{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:04:37Z","timestamp":1791295477803,"version":"4.1.0"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YJ202555"],"award-info":[{"award-number":["YJ202555"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22205175"],"award-info":[{"award-number":["22205175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275129"],"award-info":[{"award-number":["22275129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2267052254"],"award-info":[{"award-number":["2267052254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The intrinsic spatiotemporal discord between augmenting tumor radiosensitivity and safeguarding normal tissue has persistently circumscribed the therapeutic horizon of radiotherapy. Here, we introduce a microenvironment-adaptive platform, cross-linked lipoic acid nanoadjuvant (cLAN), designed to strategically navigate this dilemma. Upon cellular internalization, cLAN dissociates into the lipoic acid (LA)\/dihydrolipoic acid (DHLA) redox pair, which elicits distinct biological responses in normal vs tumor cells. In irradiated normal cells, the LA\/DHLA system primarily scavenges radiation-induced reactive oxygen species (ROS), thereby conferring radioprotection. In tumor cells, the relatively high reducing environment shifts the LA\/DHLA equilibrium toward the reduced DHLA state, which further promotes Fenton reactions and aggravates oxidative stress. Together with the suppression of NF-\u03baB-mediated DNA damage repair, these effects ultimately potentiate tumor radiosensitivity. Under total body irradiation, cLAN efficiently mitigates radiation-induced damage, particularly preserving marrow DNA content and maintaining nucleated cell counts at normal levels, far surpassing clinical standard radioprotector amifostine. Meanwhile, cLAN elicits tumor radiosensitization comparable to clinical standard radiosensitizer sodium glycididazole. Such compatibility of efficacy-safety achieves 100% 30-day survival in both subcutaneous and orthotopic mouse tumor models. This study demonstrates the potential of this microenvironment-adaptive strategy for radiotherapy by simultaneously achieving radioprotection and radiosensitization within the same spatiotemporal domain.<\/jats:p>","DOI":"10.1021\/acsnano.6c13287","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:02:25Z","timestamp":1789977745000},"page":"26806-26821","source":"Crossref","is-referenced-by-count":0,"title":["A Microenvironment-Adaptive\nNanoadjuvant Resolves\nthe Radioprotection and Radiosensitization Paradox in Cancer Therapy"],"prefix":"10.1021","volume":"20","author":[{"given":"Hao","family":"Guo","sequence":"first","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Shao","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-3015","authenticated-orcid":true,"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-6610","authenticated-orcid":true,"given":"Yangyang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-358X","authenticated-orcid":true,"given":"Shiyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, China, 610064"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"2026100609083654200_cit1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0140-6736(21)00233-6","article-title":"Contemporary radiotherapy:\npresent and future","volume":"398","author":"Chandra","year":"2021","journal-title":"Lancet"},{"key":"2026100609083654200_cit2","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1038\/s43018-023-00619-7","article-title":"Harnessing\nprogress in radiotherapy for global cancer control","volume":"4","author":"Jaffray","year":"2023","journal-title":"Nat. Cancer"},{"key":"2026100609083654200_cit3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41571-022-00709-y","article-title":"Predicting tumour\nradiosensitivity\nto deliver precision radiotherapy","volume":"20","author":"Price","year":"2023","journal-title":"Nat. Rev.\nClin. Oncol."},{"key":"2026100609083654200_cit4","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.trecan.2022.05.005","article-title":"Radiotherapy-induced metabolic hallmarks in the tumor\nmicroenvironment","volume":"8","author":"Mittal","year":"2022","journal-title":"Trends Cancer"},{"key":"2026100609083654200_cit5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12943-023-01801-2","article-title":"Molecular mechanisms\nof tumor resistance to radiotherapy","volume":"22","author":"Wu","year":"2023","journal-title":"Mol. Cancer"},{"key":"2026100609083654200_cit6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-019-0064-5","article-title":"Radiotherapy toxicity","volume":"5","author":"De Ruysscher","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2026100609083654200_cit7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/S0140-6736(24)02319-5","article-title":"Radiotherapy\ntoxicities: mechanisms,\nmanagement, and future directions","volume":"405","author":"Verginadis","year":"2025","journal-title":"Lancet"},{"key":"2026100609083654200_cit8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nrd4003","article-title":"Strategies\nfor optimizing the response\nof cancer and normal tissues to radiation","volume":"12","author":"Moding","year":"2013","journal-title":"Nat.\nRev. Drug Discovery"},{"key":"2026100609083654200_cit9","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.3390\/ijms23062981","article-title":"Combined treatment\nwith cryptocaryone and ultraviolet C promotes antiproliferation and\napoptosis of oral cancer cells","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol.\nSci."},{"key":"2026100609083654200_cit10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ctrv.2009.12.001","article-title":"Combined treatment\nwith cytoprotective agents and radiotherapy","volume":"36","author":"Winczura","year":"2010","journal-title":"Cancer Treat Rev."},{"key":"2026100609083654200_cit11","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.1200\/JCO.2007.11.5816","article-title":"Pharmacologic\napproaches to radiation protection","volume":"25","author":"Brizel","year":"2007","journal-title":"J. Clin.\nOncol."},{"key":"2026100609083654200_cit12","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1021\/acs.molpharmaceut.3c00600","article-title":"Advances of amifostine in radiation protection: administration and\ndelivery","volume":"20","author":"Ji","year":"2023","journal-title":"Mol. Pharmaceutics"},{"key":"2026100609083654200_cit13","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/S0140-6736(03)14361-9","article-title":"Five compared\nwith six\nfractions per week of conventional radiotherapy of squamous-cell carcinoma\nof head and neck: DAHANCA 6&7 randomised controlled trial","volume":"362","author":"Overgaard","year":"2003","journal-title":"The Lancet"},{"key":"2026100609083654200_cit14","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.3892\/ol.2015.3039","article-title":"Sodium glycididazole\nenhances the\nefficacy of combined iodine-125 seed implantation and chemotherapy\nin patients with non small-cell lung cancer","volume":"9","author":"Zhang","year":"2015","journal-title":"Oncol Lett."},{"key":"2026100609083654200_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311291","article-title":"Octadecyl gallate and\nlipid-modified MnSe2 nanoparticles\nenhance radiosensitivity in esophageal squamous cell carcinoma and\npromote radioprotection in normal tissues","volume":"36","author":"Li","year":"2024","journal-title":"Adv.\nMater."},{"key":"2026100609083654200_cit16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bioactmat.2021.05.015","article-title":"Complete ablation of\ntumors using synchronous chemoradiation with bimetallic theranostic\nnanoparticles","volume":"7","author":"Nosrati","year":"2022","journal-title":"Bioact. Mater."},{"key":"2026100609083654200_cit17","doi-asserted-by":"publisher","first-page":"157554","DOI":"10.1016\/j.cej.2024.157554","article-title":"Emerging nanoradiosensitizers and\nnanoradioprotectants for enhanced cancer theranostics","volume":"501","author":"Zhao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026100609083654200_cit18","doi-asserted-by":"publisher","first-page":"102339","DOI":"10.1016\/j.nantod.2024.102339","article-title":"Fullerenol-mediated\nvascular regeneration and radioprotection:\na strategy for tissue recovery post-radiation","volume":"57","author":"Guo","year":"2024","journal-title":"Nano Today"},{"key":"2026100609083654200_cit19","doi-asserted-by":"publisher","first-page":"158959","DOI":"10.1016\/j.cej.2024.158959","article-title":"A ferroptosis-targeting\ndetachable dissolvable microneedle as a combined therapeutic strategy\nfor radiation-induced oral mucositis","volume":"505","author":"Xiao","year":"2025","journal-title":"Chem.\nEng. J."},{"key":"2026100609083654200_cit20","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303459","article-title":"Natural antioxidant-based\nnanodrug for atherosclerosis treatment","volume":"19","author":"Lu","year":"2023","journal-title":"Small"},{"key":"2026100609083654200_cit21","doi-asserted-by":"publisher","first-page":"111609","DOI":"10.1016\/j.cclet.2025.111609","article-title":"Chain architecture-engineered\nartesunate nanoassemblies\ntarget LONP1 to induce oxidative damage for enhanced anti-tumor therapy","volume":"37","author":"Wang","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"2026100609083654200_cit22","doi-asserted-by":"publisher","first-page":"10288","DOI":"10.1021\/acsnano.4c01625","article-title":"Reactive oxygen species amplifier for apoptosis-ferroptosis mediated\nhigh-efficiency radiosensitization of tumors","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"2026100609083654200_cit23","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s41587-024-02448-0","article-title":"Gold-siRNA supraclusters enhance the anti-tumor immune\nresponse of stereotactic ablative radiotherapy at primary and metastatic\ntumors","volume":"43","author":"Jiang","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"2026100609083654200_cit24","doi-asserted-by":"publisher","first-page":"111261","DOI":"10.1016\/j.cclet.2025.111261","article-title":"ROS-neutralizing surface\nengineering protects immunotoxicity of organic\nnanoscintillator-directed radiodynamic therapy","volume":"36","author":"Li","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"2026100609083654200_cit25","doi-asserted-by":"publisher","first-page":"109632","DOI":"10.1016\/j.cclet.2024.109632","article-title":"Macrophages-mediated\ntumor accumulation and deep penetration of bismuth\/manganese biomineralized\nnanoparticles for enhanced radiotherapy","volume":"35","author":"Liu","year":"2024","journal-title":"Chin.\nChem. Lett."},{"key":"2026100609083654200_cit26","doi-asserted-by":"publisher","first-page":"1804046","DOI":"10.1002\/adma.201804046","article-title":"X-ray-controlled generation\nof peroxynitrite based on nanosized LiLuF4: Ce3+ scintillators and their applications for radiosensitization","volume":"30","author":"Du","year":"2018","journal-title":"Adv. Mater."},{"key":"2026100609083654200_cit27","doi-asserted-by":"publisher","first-page":"101819","DOI":"10.1016\/j.nantod.2023.101819","article-title":"Reversing\nlung cancer\nradioresistance by hyperpermeable tellurium nanotherapeutics via remodeling\ntumor microenvironment","volume":"50","author":"Zhao","year":"2023","journal-title":"Nano Today"},{"key":"2026100609083654200_cit28","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jconrel.2024.08.035","article-title":"Harnessing transcription factor-driven ROS\nfor synergistic\nmultimodal lung cancer treatment","volume":"374","author":"Zhou","year":"2024","journal-title":"J. Controlled\nRelease"},{"key":"2026100609083654200_cit29","doi-asserted-by":"publisher","first-page":"6013","DOI":"10.1039\/D0CS00718H","article-title":"Engineering nanomedicine\nfor glutathione depletion-augmented cancer therapy","volume":"50","author":"Xiong","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"2026100609083654200_cit30","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.tips.2017.06.001","article-title":"Targeting the thioredoxin\nsystem for cancer therapy","volume":"38","author":"Zhang","year":"2017","journal-title":"Trends Pharmacol.\nSci."},{"key":"2026100609083654200_cit31","doi-asserted-by":"publisher","first-page":"8567","DOI":"10.1021\/jacs.4c00395","article-title":"Nanodrug hijacking blood transferrin\nfor ferroptosis-mediated cancer treatment","volume":"146","author":"Zhang","year":"2024","journal-title":"J.\nAm. Chem. Soc."},{"key":"2026100609083654200_cit32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.mehy.2005.07.020","article-title":"Pro-oxidant\nactions of \u03b1-lipoic acid and dihydrolipoic acid","volume":"66","author":"C\u0327akatay","year":"2006","journal-title":"Med. Hypotheses"},{"key":"2026100609083654200_cit33","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41392-021-00648-7","article-title":"DNA damage repair: historical perspectives,\nmechanistic\npathways and clinical translation for targeted cancer therapy","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"2026100609083654200_cit34","doi-asserted-by":"publisher","first-page":"10407","DOI":"10.1021\/acsnano.3c01102","article-title":"Bioengineered\nbacteriophage-like nanoparticles as RNAi therapeutics to enhance radiotherapy\nagainst glioblastomas","volume":"17","author":"Pang","year":"2023","journal-title":"ACS Nano"},{"key":"2026100609083654200_cit35","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.ccell.2023.04.019","article-title":"YTHDF2 inhibition potentiates\nradiotherapy antitumor efficacy","volume":"41","author":"Wang","year":"2023","journal-title":"Cancer Cell"},{"key":"2026100609083654200_cit36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1080\/10715760500312305","article-title":"\u03b1-lipoic acid\nand N-acetyl cysteine\nprevent zinc deficiency-induced activation of NF-\u03baB and AP-1\ntranscription factors in human neuroblastoma IMR-32 cells","volume":"40","author":"MacKenzie","year":"2006","journal-title":"Free Radical Res."},{"key":"2026100609083654200_cit37","doi-asserted-by":"publisher","first-page":"172938","DOI":"10.1016\/j.ejphar.2020.172938","article-title":"\u03b1-Lipoic\nacid prevents the ionizing radiation-induced epithelial-mesenchymal\ntransition and enhances the radiosensitivity in breast cancer cells","volume":"871","author":"Tripathy","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"2026100609083654200_cit38","doi-asserted-by":"publisher","first-page":"1806567","DOI":"10.1002\/adfm.201806567","article-title":"Biogenic (R)-(+)-lipoic acid only constructed cross-linked vesicles\nwith synergistic anticancer potency","volume":"29","author":"Liao","year":"2019","journal-title":"Adv. Funct.\nMater."},{"key":"2026100609083654200_cit39","doi-asserted-by":"publisher","first-page":"2001566","DOI":"10.1002\/adma.202001566","article-title":"Epitaxially strained CeO2\/Mn3O4 nanocrystals as an enhanced antioxidant for\nradioprotection","volume":"32","author":"Han","year":"2020","journal-title":"Adv. Mater."},{"key":"2026100609083654200_cit40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bioactmat.2024.05.017","article-title":"A DNA tetrahedron-based nanosuit for efficient delivery\nof amifostine and multi-organ radioprotection","volume":"39","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"key":"2026100609083654200_cit41","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1038\/s41467-023-40794-w","article-title":"A ferroptosis-targeting\nceria anchored halloysite as orally drug\ndelivery system for radiation colitis therapy","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"2026100609083654200_cit42","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/nm1061","article-title":"Anti-obesity\neffects of \u03b1-lipoic acid mediated\nby suppression of hypothalamic AMP-activated protein kinase","volume":"10","author":"Kim","year":"2004","journal-title":"Nat. Med."},{"key":"2026100609083654200_cit43","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/antiox13101228","article-title":"Alpha-lipoic acid: biological mechanisms and health benefits","volume":"13","author":"Superti","year":"2024","journal-title":"Antioxidants"},{"key":"2026100609083654200_cit44","doi-asserted-by":"publisher","first-page":"216554","DOI":"10.1016\/j.ccr.2025.216554","article-title":"GSH-responsive nanomedicine\nfor disease smart imaging and therapy","volume":"533","author":"Fu","year":"2025","journal-title":"Coord.\nChem. Rev."},{"key":"2026100609083654200_cit45","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-responsive\nnanocarriers for\ndrug delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"2026100609083654200_cit46","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1021\/acsnano.5c21831","article-title":"A redox-responsive\nselenium-containing nanomedicine\nenables dual antioxidant system inhibition to overcome platinum resistance\nand enhance immunotherapy in bladder cancer","volume":"20","author":"Gao","year":"2026","journal-title":"ACS Nano"},{"key":"2026100609083654200_cit47","doi-asserted-by":"publisher","first-page":"22675","DOI":"10.1021\/jacs.4c07312","article-title":"Carbon-spaced tandem-disulfide bond bridge design addresses limitations\nof homodimer prodrug nanoassemblies: enhancing both stability and\nactivatability","volume":"146","author":"Zhang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"2026100609083654200_cit48","doi-asserted-by":"publisher","first-page":"2504621","DOI":"10.1002\/adfm.202504621","article-title":"Four-pronged nanomotor\nstrategy achieves efficient\nTNBC treatment via synergistic chemo-photothermal-immune therapy","volume":"35","author":"Chen","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"2026100609083654200_cit49","doi-asserted-by":"publisher","first-page":"123730","DOI":"10.1016\/j.biomaterials.2025.123730","article-title":"Dual-responsive\nnanoparticle system for enhanced blood-brain\nbarrier crossing and glioblastoma penetration","volume":"327","author":"Zheng","year":"2026","journal-title":"Biomaterials"},{"key":"2026100609083654200_cit50","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jconrel.2021.02.030","article-title":"Recent advances\nof redox-responsive nanoplatforms for tumor theranostics","volume":"332","author":"Chen","year":"2021","journal-title":"J. Controlled Release"},{"key":"2026100609083654200_cit51","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s12951-024-02859-w","article-title":"Redox-manipulating nanocarriers for\nanticancer drug delivery: a systematic\nreview","volume":"22","author":"Meng","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"2026100609083654200_cit52","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.7150\/thno.38069","article-title":"Stimuli-responsive\nnanocarriers for drug delivery, tumor imaging, therapy and theranostics","volume":"10","author":"Mi","year":"2020","journal-title":"Theranostics"},{"key":"2026100609083654200_cit53","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s12672-026-04456-9","article-title":"Glutathione responsive nanomedicine leverages tumor\nredox imbalance for targeted cancer theranostics","volume":"17","author":"El Sadda","year":"2026","journal-title":"Discover Oncol."},{"key":"2026100609083654200_cit54","doi-asserted-by":"publisher","first-page":"2203630","DOI":"10.1002\/advs.202203630","article-title":"Poly(thioctic\nacid): from bottom-up self-assembly to 3D-fused deposition modeling\nprinting","volume":"9","author":"Cai","year":"2022","journal-title":"Adv. Sci."},{"key":"2026100609083654200_cit55","doi-asserted-by":"publisher","first-page":"148816","DOI":"10.1016\/j.cej.2024.148816","article-title":"Cationic ring-opening polymerization of natural thioctic\nacid to chemically recyclable and self-healable poly(thioctic acid)\nsupramolecular material","volume":"482","author":"Zhang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"2026100609083654200_cit56","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.redox.2018.02.012","article-title":"A robust\nand versatile mass spectrometry platform\nfor comprehensive assessment of the thiol redox metabolome","volume":"16","author":"Sutton","year":"2018","journal-title":"Redox Biol."},{"key":"2026100609083654200_cit57","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0378-4347(97)00488-X","article-title":"Determination of lipoic acid by precolumn\nderivatization\nwith monobromobimane and reversed-phase high-performance liquid chromatography","volume":"705","author":"Witt","year":"1998","journal-title":"J. Chromatogr. B"},{"key":"2026100609083654200_cit58","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.cmet.2019.02.003","article-title":"Improving drug discovery\nby nucleic acid delivery in engineered human microlivers","volume":"29","author":"Mancio-Silva","year":"2019","journal-title":"Cell Metab."},{"key":"2026100609083654200_cit59","doi-asserted-by":"publisher","first-page":"11449","DOI":"10.1021\/jacs.1c03303","article-title":"Highly stable silica-coated\nbismuth nanoparticles deliver tumor microenvironment-responsive prodrugs\nto enhance tumor-specific photoradiotherapy","volume":"143","author":"Xiang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"2026100609083654200_cit60","doi-asserted-by":"publisher","first-page":"1701268","DOI":"10.1002\/adma.201701268","article-title":"Poly(Vinylpyrollidone)-\nand selenocysteine-modified Bi2Se3 nanoparticles\nenhance radiotherapy efficacy in tumors and promote radioprotection\nin normal tissues","volume":"29","author":"Du","year":"2017","journal-title":"Adv. Mater."},{"key":"2026100609083654200_cit61","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.scib.2018.05.008","article-title":"Enhanced catalysis\nof ultrasmall Au-MoS2 clusters against reactive oxygen\nspecies for radiation protection","volume":"63","author":"Bian","year":"2018","journal-title":"Sci. Bull."}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c13287","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/39\/26806\/68570159\/acsnano.6c13287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/39\/26806\/68570159\/acsnano.6c13287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:50:05Z","timestamp":1791294605000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/39\/26806\/5433671\/A-Microenvironment-Adaptive-Nanoadjuvant-Resolves"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":61,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,21]]},"published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c13287","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]}}}