{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:09Z","timestamp":1792784709991,"version":"4.5.0"},"reference-count":217,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2025HXBH081"],"award-info":[{"award-number":["2025HXBH081"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752237"],"award-info":[{"award-number":["2024M752237"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82272003"],"award-info":[{"award-number":["82272003"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82502381"],"award-info":[{"award-number":["82502381"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["W2511096"],"award-info":[{"award-number":["W2511096"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Department of Science and Technology of Sichuan Province","award":["2025YFHZ0145"],"award-info":[{"award-number":["2025YFHZ0145"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biological barriers, including the tumor microenvironment and the blood\u2013brain barrier, represent the primary bottleneck for the clinical translation of nanomedicines in oncology and neurology. Ultrasound, characterized by noninvasiveness, deep tissue penetration, and high spatiotemporal precision, provides a transformative platform to address this challenge. This review systematically presents sononanomedicine as an integrated paradigm that couples acoustic physics with nanoplatform engineering to overcome these physiological barriers. We delineate the core physical mechanisms\u2500cavitation, sonochemical effects, and thermal modulation\u2500and highlight major classes of sononanomedicines. In oncology, we discuss ultrasound-assisted chemotherapy, sonodynamic and photothermal combination therapy, high intensity focused ultrasound (HIFU) ablation sensitization, and synergy with immunotherapy. For neurological disorders, we cover brain tumor therapy, neurodegenerative disease intervention, and spinal cord injury repair. Finally, we identify critical translational hurdles and propose that next-generation sononanomedicine must shift from platform-centric verification toward patient-centered optimization, integrating feedback-guided design and multimodal imaging to achieve reproducible and clinically viable therapeutic outcomes.<\/jats:p>","DOI":"10.1021\/acsnano.6c12207","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:02:39Z","timestamp":1789830159000},"page":"26442-26471","source":"Crossref","is-referenced-by-count":0,"title":["Overcoming Biological\nBarriers with Sononanomedicine:\nNew Horizons in Oncology and Neurology"],"prefix":"10.1021","volume":"20","author":[{"given":"Ruiqian","family":"Guo","sequence":"first","affiliation":[{"name":"West China Hospital, Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Feng","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjiao","family":"Tang","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-9799","authenticated-orcid":true,"given":"Li","family":"Qiu","sequence":"additional","affiliation":[{"name":"West China Hospital, Sichuan University , , ,","place":["Chengdu, China, 610041"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"2026100609083921200_cit1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S570411","article-title":"Nanomedicines Reshape\nthe Tumor Microenvironment: Multidimensional Strategies from Modulating\n\u2033Barriers\u2033 to Metabolic Intervention","volume":"21","author":"Zhao","year":"2026","journal-title":"Int. J. Nanomed."},{"issue":"12","key":"2026100609083921200_cit2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/s41578-023-00581-x","article-title":"New opportunities\nand old challenges in the clinical translation of nanotheranostics","volume":"8","author":"Gawne","year":"2023","journal-title":"Nat. Rev. Mater."},{"key":"2026100609083921200_cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2026.104955","article-title":"Microvascular and stromal normalization\ncombined with nano-immunotherapy: A synergistic strategy to overcome\ndrug delivery barriers in solid tumors","volume":"166","author":"Mirala","year":"2026","journal-title":"Microvasc.\nRes."},{"issue":"3","key":"2026100609083921200_cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-026-02075-5","article-title":"A multiphysics\ncomputational model\nof focused ultrasound-enhanced drug delivery using temperature-sensitive\nliposomes","volume":"25","author":"Koutsi","year":"2026","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"1","key":"2026100609083921200_cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s44341-025-00017-3","article-title":"The synergistic potential of mechanotherapy\nand sonopermeation to enhance cancer treatment effectiveness","volume":"2","author":"Neophytou","year":"2025","journal-title":"npj Biol. Phys. Mech."},{"issue":"1","key":"2026100609083921200_cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-07268-1","article-title":"Mechanical\nforces inducing oxaliplatin resistance in\npancreatic cancer can be targeted by autophagy inhibition","volume":"7","author":"Kalli","year":"2024","journal-title":"Commun. Biol."},{"key":"2026100609083921200_cit7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.addr.2019.06.007","article-title":"Intratumoral fate of\nfunctional nanoparticles in response to microenvironment\nfactor: Implications on cancer diagnosis and therapy","volume":"143","author":"Peng","year":"2019","journal-title":"Adv. Drug Delivery Rev."},{"issue":"2","key":"2026100609083921200_cit8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s44222-022-00004-6","article-title":"Biomaterials tools to modulate the\ntumour microenvironment in immunotherapy","volume":"1","author":"Chao","year":"2023","journal-title":"Nat.\nRev. Bioeng."},{"issue":"3","key":"2026100609083921200_cit9","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment:\nFrom cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"2026100609083921200_cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2026.218539","article-title":"Biological\neffects of ultrasonic cavitation in cancer therapy: from physics to\nmechanobiology","volume":"655","author":"Xu","year":"2026","journal-title":"Cancer Lett."},{"key":"2026100609083921200_cit11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jconrel.2017.09.016","article-title":"Overcoming\nkey biological barriers\nto cancer drug delivery and efficacy","volume":"267","author":"Kim","year":"2017","journal-title":"J. Controlled\nRelease"},{"issue":"6","key":"2026100609083921200_cit12","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1007\/s13346-021-00923-8","article-title":"Overcoming\nbiological barriers to improve solid tumor immunotherapy","volume":"11","author":"Ukidve","year":"2021","journal-title":"Drug Delivery Transl. Res."},{"key":"2026100609083921200_cit13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jconrel.2021.11.024","article-title":"Engineered\nstrategies to enhance tumor penetration of drug-loaded nanoparticles","volume":"341","author":"Souri","year":"2022","journal-title":"J. Controlled Release"},{"issue":"11","key":"2026100609083921200_cit14","doi-asserted-by":"publisher","first-page":"6257","DOI":"10.1039\/D5CS01323B","article-title":"Stimuli-responsive\nnanoplatforms for central nervous system disorders: integrating delivery,\nmodulation, and imaging","volume":"55","author":"Chen","year":"2026","journal-title":"Chem. Soc. Rev."},{"issue":"3","key":"2026100609083921200_cit15","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2174\/0115672018283792240115053302","article-title":"Smart Ultrasound-responsive\nPolymers for Drug Delivery:\nAn Overview on Advanced Stimuli-sensitive Materials and Techniques","volume":"22","author":"Yazdan","year":"2025","journal-title":"Curr. Drug Delivery"},{"issue":"10","key":"2026100609083921200_cit16","doi-asserted-by":"publisher","first-page":"4734","DOI":"10.7150\/thno.69682","article-title":"Challenges and opportunities\nto penetrate the blood-brain\nbarrier for brain cancer therapy","volume":"12","author":"Upton","year":"2022","journal-title":"Theranostics"},{"issue":"3","key":"2026100609083921200_cit17","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11912-024-01497-7","article-title":"Blood\u2013Brain\nBarrier Disruption for the Treatment of Primary Brain Tumors: Advances\nin the Past Half-Decade","volume":"26","author":"Virtanen","year":"2024","journal-title":"Curr. Oncol. Rep."},{"key":"2026100609083921200_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115199","article-title":"From concept to early clinical trials: 30 years of\nmicrobubble-based ultrasound-mediated drug delivery research","volume":"206","author":"Bouakaz","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026100609083921200_cit19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3390\/genes1030413","article-title":"Programming Pluripotent Precursor\nCells Derived from\nXenopus Embryos to Generate Specific Tissues and Organs","volume":"1","author":"Borchers","year":"2010","journal-title":"In Genes"},{"key":"2026100609083921200_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2023.106346","article-title":"Barrier-breaking effects\nof ultrasonic cavitation for drug delivery and biomarker release","volume":"94","author":"Hu","year":"2023","journal-title":"Ultrason. Sonochem."},{"issue":"10","key":"2026100609083921200_cit21","doi-asserted-by":"publisher","first-page":"8910","DOI":"10.21037\/qims-2025-435","article-title":"Assessment\nof neck muscle thickness\nand stiffness in Chinese healthy individuals by ultrasound","volume":"15","author":"Wang","year":"2025","journal-title":"Quant. Imaging Med. Surgery"},{"key":"2026100609083921200_cit22","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jtos.2025.06.006","article-title":"Ultrasonography assessments of meibomian\ngland as a noninvasive method of detecting changes in morphology","volume":"38","author":"Wang","year":"2025","journal-title":"Ocular Surface"},{"issue":"8","key":"2026100609083921200_cit23","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S1474-4422(25)00210-8","article-title":"Focused\nultrasound therapy for movement disorders","volume":"24","author":"Marti\u0301nez-Ferna\u0301ndez","year":"2025","journal-title":"Lancet\nNeurology"},{"issue":"5","key":"2026100609083921200_cit24","doi-asserted-by":"publisher","first-page":"740","DOI":"10.2967\/jnumed.117.200030","article-title":"Advanced Ultrasound Technologies\nfor Diagnosis and Therapy","volume":"59","author":"Rix","year":"2018","journal-title":"J. Nucl. Med."},{"key":"2026100609083921200_cit25","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.jconrel.2021.09.014","article-title":"Sub-millimetre precision of drug delivery in the brain\nfrom ultrasound-triggered nanodroplets","volume":"338","author":"Lea-Banks","year":"2021","journal-title":"J. Controlled\nRelease"},{"issue":"1","key":"2026100609083921200_cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51620-2","article-title":"Ultrasound-mediated\nspatial and temporal control of engineered cells in vivo","volume":"15","author":"Ivanovski","year":"2024","journal-title":"Nat. Commun."},{"issue":"8050","key":"2026100609083921200_cit27","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41586-024-08401-0","article-title":"H-bonded organic frameworks as ultrasound-programmable delivery platform","volume":"638","author":"Wang","year":"2025","journal-title":"Nature"},{"issue":"31","key":"2026100609083921200_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202502699","article-title":"The application of ultrasound-induced\nblood\u2013brain barrier\nopening in neurology and immunology","volume":"21","author":"Jiang","year":"2025","journal-title":"Small"},{"key":"2026100609083921200_cit29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.addr.2021.02.015","article-title":"Opening doors\nwith ultrasound and microbubbles: Beating biological barriers to promote\ndrug delivery","volume":"172","author":"Deprez","year":"2021","journal-title":"Adv. Drug Delivery Rev."},{"issue":"1","key":"2026100609083921200_cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02217-8","article-title":"Bio-barrier-adaptable biomimetic\nnanomedicines combined with ultrasound\nfor enhanced cancer therapy","volume":"10","author":"Guo","year":"2025","journal-title":"Signal Transduction\nTargeted Ther."},{"issue":"12","key":"2026100609083921200_cit31","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/s41565-021-00971-8","article-title":"Acoustically triggered mechanotherapy using\ngenetically encoded gas vesicles","volume":"16","author":"Bar-Zion","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"2026100609083921200_cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39607-x","article-title":"Ultrasound-responsive low-dose doxorubicin\nliposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated\nantitumour immunity","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"2026100609083921200_cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2022.102757","article-title":"Liposomes as biocompatible\nand smart delivery systems\n\u2013 the current state","volume":"309","author":"Dymek","year":"2022","journal-title":"Adv. Colloid Interface\nSci."},{"key":"2026100609083921200_cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.102930","article-title":"Advanced\nliposome and polymersome-based drug delivery\nsystems: Considerations for physicochemical properties, targeting\nstrategies and stimuli-sensitive approaches","volume":"317","author":"Kans\u0131z","year":"2023","journal-title":"Adv. Colloid Interface Sci."},{"issue":"5","key":"2026100609083921200_cit35","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41416-022-02076-y","article-title":"Ultrasound-targeted\nmicrobubble destruction remodels tumour microenvironment to improve\nimmunotherapeutic effect","volume":"128","author":"Liu","year":"2023","journal-title":"Br. J. Cancer"},{"key":"2026100609083921200_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2024.103206","article-title":"Recent progress\nin stimuli-responsive polymeric micelles for targeted delivery of\nfunctional nanoparticles","volume":"330","author":"Cao","year":"2024","journal-title":"Adv. Colloid Interface\nSci."},{"issue":"9","key":"2026100609083921200_cit37","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1039\/D3MH00399J","article-title":"Stimuli-responsive\ndynamic hydrogels: design, properties and tissue engineering applications","volume":"10","author":"Amirthalingam","year":"2023","journal-title":"Mater. Horiz."},{"key":"2026100609083921200_cit38","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.addr.2019.01.005","article-title":"Iron oxide nanoparticles:\nDiagnostic, therapeutic and theranostic applications","volume":"138","author":"Dadfar","year":"2019","journal-title":"Adv. Drug Delivery Rev."},{"issue":"21","key":"2026100609083921200_cit39","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209529","article-title":"In Response to Precision Medicine:\nCurrent Subcellular\nTargeting Strategies for Cancer Therapy","volume":"35","author":"Li","year":"2023","journal-title":"Adv.\nMater."},{"issue":"3","key":"2026100609083921200_cit40","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s11684-010-0092-8","article-title":"High-intensity focused\nultrasound tumor ablation: Review\nof ten years of clinical experience","volume":"4","author":"Zhang","year":"2010","journal-title":"Front.\nMed. China"},{"issue":"14","key":"2026100609083921200_cit41","doi-asserted-by":"publisher","first-page":"7401","DOI":"10.1039\/D5NR05210F","article-title":"Recent advances in acoustic cavitation-inducible materials\nfor cancer sonotheranostics","volume":"18","author":"Park","year":"2026","journal-title":"Nanoscale"},{"issue":"10","key":"2026100609083921200_cit42","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00539","article-title":"Progress of research\nin the application of ultrasound technology for the treatment of Alzheimer\u2019s\ndisease","volume":"20","author":"Cai","year":"2025","journal-title":"Neural Regener. Res."},{"key":"2026100609083921200_cit43","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.addr.2013.11.008","article-title":"Understanding\nultrasound induced sonoporation: Definitions and underlying mechanisms","volume":"72","author":"Lentacker","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026100609083921200_cit44","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jconrel.2016.09.026","article-title":"Ultrasound-triggered\ndrug delivery for cancer treatment using drug delivery systems: From\ntheoretical considerations to practical applications","volume":"241","author":"Boissenot","year":"2016","journal-title":"J. Controlled Release"},{"key":"2026100609083921200_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114353","article-title":"Ultrasound-responsive nanocarriers for cancer therapy:\nphysiochemical\nfeatures-directed design","volume":"388","author":"Yuan","year":"2025","journal-title":"J. Controlled Release"},{"issue":"26","key":"2026100609083921200_cit46","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401384","article-title":"A T-Cell Inspired Sonoporation System\nEnhances Low-Dose X-Ray-Mediated Pyroptosis and Radioimmunotherapy\nEfficacy by Restoring Gasdermin-E Expression","volume":"36","author":"Yin","year":"2024","journal-title":"Adv. Mater."},{"issue":"1","key":"2026100609083921200_cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01398-4","article-title":"Cell-cycle\ndependent nuclear gene delivery enhances the effects of E-cadherin\nagainst tumor invasion and metastasis","volume":"8","author":"Xie","year":"2023","journal-title":"Signal\nTransduction Targeted Ther."},{"key":"2026100609083921200_cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114539","article-title":"Ultrasound-mediated\nblood\u2013brain barrier opening:\nAn effective drug delivery system for theranostics of brain diseases","volume":"190","author":"Wang","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"issue":"26","key":"2026100609083921200_cit49","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202519435","article-title":"High-Concentrated Reactive Oxygen Species from Chiral\nThyroxine for\nPiezocatalytic Antitumor Therapy","volume":"36","author":"Yang","year":"2026","journal-title":"Adv. Funct.\nMater."},{"issue":"22","key":"2026100609083921200_cit50","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202518245","article-title":"Remote-Controllable Immune-Priming Spot Formation Via\nNanocomplexed Hydrogel-Assisted Histotripsy: Immunoasis","volume":"38","author":"Kim","year":"2026","journal-title":"Adv. Mater."},{"issue":"5","key":"2026100609083921200_cit51","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S1470-2045(23)00112-2","article-title":"Repeated blood-brain barrier opening with an\nimplantable ultrasound device for delivery of albumin-bound paclitaxel\nin patients with recurrent glioblastoma: a phase 1 trial","volume":"24","author":"Sonabend","year":"2023","journal-title":"Lancet Oncol."},{"issue":"1","key":"2026100609083921200_cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45818-7","article-title":"Repeated\nblood\u2013brain barrier opening with a\nnine-emitter implantable ultrasound device in combination with carboplatin\nin recurrent glioblastoma: a phase I\/II clinical trial","volume":"15","author":"Carpentier","year":"2024","journal-title":"Nat. Commun."},{"issue":"13","key":"2026100609083921200_cit53","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1158\/1078-0432.CCR-18-3643","article-title":"Safety and feasibility of repeated and transient blood\u2013brain\nbarrier disruption by pulsed ultrasound in patients with recurrent\nglioblastoma","volume":"25","author":"Idbaih","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"2026100609083921200_cit54","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.jconrel.2016.10.007","article-title":"A human clinical trial using ultrasound and\nmicrobubbles to enhance gemcitabine treatment of inoperable pancreatic\ncancer","volume":"243","author":"Dimcevski","year":"2016","journal-title":"J. Control Release"},{"issue":"5","key":"2026100609083921200_cit55","doi-asserted-by":"publisher","first-page":"553","DOI":"10.21147\/j.issn.1000-9604.2018.05.09","article-title":"Clinical study\nof ultrasound and microbubbles for enhancing chemotherapeutic\nsensitivity of malignant tumors in digestive system","volume":"30","author":"Wang","year":"2018","journal-title":"Chin J. Cancer Res."},{"issue":"4","key":"2026100609083921200_cit56","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.ultsonch.2010.11.016","article-title":"The characterization\nof acoustic cavitation bubbles \u2013 An overview","volume":"18","author":"Ashokkumar","year":"2011","journal-title":"Ultrason. Sonochem."},{"issue":"11","key":"2026100609083921200_cit57","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1039\/C9CS00648F","article-title":"Multifunctional\nsonosensitizers in sonodynamic cancer\ntherapy","volume":"49","author":"Son","year":"2020","journal-title":"Chem. Soc. Rev."},{"issue":"4","key":"2026100609083921200_cit58","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904011","article-title":"Biodegradable Nanoprodrugs:\n\u201cDelivering\u201d ROS to Cancer\nCells for Molecular Dynamic Therapy","volume":"32","author":"Tang","year":"2020","journal-title":"Adv. Mater."},{"issue":"47","key":"2026100609083921200_cit59","doi-asserted-by":"publisher","first-page":"22266","DOI":"10.1039\/D5SC06387F","article-title":"Ultrasound-activatable\ntransition metal complexes to\npotentiate sonodynamic therapy","volume":"16","author":"Lee","year":"2025","journal-title":"Chem. Sci."},{"issue":"3","key":"2026100609083921200_cit60","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pbiomolbio.2012.01.004","article-title":"Bio-effects and safety\nof low-intensity, low-frequency ultrasonic exposure","volume":"108","author":"Ahmadi","year":"2012","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"24","key":"2026100609083921200_cit61","doi-asserted-by":"publisher","first-page":"E4802","DOI":"10.1073\/pnas.1700790114","article-title":"Thermal combination\ntherapies for\nlocal drug delivery by magnetic resonance-guided high-intensity focused\nultrasound","volume":"114","author":"Hijnen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"2026100609083921200_cit62","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3109\/02656736.2012.665567","article-title":"Ultrasound-mediated\nmicellar drug delivery","volume":"28","author":"Rapoport","year":"2012","journal-title":"Int. J. Hyperthermia"},{"key":"2026100609083921200_cit63","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jconrel.2024.10.023","article-title":"Low-boiling-point perfluorocarbon nanodroplets\nfor adaptable ultrasound-induced blood-brain barrier opening","volume":"376","author":"Dauba","year":"2024","journal-title":"J. Controlled Release"},{"issue":"15","key":"2026100609083921200_cit64","doi-asserted-by":"publisher","first-page":"7276","DOI":"10.7150\/thno.54630","article-title":"Closed-loop trans-skull ultrasound hyperthermia leads\nto improved drug delivery from thermosensitive drugs and promotes\nchanges in vascular transport dynamics in brain tumors","volume":"11","author":"Kim","year":"2021","journal-title":"Theranostics"},{"issue":"10","key":"2026100609083921200_cit65","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.3390\/pharmaceutics14102012","article-title":"Large-Volume Focused-Ultrasound\nMild Hyperthermia for Improving Blood-Brain Tumor Barrier Permeability\nApplication","volume":"14","author":"Chan","year":"2022","journal-title":"Pharmaceutics"},{"issue":"2","key":"2026100609083921200_cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.omton.2025.200994","article-title":"Regulation of the brain\ntumor microenvironment by focused ultrasound","volume":"33","author":"Fu","year":"2025","journal-title":"Mol. Therapy Oncol."},{"key":"2026100609083921200_cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2020.106210","article-title":"Minimally\ninvasive therapeutic ultrasound: Ultrasound-guided\nultrasound ablation in neuro-oncology","volume":"108","author":"Belzberg","year":"2020","journal-title":"Ultrasonics"},{"issue":"4","key":"2026100609083921200_cit68","doi-asserted-by":"publisher","first-page":"623","DOI":"10.7863\/jum.2012.31.4.623","article-title":"Bioeffects Committee\nof the American Institute of Ultrasound\nin, M. Overview of Therapeutic Ultrasound Applications and Safety\nConsiderations","volume":"31","author":"Miller","year":"2012","journal-title":"J. Ultrasound Med."},{"issue":"1","key":"2026100609083921200_cit69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04529-6","article-title":"Blood\u2013brain\nbarrier opening in alzheimer\u2019s\ndisease using MR-guided focused ultrasound","volume":"9","author":"Lipsman","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"2026100609083921200_cit70","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1021\/acs.bioconjchem.1c00437","article-title":"Enhancing Cancer Immunotherapeutic\nEfficacy with Sonotheranostic Strategies","volume":"33","author":"Zafar","year":"2022","journal-title":"Bioconjugate\nChem."},{"key":"2026100609083921200_cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2024.107105","article-title":"Progress in application of nanomedicines\nfor enhancing cancer sono-immunotherapy","volume":"111","author":"Zhao","year":"2024","journal-title":"Ultrason.\nSonochem."},{"issue":"4","key":"2026100609083921200_cit72","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.4049\/jimmunol.1500541","article-title":"Low-Intensity Focused\nUltrasound Induces Reversal of Tumor-Induced T Cell Tolerance and\nPrevents Immune Escape","volume":"196","author":"Bandyopadhyay","year":"2016","journal-title":"J. Immunol."},{"issue":"8","key":"2026100609083921200_cit73","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081295","article-title":"Ruthenium Complexes:\nAn Alternative to Platinum Drugs in Colorectal Cancer Treatment","volume":"13","author":"Mahmud","year":"2021","journal-title":"Pharmaceutics"},{"issue":"2","key":"2026100609083921200_cit74","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41551-022-00846-w","article-title":"Synergistic checkpoint-blockade and radiotherapy\u2013radiodynamic\ntherapy via an immunomodulatory nanoscale metal\u2013organic framework","volume":"6","author":"Ni","year":"2022","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"2026100609083921200_cit75","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38796-9","article-title":"Microbial synthesis\nof Prussian blue for potentiating checkpoint\nblockade immunotherapy","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"2026100609083921200_cit76","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41551-022-00978-z","article-title":"Nanoparticles with ultrasound-induced\nafterglow luminescence for\ntumour-specific theranostics","volume":"7","author":"Xu","year":"2023","journal-title":"Nat. Biomed. Eng."},{"issue":"45","key":"2026100609083921200_cit77","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408242","article-title":"Bimetal-Biligand Frameworks for Spatiotemporal\nNitric Oxide-Enhanced Sono-Immunotherapy","volume":"36","author":"Cheng","year":"2024","journal-title":"Adv.\nMater."},{"issue":"4","key":"2026100609083921200_cit78","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","article-title":"Immunogenic cell stress\nand death","volume":"23","author":"Kroemer","year":"2022","journal-title":"Nat. Immunol."},{"issue":"2","key":"2026100609083921200_cit79","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41578-023-00617-2","article-title":"Responsive\nbiomaterials: optimizing control of cancer immunotherapy","volume":"9","author":"Xue","year":"2024","journal-title":"Nat. Rev. Mater."},{"issue":"27","key":"2026100609083921200_cit80","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106909","article-title":"Understanding\nHeterogeneities in Quantum Materials","volume":"35","author":"Ko","year":"2023","journal-title":"Adv. Mater."},{"issue":"11","key":"2026100609083921200_cit81","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development\nand potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"2026100609083921200_cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216969","article-title":"Structure-property relationships\nof main-group element phthalocyanines in photo\/sono-driven cancer\ntherapy","volume":"544","author":"Liu","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"2026100609083921200_cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216169","article-title":"Current roles of metals in arming\nsonodynamic cancer therapy","volume":"521","author":"Chen","year":"2024","journal-title":"Coord. Chem. Rev."},{"issue":"9","key":"2026100609083921200_cit84","doi-asserted-by":"publisher","first-page":"7161","DOI":"10.1021\/jacs.4c18328","article-title":"Intracellular\nPhotocatalytic NADH\/NAD(P)H Oxidation for Cancer Drug Development","volume":"147","author":"Yadav","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"13","key":"2026100609083921200_cit85","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202523608","article-title":"Self-Assembled Ruthenium Complexes\nWith Sonobleaching Ligand for\nEnhanced Tumor Penetration and Immunogenic Sonotherapy","volume":"38","author":"He","year":"2026","journal-title":"Adv. Mater."},{"issue":"3","key":"2026100609083921200_cit86","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1021\/acsnano.4c13356","article-title":"PEGylated Ultrasmall Iron Oxide Nanoparticles as MRI Contrast Agents\nfor Vascular Imaging and Real-Time Monitoring","volume":"19","author":"Lu","year":"2025","journal-title":"ACS Nano"},{"issue":"5","key":"2026100609083921200_cit87","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41577-019-0269-6","article-title":"Enhancing cancer immunotherapy with nanomedicine","volume":"20","author":"Irvine","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"2026100609083921200_cit88","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","article-title":"Delivery technologies\nfor cancer immunotherapy","volume":"18","author":"Riley","year":"2019","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"31","key":"2026100609083921200_cit89","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007630","article-title":"Recent Advances\nin Engineered Materials for Immunotherapy-Involved Combination Cancer\nTherapy","volume":"33","author":"Liang","year":"2021","journal-title":"Adv. Mater."},{"key":"2026100609083921200_cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115110","article-title":"Lipid bilayer-based biological nanoplatforms\nfor sonodynamic cancer therapy","volume":"202","author":"Li","year":"2023","journal-title":"Adv. Drug Delivery\nRev."},{"issue":"13","key":"2026100609083921200_cit91","doi-asserted-by":"publisher","first-page":"7673","DOI":"10.1039\/D4NR05298F","article-title":"Advanced disease therapeutics using\nengineered living drug delivery systems","volume":"17","author":"Mamidi","year":"2025","journal-title":"Nanoscale"},{"key":"2026100609083921200_cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome composition\nin drug delivery design, synthesis, characterization, and clinical\napplication","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Delivery Rev."},{"issue":"10","key":"2026100609083921200_cit93","doi-asserted-by":"publisher","first-page":"6360","DOI":"10.1021\/acs.nanolett.8b02720","article-title":"Self-Supplied Tumor Oxygenation through\nSeparated Liposomal Delivery of H2O2 and Catalase for Enhanced Radio-Immunotherapy\nof Cancer","volume":"18","author":"Song","year":"2018","journal-title":"Nano Lett."},{"key":"2026100609083921200_cit94","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11080788","article-title":"Supercritical\nFluids: An Innovative Strategy for Drug Development","volume":"11","author":"Liu","year":"2024","journal-title":"Bioengineering"},{"key":"2026100609083921200_cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115178","article-title":"Ultrasound-responsive\nmicrobubbles and nanodroplets:\na pathway to targeted drug delivery","volume":"206","author":"Shakya","year":"2024","journal-title":"Adv. Drug\nDelivery Rev."},{"issue":"1","key":"2026100609083921200_cit96","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s42254-018-0001-7","article-title":"Atomic force microscopy-based mechanobiology","volume":"1","author":"Krieg","year":"2019","journal-title":"Nat. Rev. Phys."},{"key":"2026100609083921200_cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2021.105482","article-title":"Tailoring the size of ultrasound\nresponsive lipid-shelled nanodroplets by varying production parameters\nand environmental conditions","volume":"73","author":"Ferri","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"2026100609083921200_cit98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113830","article-title":"Biomimetic liposomal\nnanovesicles remodel the tumor immune microenvironment\nto augment sono-immunotherapy","volume":"383","author":"Zhao","year":"2025","journal-title":"J. Controlled\nRelease"},{"key":"2026100609083921200_cit99","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jconrel.2016.02.021","article-title":"Sonoporation enhances\nliposome accumulation and penetration in tumors with low EPR","volume":"231","author":"Theek","year":"2016","journal-title":"J. Controlled Release"},{"key":"2026100609083921200_cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2026.119622","article-title":"Focused ultrasound-mediated\nnanocarrier delivery across the blood-brain barrier for neurodegenerative\ndiseases","volume":"201","author":"Jaberi","year":"2026","journal-title":"Biomed.. Pharmacother."},{"key":"2026100609083921200_cit101","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.addr.2014.01.008","article-title":"Ultrasound-mediated blood\u2013brain\nbarrier disruption\nfor targeted drug delivery in the central nervous system","volume":"72","author":"Aryal","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"issue":"4","key":"2026100609083921200_cit102","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1007\/s13346-021-00963-0","article-title":"Ultrasound-responsive\npolymer-based\ndrug delivery systems","volume":"11","author":"Wei","year":"2021","journal-title":"Drug Delivery Transl.\nRes."},{"issue":"43","key":"2026100609083921200_cit103","doi-asserted-by":"publisher","first-page":"11941","DOI":"10.1039\/D3SC04339H","article-title":"Polymeric materials\nfor ultrasound imaging and therapy","volume":"14","author":"Barmin","year":"2023","journal-title":"Chem. Sci."},{"key":"2026100609083921200_cit104","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.jconrel.2022.12.023","article-title":"Oxygen-generating polymer\nvesicles for enhanced sonodynamic tumor therapy","volume":"353","author":"Wei","year":"2023","journal-title":"J. Controlled Release"},{"issue":"8","key":"2026100609083921200_cit105","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.1021\/acs.biomac.3c01432","article-title":"Supramolecularly-Cross-Linked\nNanogel Assemblies for On-Demand, Ultrasound-Triggered Chemotherapy","volume":"25","author":"Campea","year":"2024","journal-title":"Biomacromolecules"},{"issue":"20","key":"2026100609083921200_cit106","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102001","article-title":"Tuning the Elasticity\nof Polymersomes\nfor Brain Tumor Targeting","volume":"8","author":"Zheng","year":"2021","journal-title":"Adv. Sci."},{"issue":"3","key":"2026100609083921200_cit107","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.504","article-title":"A tumor-targeting\nnano-adjuvant\nfor in situ vaccine based on ultrasound therapy","volume":"5","author":"Cui","year":"2024","journal-title":"Aggregate"},{"key":"2026100609083921200_cit108","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jconrel.2015.11.009","article-title":"Nanogels:\nAn overview\nof properties, biomedical applications and obstacles to clinical translation","volume":"240","author":"Soni","year":"2016","journal-title":"J. Controlled Release"},{"issue":"12","key":"2026100609083921200_cit109","doi-asserted-by":"publisher","first-page":"9472","DOI":"10.1039\/C8NJ00392K","article-title":"Redox\/ultrasound dual stimuli-responsive nanogel for precisely controllable\ndrug release","volume":"42","author":"Shen","year":"2018","journal-title":"New J. Chem."},{"issue":"9","key":"2026100609083921200_cit110","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/s44222-024-00203-3","article-title":"Nanoparticle delivery to tumours: from EPR and ATR\nmechanisms to clinical impact","volume":"2","author":"Dasgupta","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"issue":"22","key":"2026100609083921200_cit111","doi-asserted-by":"publisher","first-page":"13983","DOI":"10.1021\/acsnano.4c00182","article-title":"Mechanisms\nand barriers in nanomedicine: progress in the field and future directions","volume":"18","author":"Anchordoquy","year":"2024","journal-title":"ACS Nano"},{"issue":"9","key":"2026100609083921200_cit112","doi-asserted-by":"publisher","first-page":"14080","DOI":"10.1021\/acsnano.1c04510","article-title":"Specific endothelial cells govern nanoparticle entry\ninto solid tumors","volume":"15","author":"Kingston","year":"2021","journal-title":"ACS Nano"},{"key":"2026100609083921200_cit113","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103745","article-title":"Monitoring EPR effect\ndynamics during nanotaxane treatment with theranostic polymeric micelles","volume":"9","author":"Biancacci","year":"2022","journal-title":"Adv. Sci."},{"key":"2026100609083921200_cit114","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jconrel.2024.01.028","article-title":"Efficient ultrasound-mediated\ndrug delivery to orthotopic liver tumors \u2013 direct comparison\nof doxorubicin-loaded nanobubbles and microbubbles","volume":"367","author":"Nittayacharn","year":"2024","journal-title":"J. Controlled Release"},{"issue":"1","key":"2026100609083921200_cit115","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02217-8","article-title":"Bio-Barrier-adaptable biomimetic\nnanomedicines combined with ultrasound\nfor enhanced cancer therapy","volume":"10","author":"Guo","year":"2025","journal-title":"Signal Transduction\nTargeted Ther."},{"issue":"4","key":"2026100609083921200_cit116","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41567-025-02785-0","article-title":"Cyclic jetting enables\nmicrobubble-mediated drug delivery","volume":"21","author":"Cattaneo","year":"2025","journal-title":"Nat. Phys."},{"issue":"1","key":"2026100609083921200_cit117","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02428-z","article-title":"Drug transport\nkinetics of intravascular triggered drug delivery systems","volume":"4","author":"ten Hagen","year":"2021","journal-title":"Commun. Biol."},{"issue":"7","key":"2026100609083921200_cit118","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071314","article-title":"Ultrasound-responsive\nliposomes for targeted drug delivery combined with focused ultrasound","volume":"14","author":"Kim","year":"2022","journal-title":"Pharmaceutics"},{"key":"2026100609083921200_cit119","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114389","article-title":"Focused ultrasound-triggered\ndoxorubicin liposomes reshape tumor microenvironment to boost checkpoint\ndepletion in triple-negative breast cancer model","volume":"388","author":"Lee","year":"2025","journal-title":"J. Controlled Release"},{"issue":"1","key":"2026100609083921200_cit120","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-30612-2","article-title":"Effect of microbubble-assisted gemcitabine delivery\nwith repeated ultrasound exposure in a pancreatic cancer organ-on-a-chip\nmodel","volume":"15","author":"Kpeglo","year":"2025","journal-title":"Sci. Rep."},{"issue":"25","key":"2026100609083921200_cit121","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg5964","article-title":"An ultrasound-activatable\nplatinum prodrug for sono-sensitized\nchemotherapy","volume":"9","author":"Liu","year":"2023","journal-title":"Sci. Adv."},{"key":"2026100609083921200_cit122","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.actbio.2021.04.005","article-title":"Ultrasound-responsive nutlin-loaded nanoparticles for\ncombined chemotherapy and piezoelectric treatment of glioblastoma\ncells","volume":"139","author":"Pucci","year":"2022","journal-title":"Acta Biomater."},{"issue":"9","key":"2026100609083921200_cit123","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/s44222-024-00196-z","article-title":"Engineering photodynamics for treatment, priming and\nimaging","volume":"2","author":"Obaid","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"issue":"1","key":"2026100609083921200_cit124","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/biom12010081","article-title":"Recent advances\nin strategies for addressing hypoxia in tumor photodynamic therapy","volume":"12","author":"Hong","year":"2022","journal-title":"Biomolecules"},{"issue":"3","key":"2026100609083921200_cit125","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41551-022-00978-z","article-title":"Nanoparticles with Ultrasound-induced afterglow luminescence for\ntumour-specific theranostics","volume":"7","author":"Xu","year":"2023","journal-title":"Nat. Biomed. Eng."},{"issue":"7","key":"2026100609083921200_cit126","doi-asserted-by":"publisher","first-page":"11326","DOI":"10.1021\/acsnano.1c00616","article-title":"Ultrasmall\nbarium titanate nanoparticles for highly efficient hypoxic tumor therapy\nvia ultrasound triggered piezocatalysis and water splitting","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"2026100609083921200_cit127","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33474-8","article-title":"Near-infrared\nphosphorescent carbon\ndots for sonodynamic precision tumor therapy","volume":"13","author":"Geng","year":"2022","journal-title":"Nat. Commun."},{"key":"2026100609083921200_cit128","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2026.100348","article-title":"Sonophoto-activable\nartificial cupreous peroxidases\nfor controllable and redox-targeted ablation of primary and metastatic\ncancers","author":"Guo","year":"2026","journal-title":"Cell Biomater."},{"issue":"32","key":"2026100609083921200_cit129","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300348","article-title":"GSH-Activated Porphyrin\nSonosensitizer Prodrug for Fluorescence Imaging-Guided Cancer Sonodynamic\nTherapy","volume":"33","author":"Deng","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"2026100609083921200_cit130","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.fmre.2022.06.020","article-title":"Epigenetics disruptions enabled by porphyrin-derived\nmetal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor\nactions","volume":"5","author":"Zhang","year":"2025","journal-title":"Fundam. Res."},{"issue":"1","key":"2026100609083921200_cit131","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53488-8","article-title":"Zn\/Pt dual-site\nsingle-atom driven difunctional superimposition-augmented sonosensitizer\nfor sonodynamic therapy boosted ferroptosis of cancer","volume":"15","author":"Wen","year":"2024","journal-title":"Nat. Commun."},{"issue":"21","key":"2026100609083921200_cit132","doi-asserted-by":"publisher","first-page":"15534","DOI":"10.1021\/acsnano.6c04010","article-title":"Ultrasound-Triggered\nLocalized Surface Plasmon Resonance Enhances Electron Transfer for\nMelanoma Sonodynamic Therapy","volume":"20","author":"Huo","year":"2026","journal-title":"ACS Nano"},{"issue":"36","key":"2026100609083921200_cit133","doi-asserted-by":"publisher","first-page":"40535","DOI":"10.1021\/acsami.2c08951","article-title":"Collagenase-loaded\nH-TiO2 nanoparticles enhance ultrasound\nimaging-guided sonodynamic therapy in a pancreatic carcinoma xenograft\nmodel via digesting stromal barriers","volume":"14","author":"Luo","year":"2022","journal-title":"ACS Appl.\nMater. Interfaces"},{"key":"2026100609083921200_cit134","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01979-z","article-title":"CAFs targeted\nultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit\nmelanoma growth via glutamine metabolic reprogramming and tumor microenvironment\nremodeling","volume":"21","author":"Ai","year":"2023","journal-title":"J. Nanobiotechnol."},{"issue":"30","key":"2026100609083921200_cit135","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315394","article-title":"Targeting Vascular Destruction by Sonosensitizer-Free\nSonocatalytic Nanomissiles Instigates Thrombus Aggregation and Nutrition\nDeprivation to Starve Pancreatic Cancer","volume":"34","author":"He","year":"2024","journal-title":"Adv.\nFunct. Mater."},{"issue":"1","key":"2026100609083921200_cit136","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7","article-title":"Nanosensitizer-mediated\naugmentation of sonodynamic therapy efficacy\nand antitumor immunity","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"2026100609083921200_cit137","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.7150\/thno.65516","article-title":"Engineered\nextracellular vesicle-based sonotheranostics for dual stimuli-sensitive\ndrug release and photoacoustic imaging-guided chemo-sonodynamic cancer\ntherapy","volume":"12","author":"Nguyen Cao","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"2026100609083921200_cit138","doi-asserted-by":"publisher","first-page":"59","DOI":"10.7150\/thno.64862","article-title":"A hydrogen peroxide economizer for on-demand\noxygen production-assisted robust sonodynamic immunotherapy","volume":"12","author":"Jiang","year":"2022","journal-title":"Theranostics"},{"issue":"9","key":"2026100609083921200_cit139","doi-asserted-by":"publisher","first-page":"8000","DOI":"10.1021\/acsnano.6c00143","article-title":"High-Entropy\nOxide-Phosphomolybdic Acid Ultrathin Nanoleaves with Lattice Strain\nand Periodic Heterostructures for Enhanced Synthetic Catalytic\/Sonodynamic\/Immune\nTherapy","volume":"20","author":"Wang","year":"2026","journal-title":"ACS Nano"},{"issue":"17","key":"2026100609083921200_cit140","doi-asserted-by":"publisher","first-page":"8587","DOI":"10.7150\/thno.62572","article-title":"Mitochondria-targeted\nand ultrasound-responsive nanoparticles for oxygen and nitric oxide\ncodelivery to reverse immunosuppression and enhance sonodynamic therapy\nfor immune activation","volume":"11","author":"Ji","year":"2021","journal-title":"Theranostics"},{"issue":"11","key":"2026100609083921200_cit141","doi-asserted-by":"publisher","first-page":"15904","DOI":"10.1021\/acsnano.0c07287","article-title":"High intensity focused\nultrasound-responsive and ultrastable cerasomal perfluorocarbon nanodroplets\nfor alleviating tumor multidrug resistance and epithelial\u2013mesenchymal\ntransition","volume":"14","author":"Ma","year":"2020","journal-title":"ACS Nano"},{"issue":"1","key":"2026100609083921200_cit142","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1021\/acsnano.5c16697","article-title":"A Sonosensitizing Nanoshuttle\nfor Synergistic Hypoxia Relief and\nImmune Activation To Strengthen Sonodynamic Immunotherapy Against\nTriple-Negative Breast Cancer","volume":"20","author":"Zhang","year":"2026","journal-title":"ACS Nano"},{"issue":"45","key":"2026100609083921200_cit143","doi-asserted-by":"publisher","first-page":"39228","DOI":"10.1021\/acsnano.5c12847","article-title":"A Tumor Microenvironment-Responsive\nSelf-Oxygenating Nanoplatform for Dual-Enhanced Cuproptosis and Sonodynamic\nSynergistic Immunotherapy","volume":"19","author":"Tang","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"2026100609083921200_cit144","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01253-8","article-title":"In-situ TiO2-x decoration of titanium carbide MXene for\nphoto\/sono-responsive\nantitumor theranostics","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026100609083921200_cit145","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7","article-title":"Nanosensitizer-mediated\naugmentation of sonodynamic therapy efficacy\nand antitumor immunity","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"2026100609083921200_cit146","doi-asserted-by":"publisher","first-page":"7774","DOI":"10.1021\/acsnano.1c01830","article-title":"Ultrasmall Alloy Nanozyme for Ultrasound-\nand Near-Infrared\nLight-Promoted Tumor Ablation","volume":"15","author":"Jana","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"2026100609083921200_cit147","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01287-y","article-title":"Biomimetic\nnanoprobe-augmented triple therapy with\nphotothermal, sonodynamic and checkpoint blockade inhibits tumor growth\nand metastasis","volume":"20","author":"Lin","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026100609083921200_cit148","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02688-x","article-title":"Endogenous and exogeneous\nstimuli-triggered\nreactive oxygen species evoke long-lived carbon monoxide to fight\nagainst lung cancer","volume":"22","author":"Fang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"2026100609083921200_cit149","doi-asserted-by":"publisher","DOI":"10.1186\/2050-5736-2-17","article-title":"First noninvasive\nthermal ablation of a brain tumor with MR-guided focused ultrasound","volume":"2","author":"Coluccia","year":"2014","journal-title":"J. Ther. Ultrasound"},{"key":"2026100609083921200_cit150","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.actbio.2025.01.061","article-title":"Perfluorohexane\nnanodroplet-assisted mechanical high intensity focused ultrasound\ncavitation: a strategy for hepatocellular carcinoma treatment","volume":"195","author":"Yang","year":"2025","journal-title":"Acta Biomater."},{"issue":"26","key":"2026100609083921200_cit151","doi-asserted-by":"publisher","first-page":"37562","DOI":"10.1021\/acsami.5c05638","article-title":"The role of acoustic parameters in\ndroplet vaporization of perfluoropentane nanodroplets for In Vivo applications","volume":"17","author":"Eom","year":"2025","journal-title":"ACS Appl. Mater.\nInterfaces"},{"issue":"1","key":"2026100609083921200_cit152","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01087-w","article-title":"Neutrophil-mediated\nclinical nanodrug for treatment of residual tumor after focused ultrasound\nablation","volume":"19","author":"Shen","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"15","key":"2026100609083921200_cit153","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305546","article-title":"High intensity focused ultrasound-driven nanomotor\nfor effective\nferroptosis-immunotherapy of TNBC","volume":"11","author":"Yu","year":"2024","journal-title":"Adv. Sci."},{"issue":"5","key":"2026100609083921200_cit154","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/cac2.12539","article-title":"Immunologic tumor microenvironment\nmodulators for turning cold tumors hot","volume":"44","author":"Khosravi","year":"2024","journal-title":"Cancer\nCommun."},{"issue":"1","key":"2026100609083921200_cit155","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02355-z","article-title":"Ultrasound-enhanced Pt-coordinated\npolymer immunopotentiators and heterogenic fusion membrane-based multifunctional\ntumor vaccine nanoplatforms for melanoma treatment","volume":"10","author":"Guo","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"issue":"4","key":"2026100609083921200_cit156","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1158\/2326-6066.CIR-20-0586","article-title":"Hallmarks of Resistance\nto Immune-Checkpoint Inhibitors","volume":"10","author":"Karasarides","year":"2022","journal-title":"Cancer Immunol.\nRes."},{"issue":"6","key":"2026100609083921200_cit157","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1038\/s41591-023-02345-0","article-title":"Intratumoral dendritic\ncell\u2013CD4+ T helper cell niches enable CD8+ T cell differentiation\nfollowing PD-1 blockade in hepatocellular carcinoma","volume":"29","author":"Magen","year":"2023","journal-title":"Nat. Med."},{"issue":"32","key":"2026100609083921200_cit158","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203106","article-title":"Intraparticle Double-Scattering-Decoded\nSonogenetics for Augmenting Immune Checkpoint Blockade and CAR-T Therapy","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci."},{"issue":"3","key":"2026100609083921200_cit159","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202512230","article-title":"Multichannel Immune\nNanoregulators Suppress Lactic Acid Metabolism and Lactic Acid-Shaped\nAcidic Microenvironment to Uproot Anti-Tumor Immunosuppression","volume":"38","author":"Fang","year":"2026","journal-title":"Adv. Mater."},{"issue":"5","key":"2026100609083921200_cit160","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1021\/acs.nanolett.0c04778","article-title":"Ultrasound-augmented mitochondrial\ncalcium ion overload by calcium nanomodulator to induce immunogenic\ncell death","volume":"21","author":"Zheng","year":"2021","journal-title":"Nano Lett."},{"issue":"29","key":"2026100609083921200_cit161","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507388","article-title":"Ultrasound-responsive\nlipid nanosonosensitizers with\nsize reduction and NO release: synergistic sonodynamic-chemo-immunotherapy\nfor pancreatic tumors","volume":"64","author":"Fang","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"issue":"7","key":"2026100609083921200_cit162","doi-asserted-by":"publisher","first-page":"10979","DOI":"10.1021\/acsnano.2c03395","article-title":"Immunosonodynamic\nTherapy Designed with Activatable Sonosensitizer and Immune Stimulant\nImiquimod","volume":"16","author":"Lei","year":"2022","journal-title":"ACS Nano"},{"issue":"30","key":"2026100609083921200_cit163","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300854","article-title":"Sono-Driven STING Activation\nusing Semiconducting Polymeric Nanoagonists\nfor Precision Sono-Immunotherapy of Head and Neck Squamous Cell Carcinoma","volume":"35","author":"Jiang","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"2026100609083921200_cit164","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01453-2","article-title":"Enhancement of antitumor\nimmunotherapy using mitochondria-targeted cancer cell membrane-biomimetic\nMOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy","volume":"20","author":"Luo","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"2026100609083921200_cit165","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006226","article-title":"Novel combination strategy of high intensity focused\nultrasound (HIFU) and checkpoint blockade boosted by bioinspired and\noxygen-supplied nanoprobe for multimodal imaging-guided cancer therapy","volume":"11","author":"Tang","year":"2023","journal-title":"J. ImmunoTher. Cancer"},{"issue":"1","key":"2026100609083921200_cit166","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53392-1","article-title":"Ultrasound-triggered\nand glycosylation inhibition-enhanced tumor\npiezocatalytic immunotherapy","volume":"15","author":"Pu","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"2026100609083921200_cit167","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41568-019-0205-x","article-title":"The blood\u2013brain\nbarrier and blood\u2013tumour barrier in brain tumours and metastases","volume":"20","author":"Arvanitis","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"2026100609083921200_cit168","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031711","article-title":"Delivering Therapeutics to Glioblastoma:\nOvercoming\nBiological Constraints","volume":"23","author":"Mathew","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"2026100609083921200_cit169","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11910-024-01338-x","article-title":"Strategies\nto Improve Drug Delivery Across the Blood\u2013Brain Barrier for\nGlioblastoma","volume":"24","author":"Narsinh","year":"2024","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"2026100609083921200_cit170","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jconrel.2019.10.044","article-title":"An advanced focused\nultrasound protocol improves the blood-brain\nbarrier permeability and doxorubicin delivery into the rat brain","volume":"315","author":"Jung","year":"2019","journal-title":"J. Controlled Release"},{"key":"2026100609083921200_cit171","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114539","article-title":"Ultrasound-mediated\nblood-brain barrier opening: an effective drug delivery system for\ntheranostics of brain diseases","volume":"190","author":"Wang","year":"2022","journal-title":"Adv. Drug Delivery\nRev."},{"issue":"1","key":"2026100609083921200_cit172","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010015","article-title":"Focused Ultrasound\nand Microbubbles-Mediated Drug Delivery to Brain Tumor","volume":"13","author":"Wu","year":"2021","journal-title":"Pharmaceutics"},{"key":"2026100609083921200_cit173","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.jconrel.2024.07.006","article-title":"The road\nahead to successful BBB\nopening and drug-delivery with focused ultrasound","volume":"372","author":"Lo\u0301pez-Aguirre","year":"2024","journal-title":"J. Controlled Release"},{"issue":"48","key":"2026100609083921200_cit174","doi-asserted-by":"publisher","first-page":"E10281","DOI":"10.1073\/pnas.1713328114","article-title":"Closed-loop control of targeted ultrasound\ndrug delivery across the blood-brain\/tumor barriers in a rat glioma\nmodel","volume":"114","author":"Sun","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"2026100609083921200_cit175","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75253-9","article-title":"Investigating the optimum\nsize of\nnanoparticles for their delivery into the brain assisted by focused\nultrasound-induced blood\u2013brain barrier opening","volume":"10","author":"Ohta","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"2026100609083921200_cit176","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11060-024-04795-z","article-title":"Focused\nultrasound-mediated enhancement of blood\u2013brain barrier permeability\nfor brain tumor treatment: a systematic review of clinical trials","volume":"170","author":"Zhu","year":"2024","journal-title":"J. Neurooncol."},{"issue":"5","key":"2026100609083921200_cit177","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S1470-2045(23)00112-2","article-title":"Repeated\nblood\u2013brain\nbarrier opening with an implantable ultrasound device for delivery\nof albumin-bound paclitaxel in patients with recurrent glioblastoma:\na phase 1 trial","volume":"24","author":"Sonabend","year":"2023","journal-title":"Lancet Oncol."},{"issue":"1","key":"2026100609083921200_cit178","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48326-w","article-title":"Ultrasound-mediated\ndelivery of doxorubicin to the brain results in immune modulation\nand improved responses to PD-1 blockade in gliomas","volume":"15","author":"Arrieta","year":"2024","journal-title":"Nat. Commun."},{"key":"2026100609083921200_cit179","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114018","article-title":"Low-frequency\nultrasound-mediated blood-brain barrier opening enables non-invasive\nlipid nanoparticle RNA delivery to glioblastoma","volume":"385","author":"Elbaz","year":"2025","journal-title":"J. Controlled Release"},{"issue":"4","key":"2026100609083921200_cit180","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/s41578-021-00394-w","article-title":"Drug delivery\nto the central nervous system","volume":"7","author":"Nance","year":"2022","journal-title":"Nat. Rev. Mater."},{"key":"2026100609083921200_cit181","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.addr.2019.11.009","article-title":"The blood-brain\nbarrier: physiology and strategies for drug delivery","volume":"165-166","author":"Pandit","year":"2020","journal-title":"Adv. Drug Delivery Rev."},{"key":"2026100609083921200_cit182","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115323","article-title":"Recent advances of focused ultrasound induced blood-brain barrier\nopening for clinical applications of neurodegenerative diseases","volume":"209","author":"Zhao","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"issue":"11","key":"2026100609083921200_cit183","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.7150\/thno.94206","article-title":"Transcranial blood-brain barrier opening in\nalzheimer\u2019s disease patients using a portable focused ultrasound\nsystem with real-time 2-D cavitation mapping","volume":"14","author":"Bae","year":"2024","journal-title":"Theranostics"},{"issue":"3","key":"2026100609083921200_cit184","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00352","article-title":"Current clinical\ninvestigations of focused ultrasound blood-brain barrier disruption:\na review","volume":"21","author":"Durham","year":"2024","journal-title":"Neurotherapeutics"},{"issue":"16","key":"2026100609083921200_cit185","doi-asserted-by":"publisher","first-page":"6826","DOI":"10.7150\/thno.72685","article-title":"A sporadic Alzheimer\u2019s\nblood-brain barrier model for developing ultrasound-mediated delivery\nof Aducanumab and anti-Tau antibodies","volume":"12","author":"Wasielewska","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"2026100609083921200_cit186","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-02412-1","article-title":"Aducanumab delivery\nvia focused ultrasound-induced\ntransient blood\u2013brain barrier opening in vivo","volume":"15","author":"Jeong","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"2026100609083921200_cit187","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00809-4","article-title":"A comparative\nstudy of the effects of aducanumab and scanning ultrasound on amyloid\nplaques and behavior in the APP23 mouse model of alzheimer disease","volume":"13","author":"Leinenga","year":"2021","journal-title":"Alzheimers Res. Ther."},{"issue":"18","key":"2026100609083921200_cit188","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.7150\/thno.28717","article-title":"Unilateral Focused Ultrasound-Induced\nBlood-Brain Barrier\nOpening Reduces Phosphorylated Tau from The rTg4510 Mouse Model","volume":"9","author":"Karakatsani","year":"2019","journal-title":"Theranostics"},{"key":"2026100609083921200_cit189","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.jconrel.2025.01.056","article-title":"Effects of blood-brain barrier opening\nusing ultrasound\non tauopathies: a systematic review","volume":"379","author":"Ge\u0301raudie","year":"2025","journal-title":"J. Controlled\nRelease"},{"issue":"1","key":"2026100609083921200_cit190","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-024-04005-9","article-title":"Focused ultrasound on the substantia nigra\nenables safe neurotensin-polyplex nanoparticle-mediated gene delivery\nto dopaminergic neurons intranasally and by blood circulation","volume":"19","author":"Mascotte-Cruz","year":"2024","journal-title":"Discovery Nano"},{"issue":"1","key":"2026100609083921200_cit191","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1080\/10717544.2022.2035855","article-title":"Microbubble drug conjugate\nand focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3","volume":"29","author":"Trinh","year":"2022","journal-title":"Drug Delivery"},{"key":"2026100609083921200_cit192","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jconrel.2024.11.074","article-title":"Lipid\nnanoparticles\nand transcranial focused ultrasound enhance the delivery of SOD1 antisense\noligonucleotides to the murine brain for ALS therapy","volume":"378","author":"Ediriweera","year":"2025","journal-title":"J. Controlled Release"},{"key":"2026100609083921200_cit193","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jconrel.2021.12.005","article-title":"Liposome delivery to the brain with\nrapid short-pulses of focused ultrasound and microbubbles","volume":"341","author":"Morse","year":"2022","journal-title":"J. Controlled Release"},{"issue":"9","key":"2026100609083921200_cit194","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.7150\/thno.52436","article-title":"Ultrasound-mediated\naugmented exosome release from astrocytes alleviates amyloid-\u03b2-induced\nneurotoxicity","volume":"11","author":"Deng","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"2026100609083921200_cit195","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2025.103015","article-title":"Low intensity\nultrasound-facilitated exosome delivery\npromotes hippocampal neurogenesis in alzheimer\u2019s disease","volume":"19","author":"Yan","year":"2026","journal-title":"Brain Stimulat."},{"issue":"1","key":"2026100609083921200_cit196","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46461-y","article-title":"Nanobubble-actuated\nultrasound neuromodulation for selectively shaping\nbehavior in mice","volume":"15","author":"Hou","year":"2024","journal-title":"Nat. Commun."},{"issue":"27","key":"2026100609083921200_cit197","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501765","article-title":"Accurate\nneurotransmitter release by ultrasound-responsive nanomaterials for\nalleviating L-DOPA-induced dyskinesia in parkinson\u2019s disease","volume":"14","author":"Jia","year":"2025","journal-title":"Adv. Healthcare Mater."},{"issue":"1","key":"2026100609083921200_cit198","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02406-7","article-title":"Neuromodulation by nanozymes and ultrasound during\nalzheimer\u2019s disease management","volume":"22","author":"Karthika","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"8","key":"2026100609083921200_cit199","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.7150\/thno.125686","article-title":"Sono-piezoelectric cues\nregulate neuroinflammatory reflex-arc-mediated \u03b17nAChR-P2RX7\naxis to dampen osteoarthritis-correlated pain with osteoarthritis\nattenuation","volume":"16","author":"Zhong","year":"2026","journal-title":"Theranostics"},{"key":"2026100609083921200_cit200","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115274","article-title":"Translating ultrasound-mediated\ndrug\ndelivery technologies for CNS applications","volume":"208","author":"Perolina","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"issue":"1","key":"2026100609083921200_cit201","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Sig Transduct Target Ther"},{"issue":"1","key":"2026100609083921200_cit202","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after\nspinal cord injury:\na review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"2026100609083921200_cit203","doi-asserted-by":"publisher","DOI":"10.1016\/j.bas.2025.104298","article-title":"Potential applications of focused\nultrasound for spinal cord diseases: a narrative review of preclinical\nstudies","volume":"5","author":"Nguyen","year":"2025","journal-title":"Brain Spine"},{"issue":"6","key":"2026100609083921200_cit204","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.ultrasmedbio.2020.01.002","article-title":"Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery","volume":"46","author":"Kooiman","year":"2020","journal-title":"Ultrasound Med. Biol."},{"issue":"12","key":"2026100609083921200_cit205","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.4103\/1673-5374.221162","article-title":"Magnetic resonance imaging-guided\nfocused ultrasound\nto increase localized blood-spinal cord barrier permeability","volume":"12","author":"Payne","year":"2017","journal-title":"Neural Regener. Res."},{"issue":"193","key":"2026100609083921200_cit206","doi-asserted-by":"publisher","DOI":"10.3791\/65113","article-title":"Disruption of the blood-spinal cord barrier\nusing low-intensity focused\nultrasound in a rat model","author":"Bhimreddy","year":"2023","journal-title":"J. Vis. Exp."},{"issue":"7","key":"2026100609083921200_cit207","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.ultrasmedbio.2021.03.007","article-title":"Focused\nultrasound-induced blood\u2013spinal cord barrier opening using\nshort-burst phase-keying exposures in rats: a parameter study","volume":"47","author":"Fletcher","year":"2021","journal-title":"Ultrasound Med. Biol."},{"issue":"17","key":"2026100609083921200_cit208","doi-asserted-by":"publisher","first-page":"7758","DOI":"10.7150\/thno.46821","article-title":"A porcine\nmodel of transvertebral ultrasound and microbubble-mediated blood-spinal\ncord barrier opening","volume":"10","author":"Fletcher","year":"2020","journal-title":"Theranostics"},{"key":"2026100609083921200_cit209","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83874-x","article-title":"Characterization\nof ultrasound-mediated delivery of\ntrastuzumab to normal and pathologic spinal cord tissue","volume":"11","author":"Smith","year":"2021","journal-title":"Sci. Rep."},{"key":"2026100609083921200_cit210","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.2147\/IJN.S128848","article-title":"Nerve growth factor delivery by ultrasound-mediated\nnanobubble destruction\nas a treatment for acute spinal cord injury in rats","volume":"12","author":"Song","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"2026100609083921200_cit211","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.bbrc.2018.01.123","article-title":"Noninvasive, targeted gene therapy\nfor acute spinal cord injury using LIFU-mediated BDNF-loaded cationic\nnanobubble destruction","volume":"496","author":"Song","year":"2018","journal-title":"Biochem. Biophys. Res.\nCommun."},{"key":"2026100609083921200_cit212","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.bioactmat.2025.07.050","article-title":"Spatiotemporal-controlled ultrasound-driven Li-PDA@ZnO\nnanoparticles promote neural stem cell differentiation synergy with\nbiohydrogel repair spinal cord injury","volume":"55","author":"Zhang","year":"2026","journal-title":"Bioact.\nMater."},{"issue":"11","key":"2026100609083921200_cit213","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.7150\/thno.108329","article-title":"Biomimetic piezoelectric hydrogel system for energy metabolism reprogramming\nin spinal cord injury repair","volume":"15","author":"Shi","year":"2025","journal-title":"Theranostics"},{"issue":"3","key":"2026100609083921200_cit214","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s44222-024-00257-3","article-title":"Imaging-guided precision hyperthermia\nwith magnetic nanoparticles","volume":"3","author":"Shakeri-Zadeh","year":"2025","journal-title":"Nat. Rev. Bioeng."},{"issue":"1","key":"2026100609083921200_cit215","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94188-3","article-title":"Safety evaluation of\na clinical focused ultrasound system for neuronavigation guided blood-brain\nbarrier opening in non-human primates","volume":"11","author":"Pouliopoulos","year":"2021","journal-title":"Sci.\nRep."},{"issue":"1","key":"2026100609083921200_cit216","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1073\/pnas.1614777114","article-title":"Disrupting the blood\u2013brain\nbarrier by focused\nultrasound induces sterile inflammation","volume":"114","author":"Kovacs","year":"2017","journal-title":"Proc.\nNatl. Acad. Sci. U.S.A."},{"issue":"1","key":"2026100609083921200_cit217","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-019-0166-x","article-title":"Therapeutic\nefficacy of nanoparticles and routes of administration","volume":"23","author":"Chenthamara","year":"2019","journal-title":"Biomater. Res."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c12207","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/39\/26442\/68564088\/acsnano.6c12207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/39\/26442\/68564088\/acsnano.6c12207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:50:08Z","timestamp":1791294608000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/39\/26442\/5433288\/Overcoming-Biological-Barriers-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":217,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,19]]},"published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c12207","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]}}}