range electronic effects. GFeN SAzymes possess multi-enzyme activities, including oxidase, peroxidase, catalase, and superoxide dismutase. Catalytic performance was modulated by N type: pyridinic-N provides more favorable regulation of Fe-centered catalysis, whereas amino-N is associated with less favorable catalytic behavior. Remarkably, SAzymes are pH-responsive, scavenging reactive oxygen species (ROS) under neutral conditions and generating ROS in acidic environments, enabling adaptive antibacterial action and wound repair. GFeN SAzyme pyrolyzed at 700 \u00b0C exhibited a photothermal conversion efficiency of 28.3% under 808 nm laser irradiation, synergistically enhancing catalytic sterilization. In vitro and in vivo experiments confirmed excellent wound disinfection and healing via photothermal amplified catalytic therapy. This work highlights the crucial role of long-range interactions in regulating catalytic activity and offers a strategy for designing highly efficient SAzymes.<\/jats:p>","DOI":"10.1021\/acsnano.6c10932","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:03:04Z","timestamp":1789995784000},"page":"26623-26636","source":"Crossref","is-referenced-by-count":0,"title":["N-Modulated\nGraphdiyne Iron Single-Atom Nanozyme\nthrough Long-Range Interactions for Photothermal Amplified Multifunctional\nCatalytic Antibacterial Therapy"],"prefix":"10.1021","volume":"20","author":[{"given":"Fuchun","family":"Nan","sequence":"first","affiliation":[{"name":"Qingdao University of Science and Technology , , ,","place":["Qingdao, China, 266000"]},{"name":"Shandong University , , ,","place":["Jinan, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University , , ,","place":["Jinan, China, 250063"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengqin","family":"Li","sequence":"additional","affiliation":[{"name":"Central Hospital Affiliated to Shandong First Medical University , ,","place":["Jinan, China, 250013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University , , ,","place":["Jinan, China, 250063"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Wu","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5583-2822","authenticated-orcid":true,"given":"Lingyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250101"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Lang","sequence":"additional","affiliation":[{"name":"Qingdao University , , ,","place":["Jinan, China, 250014"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-0733","authenticated-orcid":true,"given":"Xinxin","family":"Han","sequence":"additional","affiliation":[{"name":"Guangxi University , , ,","place":["Nanning, China, 530004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-7092","authenticated-orcid":true,"given":"Lanbo","family":"Shen","sequence":"additional","affiliation":[{"name":"Shandong First Medical University , , ,","place":["Jinan, China, 250000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-6718","authenticated-orcid":true,"given":"William W.","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Jinan, China, 250100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026100609082385800_cit1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/s41929-018-0090-9","article-title":"Bridging homogeneous\nand heterogeneous catalysis by heterogeneous single-metal-site catalysts","volume":"1","author":"Cui","year":"2018","journal-title":"Nat. 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Healthcare Mater."},{"key":"2026100609082385800_cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62063-8","article-title":"Nanozymes expanding the boundaries\nof biocatalysis","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100609082385800_cit35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307798","article-title":"Using Cu-Based\nMetal\u2013Organic Framework as a Comprehensive and Powerful Antioxidant\nNanozyme for Efficient Osteoarthritis Treatment","volume":"11","author":"Yu","year":"2024","journal-title":"Adv. Sci."},{"key":"2026100609082385800_cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53824-y","article-title":"Electron-donable heterojunctions\nwith synergetic Ru-Cu pair sites\nfor biocatalytic microenvironment modulations in inflammatory mandible\ndefects","volume":"15","author":"Bai","year":"2024","journal-title":"Nat. Commun."},{"key":"2026100609082385800_cit37","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202210242","article-title":"A Deprotection-free\nMethod for High-yield Synthesis of Graphdiyne Powder with In Situ\nFormed CuO Nanoparticles","volume":"61","author":"Li","year":"2022","journal-title":"Angew. Chem., Int.\nEd."},{"key":"2026100609082385800_cit38","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1039\/b922733d","article-title":"Architecture\nof graphdiyne nanoscale films","volume":"46","author":"Li","year":"2010","journal-title":"Chem. Commun."},{"key":"2026100609082385800_cit39","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1351\/pac200880030519","article-title":"Synthesis\nand properties of annulenic subunits of graphyne and graphdiyne nanoarchitectures","volume":"80","author":"Haley","year":"2008","journal-title":"Pure Appl. 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Sci."},{"key":"2026100609082385800_cit42","doi-asserted-by":"publisher","first-page":"12055","DOI":"10.1039\/c0cp00789g","article-title":"Identification of\nthe nitrogen species on N-doped graphene layers and Pt\/NG composite\ncatalyst for direct methanol fuel cell","volume":"12","author":"Zhang","year":"2010","journal-title":"Phys.\nChem. Chem. Phys."},{"key":"2026100609082385800_cit43","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.carbon.2011.08.046","article-title":"Probing\nsolid state N-doping in graphene by X-ray absorption near-edge structure\nspectroscopy","volume":"50","author":"Zhong","year":"2012","journal-title":"Carbon"},{"key":"2026100609082385800_cit44","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s41557-018-0100-1","article-title":"Few-layer\ngraphdiyne doped with sp-hybridized nitrogen atoms at acetylenic sites\nfor oxygen reduction electrocatalysis","volume":"10","author":"Zhao","year":"2018","journal-title":"Nat.\nChem."},{"key":"2026100609082385800_cit45","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1038\/s41596-018-0001-1","article-title":"Standardized assays for determining\nthe catalytic activity and kinetics of peroxidase-like nanozymes","volume":"13","author":"Jiang","year":"2018","journal-title":"Nat. Protoc."},{"key":"2026100609082385800_cit46","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1021\/acsestengg.5c00434","article-title":"Unlocking\nthe Cross-Scale\nRegulation of Nonlocal Electronic Interactions: Long-Range Electronic-Regulation-Driven\nSingle-Atom Catalysts (LRER-SACs) as Pioneers in Environmental Catalysis","volume":"5","author":"Yin","year":"2025","journal-title":"ACS ES&T Eng."},{"key":"2026100609082385800_cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52074-2","article-title":"Long-range interactions driving neighboring Fe\u2013N4 sites in Fenton-like reactions for sustainable water decontamination","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. 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