{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:46:52Z","timestamp":1792784812444,"version":"4.5.0"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2022836"],"award-info":[{"award-number":["BE2022836"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0709200"],"award-info":[{"award-number":["2019YFA0709200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF1200700"],"award-info":[{"award-number":["2021YFF1200700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YB3813001"],"award-info":[{"award-number":["2023YB3813001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["202200325"],"award-info":[{"award-number":["202200325"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2026300425"],"award-info":[{"award-number":["2026300425"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374071"],"award-info":[{"award-number":["22374071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2512074"],"award-info":[{"award-number":["W2512074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011400","name":"State Key Laboratory of Analytical Chemistry for Life Science","doi-asserted-by":"publisher","award":["5431ZZXM2306"],"award-info":[{"award-number":["5431ZZXM2306"]}],"id":[{"id":"10.13039\/501100011400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011400","name":"State Key Laboratory of Analytical Chemistry for Life Science","doi-asserted-by":"publisher","award":["5431ZZXM2501"],"award-info":[{"award-number":["5431ZZXM2501"]}],"id":[{"id":"10.13039\/501100011400","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yachen Foundation of Nanjing University","id":[{"id":"https:\/\/ror.org\/01rxvg760","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The lack of vascular and neural innervations in cartilage often results in poor drug delivery and penetration, compromising the efficacy of current therapeutics. To tackle this clinical challenge, we designed positively charged manganese-doped CeO2 nanozymes that combine reactive oxygen species (ROS)-scavenging activity with prolonged retention in the joint cavity by taking advantage of the negatively charged cartilage matrix. Integrating coarse-grained molecular dynamics simulations with experimental validation, we identified chondroitin sulfate as the key glycosaminoglycan responsible for mediating the retention of these positively charged nanozymes in the joint cavity. After intra-articular administration, manganese-doped CeO2 promoted cartilage defect repair and subchondral bone remodeling in a rat model within 4 weeks. In addition, benefiting from the multiple enzyme mimicking activity of nanozymes, the peroxidase-like activity of manganese-doped CeO2 was explored to develop a pathological assay to detect the state of cartilage repair. This study establishes an integrated framework combining theoretical modeling with experimental validation to elucidate intra-articular retention mechanisms. The framework enables the rational design of theranostic nanozymes that exploit disease-specific pathological features for both diagnosis and therapy.<\/jats:p>","DOI":"10.1021\/acsnano.6c15540","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:01:35Z","timestamp":1789380095000},"page":"25841-25858","source":"Crossref","is-referenced-by-count":0,"title":["A Theranostic Nanozyme\nfor Osteoarthritis Treatment\nand Glycosaminoglycan-Targeted Diagnosis of Cartilage Pathology"],"prefix":"10.1021","volume":"20","author":[{"given":"Dongze","family":"Mo","sequence":"first","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9663-512X","authenticated-orcid":true,"given":"Yanbing","family":"Wen","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]},{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3613-2774","authenticated-orcid":true,"given":"Qi","family":"Sun","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7174-7736","authenticated-orcid":true,"given":"Hanjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0882-623X","authenticated-orcid":true,"given":"Xueying","family":"An","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanling","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5594-9390","authenticated-orcid":true,"given":"Xiaomiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210008"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-7506","authenticated-orcid":true,"given":"Hao","family":"Dong","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]},{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-7142","authenticated-orcid":true,"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]},{"name":"Nanjing University , , , ,","place":["Nanjing, Jiangsu, China, 210023"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"2026092210071732800_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2025.11.005","article-title":"Global prevalence, incidence, and years lived with disability (YLDs)\nof osteoarthritis: trends from 1990 to 2021 and projections to 2050","volume":"56","author":"Chen","year":"2026","journal-title":"J. Orthop. Transl."},{"key":"2026092210071732800_cit2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c998","article-title":"Treating articular cartilage injuries of the knee in\nyoung people","volume":"340","author":"Macmull","year":"2010","journal-title":"BMJ"},{"key":"2026092210071732800_cit3","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/s41584-021-00673-4","article-title":"Early-stage\nsymptomatic osteoarthritis of the knee \u2500 time for action","volume":"17","author":"Mahmoudian","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026092210071732800_cit4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen\nspecies, aging and\narticular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radical\nBiol. Med."},{"key":"2026092210071732800_cit5","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and\nknee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"J. Am. Med. Assoc."},{"key":"2026092210071732800_cit6","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41584-019-0278-7","article-title":"Rethinking\narticular cartilage regeneration\nbased on a 250-year-old statement","volume":"15","author":"Malda","year":"2019","journal-title":"Nat. Rev.\nRheumatol."},{"key":"2026092210071732800_cit7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41584-018-0123-4","article-title":"Intra-articular treatment options for knee osteoarthritis","volume":"15","author":"Jones","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026092210071732800_cit8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh9751","article-title":"Chondrocyte membrane\u2013coated\nnanoparticles promote drug retention and halt cartilage damage in\nrat and canine osteoarthritis","volume":"16","author":"Deng","year":"2024","journal-title":"Sci. Transl.\nMed."},{"key":"2026092210071732800_cit9","doi-asserted-by":"publisher","first-page":"4622","DOI":"10.1002\/jps.21346","article-title":"Intra-articular depot formulation\nprinciples: role in the management of postoperative pain and arthritic\ndisorders","volume":"97","author":"Larsen","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"2026092210071732800_cit10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.jsb.2003.08.006","article-title":"Individual\ncartilage aggrecan macromolecules and their constituent\nglycosaminoglycans visualized via atomic force microscopy","volume":"143","author":"Ng","year":"2003","journal-title":"J. Struct. Biol."},{"key":"2026092210071732800_cit11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular\ntherapy","volume":"10","author":"Evans","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026092210071732800_cit12","first-page":"971","article-title":"Musculoskeletal\ninjections: a review\nof the evidence","volume":"78","author":"Stephens","year":"2008","journal-title":"Am. Fam. Phys."},{"key":"2026092210071732800_cit13","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adl5623","article-title":"A cationic polymer drives glycosaminoglycan\nassembly and secretion for preclinical osteoarthritis therapy","volume":"17","author":"Chen","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"2026092210071732800_cit14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.actbio.2021.01.003","article-title":"Recent developments\nin natural and synthetic polymeric drug delivery systems used for\nthe treatment of osteoarthritis","volume":"123","author":"Rahimi","year":"2021","journal-title":"Acta Biomater."},{"key":"2026092210071732800_cit15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat8800","article-title":"Cartilage-penetrating nanocarriers\nimprove delivery\nand efficacy of growth factor treatment of osteoarthritis","volume":"10","author":"Geiger","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"2026092210071732800_cit16","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202107678","article-title":"Charge-guided\nmicro\/nano-hydrogel microsphere for penetrating cartilage matrix","volume":"31","author":"Lin","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"2026092210071732800_cit17","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6449","article-title":"Injectable hydrogel microspheres with self-renewable\nhydration layers\nalleviate osteoarthritis","volume":"8","author":"Lei","year":"2022","journal-title":"Sci. Adv."},{"key":"2026092210071732800_cit18","doi-asserted-by":"publisher","first-page":"6060","DOI":"10.1039\/c3cs35486e","article-title":"Nanomaterials with enzyme-like characteristics (nanozymes): next-generation\nartificial enzymes","volume":"42","author":"Wei","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"2026092210071732800_cit19","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1039\/C8CS00457A","article-title":"Nanomaterials\nwith enzyme-like characteristics\n(nanozymes): next-generation artificial enzymes (II)","volume":"48","author":"Wu","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"2026092210071732800_cit20","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.trac.2018.05.012","article-title":"Nanozyme: An emerging\nalternative to natural enzyme for biosensing and immunoassay","volume":"105","author":"Wang","year":"2018","journal-title":"TrAC, Trends Anal. Chem."},{"key":"2026092210071732800_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101269","article-title":"Nanozymes: a clear\ndefinition with fuzzy edges","volume":"40","author":"Wei","year":"2021","journal-title":"Nano Today"},{"key":"2026092210071732800_cit22","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1021\/acs.accounts.9b00140","article-title":"Nanozymes: from new\nconcepts, mechanisms, and standards to applications","volume":"52","author":"Liang","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"2026092210071732800_cit23","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412211","article-title":"Nanozymes and their potential roles in the origin of life","volume":"37","author":"Ma","year":"2025","journal-title":"Adv. Mater."},{"key":"2026092210071732800_cit24","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/s44222-024-00205-1","article-title":"Designing\nnanozymes for in vivo applications","volume":"2","author":"Zhang","year":"2024","journal-title":"Nat. Rev.\nBioeng."},{"key":"2026092210071732800_cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34248-y","article-title":"Small molecule-assisted assembly of multifunctional ceria nanozymes\nfor synergistic treatment of atherosclerosis","volume":"13","author":"Fu","year":"2022","journal-title":"Nat. Commun."},{"key":"2026092210071732800_cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40794-w","article-title":"A ferroptosis-targeting\nceria anchored halloysite as orally drug\ndelivery system for radiation colitis therapy","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"2026092210071732800_cit27","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/s41563-024-02041-5","article-title":"Inhalable nanocatalytic\ntherapeutics for viral pneumonia","volume":"24","author":"Peng","year":"2025","journal-title":"Nat. Mater."},{"key":"2026092210071732800_cit28","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1021\/acs.analchem.1c05300","article-title":"Two-Dimensional Cobalt-Doped Ti3C2 MXene Nanozyme-Mediated\nHomogeneous Electrochemical Strategy for Pesticides Assay Based on\nIn Situ Generation of Electroactive Substances","volume":"94","author":"Yu","year":"2022","journal-title":"Anal. Chem."},{"key":"2026092210071732800_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114841","article-title":"CeO2@NC\nnanozyme with robust dephosphorylation ability of phosphotriester:\nA simple colorimetric assay for rapid and selective detection of paraoxon","volume":"220","author":"Gai","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"2026092210071732800_cit30","doi-asserted-by":"publisher","first-page":"11399","DOI":"10.1002\/anie.201704904","article-title":"Ceria\u2013zirconia nanoparticles\nas an enhanced multi-antioxidant for sepsis treatment","volume":"56","author":"Soh","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026092210071732800_cit31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1126\/science.87.2245.18.b","article-title":"The essentialness of manganese for the normal development\nof bone","volume":"87","author":"Gallup","year":"1938","journal-title":"Science"},{"key":"2026092210071732800_cit32","doi-asserted-by":"publisher","first-page":"23245","DOI":"10.1021\/acsami.2c05110","article-title":"Modulation of 3D printed calcium-deficient apatite\nconstructs with varying Mn concentrations for osteochondral regeneration\nvia endochondral differentiation","volume":"14","author":"Kamaraj","year":"2022","journal-title":"ACS Appl.\nMater. Interfaces"},{"key":"2026092210071732800_cit33","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1079\/NRR19920013","article-title":"Trace element nutrition and bone metabolism","volume":"5","author":"Beattie","year":"1992","journal-title":"Nutr. Res. Rev."},{"key":"2026092210071732800_cit34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1021\/bk-1987-0354.ch005","article-title":"Role of Manganese\nin Bone Metabolism","volume-title":"Nutritional bioavailability\nof manganese","author":"Strause","year":"1987"},{"key":"2026092210071732800_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2020.107937","article-title":"Calcium silicate scaffolds\npromoting bone regeneration via the doping\nof Mg2+ or Mn2+ ion","volume":"190","author":"Du","year":"2020","journal-title":"Composites,\nPart B"},{"key":"2026092210071732800_cit36","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0092-8674(02)00935-2","article-title":"Global conformational\nrearrangements in integrin extracellular domains in outside-in and\ninside-out signaling","volume":"110","author":"Takagi","year":"2002","journal-title":"Cell"},{"key":"2026092210071732800_cit37","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1432-1033.1985.tb08862.x","article-title":"Two N-acetylgalactosaminyltransferase\nare involved in the biosynthesis of chondroitin sulfate","volume":"148","author":"Rohrmann","year":"1985","journal-title":"Eur. J. Biochem."},{"key":"2026092210071732800_cit38","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9446","article-title":"Mesoporous MnCeOx solid\nsolutions for low temperature and selective oxidation\nof hydrocarbons","volume":"6","author":"Zhang","year":"2015","journal-title":"Nat. Commun."},{"key":"2026092210071732800_cit39","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.saa.2012.07.038","article-title":"EPR and photoluminescence\nproperties of Mn2+ doped CdS nanoparticles synthesized\nvia co-precipitation method","volume":"96","author":"Gupta","year":"2012","journal-title":"Spectrochim. Acta,\nPart A"},{"key":"2026092210071732800_cit40","doi-asserted-by":"publisher","first-page":"43460","DOI":"10.1039\/C4RA07450E","article-title":"Structural\nevaluation and catalytic performance of nano-Au supported on nanocrystalline\nCe0.9Fe0.1O2\u2212\u03b4 solid\nsolution for oxidation of carbon monoxide and benzylamine","volume":"4","author":"Sudarsanam","year":"2014","journal-title":"RSC Adv."},{"key":"2026092210071732800_cit41","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.jallcom.2016.08.183","article-title":"Template-free\ncontrolled hydrothermal synthesis for monodisperse flowerlike porous\nCeO2 microspheres and their superior catalytic reduction\nof NO with NH3","volume":"690","author":"Gong","year":"2017","journal-title":"J. Alloys Compd."},{"key":"2026092210071732800_cit42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jallcom.2017.11.023","article-title":"Structural,\noptical and magnetic properties of CeO2 nanowires with\nnonmagnetic Mg2+ doping","volume":"734","author":"Ma","year":"2018","journal-title":"J. Alloys\nCompd."},{"key":"2026092210071732800_cit43","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.spmi.2018.07.033","article-title":"Structural, optical and mechanical\nproperties of sol-gel synthesized Mn-doped CeO2","volume":"122","author":"Tiwari","year":"2018","journal-title":"Superlattices Microstruct."},{"key":"2026092210071732800_cit44","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01771-z","article-title":"Metal ions and nanometallic\nmaterials in antitumor immunity: function,\napplication, and perspective","volume":"21","author":"Shen","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"2026092210071732800_cit45","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","article-title":"The role of reactive\noxygen species\nin homeostasis and degradation of cartilage","volume":"11","author":"Henrotin","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"2026092210071732800_cit46","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages:\nmechanism and\nfunctions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"2026092210071732800_cit47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-19560-5_1","article-title":"Pathogenesis of\nOsteoarthritis","volume-title":"Osteoarthritis: Pathogenesis,\nDiagnosis, Available Treatments, Drug Safety, Regenerative and Precision\nMedicine","author":"Kapoor","year":"2015"},{"key":"2026092210071732800_cit48","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.joca.2007.02.022","article-title":"Chondrocyte\nmoves: clever strategies?","volume":"15","author":"Morales","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"2026092210071732800_cit49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41584-018-0151-0","article-title":"Cell migration:\nimplications for\nrepair and regeneration in joint disease","volume":"15","author":"Qu","year":"2019","journal-title":"Nat.\nRev. Rheumatol."},{"key":"2026092210071732800_cit50","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.joca.2005.10.009","article-title":"NF-\u03baBp65-specific\nsiRNA inhibits\nexpression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1\u03b2-induced\nand TNF-\u03b1-induced chondrocytes","volume":"14","author":"Lianxu","year":"2006","journal-title":"Osteoarthr.\nCartil."},{"key":"2026092210071732800_cit51","doi-asserted-by":"publisher","first-page":"30488","DOI":"10.1073\/pnas.2017056117","article-title":"FoxO1 is\na crucial mediator of TGF-\u03b2\/TAK1 signaling and protects against\nosteoarthritis by maintaining articular cartilage homeostasis","volume":"117","author":"Wang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026092210071732800_cit52","doi-asserted-by":"publisher","DOI":"10.1186\/ar630","article-title":"Aggrecanases\nand cartilage matrix degradation","volume":"5","author":"Nagase","year":"2003","journal-title":"Arthritis\nRes. Ther."},{"key":"2026092210071732800_cit53","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1016\/j.joca.2015.06.014","article-title":"SOX9 is a regulator\nof ADAMTSs-induced cartilage degeneration at the early stage of human\nosteoarthritis","volume":"23","author":"Zhang","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"2026092210071732800_cit54","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.jconrel.2022.11.018","article-title":"Applications\nand prospects of intra-articular drug\ndelivery system in arthritis therapeutics","volume":"352","author":"Song","year":"2022","journal-title":"J.\nControlled Release"},{"key":"2026092210071732800_cit55","doi-asserted-by":"publisher","DOI":"10.1186\/ar380","article-title":"Articular\ncartilage and changes in arthritis: collagen of articular cartilage","volume":"4","author":"Eyre","year":"2002","journal-title":"Arthritis Res. Ther."},{"key":"2026092210071732800_cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-022-06695-y","article-title":"Chondrogenic\npotential of manganese-loaded composite scaffold combined with chondrocytes\nfor articular cartilage defect","volume":"33","author":"Wei","year":"2022","journal-title":"J. Mater. Sci.:\nMater. Med."},{"key":"2026092210071732800_cit57","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41584-025-01236-7","article-title":"Restoring articular cartilage: insights\nfrom structure, composition and development","volume":"21","author":"Pueyo Moliner","year":"2025","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026092210071732800_cit58","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1016\/j.joca.2007.05.005","article-title":"International\nCartilage Repair Society (ICRS) and Oswestry macroscopic cartilage\nevaluation scores validated for use in Autologous Chondrocyte Implantation\n(ACI) and microfracture","volume":"15","author":"van den Borne","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"2026092210071732800_cit59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-1-4557-5969-9.00001-2","article-title":"1-General Anatomy and Physiology of Joints","volume-title":"Joint disease in the horse","author":"van Weeren","year":"2016","edition":"2"},{"key":"2026092210071732800_cit60","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2014.2371","article-title":"Histochemistry as a unique approach\nfor investigating normal and osteoarthritic cartilage","volume":"58","author":"Musumeci","year":"2014","journal-title":"Eur. J. Histochem."},{"key":"2026092210071732800_cit61","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1016\/j.joca.2010.05.029","article-title":"The\nOARSI histopathology initiative \u2013 recommendations for histological\nassessments of osteoarthritis in the rabbit","volume":"18","author":"Laverty","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"2026092210071732800_cit62","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2106\/00004623-200300002-00007","article-title":"Histological\nassessment of cartilage\nrepair: a report by the histology endpoint committee of the International\nCartilage Repair Society (ICRS)","volume":"85","author":"Mainil-Varlet","year":"2003","journal-title":"J. Bone Joint\nSurg."},{"key":"2026092210071732800_cit63","doi-asserted-by":"publisher","first-page":"S118","DOI":"10.1097\/01.blo.0000144855.48640.b9","article-title":"Collagens\nand cartilage matrix homeostasis","volume":"427","author":"Eyre","year":"2004","journal-title":"Clin. Orthop.\nRelat. Res."},{"key":"2026092210071732800_cit64","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1038\/nnano.2012.235","article-title":"Magnetoferritin nanoparticles\nfor targeting and visualizing tumour tissues","volume":"7","author":"Fan","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"2026092210071732800_cit65","doi-asserted-by":"publisher","first-page":"19175","DOI":"10.1021\/acsnano.1c03375","article-title":"Tantalum\noxide nanoparticles for the quantitative contrast-enhanced computed\ntomography of ex vivo human cartilage: assessment of biochemical composition\nand biomechanics","volume":"15","author":"Lawson","year":"2021","journal-title":"ACS Nano"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.6c15540","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/37\/25841\/68497208\/acsnano.6c15540.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/ancac3\/article-pdf\/20\/37\/25841\/68497208\/acsnano.6c15540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:32:50Z","timestamp":1790087570000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/ancac3\/article\/20\/37\/25841\/5429231\/A-Theranostic-Nanozyme-for-Osteoarthritis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":65,"journal-issue":{"issue":"37","published-online":{"date-parts":[[2026,9,14]]},"published-print":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1021\/acsnano.6c15540","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}